1u1w - Revision history

OCA at 06:36, 23 August 2023

2023-08-23T06:36:44Z

←Older revision		Revision as of 06:36, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1u1w' size='340' side='right'caption='[[1u1w]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='1u1w' size='340' side='right'caption='[[1u1w]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u1w]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus~~ fluorescens ~~liquefaciens" flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1U1W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u1w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U1W FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=3HA:3~~-~~HYDROXYANTHRANILIC+ACID'>3HA</scene>~~, ~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3HA:3-HYDROXYANTHRANILIC+ACID'>3HA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [https://pdbe.org/1u1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [https://www.ebi.ac.uk/pdbsum/1u1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1w ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [~~http~~://pdbe.org/1u1w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u1w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1w ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PHZF_PSEFL PHZF_PSEFL]] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known.<ref>PMID:19053436</ref> <ref>PMID:15545603</ref>	+	[https://www.uniprot.org/uniprot/PHZF_PSEFL PHZF_PSEFL] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known.<ref>PMID:19053436</ref> <ref>PMID:15545603</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bayer, P]]	+	[[Category: Pseudomonas fluorescens]]
-	[[Category: Blankenfeldt, W]]	+	[[Category: Bayer P]]
-	[[Category: Janning, P]]	+	[[Category: Blankenfeldt W]]
-	[[Category: Korniyenko, Y]]	+	[[Category: Janning P]]
-	[[Category: Kuzin~~, A P~~]]	+	[[Category: Korniyenko Y]]
-	[[Category: Mavrodi~~, D V~~]]	+	[[Category: Kuzin AP]]
-	[[Category: Skarina, T]]	+	[[Category: Mavrodi DV]]
-	[[Category: Thomashow~~, L S~~]]	+	[[Category: Skarina T]]
-	[[Category: Tong, L]]	+	[[Category: Thomashow LS]]
-	~~[[Category: Acid/base catalysis]]~~	+	[[Category: Tong L]]
-	~~[[Category: Closed form]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Phenazine biosynthesis~~]]	+

OCA at 07:18, 30 December 2020

2020-12-30T07:18:57Z

←Older revision		Revision as of 07:18, 30 December 2020
Line 1:		Line 1:

	==Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79==		==Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79==
-	<StructureSection load='1u1w' size='340' side='right' caption='[[1u1w]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='1u1w' size='340' side='right'caption='[[1u1w]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U1W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U1W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HA:3-HYDROXYANTHRANILIC+ACID'>3HA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3HA:3-HYDROXYANTHRANILIC+ACID'>3HA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [http://pdbe.org/1u1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [http://www.ebi.ac.uk/pdbsum/1u1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [http://pdbe.org/1u1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [http://www.ebi.ac.uk/pdbsum/1u1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]		[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
		+	[[Category: Large Structures]]
	[[Category: Bayer, P]]		[[Category: Bayer, P]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]

OCA at 08:50, 21 March 2018

2018-03-21T08:50:17Z

←Older revision		Revision as of 08:50, 21 March 2018
Line 1:		Line 1:
		+
	==Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79==		==Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79==
	<StructureSection load='1u1w' size='340' side='right' caption='[[1u1w]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='1u1w' size='340' side='right' caption='[[1u1w]], [[Resolution\|resolution]] 1.35Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [http://pdbe.org/1u1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [http://www.ebi.ac.uk/pdbsum/1u1w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [http://pdbe.org/1u1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [http://www.ebi.ac.uk/pdbsum/1u1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u1/1u1w_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u1/1u1w_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:23, 10 February 2016

2016-02-10T03:23:01Z

←Older revision		Revision as of 03:23, 10 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u1w ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:53, 11 September 2015

2015-09-11T04:53:25Z

←Older revision		Revision as of 04:53, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [http://www.ebi.ac.uk/pdbsum/1u1w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [http://pdbe.org/1u1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [http://www.ebi.ac.uk/pdbsum/1u1w PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u1w" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:27, 25 December 2014

2014-12-25T11:27:23Z

←Older revision		Revision as of 11:27, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U1W FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U1W FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HA:3-HYDROXYANTHRANILIC+ACID'>3HA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HA:3-HYDROXYANTHRANILIC+ACID'>3HA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [http://www.ebi.ac.uk/pdbsum/1u1w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [http://www.ebi.ac.uk/pdbsum/1u1w PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PHZF_PSEFL PHZF_PSEFL]] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known.<ref>PMID:19053436</ref> <ref>PMID:15545603</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]		[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
-	[[Category: Bayer, P.]]	+	[[Category: Bayer, P]]
-	[[Category: Blankenfeldt, W.]]	+	[[Category: Blankenfeldt, W]]
-	[[Category: Janning, P.]]	+	[[Category: Janning, P]]
-	[[Category: Korniyenko, Y.]]	+	[[Category: Korniyenko, Y]]
-	[[Category: Kuzin, A P.]]	+	[[Category: Kuzin, A P]]
-	[[Category: Mavrodi, D V.]]	+	[[Category: Mavrodi, D V]]
-	[[Category: Skarina, T.]]	+	[[Category: Skarina, T]]
-	[[Category: Thomashow, L S.]]	+	[[Category: Thomashow, L S]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
	[[Category: Acid/base catalysis]]		[[Category: Acid/base catalysis]]
	[[Category: Closed form]]		[[Category: Closed form]]

