1u39 - Revision history

OCA at 18:16, 29 May 2024

2024-05-29T18:16:51Z

←Older revision		Revision as of 18:16, 29 May 2024
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u39 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u39 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Members of the X11/Mint family of multidomain adaptor proteins are composed of a divergent N terminus, a conserved PTB domain and a pair of C-terminal PDZ domains. Many proteins can interact with the PDZ tandem of X11 proteins, although the mechanism of such interactions is unclear. Here we show that the highly conserved C-terminal tail of X11alpha folds back and inserts into the target-binding groove of the first PDZ domain. The binding of this tail occludes the binding of other target peptides. This autoinhibited conformation of X11 requires that the two PDZ domains and the entire C-terminal tail be covalently connected to form an integral structural unit. The autoinhibited conformation of the X11 PDZ tandem provides a mechanistic explanation for the unique target-binding properties of the protein and hints at potential regulatory mechanisms for the X11-target interactions.
		+
		+	Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem.,Long JF, Feng W, Wang R, Chan LN, Ip FC, Xia J, Ip NY, Zhang M Nat Struct Mol Biol. 2005 Aug;12(8):722-8. Epub 2005 Jul 10. PMID:16007100<ref>PMID:16007100</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1u39" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:46, 1 May 2024

2024-05-01T08:46:30Z

←Older revision		Revision as of 08:46, 1 May 2024
Line 1:		Line 1:

	==Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains==		==Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains==
-	<StructureSection load='1u39' size='340' side='right'caption='[[1u39~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1u39' size='340' side='right'caption='[[1u39]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U39 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U39 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [https://pdbe.org/1u39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [https://www.ebi.ac.uk/pdbsum/1u39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u39 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [https://pdbe.org/1u39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [https://www.ebi.ac.uk/pdbsum/1u39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u39 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.	+	[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u39 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u39 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Members of the X11/Mint family of multidomain adaptor proteins are composed of a divergent N terminus, a conserved PTB domain and a pair of C-terminal PDZ domains. Many proteins can interact with the PDZ tandem of X11 proteins, although the mechanism of such interactions is unclear. Here we show that the highly conserved C-terminal tail of X11alpha folds back and inserts into the target-binding groove of the first PDZ domain. The binding of this tail occludes the binding of other target peptides. This autoinhibited conformation of X11 requires that the two PDZ domains and the entire C-terminal tail be covalently connected to form an integral structural unit. The autoinhibited conformation of the X11 PDZ tandem provides a mechanistic explanation for the unique target-binding properties of the protein and hints at potential regulatory mechanisms for the X11-target interactions.
-
-	Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem.,Long JF, Feng W, Wang R, Chan LN, Ip FC, Xia J, Ip NY, Zhang M Nat Struct Mol Biol. 2005 Aug;12(8):722-8. Epub 2005 Jul 10. PMID:16007100<ref>PMID:16007100</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1u39" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chan, L N]]	+	[[Category: Chan L-N]]
-	[[Category: Feng, W]]	+	[[Category: Feng W]]
-	[[Category: Fu, A]]	+	[[Category: Fu A]]
-	[[Category: He, C]]	+	[[Category: He C]]
-	[[Category: Ip~~, N Y~~]]	+	[[Category: Ip NY]]
-	[[Category: Long, J F]]	+	[[Category: Long J-F]]
-	[[Category: Xia, J]]	+	[[Category: Xia J]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Protein trafficking]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Scaffold protein]]~~	+
-	~~[[Category: X11s/mint~~]]	+

OCA at 09:35, 29 September 2021

2021-09-29T09:35:56Z

←Older revision		Revision as of 09:35, 29 September 2021
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	<StructureSection load='1u39' size='340' side='right'caption='[[1u39]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1u39' size='340' side='right'caption='[[1u39]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U39 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U39 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [~~http~~://pdbe.org/1u39 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u39 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u39 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [https://pdbe.org/1u39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [https://www.ebi.ac.uk/pdbsum/1u39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u39 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.	+	[[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:45, 25 December 2019

2019-12-25T13:45:44Z

←Older revision		Revision as of 13:45, 25 December 2019
Line 1:		Line 1:

	==Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains==		==Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains==
-	<StructureSection load='1u39' size='340' side='right' caption='[[1u39]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1u39' size='340' side='right'caption='[[1u39]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U39 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U39 FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chan, L N]]		[[Category: Chan, L N]]
	[[Category: Feng, W]]		[[Category: Feng, W]]

