1ueu - Revision history

OCA at 23:52, 27 December 2023

2023-12-27T23:52:11Z

←Older revision		Revision as of 23:52, 27 December 2023
Line 3:		Line 3:
	<StructureSection load='1ueu' size='340' side='right'caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ueu' size='340' side='right'caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arcfl Arcfl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UEU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CTP:CYTIDINE~~-~~5-TRIPHOSPHATE'>CTP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1uet\|1uet]], [[1uev\|1uev]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/CCA_tRNA_nucleotidyltransferase CCA tRNA nucleotidyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.72 2.7.7.72]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [https://pdbe.org/1ueu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [https://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ueu ProSAT], [https://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [https://pdbe.org/1ueu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [https://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ueu ProSAT], [https://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU]] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>	+	[https://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arcfl]]~~	+	[[Category: Archaeoglobus fulgidus]]
-	~~[[Category: CCA tRNA nucleotidyltransferase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nureki, O]]	+	[[Category: Nureki O]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:09, 6 October 2021

2021-10-06T06:09:15Z

←Older revision		Revision as of 06:09, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='1ueu' size='340' side='right'caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ueu' size='340' side='right'caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UEU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uet\|1uet]], [[1uev\|1uev]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uet\|1uet]], [[1uev\|1uev]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/CCA_tRNA_nucleotidyltransferase CCA tRNA nucleotidyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.72 2.7.7.72] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/CCA_tRNA_nucleotidyltransferase CCA tRNA nucleotidyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.72 2.7.7.72] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [~~http~~://pdbe.org/1ueu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ueu ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [https://pdbe.org/1ueu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [https://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ueu ProSAT], [https://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU]] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>	+	[[https://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU]] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:12, 1 January 2020

2020-01-01T13:12:52Z

←Older revision		Revision as of 13:12, 1 January 2020
Line 1:		Line 1:

	==Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure==		==Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure==
-	<StructureSection load='1ueu' size='340' side='right' caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1ueu' size='340' side='right'caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UEU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UEU FirstGlance]. <br>
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[CCA-adding enzyme\|CCA-adding enzyme]]	+	*[[CCA-adding enzyme 3D structures\|CCA-adding enzyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	[[Category: Arcfl]]		[[Category: Arcfl]]
	[[Category: CCA tRNA nucleotidyltransferase]]		[[Category: CCA tRNA nucleotidyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Nureki, O]]		[[Category: Nureki, O]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:02, 28 March 2018

2018-03-28T08:02:03Z

←Older revision		Revision as of 08:02, 28 March 2018
Line 1:		Line 1:
		+
	==Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure==		==Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure==
	<StructureSection load='1ueu' size='340' side='right' caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ueu' size='340' side='right' caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uet\|1uet]], [[1uev\|1uev]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uet\|1uet]], [[1uev\|1uev]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CCA_tRNA_nucleotidyltransferase CCA tRNA nucleotidyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.72 2.7.7.72] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CCA_tRNA_nucleotidyltransferase CCA tRNA nucleotidyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.72 2.7.7.72] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [http://pdbe.org/1ueu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [http://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [http://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [http://pdbe.org/1ueu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [http://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ueu ProSAT], [http://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ue/1ueu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ue/1ueu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:11, 8 February 2016

2016-02-08T22:11:28Z

←Older revision		Revision as of 22:11, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ueu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:50, 10 September 2015

2015-09-10T15:50:38Z

←Older revision		Revision as of 15:50, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ueu' size='340' side='right' caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1ueu' size='340' side='right' caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Archaeoglobus_fulgidus Archaeoglobus fulgidus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UEU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uet\|1uet]], [[1uev\|1uev]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uet\|1uet]], [[1uev\|1uev]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~tRNA_adenylyltransferase~~ tRNA ~~adenylyltransferase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.25 2.7.7.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CCA_tRNA_nucleotidyltransferase CCA tRNA nucleotidyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.72 2.7.7.72] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [http://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [http://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [http://pdbe.org/1ueu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [http://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [http://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ueu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Archaeoglobus fulgidus~~]]	+	[[Category: Arcfl]]
-	[[Category: ~~TRNA adenylyltransferase~~]]	+	[[Category: CCA tRNA nucleotidyltransferase]]
	[[Category: Nureki, O]]		[[Category: Nureki, O]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 02:28, 25 December 2014

