1v04 - Revision history

OCA at 13:23, 9 May 2024

2024-05-09T13:23:36Z

←Older revision		Revision as of 13:23, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='1v04' size='340' side='right'caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1v04' size='340' side='right'caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1V04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus], [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] and [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V04 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [~~http~~://pdbe.org/1v04 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1v04 ProSAT], [~~http~~://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [https://pdbe.org/1v04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [https://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v04 ProSAT], [https://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PON1_RABIT PON1_RABIT] Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.<ref>PMID:11266077</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Joel Sussman's Favorites\|Joel Sussman's Favorites]]
	*[[Serum Paraoxonase\|Serum Paraoxonase]]		*[[Serum Paraoxonase\|Serum Paraoxonase]]
-	*[[User:Boris Brumshtein\|User:Boris Brumshtein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aharoni, A]]	+	[[Category: Mus musculus]]
-	[[Category: Brumshtein, B]]	+	[[Category: Oryctolagus cuniculus]]
-	[[Category: Dvir, H]]	+	[[Category: Rattus rattus]]
-	[[Category: Gaidukov, L]]	+	[[Category: Aharoni A]]
-	[[Category: Harel, M]]	+	[[Category: Brumshtein B]]
-	[[Category: Khersonsky, O]]	+	[[Category: Dvir H]]
-	[[Category: McCarthy, A]]	+	[[Category: Gaidukov L]]
-	[[Category: Meged, R]]	+	[[Category: Harel M]]
-	[[Category: Ravelli~~, R B.G~~]]	+	[[Category: Khersonsky O]]
-	[[Category: Silman, I]]	+	[[Category: McCarthy A]]
-	[[Category: Sussman~~, J L~~]]	+	[[Category: Meged R]]
-	[[Category: Tawfik~~, D S~~]]	+	[[Category: Ravelli RBG]]
-	[[Category: Toker, L]]	+	[[Category: Silman I]]
-	[[Category: Yagur, S]]	+	[[Category: Sussman JL]]
-	~~[[Category: Antioxidant]]~~	+	[[Category: Tawfik DS]]
-	~~[[Category: Directed evolution]]~~	+	[[Category: Toker L]]
-	~~[[Category: Hydrolase]]~~	+	[[Category: Yagur S]]
-	~~[[Category: ISPC, Israel Structural Proteomics Center]]~~	+
-	~~[[Category: Paraoxonase]]~~	+
-	~~[[Category: Structural genomic~~]]	+

OCA at 06:54, 7 October 2020

2020-10-07T06:54:09Z

←Older revision		Revision as of 06:54, 7 October 2020
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	==serum paraoxonase by directed evolution==		==serum paraoxonase by directed evolution==
-	<StructureSection load='1v04' size='340' side='right' caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1v04' size='340' side='right'caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1V04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1V04 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://pdbe.org/1v04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v04 ProSAT], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://pdbe.org/1v04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v04 ProSAT], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Aharoni, A]]		[[Category: Aharoni, A]]
	[[Category: Brumshtein, B]]		[[Category: Brumshtein, B]]

OCA at 09:33, 26 December 2018

2018-12-26T09:33:40Z

←Older revision		Revision as of 09:33, 26 December 2018
Line 3:		Line 3:
	<StructureSection load='1v04' size='340' side='right' caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1v04' size='340' side='right' caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V04 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://pdbe.org/1v04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v04 ProSAT], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://pdbe.org/1v04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v04 ProSAT], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v04_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v04_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Aharoni, A]]		[[Category: Aharoni, A]]
	[[Category: Brumshtein, B]]		[[Category: Brumshtein, B]]

OCA at 13:41, 15 March 2017

2017-03-15T13:41:36Z

←Older revision		Revision as of 13:41, 15 March 2017
Line 1:		Line 1:
-	==~~SERUM PARAOXONASE BY DIRECTED EVOLUTION~~==	+
		+	==serum paraoxonase by directed evolution==
	<StructureSection load='1v04' size='340' side='right' caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1v04' size='340' side='right' caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_oryctolagus_cuniculus,_mus_musculus,_rattus_rattus Homo sapiens, oryctolagus cuniculus, mus musculus, rattus rattus]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V04 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://pdbe.org/1v04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://pdbe.org/1v04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v04 ProSAT], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v04 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Homo sapiens, oryctolagus cuniculus, mus musculus, rattus rattus]]
	[[Category: Aharoni, A]]		[[Category: Aharoni, A]]
	[[Category: Brumshtein, B]]		[[Category: Brumshtein, B]]
Line 41:		Line 41:
	[[Category: Harel, M]]		[[Category: Harel, M]]
	[[Category: Khersonsky, O]]		[[Category: Khersonsky, O]]
-	[[Category: ~~Mccarthy~~, A]]	+	[[Category: McCarthy, A]]
	[[Category: Meged, R]]		[[Category: Meged, R]]
	[[Category: Ravelli, R B.G]]		[[Category: Ravelli, R B.G]]