OCA at 08:36, 21 March 2018

2018-03-21T08:36:22Z

←Older revision		Revision as of 08:36, 21 March 2018
Line 1:		Line 1:
		+
	==Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains==		==Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains==
	<StructureSection load='1u39' size='340' side='right' caption='[[1u39]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1u39' size='340' side='right' caption='[[1u39]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U39 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U39 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [http://pdbe.org/1u39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [http://www.ebi.ac.uk/pdbsum/1u39 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [http://pdbe.org/1u39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [http://www.ebi.ac.uk/pdbsum/1u39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u39 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u39_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u39_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:54, 8 February 2016

2016-02-08T19:54:26Z

←Older revision		Revision as of 19:54, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u39 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:51, 10 September 2015

2015-09-10T14:51:34Z

←Older revision		Revision as of 14:51, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1u39' size='340' side='right' caption='[[1u39]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1u39' size='340' side='right' caption='[[1u39]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U39 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U39 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [http://www.ebi.ac.uk/pdbsum/1u39 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [http://pdbe.org/1u39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [http://www.ebi.ac.uk/pdbsum/1u39 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u39" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chan, L N]]		[[Category: Chan, L N]]
	[[Category: Feng, W]]		[[Category: Feng, W]]

OCA at 01:47, 25 December 2014

2014-12-25T01:47:15Z

←Older revision		Revision as of 01:47, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U39 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U39 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [http://www.ebi.ac.uk/pdbsum/1u39 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [http://www.ebi.ac.uk/pdbsum/1u39 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chan, L N.]]	+	[[Category: Chan, L N]]
-	[[Category: Feng, W.]]	+	[[Category: Feng, W]]
-	[[Category: Fu, A.]]	+	[[Category: Fu, A]]
-	[[Category: He, C.]]	+	[[Category: He, C]]
-	[[Category: Ip, N Y.]]	+	[[Category: Ip, N Y]]
-	[[Category: Long, J F.]]	+	[[Category: Long, J F]]
-	[[Category: Xia, J.]]	+	[[Category: Xia, J]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
	[[Category: Protein trafficking]]		[[Category: Protein trafficking]]

OCA at 21:24, 29 September 2014

2014-09-29T21:24:04Z

←Older revision		Revision as of 21:24, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1u39.~~png~~\|~~left~~\|200px]]	+	==Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains==
		+	<StructureSection load='1u39' size='340' side='right' caption='[[1u39]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U39 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u37\|1u37]], [[1u38\|1u38]], [[1u3b\|1u3b]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u39 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u39 RCSB], [http://www.ebi.ac.uk/pdbsum/1u39 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u39_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Members of the X11/Mint family of multidomain adaptor proteins are composed of a divergent N terminus, a conserved PTB domain and a pair of C-terminal PDZ domains. Many proteins can interact with the PDZ tandem of X11 proteins, although the mechanism of such interactions is unclear. Here we show that the highly conserved C-terminal tail of X11alpha folds back and inserts into the target-binding groove of the first PDZ domain. The binding of this tail occludes the binding of other target peptides. This autoinhibited conformation of X11 requires that the two PDZ domains and the entire C-terminal tail be covalently connected to form an integral structural unit. The autoinhibited conformation of the X11 PDZ tandem provides a mechanistic explanation for the unique target-binding properties of the protein and hints at potential regulatory mechanisms for the X11-target interactions.

-	~~{{STRUCTURE_1u39\| PDB=1u39 \| SCENE= }}~~	+	Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem.,Long JF, Feng W, Wang R, Chan LN, Ip FC, Xia J, Ip NY, Zhang M Nat Struct Mol Biol. 2005 Aug;12(8):722-8. Epub 2005 Jul 10. PMID:16007100<ref>PMID:16007100</ref>

-	~~===Auto-inhibition Mechanism of X11s~~/~~Mints Family Scaffold Proteins Revealed by the Closed Conformation~~ of the ~~Tandem PDZ Domains===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16007100}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1u39]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1U39 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016007100<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chan, L N.]]		[[Category: Chan, L N.]]

OCA: Protected "1u39" [edit=sysop:move=sysop]

2013-01-05T12:36:38Z

Protected "1u39" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:36, 5 January 2013