1ulg - Revision history

OCA at 06:16, 3 April 2024

2024-04-03T06:16:53Z

←Older revision		Revision as of 06:16, 3 April 2024
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ulg ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ulg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Recognition of and discrimination between potential glyco-substrates is central to the function of galectins. Here we dissect the fundamental parameters responsible for such selectivity by the fungal representative, CGL2. The 2.1 A crystal structure of CGL2 and five substrate complexes reveal that this prototype galectin achieves increased substrate specificity by accommodating substituted oligosaccharides of the mammalian blood group A/B type in an extended binding cleft. Kinetic studies on wild-type and mutant CGL2 proteins demonstrate that the tetrameric organization is essential for functionality. The geometric constraints due to the orthogonal orientation of the four binding sites have important consequences on substrate binding and selectivity.
-
-	Structure and functional analysis of the fungal galectin CGL2.,Walser PJ, Haebel PW, Kunzler M, Sargent D, Kues U, Aebi M, Ban N Structure. 2004 Apr;12(4):689-702. PMID:15062091<ref>PMID:15062091</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1ulg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 23:55, 27 December 2023

2023-12-27T23:55:46Z

←Older revision		Revision as of 23:55, 27 December 2023
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	<StructureSection load='1ulg' size='340' side='right'caption='[[1ulg]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1ulg' size='340' side='right'caption='[[1ulg]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Agaricus_cinereus Agaricus cinereus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1ULG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ULG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GAL:BETA~~-~~D-GALACTOSE'>GAL</scene>~~, ~~<scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 Agaricus cinereus])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [https://pdbe.org/1ulg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [https://www.ebi.ac.uk/pdbsum/1ulg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ulg ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [~~http~~://pdbe.org/1ulg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ulg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ulg ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CGL2_COPCI CGL2_COPCI] Binds lactose. May play a role in fruiting body formation.<ref>PMID:8999822</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Agaricus cinereus~~]]	+	[[Category: Coprinopsis cinerea]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aebi, M]]	+	[[Category: Aebi M]]
-	[[Category: Ban, N]]	+	[[Category: Ban N]]
-	[[Category: Haebel~~, P W~~]]	+	[[Category: Haebel PW]]
-	[[Category: Kuenzler, M]]	+	[[Category: Kuenzler M]]
-	[[Category: Kues, U]]	+	[[Category: Kues U]]
-	[[Category: Walser~~, P J]]~~	+	[[Category: Walser PJ]]
-	~~[[Category: Beta-galactoside binding lectin]]~~	+
-	~~[[Category: Galectin]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Sugar binding]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 07:29, 30 December 2020

2020-12-30T07:29:47Z

←Older revision		Revision as of 07:29, 30 December 2020
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	==CGL2 in complex with Thomsen-Friedenreich antigen==		==CGL2 in complex with Thomsen-Friedenreich antigen==
-	<StructureSection load='1ulg' size='340' side='right' caption='[[1ulg]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1ulg' size='340' side='right'caption='[[1ulg]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Copci Copci~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ULG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Agaricus_cinereus Agaricus cinereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ULG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 ~~COPCI~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 Agaricus cinereus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [http://pdbe.org/1ulg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [http://www.ebi.ac.uk/pdbsum/1ulg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ulg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [http://pdbe.org/1ulg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [http://www.ebi.ac.uk/pdbsum/1ulg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ulg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Galectin\|Galectin]]	+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Copci~~]]	+	[[Category: Agaricus cinereus]]
		+	[[Category: Large Structures]]
	[[Category: Aebi, M]]		[[Category: Aebi, M]]
	[[Category: Ban, N]]		[[Category: Ban, N]]

OCA at 07:57, 28 March 2018

2018-03-28T07:57:08Z

←Older revision		Revision as of 07:57, 28 March 2018
Line 1:		Line 1:
		+
	==CGL2 in complex with Thomsen-Friedenreich antigen==		==CGL2 in complex with Thomsen-Friedenreich antigen==
	<StructureSection load='1ulg' size='340' side='right' caption='[[1ulg]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1ulg' size='340' side='right' caption='[[1ulg]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 COPCI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 COPCI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [http://pdbe.org/1ulg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [http://www.ebi.ac.uk/pdbsum/1ulg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [http://pdbe.org/1ulg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [http://www.ebi.ac.uk/pdbsum/1ulg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ulg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ul/1ulg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ul/1ulg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:08, 7 February 2016

2016-02-07T09:08:18Z

←Older revision		Revision as of 09:08, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ulg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:54, 9 September 2015

2015-09-09T23:54:43Z

←Older revision		Revision as of 23:54, 9 September 2015
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	<StructureSection load='1ulg' size='340' side='right' caption='[[1ulg]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1ulg' size='340' side='right' caption='[[1ulg]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Coprinopsis_cinerea Coprinopsis cinerea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ULG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Copci Copci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ULG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 ~~Coprinopsis cinerea~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 COPCI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [http://www.ebi.ac.uk/pdbsum/1ulg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [http://pdbe.org/1ulg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [http://www.ebi.ac.uk/pdbsum/1ulg PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ulg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Coprinopsis cinerea~~]]	+	[[Category: Copci]]
	[[Category: Aebi, M]]		[[Category: Aebi, M]]
	[[Category: Ban, N]]		[[Category: Ban, N]]

