1u76 - Revision history

OCA at 06:39, 23 August 2023

2023-08-23T06:39:23Z

←Older revision		Revision as of 06:39, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1u76' size='340' side='right'caption='[[1u76]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1u76' size='340' side='right'caption='[[1u76]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u76]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1U76 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u76]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U76 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1u7b\|1u7b]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">PCNA ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [https://pdbe.org/1u76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [https://www.ebi.ac.uk/pdbsum/1u76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u76 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [~~http~~://pdbe.org/1u76 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u76 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u76 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref> ~~[[http://www.uniprot.org/uniprot/DPOD3_HUMAN DPOD3_HUMAN]] Required for optimal DNA polymerase delta activity.<ref>PMID:10219083</ref> <ref>PMID:10852724</ref> <ref>PMID:16510448</ref>~~	+	[https://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bruning~~, J B~~]]	+	[[Category: Bruning JB]]
-	[[Category: Shamoo, Y]]	+	[[Category: Shamoo Y]]
-	~~[[Category: Dna polymerase delta]]~~	+
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: P66]]~~	+
-	~~[[Category: Pip-box]]~~	+
-	~~[[Category: Replication]]~~	+
-	~~[[Category: Sliding clamp~~]]	+

OCA at 07:23, 30 December 2020

2020-12-30T07:23:39Z

←Older revision		Revision as of 07:23, 30 December 2020
Line 1:		Line 1:

	==Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit==		==Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit==
-	<StructureSection load='1u76' size='340' side='right' caption='[[1u76]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1u76' size='340' side='right'caption='[[1u76]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u76]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U76 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u76]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U76 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u7b\|1u7b]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u7b\|1u7b]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [http://pdbe.org/1u76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [http://www.ebi.ac.uk/pdbsum/1u76 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u76 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [http://pdbe.org/1u76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [http://www.ebi.ac.uk/pdbsum/1u76 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u76 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Proliferating ~~Cell Nuclear Antigen~~\|Proliferating ~~Cell Nuclear Antigen~~]]	+	*[[Proliferating cell nuclear antigen 3D structures\|Proliferating cell nuclear antigen 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bruning, J B]]		[[Category: Bruning, J B]]
	[[Category: Shamoo, Y]]		[[Category: Shamoo, Y]]

OCA at 08:39, 21 March 2018

2018-03-21T08:39:52Z

←Older revision		Revision as of 08:39, 21 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit==		==Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit==
	<StructureSection load='1u76' size='340' side='right' caption='[[1u76]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1u76' size='340' side='right' caption='[[1u76]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u7b\|1u7b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u7b\|1u7b]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [http://pdbe.org/1u76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [http://www.ebi.ac.uk/pdbsum/1u76 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [http://pdbe.org/1u76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [http://www.ebi.ac.uk/pdbsum/1u76 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u76 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u7/1u76_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u7/1u76_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u76 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:16, 11 September 2015

2015-09-11T15:16:22Z

←Older revision		Revision as of 15:16, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1u76' size='340' side='right' caption='[[1u76]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1u76' size='340' side='right' caption='[[1u76]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u76]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U76 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u76]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U76 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u7b\|1u7b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u7b\|1u7b]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [http://www.ebi.ac.uk/pdbsum/1u76 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [http://pdbe.org/1u76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [http://www.ebi.ac.uk/pdbsum/1u76 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u76" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bruning, J B]]		[[Category: Bruning, J B]]
	[[Category: Shamoo, Y]]		[[Category: Shamoo, Y]]

OCA at 18:15, 25 December 2014

2014-12-25T18:15:47Z

←Older revision		Revision as of 18:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u76]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U76 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u76]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U76 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u7b\|1u7b]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u7b\|1u7b]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [http://www.ebi.ac.uk/pdbsum/1u76 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [http://www.ebi.ac.uk/pdbsum/1u76 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref> [[http://www.uniprot.org/uniprot/DPOD3_HUMAN DPOD3_HUMAN]] Required for optimal DNA polymerase delta activity.<ref>PMID:10219083</ref> <ref>PMID:10852724</ref> <ref>PMID:16510448</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bruning, J B.]]	+	[[Category: Bruning, J B]]
-	[[Category: Shamoo, Y.]]	+	[[Category: Shamoo, Y]]
	[[Category: Dna polymerase delta]]		[[Category: Dna polymerase delta]]
	[[Category: Dna replication]]		[[Category: Dna replication]]

