1uow - Revision history

OCA at 12:53, 13 December 2023

2023-12-13T12:53:59Z

←Older revision		Revision as of 12:53, 13 December 2023
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	<StructureSection load='1uow' size='340' side='right'caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>		<StructureSection load='1uow' size='340' side='right'caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UOW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UOW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.04Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [https://pdbe.org/1uow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [https://www.ebi.ac.uk/pdbsum/1uow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uow ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [https://pdbe.org/1uow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [https://www.ebi.ac.uk/pdbsum/1uow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uow ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cheng, Y~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Patel, D J~~]]	+	[[Category: Cheng Y]]
-	[[Category: ~~Sequeira, S M~~]]	+	[[Category: Patel DJ]]
-	[[Category: ~~Sollner, T H~~]]	+	[[Category: Sequeira SM]]
-	[[Category: ~~Glycoprotein]]~~	+	[[Category: Sollner TH]]
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 06:15, 6 October 2021

2021-10-06T06:15:19Z

←Older revision		Revision as of 06:15, 6 October 2021
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	<StructureSection load='1uow' size='340' side='right'caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>		<StructureSection load='1uow' size='340' side='right'caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UOW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UOW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [~~http~~://pdbe.org/1uow PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uow PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uow ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [https://pdbe.org/1uow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [https://www.ebi.ac.uk/pdbsum/1uow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uow ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Synaptotagmin\|Synaptotagmin]]	+	*[[Synaptotagmin 3D structures\|Synaptotagmin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:40, 1 January 2020

2020-01-01T12:40:10Z

←Older revision		Revision as of 12:40, 1 January 2020
Line 1:		Line 1:

	==Calcium binding domain C2B==		==Calcium binding domain C2B==
-	<StructureSection load='1uow' size='340' side='right' caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>	+	<StructureSection load='1uow' size='340' side='right'caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UOW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UOW FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1uow" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1uow" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Synaptotagmin\|Synaptotagmin]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Cheng, Y]]		[[Category: Cheng, Y]]
	[[Category: Patel, D J]]		[[Category: Patel, D J]]

OCA at 07:30, 28 March 2018

2018-03-28T07:30:22Z

←Older revision		Revision as of 07:30, 28 March 2018
Line 1:		Line 1:
-	==~~CALCIUM BINDING DOMAIN~~ C2B==	+
		+	==Calcium binding domain C2B==
	<StructureSection load='1uow' size='340' side='right' caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>		<StructureSection load='1uow' size='340' side='right' caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [http://pdbe.org/1uow PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [http://www.ebi.ac.uk/pdbsum/1uow PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [http://pdbe.org/1uow PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [http://www.ebi.ac.uk/pdbsum/1uow PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uow ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uo/1uow_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uo/1uow_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:10, 8 February 2016

2016-02-08T14:10:46Z

←Older revision		Revision as of 14:10, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uow ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:20, 10 September 2015

2015-09-10T12:20:09Z

←Older revision		Revision as of 12:20, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1uow' size='340' side='right' caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>		<StructureSection load='1uow' size='340' side='right' caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UOW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UOW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [http://www.ebi.ac.uk/pdbsum/1uow PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [http://pdbe.org/1uow PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [http://www.ebi.ac.uk/pdbsum/1uow PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uow" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Cheng, Y]]		[[Category: Cheng, Y]]
	[[Category: Patel, D J]]		[[Category: Patel, D J]]

OCA at 13:17, 6 January 2015

2015-01-06T13:17:31Z

←Older revision		Revision as of 13:17, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UOW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UOW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [http://www.ebi.ac.uk/pdbsum/1uow PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [http://www.ebi.ac.uk/pdbsum/1uow PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Cheng, Y.]]	+	[[Category: Cheng, Y]]
-	[[Category: Patel, D J.]]	+	[[Category: Patel, D J]]
-	[[Category: Sequeira, S M.]]	+	[[Category: Sequeira, S M]]
-	[[Category: Sollner, T H.]]	+	[[Category: Sollner, T H]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

OCA at 19:48, 29 September 2014

2014-09-29T19:48:46Z

←Older revision		Revision as of 19:48, 29 September 2014
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-	[[~~Image:~~1uow.~~png~~\|~~left~~\|200px]]	+	==CALCIUM BINDING DOMAIN C2B==
		+	<StructureSection load='1uow' size='340' side='right' caption='[[1uow]], [[Resolution\|resolution]] 1.04Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UOW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byn\|1byn]], [[1k5w\|1k5w]], [[1rsy\|1rsy]], [[1tjx\|1tjx]], [[1uov\|1uov]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uow RCSB], [http://www.ebi.ac.uk/pdbsum/1uow PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uo/1uow_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Synaptotagmin I has two tandem Ca(2+)-binding C(2) domains, which are essential for fast synchronous synaptic transmission in the central nervous system. We have solved four crystal structures of the C(2)B domain, one of them in the cation-free form at 1.50 A resolution, two in the Ca(2+)-bound form at 1.04 A (two bound Ca(2+) ions) and 1.65 A (three bound Ca(2+) ions) resolution and one in the Sr(2+)-bound form at 1.18 A (one bound Sr(2+) ion) resolution. The side chains of four highly conserved aspartic acids (D303, D309, D363, and D365) and two main chain oxygens (M302:O and Y364:O), together with water molecules, are in direct contact with two bound Ca(2+) ions (sites 1 and 2). At higher Ca(2+) concentrations, the side chain of N333 rotates and cooperates with D309 to generate a third Ca(2+) coordination site (site 3). Divalent cation binding sites 1 and 2 in the C(2)B domain were previously identified from NMR NOE patterns and titration studies, supplemented by site-directed mutation analysis. One difference between the crystal and NMR studies involves D371, which is not involved in coordination with any of the identified Ca(2+) sites in the crystal structures, while it is coordinated to Ca(2+) in site 2 in the NMR structure. In the presence of Sr(2+), which is also capable of triggering exocytosis, but with lower efficiency, only one cation binding site (site 1) was occupied in the crystallographic structure.

-	~~{{STRUCTURE_1uow\| PDB=1uow \| SCENE= }}~~	+	Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain.,Cheng Y, Sequeira SM, Malinina L, Tereshko V, Sollner TH, Patel DJ Protein Sci. 2004 Oct;13(10):2665-72. Epub 2004 Aug 31. PMID:15340165<ref>PMID:15340165</ref>

-	~~===CALCIUM BINDING DOMAIN C2B===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15340165}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1uow]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015340165<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Cheng, Y.]]		[[Category: Cheng, Y.]]

OCA: Protected "1uow" [edit=sysop:move=sysop]

2013-01-05T13:08:48Z

Protected "1uow" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:08, 5 January 2013

OCA at 13:08, 5 January 2013

2013-01-05T13:08:45Z

←Older revision		Revision as of 13:08, 5 January 2013
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-	{{Seed}}
	[[Image:1uow.png\|left\|200px]]		[[Image:1uow.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1uow\| PDB=1uow \| SCENE= }}		{{STRUCTURE_1uow\| PDB=1uow \| SCENE= }}

	===CALCIUM BINDING DOMAIN C2B===		===CALCIUM BINDING DOMAIN C2B===

-
-	<!--
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	{{ABSTRACT_PUBMED_15340165}}		{{ABSTRACT_PUBMED_15340165}}

	==About this Structure==		==About this Structure==
-	~~1UOW~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA].	+	[[1uow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15340165~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015340165</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Cheng, Y.]]		[[Category: Cheng, Y.]]
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	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:30:21 2009''