1ugn - Revision history

OCA at 07:35, 25 October 2023

2023-10-25T07:35:59Z

←Older revision		Revision as of 07:35, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1ugn' size='340' side='right'caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ugn' size='340' side='right'caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1g0x\|1g0x]]~~, [[~~1ufu~~\|~~1ufu~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [https://pdbe.org/1ugn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [https://www.ebi.ac.uk/pdbsum/1ugn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [https://pdbe.org/1ugn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [https://www.ebi.ac.uk/pdbsum/1ugn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>	+	[https://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amano, K]]	+	[[Category: Amano K]]
-	[[Category: Kohda, D]]	+	[[Category: Kohda D]]
-	[[Category: Kuroki, K]]	+	[[Category: Kuroki K]]
-	[[Category: Maenaka, K]]	+	[[Category: Maenaka K]]
-	[[Category: Rasubala, L]]	+	[[Category: Rasubala L]]
-	[[Category: Shiroishi, M]]	+	[[Category: Shiroishi M]]
-	[[Category: Tokunaga, K]]	+	[[Category: Tokunaga K]]
-	[[Category: Tsuchiya, N]]	+	[[Category: Tsuchiya N]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin-like fold~~]]	+

OCA at 06:10, 6 October 2021

2021-10-06T06:10:10Z

←Older revision		Revision as of 06:10, 6 October 2021
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	<StructureSection load='1ugn' size='340' side='right'caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ugn' size='340' side='right'caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g0x\|1g0x]], [[1ufu\|1ufu]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [~~http~~://pdbe.org/1ugn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ugn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [https://pdbe.org/1ugn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [https://www.ebi.ac.uk/pdbsum/1ugn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>	+	[[https://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:40, 1 January 2020

2020-01-01T12:40:07Z

←Older revision		Revision as of 12:40, 1 January 2020
Line 1:		Line 1:

	==Crystal structure of LIR1.02, one of the alleles of LIR1==		==Crystal structure of LIR1.02, one of the alleles of LIR1==
-	<StructureSection load='1ugn' size='340' side='right' caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1ugn' size='340' side='right'caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Amano, K]]		[[Category: Amano, K]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]

OCA at 07:30, 28 March 2018

2018-03-28T07:30:16Z

←Older revision		Revision as of 07:30, 28 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of LIR1.02, one of the alleles of LIR1==		==Crystal structure of LIR1.02, one of the alleles of LIR1==
	<StructureSection load='1ugn' size='340' side='right' caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ugn' size='340' side='right' caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [http://pdbe.org/1ugn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [http://www.ebi.ac.uk/pdbsum/1ugn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [http://pdbe.org/1ugn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [http://www.ebi.ac.uk/pdbsum/1ugn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ugn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:28, 11 September 2015

2015-09-11T13:28:25Z

←Older revision		Revision as of 13:28, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1ugn' size='340' side='right' caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ugn' size='340' side='right' caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [http://www.ebi.ac.uk/pdbsum/1ugn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [http://pdbe.org/1ugn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [http://www.ebi.ac.uk/pdbsum/1ugn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ugn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Amano, K]]		[[Category: Amano, K]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]

OCA at 17:04, 25 December 2014

2014-12-25T17:04:49Z

←Older revision		Revision as of 17:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [http://www.ebi.ac.uk/pdbsum/1ugn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [http://www.ebi.ac.uk/pdbsum/1ugn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Amano, K.]]	+	[[Category: Amano, K]]
-	[[Category: Kohda, D.]]	+	[[Category: Kohda, D]]
-	[[Category: Kuroki, K.]]	+	[[Category: Kuroki, K]]
-	[[Category: Maenaka, K.]]	+	[[Category: Maenaka, K]]
-	[[Category: Rasubala, L.]]	+	[[Category: Rasubala, L]]
-	[[Category: Shiroishi, M.]]	+	[[Category: Shiroishi, M]]
-	[[Category: Tokunaga, K.]]	+	[[Category: Tokunaga, K]]
-	[[Category: Tsuchiya, N.]]	+	[[Category: Tsuchiya, N]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin-like fold]]		[[Category: Immunoglobulin-like fold]]

