1uyl - Revision history

OCA at 13:04, 13 December 2023

2023-12-13T13:04:35Z

←Older revision		Revision as of 13:04, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1uyl' size='340' side='right'caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='1uyl' size='340' side='right'caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UYL FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1byq\|1byq]]~~, [[~~1osf~~\|~~1osf~~]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</div></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [https://pdbe.org/1uyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [https://www.ebi.ac.uk/pdbsum/1uyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uyl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [https://pdbe.org/1uyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [https://www.ebi.ac.uk/pdbsum/1uyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uyl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aherne, W]]	+	[[Category: Aherne W]]
-	[[Category: Barril, X]]	+	[[Category: Barril X]]
-	[[Category: Beswick, M]]	+	[[Category: Beswick M]]
-	[[Category: Boxall, K]]	+	[[Category: Boxall K]]
-	[[Category: Collier, A]]	+	[[Category: Collier A]]
-	[[Category: Davies, N]]	+	[[Category: Davies N]]
-	[[Category: Drysdale, M]]	+	[[Category: Drysdale M]]
-	[[Category: Dymock, B]]	+	[[Category: Dymock B]]
-	[[Category: Fink, A]]	+	[[Category: Fink A]]
-	[[Category: Fromont, C]]	+	[[Category: Fromont C]]
-	[[Category: Hubbard~~, R E~~]]	+	[[Category: Hubbard RE]]
-	[[Category: Massey, A]]	+	[[Category: Massey A]]
-	[[Category: Sharp, S]]	+	[[Category: Sharp S]]
-	[[Category: Sheridan, L]]	+	[[Category: Sheridan L]]
-	[[Category: Surgenor, A]]	+	[[Category: Surgenor A]]
-	[[Category: Workman, P]]	+	[[Category: Workman P]]
-	[[Category: Wright, L]]	+	[[Category: Wright L]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Atpase]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Heat shock]]~~	+
-	~~[[Category: Hsp90~~]]	+

OCA at 06:20, 6 October 2021

2021-10-06T06:20:49Z

←Older revision		Revision as of 06:20, 6 October 2021
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	<StructureSection load='1uyl' size='340' side='right'caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='1uyl' size='340' side='right'caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UYL FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1byq\|1byq]], [[1osf\|1osf]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [~~http~~://pdbe.org/1uyl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uyl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uyl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [https://pdbe.org/1uyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [https://www.ebi.ac.uk/pdbsum/1uyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uyl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 13:05, 1 January 2020

2020-01-01T13:05:08Z

←Older revision		Revision as of 13:05, 1 January 2020
Line 1:		Line 1:

	==Structure-Activity Relationships in purine-based inhibitor binding to HSP90 isoforms==		==Structure-Activity Relationships in purine-based inhibitor binding to HSP90 isoforms==
-	<StructureSection load='1uyl' size='340' side='right' caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='1uyl' size='340' side='right'caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UYL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UYL FirstGlance]. <br>
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	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Aherne, W]]		[[Category: Aherne, W]]
	[[Category: Barril, X]]		[[Category: Barril, X]]

OCA at 07:54, 28 March 2018

2018-03-28T07:54:20Z

←Older revision		Revision as of 07:54, 28 March 2018
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-	==~~STRUCTURE~~-~~ACTIVITY RELATIONSHIPS IN PURINE~~-~~BASED INHIBITOR BINDING TO~~ HSP90 ~~ISOFORMS~~==	+
		+	==Structure-Activity Relationships in purine-based inhibitor binding to HSP90 isoforms==
	<StructureSection load='1uyl' size='340' side='right' caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='1uyl' size='340' side='right' caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UYL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UYL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [http://pdbe.org/1uyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [http://www.ebi.ac.uk/pdbsum/1uyl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [http://pdbe.org/1uyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [http://www.ebi.ac.uk/pdbsum/1uyl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uyl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/1uyl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/1uyl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:14, 9 February 2016

2016-02-09T06:14:54Z

←Older revision		Revision as of 06:14, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uyl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:24, 10 September 2015

2015-09-10T19:24:31Z

←Older revision		Revision as of 19:24, 10 September 2015
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	<StructureSection load='1uyl' size='340' side='right' caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='1uyl' size='340' side='right' caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UYL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [http://www.ebi.ac.uk/pdbsum/1uyl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [http://pdbe.org/1uyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [http://www.ebi.ac.uk/pdbsum/1uyl PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uyl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Aherne, W]]		[[Category: Aherne, W]]
	[[Category: Barril, X]]		[[Category: Barril, X]]