OCA at 08:36, 3 October 2014

2014-10-03T08:36:09Z

←Older revision		Revision as of 08:36, 3 October 2014
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-	~~{{STRUCTURE_1u1w\| PDB=1u1w \| SCENE= }}~~	+	==Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79==
-	===Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79===	+	<StructureSection load='1u1w' size='340' side='right' caption='[[1u1w]], [[Resolution\|resolution]] 1.35Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15545603}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U1W FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HA:3-HYDROXYANTHRANILIC+ACID'>3HA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bwz\|1bwz]], [[1sdj\|1sdj]], [[1s7j\|1s7j]], [[1u1v\|1u1v]], [[1u1x\|1u1x]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u1w RCSB], [http://www.ebi.ac.uk/pdbsum/1u1w PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u1/1u1w_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phenazines produced by Pseudomonas and Streptomyces spp. are heterocyclic nitrogen-containing metabolites with antibiotic, antitumor, and antiparasitic activity. The antibiotic properties of pyocyanin, produced by Pseudomonas aeruginosa, were recognized in the 1890s, although this blue phenazine is now known to be a virulence factor in human disease. Despite their biological significance, the biosynthesis of phenazines is not fully understood. Here we present structural and functional studies of PhzF, an enzyme essential for phenazine synthesis in Pseudomonas spp. PhzF shares topology with diaminopimelate epimerase DapF but lacks the same catalytic residues. The structure of PhzF in complex with its substrate, trans-2,3-dihydro-3-hydroxyanthranilic acid, suggests that it is an isomerase using the conserved glutamate E45 to abstract a proton from C3 of the substrate. The proton is returned to C1 of the substrate after rearrangement of the double-bond system, yielding an enol that converts to the corresponding ketone. PhzF is a dimer that may be bifunctional, providing a shielded cavity for ketone dimerization via double Schiff-base formation to produce the phenazine scaffold. Our proposed mechanism is supported by mass and NMR spectroscopy. The results are discussed in the context of related structures and protein sequences of unknown biochemical function.

-	~~==Function==~~	+	Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens.,Blankenfeldt W, Kuzin AP, Skarina T, Korniyenko Y, Tong L, Bayer P, Janning P, Thomashow LS, Mavrodi DV Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16431-6. Epub 2004 Nov 15. PMID:15545603<ref>PMID:15545603</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/PHZF_PSEFL PHZF_PSEFL]] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid~~ (~~DHHA~~) ~~into the phenazine ring system~~. ~~The final product is not yet known~~.~~<ref>~~PMID:~~19053436</ref>~~ <ref>PMID:15545603</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1u1w]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:015545603</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]		[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
	[[Category: Bayer, P.]]		[[Category: Bayer, P.]]

OCA at 07:42, 16 April 2014

2014-04-16T07:42:30Z

←Older revision		Revision as of 07:42, 16 April 2014
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-	[[Image:1u1w.png\|left\|200px]]
-
	{{STRUCTURE_1u1w\| PDB=1u1w \| SCENE= }}		{{STRUCTURE_1u1w\| PDB=1u1w \| SCENE= }}
-
	===Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79===		===Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79===
		+	{{ABSTRACT_PUBMED_15545603}}

-	~~{{ABSTRACT_PUBMED_15545603}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PHZF_PSEFL PHZF_PSEFL]] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known.<ref>PMID:19053436</ref> <ref>PMID:15545603</ref>

	==About this Structure==		==About this Structure==
-	[[1u1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_fluorescens Pseudomonas~~ fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA].	+	[[1u1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015545603</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015545603</ref><references group="xtra"/><references/>
-	[[Category: ~~Pseudomonas~~ fluorescens]]	+	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
	[[Category: Bayer, P.]]		[[Category: Bayer, P.]]
	[[Category: Blankenfeldt, W.]]		[[Category: Blankenfeldt, W.]]

OCA: Protected "1u1w" [edit=sysop:move=sysop]

2013-01-05T11:21:44Z

Protected "1u1w" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:21, 5 January 2013

OCA at 11:21, 5 January 2013

2013-01-05T11:21:40Z

←Older revision		Revision as of 11:21, 5 January 2013
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-	{{Seed}}
	[[Image:1u1w.png\|left\|200px]]		[[Image:1u1w.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1u1w", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1u1w\| PDB=1u1w \| SCENE= }}		{{STRUCTURE_1u1w\| PDB=1u1w \| SCENE= }}

	===Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79===		===Structure and function of phenazine-biosynthesis protein PhzF from Pseudomonas fluorescens 2-79===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15545603}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15545603 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15545603}}		{{ABSTRACT_PUBMED_15545603}}

	==About this Structure==		==About this Structure==
-	~~1U1W~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA].	+	[[1u1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1W OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15545603~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015545603</ref><references group="xtra"/>
	[[Category: Pseudomonas fluorescens]]		[[Category: Pseudomonas fluorescens]]
	[[Category: Bayer, P.]]		[[Category: Bayer, P.]]
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	[[Category: Closed form]]		[[Category: Closed form]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
		+	[[Category: Lyase]]
	[[Category: Phenazine biosynthesis]]		[[Category: Phenazine biosynthesis]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:02:18 2009''