1uaa - Revision history

OCA at 08:44, 14 February 2024

2024-02-14T08:44:52Z

←Older revision		Revision as of 08:44, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1uaa' size='340' side='right'caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1uaa' size='340' side='right'caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UAA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UAA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [https://pdbe.org/1uaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [https://www.ebi.ac.uk/pdbsum/1uaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaa ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [https://pdbe.org/1uaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [https://www.ebi.ac.uk/pdbsum/1uaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/REP_ECOLI REP_ECOLI]] Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.	+	[https://www.uniprot.org/uniprot/REP_ECOLI REP_ECOLI] Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uaa ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uaa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Crystal structures of binary and ternary complexes of the E. coli Rep helicase bound to single-stranded (ss) DNA or ssDNA and ADP were determined to a resolution of 3.0 A and 3.2 A, respectively. The asymmetric unit in the crystals contains two Rep monomers differing from each other by a large reorientation of one of the domains, corresponding to a swiveling of 130 degrees about a hinge region. Such domain movements are sufficiently large to suggest that these may be coupled to translocation of the Rep dimer along DNA. The ssDNA binding site involves the helicase motifs Ia, III, and V, whereas the ADP binding site involves helicase motifs I and IV. Residues in motifs II and VI may function to transduce the allosteric effects of nucleotides on DNA binding. These structures represent the first view of a DNA helicase bound to DNA.
-
-	Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP.,Korolev S, Hsieh J, Gauss GH, Lohman TM, Waksman G Cell. 1997 Aug 22;90(4):635-47. PMID:9288744<ref>PMID:9288744</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1uaa" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Helicase\|Helicase]]		*[[Helicase\|Helicase]]
	*[[Helicase 3D structures\|Helicase 3D structures]]		*[[Helicase 3D structures\|Helicase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Korolev, S]]	+	[[Category: Korolev S]]
-	[[Category: Waksman, G]]	+	[[Category: Waksman G]]
-	~~[[Category: Dna unwinding]]~~	+
-	~~[[Category: Helicase]]~~	+
-	~~[[Category: Hydrolase-dna complex~~]]	+

OCA at 09:38, 29 September 2021

2021-09-29T09:38:32Z

←Older revision		Revision as of 09:38, 29 September 2021
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	<StructureSection load='1uaa' size='340' side='right'caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1uaa' size='340' side='right'caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UAA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UAA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [~~http~~://pdbe.org/1uaa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uaa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaa ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [https://pdbe.org/1uaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [https://www.ebi.ac.uk/pdbsum/1uaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/REP_ECOLI REP_ECOLI]] Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.	+	[[https://www.uniprot.org/uniprot/REP_ECOLI REP_ECOLI]] Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	*[[Helicase\|Helicase]]		*[[Helicase\|Helicase]]
	*[[Helicase 3D structures\|Helicase 3D structures]]		*[[Helicase 3D structures\|Helicase 3D structures]]
-	*[[Molecular Playground/PcrA Helicase\|Molecular Playground/PcrA Helicase]]
-	*[[PcrA helicase\|PcrA helicase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:32, 25 December 2019

2019-12-25T13:32:35Z

←Older revision		Revision as of 13:32, 25 December 2019
Line 1:		Line 1:

	==E. COLI REP HELICASE/DNA COMPLEX==		==E. COLI REP HELICASE/DNA COMPLEX==
-	<StructureSection load='1uaa' size='340' side='right' caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='1uaa' size='340' side='right'caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAA FirstGlance]. <br>
Line 30:		Line 30:
	==See Also==		==See Also==
	*[[Helicase\|Helicase]]		*[[Helicase\|Helicase]]
		+	*[[Helicase 3D structures\|Helicase 3D structures]]
	*[[Molecular Playground/PcrA Helicase\|Molecular Playground/PcrA Helicase]]		*[[Molecular Playground/PcrA Helicase\|Molecular Playground/PcrA Helicase]]
	*[[PcrA helicase\|PcrA helicase]]		*[[PcrA helicase\|PcrA helicase]]
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Korolev, S]]		[[Category: Korolev, S]]
	[[Category: Waksman, G]]		[[Category: Waksman, G]]

OCA at 08:24, 21 March 2018

2018-03-21T08:24:44Z

←Older revision		Revision as of 08:24, 21 March 2018
Line 1:		Line 1:
		+
	==E. COLI REP HELICASE/DNA COMPLEX==		==E. COLI REP HELICASE/DNA COMPLEX==
	<StructureSection load='1uaa' size='340' side='right' caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1uaa' size='340' side='right' caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [http://pdbe.org/1uaa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [http://www.ebi.ac.uk/pdbsum/1uaa PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [http://pdbe.org/1uaa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [http://www.ebi.ac.uk/pdbsum/1uaa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uaa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ua/1uaa_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ua/1uaa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uaa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:01, 12 September 2015

