1uwe - Revision history

OCA at 13:01, 13 December 2023

2023-12-13T13:01:40Z

←Older revision		Revision as of 13:01, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1uwe' size='340' side='right'caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='1uwe' size='340' side='right'caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1UWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UWE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~1uwg~~\|~~1uwg~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.67Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [~~http~~://pdbe.org/1uwe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uwe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uwe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [https://pdbe.org/1uwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [https://www.ebi.ac.uk/pdbsum/1uwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uwe ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Baumann, U]]	+	[[Category: Baumann U]]
-	[[Category: Reymond~~, J L]]~~	+	[[Category: Reymond JL]]
-	~~[[Category: Antibody~~]]	+

OCA at 11:46, 23 September 2020

2020-09-23T11:46:56Z

←Older revision		Revision as of 11:46, 23 September 2020
Line 1:		Line 1:

	==MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9==		==MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9==
-	<StructureSection load='1uwe' size='340' side='right' caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>	+	<StructureSection load='1uwe' size='340' side='right'caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1UWE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://pdbe.org/1uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uwe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://pdbe.org/1uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uwe ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]
	[[Category: Reymond, J L]]		[[Category: Reymond, J L]]
	[[Category: Antibody]]		[[Category: Antibody]]

OCA at 09:29, 19 December 2018

2018-12-19T09:29:11Z

←Older revision		Revision as of 09:29, 19 December 2018
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	<StructureSection load='1uwe' size='340' side='right' caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='1uwe' size='340' side='right' caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://pdbe.org/1uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uwe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://pdbe.org/1uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uwe ProSAT]</span></td></tr>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uwe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uwe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]
	[[Category: Reymond, J L]]		[[Category: Reymond, J L]]
	[[Category: Antibody]]		[[Category: Antibody]]

OCA at 13:41, 15 March 2017

2017-03-15T13:41:18Z

←Older revision		Revision as of 13:41, 15 March 2017
Line 1:		Line 1:
		+
	==MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9==		==MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9==
	<StructureSection load='1uwe' size='340' side='right' caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='1uwe' size='340' side='right' caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://pdbe.org/1uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://pdbe.org/1uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uwe ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 28:

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lk3 transgenic mice]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]
	[[Category: Reymond, J L]]		[[Category: Reymond, J L]]
	[[Category: Antibody]]		[[Category: Antibody]]

OCA at 14:27, 8 February 2016

2016-02-08T14:27:29Z

←Older revision		Revision as of 14:27, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uwe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:27, 10 September 2015

2015-09-10T12:27:51Z

←Older revision		Revision as of 12:27, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1uwe' size='340' side='right' caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='1uwe' size='340' side='right' caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://pdbe.org/1uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uwe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens]]~~	+	[[Category: Lk3 transgenic mice]]
-	~~[[Category: Mus musculus~~]]	+
	[[Category: Baumann, U]]		[[Category: Baumann, U]]
	[[Category: Reymond, J L]]		[[Category: Reymond, J L]]
	[[Category: Antibody]]		[[Category: Antibody]]

OCA at 13:27, 6 January 2015

2015-01-06T13:27:16Z

←Older revision		Revision as of 13:27, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Baumann, U.]]	+	[[Category: Baumann, U]]
-	[[Category: Reymond, J L.]]	+	[[Category: Reymond, J L]]
	[[Category: Antibody]]		[[Category: Antibody]]

OCA at 19:53, 29 September 2014

2014-09-29T19:53:44Z

←Older revision		Revision as of 19:53, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1uwe.~~png~~\|~~left~~\|200px]]	+	==MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9==
		+	<StructureSection load='1uwe' size='340' side='right' caption='[[1uwe]], [[Resolution\|resolution]] 2.67Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uwe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UWE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uwg\|1uwg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uwe RCSB], [http://www.ebi.ac.uk/pdbsum/1uwe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uwe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Catalytic antibody 14D9 catalyzes the enantioselective protonation of prochiral enol ethers with high enantioselectivity (>99% ee) and a practical turnover (k(cat) = 0.4 s(-1)), allowing for preparative scale applications. This antibody represents one of the rare examples of catalytic antibodies promoting acid-catalyzed processes. Antibody 14D9 was cloned and expressed as a chimeric Fab fragment in Escherichia coli. Crystal structures of Fab 14D9 as apo form and of its close analog 19C9 in complex with the transition state analog were determined at 2.8-A resolution. A series of site-directed mutagenesis experiments was carried out to probe the role of individual active-site amino acids. Proton transfer to carbon is catalyzed by a hydrogen bond network formed by the side chains of Asp(H101) and Tyr(L36) with a water molecule serving as a relay. The intermediate oxocarbonium ion formed during the protonation step is trapped by the same water molecule, resulting in an overall syn-addition of water to the enol ether's double bond. The enantioselectivity is caused by steric crowding at the active site, mainly because of the side chain of Phe(H84). The 20-fold lower activity of 19C9 compared with 14D9 was traced down to residue Thr(L46), which forms a nonproductive hydrogen bond with the catalytic residue Asp(H101), which competes with the critical Asp(H101)-Tyr(L36) hydrogen bond and therefore reduces catalytic efficiency. The catalytic activity of 19C9 was restored to that of 14D9 by using either site-directed mutagenesis (Thr(L46)Ala) or chain shuffling.

-	~~{{STRUCTURE_1uwe\| PDB=1uwe \| SCENE= }}~~	+	Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9.,Zheng L, Baumann U, Reymond JL Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3387-92. Epub 2004 Feb 26. PMID:14988504<ref>PMID:14988504</ref>

-	~~===MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_14988504}}~~	+	==See Also==
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1uwe~~]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:014988504<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA: Protected "1uwe" [edit=sysop:move=sysop]

2013-01-05T13:17:02Z

Protected "1uwe" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:17, 5 January 2013

OCA at 13:17, 5 January 2013

2013-01-05T13:17:00Z

←Older revision		Revision as of 13:17, 5 January 2013
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-	{{Seed}}
	[[Image:1uwe.png\|left\|200px]]		[[Image:1uwe.png\|left\|200px]]

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	{{STRUCTURE_1uwe\| PDB=1uwe \| SCENE= }}		{{STRUCTURE_1uwe\| PDB=1uwe \| SCENE= }}

	===MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9===		===MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14988504}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14988504 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_14988504}}		{{ABSTRACT_PUBMED_14988504}}

	==About this Structure==		==About this Structure==
-	~~1UWE~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Mus_musculus~~/~~homo_sapiens~~ Mus musculus~~/homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA].	+	[[1uwe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14988504~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014988504</ref><references group="xtra"/>
-	[[Category: Mus musculus~~/homo sapiens~~]]	+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
	[[Category: Baumann, U.]]		[[Category: Baumann, U.]]
	[[Category: Reymond, J L.]]		[[Category: Reymond, J L.]]
-	[[Category: ~~Null~~]]	+	[[Category: Antibody]]
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:38:37 2009''~~	+