1ur7 - Revision history

OCA at 06:16, 6 October 2021

2021-10-06T06:16:39Z

←Older revision		Revision as of 06:16, 6 October 2021
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	<StructureSection load='1ur7' size='340' side='right'caption='[[1ur7]]' scene=''>		<StructureSection load='1ur7' size='340' side='right'caption='[[1ur7]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UR7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UR7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ur7 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1ur7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ur7 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ur7 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1ur7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ur7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:48, 1 January 2020

2020-01-01T12:48:58Z

←Older revision		Revision as of 12:48, 1 January 2020
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	==MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING==		==MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING==
-	<StructureSection load='1ur7' size='340' side='right' caption='[[1ur7]]' scene=''>	+	<StructureSection load='1ur7' size='340' side='right'caption='[[1ur7]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UR7 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UR7 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Brown, C]]		[[Category: Brown, C]]
	[[Category: Dafforn, T R]]		[[Category: Dafforn, T R]]

OCA at 07:38, 28 March 2018

2018-03-28T07:38:11Z

←Older revision		Revision as of 07:38, 28 March 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UR7 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UR7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ur7 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ur7 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ur7 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ur7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ur7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:01, 11 February 2016

2016-02-11T10:01:22Z

←Older revision		Revision as of 10:01, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING==		==MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING==
	<StructureSection load='1ur7' size='340' side='right' caption='[[1ur7]]' scene=''>		<StructureSection load='1ur7' size='340' side='right' caption='[[1ur7]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Brown, C]]		[[Category: Brown, C]]
	[[Category: Dafforn, T R]]		[[Category: Dafforn, T R]]

OCA at 00:28, 12 September 2015

2015-09-12T00:28:49Z

←Older revision		Revision as of 00:28, 12 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ur7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:42, 18 December 2014

2014-12-18T11:42:11Z

←Older revision		Revision as of 11:42, 18 December 2014
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-	~~{{Theoretical_model}}~~	+	==MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING==
		+	<StructureSection load='1ur7' size='340' side='right' caption='[[1ur7]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UR7 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ur7 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ur7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human leukocyte antigen (HLA) A2 is one of the most immunodominant HLA antigens. Through a process of light-chain variable domain (VL) shuffling, we analyzed the VL domains' role in anti-HLA-A2/A28-binding site diversity. This was achieved by combining a VH3-30-encoded HLA-A2/A28-specific heavy-chain variable domain with 10(4) non-immune VL domains. Twelve HLA-A2/A28-specific antibodies were subsequently identified. VL gene analysis demonstrated an absence of Vlambda domains and that all have VkappaI-encoded light chains. The affinities correlated with the VkappaI gene present, with the seven highest affinity antibodies using Vkappa domains encoded by the O18 gene segment. A 300-fold difference in affinity was observed between the 12 antibodies, and homology modeling demonstrated a correlation between electrostatic surface potential of the antigen-binding site and affinity for HLA. Overlap between the T-cell receptor-binding site and that of the antibodies was indicated by inhibition of cytotoxic T-lymphocyte killing of peptide-pulsed target cells. A model of antibody binding to HLA-A2 suggested contact with both alpha helices of the HLA molecule, such that the antigen-binding site spans the peptide-binding groove. These data increase the understanding of antibody recognition of HLA and may facilitate the production of clonotypic antibodies with peptide-specific binding.

-	~~{{STRUCTURE_1ur7\| PDB=1ur7 \| SCENE= }}~~	+	Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding.,Watkins NA, Dafforn TR, Kuijpers M, Brown C, Javid B, Lehner PJ, Navarrete C, Ouwehand WH Tissue Antigens. 2004 Apr;63(4):345-54. PMID:15009806<ref>PMID:15009806</ref>
-	~~===MOLECULAR REFINEMENT OF ANTI~~-HLA-A2 ~~USING LIGHT CHAIN SHUFFLING~~: ~~A STRUCTURAL MODEL FOR~~ HLA ~~ANTIBODY BINDING===~~	+
-	~~{{ABSTRACT_PUBMED_15009806}}~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:015009806</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Brown, C]]		[[Category: Brown, C]]
	[[Category: Dafforn, T R]]		[[Category: Dafforn, T R]]

OCA at 04:23, 25 March 2013

2013-03-25T04:23:06Z

←Older revision		Revision as of 04:23, 25 March 2013
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	{{Theoretical_model}}		{{Theoretical_model}}
-
-	[[Image:1ur7.png\|left\|200px]]

	{{STRUCTURE_1ur7\| PDB=1ur7 \| SCENE= }}		{{STRUCTURE_1ur7\| PDB=1ur7 \| SCENE= }}
-
	===MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING===		===MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING===
-
	{{ABSTRACT_PUBMED_15009806}}		{{ABSTRACT_PUBMED_15009806}}

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015009806</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015009806</ref><references group="xtra"/><references/>
	[[Category: Brown, C]]		[[Category: Brown, C]]
	[[Category: Dafforn, T R]]		[[Category: Dafforn, T R]]

OCA: Protected "1ur7" [edit=sysop:move=sysop]

2012-10-21T09:32:36Z

Protected "1ur7" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:32, 21 October 2012

OCA at 09:32, 21 October 2012

2012-10-21T09:32:32Z

←Older revision		Revision as of 09:32, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1ur7.png\|left\|200px]]		[[Image:1ur7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ur7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ur7\| PDB=1ur7 \| SCENE= }}		{{STRUCTURE_1ur7\| PDB=1ur7 \| SCENE= }}

	===MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING===		===MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15009806}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15009806 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15009806}}		{{ABSTRACT_PUBMED_15009806}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UR7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15009806~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015009806</ref><references group="xtra"/>
	[[Category: Brown, C]]		[[Category: Brown, C]]
	[[Category: Dafforn, T R]]		[[Category: Dafforn, T R]]
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	[[Category: Ouwehand, W H]]		[[Category: Ouwehand, W H]]
	[[Category: Watkins, N A]]		[[Category: Watkins, N A]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:31:32 2010''

OCA at 05:31, 8 April 2010

2010-04-08T05:31:33Z

←Older revision		Revision as of 05:31, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1ur7.png\|left\|200px]]

-	The ~~entry 1UR7~~ is ~~a Theoretical Model titled 'MOLECULAR REFINEMENT OF ANTI~~-~~HLA~~-~~A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING'.~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1ur7", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1ur7\| PDB=1ur7 \| SCENE= }}

-	~~[[Category~~:~~Theoretical Model]]~~	+	===MOLECULAR REFINEMENT OF ANTI-HLA-A2 USING LIGHT CHAIN SHUFFLING: A STRUCTURAL MODEL FOR HLA ANTIBODY BINDING===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:54:~~06 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_15009806}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15009806 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15009806}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UR7 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:15009806</ref><references group="xtra"/>
		+	[[Category: Brown, C]]
		+	[[Category: Dafforn, T R]]
		+	[[Category: Javid, B]]
		+	[[Category: Kuijpers, M]]
		+	[[Category: Lehner, P J]]
		+	[[Category: Naverrete, C]]
		+	[[Category: Ouwehand, W H]]
		+	[[Category: Watkins, N A]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:31:32 2010''