OCA at 20:17, 29 September 2014

2014-09-29T20:17:24Z

←Older revision		Revision as of 20:17, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ugn.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of LIR1.02, one of the alleles of LIR1==
		+	<StructureSection load='1ugn' size='340' side='right' caption='[[1ugn]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [http://www.ebi.ac.uk/pdbsum/1ugn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1/LIR1/ILT2) is an inhibitory receptor broadly expressed on leukocytes and recognizes HLA-class I and human cytomegalovirus UL18. LILRB1 is encoded within the leukocyte receptor complex on 19q13.4, previously implicated to be a susceptibility region to systemic lupus erythematosus (SLE). In this study, we screened for polymorphisms of LILRB1 and examined their association with SLE and rheumatoid arthritis (RA). In the 5' portion of LILRB1, three haplotypes containing four non-synonymous substitutions within the ligand-binding domains and two single nucleotide polymorphisms within the promoter region were identified and designated as PE01-03. In the 3' portion, two haplotypes (CY01, 02) containing a non-synonymous substitution of the cytoplasmic region were identified. CY01 and 02 did not co-segregate with PE01-03. Significant association with susceptibility to SLE or RA was not observed; however, among the subjects not carrying RA-associated HLA-DRB1 shared epitope (SE), LILRB1.PE01/01 diplotype was significantly associated with RA (odds ratio 2.05, P = 0.019 and Pc = 0.038). Gross difference was not observed in the crystal structures, thermostabilities and binding affinities to HLA-class I ligands among LILRB1.PE01-03 haplotype products; however, surface expression of LILRB1 was significantly decreased in lymphocytes and monocytes from the carriers of PE01 haplotype. These findings demonstrated that LILRB1 is highly polymorphic and is associated with susceptibility to RA in HLA-DRB1 SE negative subjects, possibly by insufficient inhibitory signaling in leukocytes. In addition, these observations suggested that the polymorphisms of LILR family members may be substantially involved in the diversity of human immune responses.

-	~~{{STRUCTURE_1ugn\| PDB=1ugn \| SCENE= }}~~	+	Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis.,Kuroki K, Tsuchiya N, Shiroishi M, Rasubala L, Yamashita Y, Matsuta K, Fukazawa T, Kusaoi M, Murakami Y, Takiguchi M, Juji T, Hashimoto H, Kohda D, Maenaka K, Tokunaga K Hum Mol Genet. 2005 Aug 15;14(16):2469-80. Epub 2005 Jul 13. PMID:16014635<ref>PMID:16014635</ref>

-	~~===Crystal structure of LIR1.02~~, ~~one~~ of the ~~alleles~~ of ~~LIR1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16014635}}~~	+	==See Also==
-		+	*[[Leukocyte immunoglobulin-like receptor\|Leukocyte immunoglobulin-like receptor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1ugn~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016014635<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Amano, K.]]		[[Category: Amano, K.]]

OCA: Protected "1ugn" [edit=sysop:move=sysop]

2013-01-05T10:54:52Z

Protected "1ugn" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:54, 5 January 2013

OCA at 10:54, 5 January 2013

2013-01-05T10:54:48Z

←Older revision		Revision as of 10:54, 5 January 2013
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-	{{Seed}}
	[[Image:1ugn.png\|left\|200px]]		[[Image:1ugn.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1ugn\| PDB=1ugn \| SCENE= }}		{{STRUCTURE_1ugn\| PDB=1ugn \| SCENE= }}

	===Crystal structure of LIR1.02, one of the alleles of LIR1===		===Crystal structure of LIR1.02, one of the alleles of LIR1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16014635}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16014635 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16014635}}		{{ABSTRACT_PUBMED_16014635}}

	==About this Structure==		==About this Structure==
-	~~1UGN~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA].	+	[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16014635~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016014635</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Amano, K.]]		[[Category: Amano, K.]]
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	[[Category: Tokunaga, K.]]		[[Category: Tokunaga, K.]]
	[[Category: Tsuchiya, N.]]		[[Category: Tsuchiya, N.]]
		+	[[Category: Immune system]]
	[[Category: Immunoglobulin-like fold]]		[[Category: Immunoglobulin-like fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:08:33 2009''

OCA at 21:08, 17 February 2009

2009-02-17T21:08:37Z

←Older revision		Revision as of 21:08, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1UGN is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA].	+	1UGN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA].

	==Reference==		==Reference==
-	Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis., Kuroki K, Tsuchiya N, Shiroishi M, Rasubala L, Yamashita Y, Matsuta K, Fukazawa T, Kusaoi M, Murakami Y, Takiguchi M, Juji T, Hashimoto H, Kohda D, Maenaka K, Tokunaga K, Hum Mol Genet. 2005 Aug 15;14(16):2469-80. Epub 2005 Jul 13. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16014635 16014635]~~	+	<ref group="xtra">PMID:16014635</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Amano, K.]]		[[Category: Amano, K.]]
	[[Category: Kohda, D.]]		[[Category: Kohda, D.]]
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	[[Category: Immunoglobulin-like fold]]		[[Category: Immunoglobulin-like fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:51:~~59 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:08:33 2009''