2015-09-12T02:01:56Z

←Older revision		Revision as of 02:01, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1uaa' size='340' side='right' caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1uaa' size='340' side='right' caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [http://www.ebi.ac.uk/pdbsum/1uaa PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [http://pdbe.org/1uaa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [http://www.ebi.ac.uk/pdbsum/1uaa PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uaa" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Escherichia coli]]
	[[Category: Korolev, S]]		[[Category: Korolev, S]]
	[[Category: Waksman, G]]		[[Category: Waksman, G]]

OCA at 22:24, 25 December 2014

2014-12-25T22:24:01Z

←Older revision		Revision as of 22:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [http://www.ebi.ac.uk/pdbsum/1uaa PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [http://www.ebi.ac.uk/pdbsum/1uaa PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/REP_ECOLI REP_ECOLI]] Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Korolev, S.]]	+	[[Category: Korolev, S]]
-	[[Category: Waksman, G.]]	+	[[Category: Waksman, G]]
	[[Category: Dna unwinding]]		[[Category: Dna unwinding]]
	[[Category: Helicase]]		[[Category: Helicase]]
	[[Category: Hydrolase-dna complex]]		[[Category: Hydrolase-dna complex]]

OCA at 21:44, 29 September 2014

2014-09-29T21:44:09Z

←Older revision		Revision as of 21:44, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1uaa\| PDB=1uaa \| SCENE= }}~~	+	==E. COLI REP HELICASE/DNA COMPLEX==
-	===E. COLI REP HELICASE/DNA COMPLEX===	+	<StructureSection load='1uaa' size='340' side='right' caption='[[1uaa]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_9288744}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uaa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UAA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB], [http://www.ebi.ac.uk/pdbsum/1uaa PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ua/1uaa_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Crystal structures of binary and ternary complexes of the E. coli Rep helicase bound to single-stranded (ss) DNA or ssDNA and ADP were determined to a resolution of 3.0 A and 3.2 A, respectively. The asymmetric unit in the crystals contains two Rep monomers differing from each other by a large reorientation of one of the domains, corresponding to a swiveling of 130 degrees about a hinge region. Such domain movements are sufficiently large to suggest that these may be coupled to translocation of the Rep dimer along DNA. The ssDNA binding site involves the helicase motifs Ia, III, and V, whereas the ADP binding site involves helicase motifs I and IV. Residues in motifs II and VI may function to transduce the allosteric effects of nucleotides on DNA binding. These structures represent the first view of a DNA helicase bound to DNA.

-	~~==About this Structure==~~	+	Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP.,Korolev S, Hsieh J, Gauss GH, Lohman TM, Waksman G Cell. 1997 Aug 22;90(4):635-47. PMID:9288744<ref>PMID:9288744</ref>
-	~~[[1uaa]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia.org/wiki/Escherichia_coli Escherichia~~ coli]. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1UAA OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
Line 10:		Line 28:
	*[[Molecular Playground/PcrA Helicase\|Molecular Playground/PcrA Helicase]]		*[[Molecular Playground/PcrA Helicase\|Molecular Playground/PcrA Helicase]]
	*[[PcrA helicase\|PcrA helicase]]		*[[PcrA helicase\|PcrA helicase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009288744<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Korolev, S.]]		[[Category: Korolev, S.]]

OCA at 10:46, 11 March 2013

2013-03-11T10:46:54Z

←Older revision		Revision as of 10:46, 11 March 2013
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-	[[Image:1uaa.png\|left\|200px]]
-
	{{STRUCTURE_1uaa\| PDB=1uaa \| SCENE= }}		{{STRUCTURE_1uaa\| PDB=1uaa \| SCENE= }}
-
	===E. COLI REP HELICASE/DNA COMPLEX===		===E. COLI REP HELICASE/DNA COMPLEX===
-
	{{ABSTRACT_PUBMED_9288744}}		{{ABSTRACT_PUBMED_9288744}}

OCA at 22:21, 20 October 2012

2012-10-20T22:21:22Z

←Older revision		Revision as of 22:21, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1uaa]] is a 3 chain structure ~~of [[Helicase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA].	+	[[1uaa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAA OCA].

	==See Also==		==See Also==

OCA: Protected "1uaa" [edit=sysop:move=sysop]

2012-07-27T16:01:53Z

Protected "1uaa" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:01, 27 July 2012