OCA at 12:45, 6 January 2015

2015-01-06T12:45:33Z

←Older revision		Revision as of 12:45, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UYL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UYL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [http://www.ebi.ac.uk/pdbsum/1uyl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [http://www.ebi.ac.uk/pdbsum/1uyl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Aherne, W.]]	+	[[Category: Aherne, W]]
-	[[Category: Barril, X.]]	+	[[Category: Barril, X]]
-	[[Category: Beswick, M.]]	+	[[Category: Beswick, M]]
-	[[Category: Boxall, K.]]	+	[[Category: Boxall, K]]
-	[[Category: Collier, A.]]	+	[[Category: Collier, A]]
-	[[Category: Davies, N.]]	+	[[Category: Davies, N]]
-	[[Category: Drysdale, M.]]	+	[[Category: Drysdale, M]]
-	[[Category: Dymock, B.]]	+	[[Category: Dymock, B]]
-	[[Category: Fink, A.]]	+	[[Category: Fink, A]]
-	[[Category: Fromont, C.]]	+	[[Category: Fromont, C]]
-	[[Category: Hubbard, R E.]]	+	[[Category: Hubbard, R E]]
-	[[Category: Massey, A.]]	+	[[Category: Massey, A]]
-	[[Category: Sharp, S.]]	+	[[Category: Sharp, S]]
-	[[Category: Sheridan, L.]]	+	[[Category: Sheridan, L]]
-	[[Category: Surgenor, A.]]	+	[[Category: Surgenor, A]]
-	[[Category: Workman, P.]]	+	[[Category: Workman, P]]
-	[[Category: Wright, L.]]	+	[[Category: Wright, L]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Atpase]]		[[Category: Atpase]]

OCA at 22:24, 28 September 2014

2014-09-28T22:24:17Z

←Older revision		Revision as of 22:24, 28 September 2014
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-	[[~~Image:~~1uyl.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE-ACTIVITY RELATIONSHIPS IN PURINE-BASED INHIBITOR BINDING TO HSP90 ISOFORMS==
		+	<StructureSection load='1uyl' size='340' side='right' caption='[[1uyl]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UYL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uym\|1uym]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uyl RCSB], [http://www.ebi.ac.uk/pdbsum/1uyl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/1uyl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibition of the ATPase activity of the chaperone protein HSP90 is a potential strategy for treatment of cancers. We have determined structures of the HSP90alpha N-terminal domain complexed with the purine-based inhibitor, PU3, and analogs with enhanced potency both in enzyme and cell-based assays. The compounds induce upregulation of HSP70 and downregulation of the known HSP90 client proteins Raf-1, CDK4, and ErbB2, confirming that the molecules inhibit cell growth by a mechanism dependent on HSP90 inhibition. We have also determined the first structure of the N-terminal domain of HSP90beta, complexed with PU3. The structures allow a detailed rationale to be developed for the observed affinity of the PU3 class of compounds for HSP90 and also provide a structural framework for design of compounds with improved binding affinity and drug-like properties.

-	~~{{STRUCTURE_1uyl\| PDB=1uyl \| SCENE= }}~~	+	Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.,Wright L, Barril X, Dymock B, Sheridan L, Surgenor A, Beswick M, Drysdale M, Collier A, Massey A, Davies N, Fink A, Fromont C, Aherne W, Boxall K, Sharp S, Workman P, Hubbard RE Chem Biol. 2004 Jun;11(6):775-85. PMID:15217611<ref>PMID:15217611</ref>

-	~~===STRUCTURE-ACTIVITY RELATIONSHIPS IN PURINE-BASED INHIBITOR BINDING TO HSP90 ISOFORMS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15217611}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1uyl]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA].~~	+

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015217611<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aherne, W.]]		[[Category: Aherne, W.]]

OCA at 12:55, 20 October 2012

2012-10-20T12:55:37Z

←Older revision		Revision as of 12:55, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1uyl]] is a 1 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA].	+	[[1uyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYL OCA].

	==See Also==		==See Also==

OCA at 10:21, 26 July 2012

2012-07-26T10:21:13Z

←Older revision		Revision as of 10:21, 26 July 2012
Line 1:		Line 1:
	[[Image:1uyl.png\|left\|200px]]		[[Image:1uyl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1uyl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1uyl\| PDB=1uyl \| SCENE= }}		{{STRUCTURE_1uyl\| PDB=1uyl \| SCENE= }}

	===STRUCTURE-ACTIVITY RELATIONSHIPS IN PURINE-BASED INHIBITOR BINDING TO HSP90 ISOFORMS===		===STRUCTURE-ACTIVITY RELATIONSHIPS IN PURINE-BASED INHIBITOR BINDING TO HSP90 ISOFORMS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15217611}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15217611 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15217611}}		{{ABSTRACT_PUBMED_15217611}}

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	==See Also==		==See Also==
-	*[[Heat Shock Proteins]]	+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15217611~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015217611</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aherne, W.]]		[[Category: Aherne, W.]]