1u3h - Revision history

OCA at 06:37, 23 August 2023

2023-08-23T06:37:32Z

←Older revision		Revision as of 06:37, 23 August 2023
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	<StructureSection load='1u3h' size='340' side='right'caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>		<StructureSection load='1u3h' size='340' side='right'caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3H FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1k2d\|1k2d]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.42Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">H2-Aa ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [https://pdbe.org/1u3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [https://www.ebi.ac.uk/pdbsum/1u3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [https://pdbe.org/1u3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [https://www.ebi.ac.uk/pdbsum/1u3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3h ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5R1B3_MOUSE Q5R1B3_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 31:
	==See Also==		==See Also==
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC II 3D structures\|MHC II 3D structures]]
	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]		*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
Line 36:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Adams~~, E J~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Blondelle~~, S E~~]]	+	[[Category: Adams EJ]]
-	[[Category: Boulanger~~, M J~~]]	+	[[Category: Blondelle SE]]
-	[[Category: Garcia~~, K C~~]]	+	[[Category: Boulanger MJ]]
-	[[Category: Maynard, J]]	+	[[Category: Garcia KC]]
-	[[Category: Petersson, K]]	+	[[Category: Maynard J]]
-	[[Category: Wilson~~, D B~~]]	+	[[Category: Petersson K]]
-	[[Category: Wilson~~, D H]]~~	+	[[Category: Wilson DB]]
-	~~[[Category: Complex]]~~	+	[[Category: Wilson DH]]
-	~~[[Category: Immune system~~]]	+

OCA at 08:15, 10 November 2021

2021-11-10T08:15:52Z

←Older revision		Revision as of 08:15, 10 November 2021
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	<StructureSection load='1u3h' size='340' side='right'caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>		<StructureSection load='1u3h' size='340' side='right'caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U3H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3H FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2d\|1k2d]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1k2d\|1k2d]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [~~http~~://pdbe.org/1u3h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u3h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [https://pdbe.org/1u3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [https://www.ebi.ac.uk/pdbsum/1u3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3h ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[MHC 3D structures ~~of MHC~~\|MHC 3D structures ~~of MHC~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
-	*[[T-cell receptor\|T-cell receptor]]	+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:22, 5 February 2020

2020-02-05T08:22:01Z

←Older revision		Revision as of 08:22, 5 February 2020
Line 1:		Line 1:

	==Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A==		==Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A==
-	<StructureSection load='1u3h' size='340' side='right' caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>	+	<StructureSection load='1u3h' size='340' side='right'caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3H FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures of MHC\|MHC 3D structures of MHC]]
	*[[T-cell receptor\|T-cell receptor]]		*[[T-cell receptor\|T-cell receptor]]
	== References ==		== References ==
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Adams, E J]]		[[Category: Adams, E J]]

OCA at 08:25, 21 March 2018

2018-03-21T08:25:52Z

←Older revision		Revision as of 08:25, 21 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A==		==Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A==
	<StructureSection load='1u3h' size='340' side='right' caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>		<StructureSection load='1u3h' size='340' side='right' caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2d\|1k2d]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2d\|1k2d]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [http://pdbe.org/1u3h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [http://www.ebi.ac.uk/pdbsum/1u3h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [http://pdbe.org/1u3h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [http://www.ebi.ac.uk/pdbsum/1u3h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3h ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3h_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3h_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:00, 9 February 2016

2016-02-09T09:00:01Z

←Older revision		Revision as of 09:00, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:41, 10 September 2015

2015-09-10T20:41:05Z

←Older revision		Revision as of 20:41, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1u3h' size='340' side='right' caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>		<StructureSection load='1u3h' size='340' side='right' caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2d\|1k2d]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2d\|1k2d]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [http://www.ebi.ac.uk/pdbsum/1u3h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [http://pdbe.org/1u3h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [http://www.ebi.ac.uk/pdbsum/1u3h PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u3h" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Adams, E J]]		[[Category: Adams, E J]]
	[[Category: Blondelle, S E]]		[[Category: Blondelle, S E]]

OCA at 12:19, 6 January 2015

2015-01-06T12:19:24Z

←Older revision		Revision as of 12:19, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3H FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2d\|1k2d]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2d\|1k2d]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [http://www.ebi.ac.uk/pdbsum/1u3h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [http://www.ebi.ac.uk/pdbsum/1u3h PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Adams, E J.]]	+	[[Category: Adams, E J]]
-	[[Category: Blondelle, S E.]]	+	[[Category: Blondelle, S E]]
-	[[Category: Boulanger, M J.]]	+	[[Category: Boulanger, M J]]
-	[[Category: Garcia, K C.]]	+	[[Category: Garcia, K C]]
-	[[Category: Maynard, J.]]	+	[[Category: Maynard, J]]
-	[[Category: Petersson, K.]]	+	[[Category: Petersson, K]]
-	[[Category: Wilson, D B.]]	+	[[Category: Wilson, D B]]
-	[[Category: Wilson, D H.]]	+	[[Category: Wilson, D H]]
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 21:16, 29 September 2014

2014-09-29T21:16:32Z

←Older revision		Revision as of 21:16, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1u3h.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A==
		+	<StructureSection load='1u3h' size='340' side='right' caption='[[1u3h]], [[Resolution\|resolution]] 2.42Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3H FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2d\|1k2d]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [http://www.ebi.ac.uk/pdbsum/1u3h PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3h_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	T cell receptor crossreactivity with different peptide ligands and biased recognition of MHC are coupled features of antigen recognition that are necessary for the T cell's diverse functional repertoire. In the crystal structure between an autoreactive, EAE T cell clone 172.10 and myelin basic protein (1-11) presented by class II MHC I-Au, recognition of the MHC is dominated by the Vbeta domain of the TCR, which interacts with the MHC alpha chain in a manner suggestive of a germline-encoded TCR/MHC "anchor point." Strikingly, there are few specific contacts between the TCR CDR3 loops and the MBP peptide. We also find that over 1,000,000 different peptides derived from combinatorial libraries can activate 172.10, yet the TCR strongly prefers the native MBP contact residues. We suggest that while TCR scanning of pMHC may be degenerate due to the TCR germline bias for MHC, recognition of structurally distinct agonist peptides is not indicative of TCR promiscuity, but rather highly specific alternative solutions to TCR engagement.

-	~~{{STRUCTURE_1u3h\| PDB=1u3h \| SCENE= }}~~	+	Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.,Maynard J, Petersson K, Wilson DH, Adams EJ, Blondelle SE, Boulanger MJ, Wilson DB, Garcia KC Immunity. 2005 Jan;22(1):81-92. PMID:15664161<ref>PMID:15664161</ref>

-	~~===Crystal structure~~ of ~~mouse TCR 172~~.~~10 complexed with MHC class II I-Au molecule at 2~~.~~4 A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15664161}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1u3h]] is a 10 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA].~~	+

	==See Also==		==See Also==
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	*[[T-cell receptor\|T-cell receptor]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:015664161<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Adams, E J.]]		[[Category: Adams, E J.]]

OCA at 13:20, 20 October 2012

2012-10-20T13:20:54Z

←Older revision		Revision as of 13:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1u3h]] is a 10 chain structure ~~of [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA].	+	[[1u3h]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA].

	==See Also==		==See Also==

OCA: Protected "1u3h" [edit=sysop:move=sysop]

2012-07-26T11:40:49Z

Protected "1u3h" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:40, 26 July 2012