1u9i - Revision history

OCA at 06:39, 23 August 2023

2023-08-23T06:39:57Z

←Older revision		Revision as of 06:39, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1u9i' size='340' side='right'caption='[[1u9i]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1u9i' size='340' side='right'caption='[[1u9i]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u9i]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Anacystis_nidulans_r2 Anacystis nidulans r2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1U9I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u9i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_7942_=_FACHB-805 Synechococcus elongatus PCC 7942 = FACHB-805]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U9I FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~SEP~~:~~PHOSPHOSERINE~~'>~~SEP~~</scene>, <scene name='pdbligand=~~TPO~~:~~PHOSPHOTHREONINE~~'>~~TPO~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[1tf7\|1tf7]]~~</~~div~~><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [https://pdbe.org/1u9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [https://www.ebi.ac.uk/pdbsum/1u9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9i ProSAT]</span></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [~~http~~://pdbe.org/1u9i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u9i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9i ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>	+	[https://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anacystis nidulans r2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Egli, M]]	+	[[Category: Synechococcus elongatus PCC 7942 = FACHB-805]]
-	[[Category: Johnson~~, C H~~]]	+	[[Category: Egli M]]
-	[[Category: Mori, T]]	+	[[Category: Johnson CH]]
-	[[Category: Pattanayek, R]]	+	[[Category: Mori T]]
-	[[Category: Pattanayek, S]]	+	[[Category: Pattanayek R]]
-	[[Category: Xu, Y]]	+	[[Category: Pattanayek S]]
-	~~[[Category: Circadian]]~~	+	[[Category: Xu Y]]
-	~~[[Category: Circadian clock protein]]~~	+
-	~~[[Category: Clock]]~~	+
-	~~[[Category: Hexamer]]~~	+
-	~~[[Category: Homohexamer]]~~	+
-	~~[[Category: Kaia]]~~	+
-	~~[[Category: Kaib]]~~	+
-	~~[[Category: Kaic~~]]	+

OCA at 07:25, 30 December 2020

2020-12-30T07:25:13Z

←Older revision		Revision as of 07:25, 30 December 2020
Line 1:		Line 1:

	==Crystal Structure of Circadian Clock Protein KaiC with Phosphorylation Sites==		==Crystal Structure of Circadian Clock Protein KaiC with Phosphorylation Sites==
-	<StructureSection load='1u9i' size='340' side='right' caption='[[1u9i]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1u9i' size='340' side='right'caption='[[1u9i]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u9i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U9I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u9i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U9I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tf7\|1tf7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tf7\|1tf7]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [http://pdbe.org/1u9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [http://www.ebi.ac.uk/pdbsum/1u9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [http://pdbe.org/1u9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [http://www.ebi.ac.uk/pdbsum/1u9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Circadian clock protein\|Circadian clock protein]]	+	*[[Circadian clock protein 3D structures\|Circadian clock protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Anacystis nidulans r2]]		[[Category: Anacystis nidulans r2]]
		+	[[Category: Large Structures]]
	[[Category: Egli, M]]		[[Category: Egli, M]]
	[[Category: Johnson, C H]]		[[Category: Johnson, C H]]

OCA at 08:28, 21 March 2018

2018-03-21T08:28:00Z

←Older revision		Revision as of 08:28, 21 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Circadian Clock Protein KaiC with Phosphorylation Sites==		==Crystal Structure of Circadian Clock Protein KaiC with Phosphorylation Sites==
	<StructureSection load='1u9i' size='340' side='right' caption='[[1u9i]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1u9i' size='340' side='right' caption='[[1u9i]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tf7\|1tf7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tf7\|1tf7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [http://pdbe.org/1u9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [http://www.ebi.ac.uk/pdbsum/1u9i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [http://pdbe.org/1u9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [http://www.ebi.ac.uk/pdbsum/1u9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u9/1u9i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u9/1u9i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:19, 7 February 2016

2016-02-07T10:19:52Z

←Older revision		Revision as of 10:19, 7 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u9i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:35, 10 September 2015

2015-09-10T00:35:19Z

←Older revision		Revision as of 00:35, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1u9i' size='340' side='right' caption='[[1u9i]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1u9i' size='340' side='right' caption='[[1u9i]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u9i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u9i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tf7\|1tf7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tf7\|1tf7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 ~~Synechococcus elongatus PCC 7942~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Anacystis nidulans R2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [http://www.ebi.ac.uk/pdbsum/1u9i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [http://pdbe.org/1u9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [http://www.ebi.ac.uk/pdbsum/1u9i PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~KAIC_SYNP7 KAIC_SYNP7~~]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>	+	[[http://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u9i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Synechococcus elongatus pcc 7942~~]]	+	[[Category: Anacystis nidulans r2]]
	[[Category: Egli, M]]		[[Category: Egli, M]]
	[[Category: Johnson, C H]]		[[Category: Johnson, C H]]

OCA at 14:22, 24 December 2014

2014-12-24T14:22:11Z

←Older revision		Revision as of 14:22, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u9i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u9i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tf7\|1tf7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tf7\|1tf7]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Synechococcus elongatus PCC 7942])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Synechococcus elongatus PCC 7942])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [http://www.ebi.ac.uk/pdbsum/1u9i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [http://www.ebi.ac.uk/pdbsum/1u9i PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAIC_SYNP7 KAIC_SYNP7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Synechococcus elongatus pcc 7942]]		[[Category: Synechococcus elongatus pcc 7942]]
-	[[Category: Egli, M.]]	+	[[Category: Egli, M]]
-	[[Category: Johnson, C H.]]	+	[[Category: Johnson, C H]]
-	[[Category: Mori, T.]]	+	[[Category: Mori, T]]
-	[[Category: Pattanayek, R.]]	+	[[Category: Pattanayek, R]]
-	[[Category: Pattanayek, S.]]	+	[[Category: Pattanayek, S]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
	[[Category: Circadian]]		[[Category: Circadian]]
	[[Category: Circadian clock protein]]		[[Category: Circadian clock protein]]