OCA at 13:43, 6 January 2015

2015-01-06T13:43:21Z

←Older revision		Revision as of 13:43, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ULG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ULG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 Coprinopsis cinerea])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 Coprinopsis cinerea])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [http://www.ebi.ac.uk/pdbsum/1ulg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [http://www.ebi.ac.uk/pdbsum/1ulg PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Coprinopsis cinerea]]		[[Category: Coprinopsis cinerea]]
-	[[Category: Aebi, M.]]	+	[[Category: Aebi, M]]
-	[[Category: Ban, N.]]	+	[[Category: Ban, N]]
-	[[Category: Haebel, P W.]]	+	[[Category: Haebel, P W]]
-	[[Category: Kuenzler, M.]]	+	[[Category: Kuenzler, M]]
-	[[Category: Kues, U.]]	+	[[Category: Kues, U]]
-	[[Category: Walser, P J.]]	+	[[Category: Walser, P J]]
	[[Category: Beta-galactoside binding lectin]]		[[Category: Beta-galactoside binding lectin]]
	[[Category: Galectin]]		[[Category: Galectin]]

OCA at 21:51, 28 September 2014

2014-09-28T21:51:25Z

←Older revision		Revision as of 21:51, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ulg.~~png~~\|~~left~~\|200px]]	+	==CGL2 in complex with Thomsen-Friedenreich antigen==
		+	<StructureSection load='1ulg' size='340' side='right' caption='[[1ulg]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ULG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sla\|1sla]], [[1qmj\|1qmj]], [[1gan\|1gan]], [[1c1f\|1c1f]], [[1bkz\|1bkz]], [[1a3k\|1a3k]], [[1lcl\|1lcl]], [[1is5\|1is5]], [[1ul9\|1ul9]], [[1ulc\|1ulc]], [[1uld\|1uld]], [[1ule\|1ule]], [[1ulf\|1ulf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 Coprinopsis cinerea])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [http://www.ebi.ac.uk/pdbsum/1ulg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ul/1ulg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recognition of and discrimination between potential glyco-substrates is central to the function of galectins. Here we dissect the fundamental parameters responsible for such selectivity by the fungal representative, CGL2. The 2.1 A crystal structure of CGL2 and five substrate complexes reveal that this prototype galectin achieves increased substrate specificity by accommodating substituted oligosaccharides of the mammalian blood group A/B type in an extended binding cleft. Kinetic studies on wild-type and mutant CGL2 proteins demonstrate that the tetrameric organization is essential for functionality. The geometric constraints due to the orthogonal orientation of the four binding sites have important consequences on substrate binding and selectivity.

-	~~{{STRUCTURE_1ulg\| PDB=1ulg \| SCENE= }}~~	+	Structure and functional analysis of the fungal galectin CGL2.,Walser PJ, Haebel PW, Kunzler M, Sargent D, Kues U, Aebi M, Ban N Structure. 2004 Apr;12(4):689-702. PMID:15062091<ref>PMID:15062091</ref>

-	~~===CGL2 in complex with Thomsen-Friedenreich antigen===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15062091}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ulg]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA].~~	+

	==See Also==		==See Also==
	*[[Galectin\|Galectin]]		*[[Galectin\|Galectin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015062091<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Coprinopsis cinerea]]		[[Category: Coprinopsis cinerea]]
	[[Category: Aebi, M.]]		[[Category: Aebi, M.]]

OCA: Protected "1ulg" [edit=sysop:move=sysop]

2012-10-20T06:12:25Z

Protected "1ulg" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:12, 20 October 2012

OCA at 06:12, 20 October 2012

2012-10-20T06:12:24Z

←Older revision		Revision as of 06:12, 20 October 2012
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-	{{Seed}}
	[[Image:1ulg.png\|left\|200px]]		[[Image:1ulg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ulg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ulg\| PDB=1ulg \| SCENE= }}		{{STRUCTURE_1ulg\| PDB=1ulg \| SCENE= }}

	===CGL2 in complex with Thomsen-Friedenreich antigen===		===CGL2 in complex with Thomsen-Friedenreich antigen===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15062091}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15062091 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15062091}}		{{ABSTRACT_PUBMED_15062091}}

	==About this Structure==		==About this Structure==
-	~~1ULG~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA].	+	[[1ulg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA].
		+
		+	==See Also==
		+	*[[Galectin\|Galectin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15062091~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015062091</ref><references group="xtra"/>
	[[Category: Coprinopsis cinerea]]		[[Category: Coprinopsis cinerea]]
	[[Category: Aebi, M.]]		[[Category: Aebi, M.]]
Line 35:		Line 26:
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Sugar binding]]		[[Category: Sugar binding]]
-		+	[[Category: Sugar binding protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 12:47:16 2009''~~	+