2014-12-25T02:28:21Z

←Older revision		Revision as of 02:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UEU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UEU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uet\|1uet]], [[1uev\|1uev]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uet\|1uet]], [[1uev\|1uev]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_adenylyltransferase tRNA adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.25 2.7.7.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_adenylyltransferase tRNA adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.25 2.7.7.25] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [http://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [http://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [http://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [http://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU]] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Archaeoglobus fulgidus]]		[[Category: Archaeoglobus fulgidus]]
	[[Category: TRNA adenylyltransferase]]		[[Category: TRNA adenylyltransferase]]
-	[[Category: Nureki, O~~.]]~~	+	[[Category: Nureki, O]]
-	~~[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]~~	+
-	~~[[Category: Riken structural genomics/proteomics initiative]]~~	+
-	~~[[Category: Rsgi~~]]	+
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Rsgi]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 21:58, 29 September 2014

2014-09-29T21:58:49Z

←Older revision		Revision as of 21:58, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ueu.~~png~~\|~~left~~\|200px]]	+	==Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure==
		+	<StructureSection load='1ueu' size='340' side='right' caption='[[1ueu]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ueu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UEU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uet\|1uet]], [[1uev\|1uev]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_adenylyltransferase tRNA adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.25 2.7.7.25] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ueu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ueu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ueu RCSB], [http://www.ebi.ac.uk/pdbsum/1ueu PDBsum], [http://www.topsan.org/Proteins/RSGI/1ueu TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ue/1ueu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CCA-adding enzyme [ATP(CTP):tRNA nucleotidyltransferase], a template-independent RNA polymerase, adds the defined 'cytidine-cytidine-adenosine' sequence onto the 3' end of tRNA. The archaeal CCA-adding enzyme (class I) and eubacterial/eukaryotic CCA-adding enzyme (class II) show little amino acid sequence homology, but catalyze the same reaction in a defined fashion. Here, we present the crystal structures of the class I archaeal CCA-adding enzyme from Archaeoglobus fulgidus, and its complexes with CTP and ATP at 2.0, 2.0 and 2.7 A resolutions, respectively. The geometry of the catalytic carboxylates and the relative positions of CTP and ATP to a single catalytic site are well conserved in both classes of CCA-adding enzymes, whereas the overall architectures, except for the catalytic core, of the class I and class II CCA-adding enzymes are fundamentally different. Furthermore, the recognition mechanisms of substrate nucleotides and tRNA molecules are distinct between these two classes, suggesting that the catalytic domains of class I and class II enzymes share a common origin, and distinct substrate recognition domains have been appended to form the two presently divergent classes.

-	~~{{STRUCTURE_1ueu\| PDB=1ueu \| SCENE= }}~~	+	Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure.,Okabe M, Tomita K, Ishitani R, Ishii R, Takeuchi N, Arisaka F, Nureki O, Yokoyama S EMBO J. 2003 Nov 3;22(21):5918-27. PMID:14592988<ref>PMID:14592988</ref>

-	~~===Divergent evolutions~~ of ~~trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_14592988}}~~	+	==See Also==
-		+	*[[CCA-adding enzyme\|CCA-adding enzyme]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1ueu~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:014592988<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Archaeoglobus fulgidus]]		[[Category: Archaeoglobus fulgidus]]
	[[Category: TRNA adenylyltransferase]]		[[Category: TRNA adenylyltransferase]]

OCA: Protected "1ueu" [edit=sysop:move=sysop]

2013-01-05T13:36:58Z

Protected "1ueu" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:36, 5 January 2013

OCA at 13:36, 5 January 2013

2013-01-05T13:36:55Z

←Older revision		Revision as of 13:36, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1ueu.png\|left\|200px]]		[[Image:1ueu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ueu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ueu\| PDB=1ueu \| SCENE= }}		{{STRUCTURE_1ueu\| PDB=1ueu \| SCENE= }}

	===Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure===		===Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14592988}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14592988 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_14592988}}		{{ABSTRACT_PUBMED_14592988}}

	==About this Structure==		==About this Structure==
-	~~1UEU~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA].	+	[[1ueu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14592988~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014592988</ref><references group="xtra"/>
	[[Category: Archaeoglobus fulgidus]]		[[Category: Archaeoglobus fulgidus]]
	[[Category: TRNA adenylyltransferase]]		[[Category: TRNA adenylyltransferase]]
Line 32:		Line 20:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:54:18 2009''