OCA at 20:20, 29 September 2014

2014-09-29T20:20:37Z

←Older revision		Revision as of 20:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1u9i.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Circadian Clock Protein KaiC with Phosphorylation Sites==
		+	<StructureSection load='1u9i' size='340' side='right' caption='[[1u9i]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u9i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tf7\|1tf7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KaiC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1140 Synechococcus elongatus PCC 7942])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u9i RCSB], [http://www.ebi.ac.uk/pdbsum/1u9i PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u9/1u9i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In cyanobacteria, KaiC is an essential hexameric clock protein that forms the core of a circadian protein complex. KaiC can be phosphorylated, and the ratio of phospho-KaiC to non-phospho-KaiC is correlated with circadian period. Structural analyses of KaiC crystals identify three potential phosphorylation sites within a 10-A radius of the ATP binding regions that are at the T432, S431, and T426 residues in the KaiCII domains. When these residues are mutated by alanine substitution singly or in combination, KaiC phosphorylation is altered, and circadian rhythmicity is abolished. These alanine substitutions do not prevent KaiC from hexamerizing. Intriguingly, the ability of KaiC overexpression to repress its own promoter is also not prevented by alanine substitutions at these sites, implying that the capability of KaiC to repress its promoter is not sufficient to allow the clockwork to oscillate. The KaiC structure and the mutational analysis suggest that S431 and T426 may share a phosphate that can shuttle between these two residues. Because the phosphorylation status of KaiC oscillates over the daily cycle, and KaiC phosphorylation is essential for clock function as shown here, daily modulations of KaiC activity by phosphorylation at T432 and S431/T426 seem to be key components of the circadian clockwork in cyanobacteria.

-	~~{{STRUCTURE_1u9i\| PDB=1u9i \| SCENE= }}~~	+	Identification of key phosphorylation sites in the circadian clock protein KaiC by crystallographic and mutagenetic analyses.,Xu Y, Mori T, Pattanayek R, Pattanayek S, Egli M, Johnson CH Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13933-8. Epub 2004 Sep 3. PMID:15347809<ref>PMID:15347809</ref>

-	~~===Crystal Structure~~ of ~~Circadian Clock Protein KaiC with Phosphorylation Sites===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15347809}}~~	+	==See Also==
-		+	*[[Circadian clock protein\|Circadian clock protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1u9i~~]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015347809<~~/~~ref~~><~~ref group="xtra">PMID:016628225</ref><references group="xtra"~~/>	+
	[[Category: Synechococcus elongatus pcc 7942]]		[[Category: Synechococcus elongatus pcc 7942]]
	[[Category: Egli, M.]]		[[Category: Egli, M.]]

OCA: Protected "1u9i" [edit=sysop:move=sysop]

2013-01-05T10:59:28Z

Protected "1u9i" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:59, 5 January 2013

OCA at 10:59, 5 January 2013

2013-01-05T10:59:25Z

←Older revision		Revision as of 10:59, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1u9i.png\|left\|200px]]		[[Image:1u9i.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1u9i", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1u9i\| PDB=1u9i \| SCENE= }}		{{STRUCTURE_1u9i\| PDB=1u9i \| SCENE= }}

	===Crystal Structure of Circadian Clock Protein KaiC with Phosphorylation Sites===		===Crystal Structure of Circadian Clock Protein KaiC with Phosphorylation Sites===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15347809}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15347809 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15347809}}		{{ABSTRACT_PUBMED_15347809}}

	==About this Structure==		==About this Structure==
-	~~1U9I~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Synechococcus_sp.~~ Synechococcus ~~sp.~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA].	+	[[1u9i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_7942 Synechococcus elongatus pcc 7942]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15347809~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015347809</ref><ref group="xtra">PMID:016628225</ref><references group="xtra"/>
-	[[Category: Synechococcus ~~sp.~~]]	+	[[Category: Synechococcus elongatus pcc 7942]]
	[[Category: Egli, M.]]		[[Category: Egli, M.]]
	[[Category: Johnson, C H.]]		[[Category: Johnson, C H.]]
Line 32:		Line 20:
	[[Category: Xu, Y.]]		[[Category: Xu, Y.]]
	[[Category: Circadian]]		[[Category: Circadian]]
		+	[[Category: Circadian clock protein]]
	[[Category: Clock]]		[[Category: Clock]]
	[[Category: Hexamer]]		[[Category: Hexamer]]
Line 38:		Line 27:
	[[Category: Kaib]]		[[Category: Kaib]]
	[[Category: Kaic]]		[[Category: Kaic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:08:52 2009''

OCA at 11:08, 16 February 2009

2009-02-16T11:08:56Z

←Older revision		Revision as of 11:08, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1U9I is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA].	+	1U9I is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9I OCA].

	==Reference==		==Reference==
-	Identification of key phosphorylation sites in the circadian clock protein KaiC by crystallographic and mutagenetic analyses., Xu Y, Mori T, Pattanayek R, Pattanayek S, Egli M, Johnson CH, Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13933-8. Epub 2004 Sep 3. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15347809 15347809]~~	+	<ref group="xtra">PMID:15347809</ref><references group="xtra"/>
-	~~[[Category: Protein complex]]~~	+
	[[Category: Synechococcus sp.]]		[[Category: Synechococcus sp.]]
	[[Category: Egli, M.]]		[[Category: Egli, M.]]
Line 40:		Line 39:
	[[Category: Kaic]]		[[Category: Kaic]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 15:31~~:08 ~~2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:08:52 2009''