1ujp - Revision history

OCA at 07:39, 25 October 2023

2023-10-25T07:39:53Z

←Older revision		Revision as of 07:39, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1ujp' size='340' side='right'caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='1ujp' size='340' side='right'caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.34Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [https://pdbe.org/1ujp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [https://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujp ProSAT], [https://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [https://pdbe.org/1ujp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [https://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujp ProSAT], [https://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TRPA_THET2 TRPA_THET2]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate (By similarity).	+	[https://www.uniprot.org/uniprot/TRPA_THET2 TRPA_THET2] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thet8]]~~	+	[[Category: Thermus thermophilus HB8]]
-	~~[[Category: Tryptophan synthase~~]]	+	[[Category: Asada Y]]
-	[[Category: Asada, Y]]	+	[[Category: Kunishima N]]
-	[[Category: Kunishima, N]]	+	[[Category: Kuramitsu S]]
-	[[Category: Kuramitsu, S]]	+	[[Category: Miyano M]]
-	[[Category: Miyano, M]]	+	[[Category: Yokoyama S]]
-	~~[[Category: Structural genomic~~]]	+
-	[[Category: Yokoyama, S]]	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Tryptophan~~]]	+

OCA at 06:12, 6 October 2021

2021-10-06T06:12:09Z

←Older revision		Revision as of 06:12, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='1ujp' size='340' side='right'caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='1ujp' size='340' side='right'caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UJP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [~~http~~://pdbe.org/1ujp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujp ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [https://pdbe.org/1ujp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [https://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujp ProSAT], [https://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TRPA_THET2 TRPA_THET2]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate (By similarity).	+	[[https://www.uniprot.org/uniprot/TRPA_THET2 TRPA_THET2]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Tryptophan synthase\|Tryptophan synthase]]	+	*[[Tryptophan synthase 3D structures\|Tryptophan synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:44, 1 January 2020

2020-01-01T12:44:09Z

←Older revision		Revision as of 12:44, 1 January 2020
Line 1:		Line 1:

	==Crystal Structure of Tryptophan Synthase A-Subunit From Thermus thermophilus HB8==		==Crystal Structure of Tryptophan Synthase A-Subunit From Thermus thermophilus HB8==
-	<StructureSection load='1ujp' size='340' side='right' caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>	+	<StructureSection load='1ujp' size='340' side='right'caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJP FirstGlance]. <br>
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Thet8]]		[[Category: Thet8]]
	[[Category: Tryptophan synthase]]		[[Category: Tryptophan synthase]]

OCA at 07:34, 28 March 2018

2018-03-28T07:34:00Z

←Older revision		Revision as of 07:34, 28 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Tryptophan Synthase A-Subunit From Thermus thermophilus HB8==		==Crystal Structure of Tryptophan Synthase A-Subunit From Thermus thermophilus HB8==
	<StructureSection load='1ujp' size='340' side='right' caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='1ujp' size='340' side='right' caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [http://pdbe.org/1ujp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [http://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [http://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [http://pdbe.org/1ujp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [http://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujp ProSAT], [http://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uj/1ujp_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uj/1ujp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:56, 8 February 2016

2016-02-08T08:56:08Z

←Older revision		Revision as of 08:56, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ujp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:57, 10 September 2015

2015-09-10T09:57:02Z

←Older revision		Revision as of 09:57, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ujp' size='340' side='right' caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='1ujp' size='340' side='right' caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [http://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [http://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [http://pdbe.org/1ujp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [http://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [http://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ujp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermus thermophilus~~]]	+	[[Category: Thet8]]
	[[Category: Tryptophan synthase]]		[[Category: Tryptophan synthase]]
	[[Category: Asada, Y]]		[[Category: Asada, Y]]

OCA at 22:06, 24 December 2014

2014-12-24T22:06:18Z

←Older revision		Revision as of 22:06, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [http://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [http://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [http://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [http://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRPA_THET2 TRPA_THET2]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Tryptophan synthase]]		[[Category: Tryptophan synthase]]
-	[[Category: Asada, Y.]]	+	[[Category: Asada, Y]]
-	[[Category: Kunishima, N.]]	+	[[Category: Kunishima, N]]
-	[[Category: Kuramitsu, S.]]	+	[[Category: Kuramitsu, S]]
-	[[Category: Miyano, M.]]	+	[[Category: Miyano, M]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Lyase]]		[[Category: Lyase]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Tryptophan]]		[[Category: Tryptophan]]
-	[[Category: Tryptophan synthase]]