OCA at 23:21, 28 September 2014

2014-09-28T23:21:54Z

←Older revision		Revision as of 23:21, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1u76.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit==
		+	<StructureSection load='1u76' size='340' side='right' caption='[[1u76]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u76]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U76 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u7b\|1u7b]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u76 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u76 RCSB], [http://www.ebi.ac.uk/pdbsum/1u76 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u7/1u76_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human Proliferating Cellular Nuclear Antigen (hPCNA), a member of the sliding clamp family of proteins, makes specific protein-protein interactions with DNA replication and repair proteins through a small peptide motif termed the PCNA-interacting protein, or PIP-box. We solved the structure of hPCNA bound to PIP-box-containing peptides from the p66 subunit of the human replicative DNA polymerase-delta (452-466) at 2.6 A and of the flap endonuclease (FEN1) (331-350) at 1.85 A resolution. Both structures demonstrate that the pol-delta p66 and FEN1 peptides interact with hPCNA at the same site shown to bind the cdk-inhibitor p21(CIP1). Binding studies indicate that peptides from the p66 subunit of the pol-delta holoenzyme and FEN1 bind hPCNA from 189- to 725-fold less tightly than those of p21. Thus, the PIP-box and flanking regions provide a small docking peptide whose affinities can be readily adjusted in accord with biological necessity to mediate the binding of DNA replication and repair proteins to hPCNA.

-	~~{{STRUCTURE_1u76\| PDB=1u76 \| SCENE= }}~~	+	Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.,Bruning JB, Shamoo Y Structure. 2004 Dec;12(12):2209-19. PMID:15576034<ref>PMID:15576034</ref>

-	~~===Crystal structure of hPCNA bound to residues 452-466~~ of the ~~DNA polymerase-delta-p66 subunit===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15576034}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1u76]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA].~~	+

	==See Also==		==See Also==
	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]		*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015576034<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bruning, J B.]]		[[Category: Bruning, J B.]]

OCA at 19:52, 20 October 2012

2012-10-20T19:52:12Z

←Older revision		Revision as of 19:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1u76]] is a 6 chain structure ~~of [[Proliferating Cell Nuclear Antigen]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA].	+	[[1u76]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA].

	==See Also==		==See Also==

OCA: Protected "1u76" [edit=sysop:move=sysop]

2012-07-27T08:44:31Z

Protected "1u76" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:44, 27 July 2012

OCA at 08:44, 27 July 2012

2012-07-27T08:44:30Z

←Older revision		Revision as of 08:44, 27 July 2012
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-	{{Seed}}
	[[Image:1u76.png\|left\|200px]]		[[Image:1u76.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1u76", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_1u76\| PDB=1u76 \| SCENE= }}		{{STRUCTURE_1u76\| PDB=1u76 \| SCENE= }}

	===Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit===		===Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15576034}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15576034 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15576034}}		{{ABSTRACT_PUBMED_15576034}}

	==About this Structure==		==About this Structure==
-	~~1U76~~ is a 6 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA].	+	[[1u76]] is a 6 chain structure of [[Proliferating Cell Nuclear Antigen]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA].
		+
		+	==See Also==
		+	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15576034~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015576034</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bruning, J B.]]		[[Category: Bruning, J B.]]
Line 31:		Line 22:
	[[Category: P66]]		[[Category: P66]]
	[[Category: Pip-box]]		[[Category: Pip-box]]
		+	[[Category: Replication]]
	[[Category: Sliding clamp]]		[[Category: Sliding clamp]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:51:12 2009''

OCA at 23:51, 17 February 2009

2009-02-17T23:51:13Z

←Older revision		Revision as of 23:51, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1U76 is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA].	+	1U76 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U76 OCA].

	==Reference==		==Reference==
-	~~Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1., Bruning JB, Shamoo Y, Structure. 2004 Dec;12(12):2209-19.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15576034 15576034]~~	+	<ref group="xtra">PMID:15576034</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Bruning, J B.]]		[[Category: Bruning, J B.]]
	[[Category: Shamoo, Y.]]		[[Category: Shamoo, Y.]]
Line 34:		Line 33:
	[[Category: Sliding clamp]]		[[Category: Sliding clamp]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 08~~:44:~~17 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:51:12 2009''