OCA at 18:22, 29 September 2014

2014-09-29T18:22:03Z

←Older revision		Revision as of 18:22, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1ujp.~~png\|left~~\|200px]]	+	==Crystal Structure of Tryptophan Synthase A-Subunit From Thermus thermophilus HB8==
		+	<StructureSection load='1ujp' size='340' side='right' caption='[[1ujp]], [[Resolution\|resolution]] 1.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ujp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ujp RCSB], [http://www.ebi.ac.uk/pdbsum/1ujp PDBsum], [http://www.topsan.org/Proteins/RSGI/1ujp TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uj/1ujp_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In order to elucidate the thermo-stabilization mechanism of the tryptophan synthase alpha-subunit from the extreme thermophile Thermus thermophilus HB8 (Tt-alpha-subunit), its crystal structure was determined and its stability was examined using DSC. The results were compared to those of other orthologs from mesophilic and hyperthermophilic organisms. The denaturation temperature of the Tt-alpha-subunit was higher than that of the alpha-subunit from S. typhimurium (St-alpha-subunit) but lower than that of the alpha-subunit from P. furiosus (Pf-alpha-subunit). Specific denaturation enthalpy and specific denaturation heat capacity values of the Tt-alpha-subunit were the lowest among the three proteins, suggesting that entropy effects are responsible for the stabilization of the Tt-alpha-subunit. Based on a structural comparison with the St-alpha-subunit, two deletions in loop regions, an increase in the number of ion pairs and a decrease in cavity volume seem to be responsible for the stabilization of the Tt-alpha-subunit. The results of structural comparison suggest that the native structure of the Tt-alpha-subunit is better adapted to an ideally stable structure than that of the St-alpha-subunit, but worse than that of the Pf-alpha-subunit. The results of calorimetry suggest that the residual structure of the Tt-alpha-subunit in the denatured state contributes to the stabilization.

-	~~{{STRUCTURE_1ujp\| PDB=1ujp \| SCENE= }}~~	+	Stabilization mechanism of the tryptophan synthase alpha-subunit from Thermus thermophilus HB8: X-ray crystallographic analysis and calorimetry.,Asada Y, Sawano M, Ogasahara K, Nakamura J, Ota M, Kuroishi C, Sugahara M, Yutani K, Kunishima N J Biochem. 2005 Oct;138(4):343-53. PMID:16272128<ref>PMID:16272128</ref>

-	~~===Crystal Structure of Tryptophan Synthase A-Subunit~~ From ~~Thermus thermophilus HB8===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16272128}}~~	+	==See Also==
-		+	*[[Tryptophan synthase\|Tryptophan synthase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1ujp~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016272128<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Tryptophan synthase]]		[[Category: Tryptophan synthase]]

OCA: Protected "1ujp" [edit=sysop:move=sysop]

2013-01-05T10:57:47Z

Protected "1ujp" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:57, 5 January 2013

OCA at 10:57, 5 January 2013

2013-01-05T10:57:43Z

←Older revision		Revision as of 10:57, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1ujp.png\|left\|200px]]		[[Image:1ujp.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ujp", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ujp\| PDB=1ujp \| SCENE= }}		{{STRUCTURE_1ujp\| PDB=1ujp \| SCENE= }}

	===Crystal Structure of Tryptophan Synthase A-Subunit From Thermus thermophilus HB8===		===Crystal Structure of Tryptophan Synthase A-Subunit From Thermus thermophilus HB8===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16272128}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16272128 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16272128}}		{{ABSTRACT_PUBMED_16272128}}

	==About this Structure==		==About this Structure==
-	~~1UJP~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA].	+	[[1ujp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJP OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16272128~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016272128</ref><references group="xtra"/>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Tryptophan synthase]]		[[Category: Tryptophan synthase]]
Line 32:		Line 20:
	[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]		[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
		+	[[Category: Lyase]]
	[[Category: Riken structural genomics/proteomics initiative]]		[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
Line 37:		Line 26:
	[[Category: Tryptophan]]		[[Category: Tryptophan]]
	[[Category: Tryptophan synthase]]		[[Category: Tryptophan synthase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:46:32 2009''