OCA at 17:01, 11 September 2015

2015-09-11T17:01:46Z

←Older revision		Revision as of 17:01, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1v04' size='340' side='right' caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1v04' size='340' side='right' caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_rattus Rattus~~ rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_oryctolagus_cuniculus,_mus_musculus,_rattus_rattus Homo sapiens, oryctolagus cuniculus, mus musculus, rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V04 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://pdbe.org/1v04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1v04" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus~~ rattus]]	+	[[Category: Homo sapiens, oryctolagus cuniculus, mus musculus, rattus rattus]]
	[[Category: Aharoni, A]]		[[Category: Aharoni, A]]
	[[Category: Brumshtein, B]]		[[Category: Brumshtein, B]]

OCA at 12:58, 6 January 2015

2015-01-06T12:58:44Z

←Older revision		Revision as of 12:58, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V04 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V04 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Rattus rattus]]		[[Category: Rattus rattus]]
-	[[Category: Aharoni, A.]]	+	[[Category: Aharoni, A]]
-	[[Category: Brumshtein, B.]]	+	[[Category: Brumshtein, B]]
-	[[Category: Dvir, H.]]	+	[[Category: Dvir, H]]
-	[[Category: Gaidukov, L.]]	+	[[Category: Gaidukov, L]]
-	[[Category: Harel, M.]]	+	[[Category: Harel, M]]
-	[[Category: Khersonsky, O.]]	+	[[Category: Khersonsky, O]]
-	[[Category: Mccarthy, A.]]	+	[[Category: Mccarthy, A]]
-	[[Category: Meged, R.]]	+	[[Category: Meged, R]]
-	[[Category: Ravelli, R B.G.]]	+	[[Category: Ravelli, R B.G]]
-	[[Category: Silman, I.]]	+	[[Category: Silman, I]]
-	[[Category: Sussman, J L.]]	+	[[Category: Sussman, J L]]
-	[[Category: Tawfik, D S.]]	+	[[Category: Tawfik, D S]]
-	[[Category: Toker, L.]]	+	[[Category: Toker, L]]
-	[[Category: Yagur, S.]]	+	[[Category: Yagur, S]]
	[[Category: Antioxidant]]		[[Category: Antioxidant]]
	[[Category: Directed evolution]]		[[Category: Directed evolution]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: ISPC]]	+	[[Category: ISPC, Israel Structural Proteomics Center]]
-	~~[[Category:~~ Israel Structural Proteomics Center]]	+
	[[Category: Paraoxonase]]		[[Category: Paraoxonase]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 18:41, 29 September 2014

2014-09-29T18:41:04Z

←Older revision		Revision as of 18:41, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1v04~~\| ~~PDB~~=1v04 \| ~~SCENE~~= }}	+	==SERUM PARAOXONASE BY DIRECTED EVOLUTION==
-	===~~SERUM PARAOXONASE BY DIRECTED EVOLUTION~~===	+	<StructureSection load='1v04' size='340' side='right' caption='[[1v04]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15098021}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V04 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v04_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Members of the serum paraoxonase (PON) family have been identified in mammals and other vertebrates, and in invertebrates. PONs exhibit a wide range of physiologically important hydrolytic activities, including drug metabolism and detoxification of nerve agents. PON1 and PON3 reside on high-density lipoprotein (HDL, 'good cholesterol') and are involved in the prevention of atherosclerosis. We describe the first crystal structure of a PON family member, a variant of PON1 obtained by directed evolution, at a resolution of 2.2 A. PON1 is a six-bladed beta-propeller with a unique active site lid that is also involved in HDL binding. The three-dimensional structure and directed evolution studies permit a detailed description of PON1's active site and catalytic mechanism, which are reminiscent of secreted phospholipase A2, and of the routes by which PON family members diverged toward different substrate and reaction selectivities.

-	~~==About this~~ Structure==	+	Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.,Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS Nat Struct Mol Biol. 2004 May;11(5):412-9. Epub 2004 Apr 18. PMID:15098021<ref>PMID:15098021</ref>
-	~~[[1v04]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Rattus_rattus Rattus rattus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1V04 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
Line 10:		Line 29:
	*[[Serum Paraoxonase\|Serum Paraoxonase]]		*[[Serum Paraoxonase\|Serum Paraoxonase]]
	*[[User:Boris Brumshtein\|User:Boris Brumshtein]]		*[[User:Boris Brumshtein\|User:Boris Brumshtein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015098021<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus rattus]]		[[Category: Rattus rattus]]
	[[Category: Aharoni, A.]]		[[Category: Aharoni, A.]]

OCA at 09:28, 11 March 2013

2013-03-11T09:28:42Z

←Older revision		Revision as of 09:28, 11 March 2013
Line 1:		Line 1:
-	[[Image:1v04.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1v04", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1v04\| PDB=1v04 \| SCENE= }}		{{STRUCTURE_1v04\| PDB=1v04 \| SCENE= }}
-
	===SERUM PARAOXONASE BY DIRECTED EVOLUTION===		===SERUM PARAOXONASE BY DIRECTED EVOLUTION===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15098021}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15098021 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15098021}}		{{ABSTRACT_PUBMED_15098021}}

	==About this Structure==		==About this Structure==
-	[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens,_oryctolagus_cuniculus,_mus_musculus,_rattus_rattus Homo sapiens, oryctolagus cuniculus, mus musculus, rattus~~ rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA].	+	[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA].

	==See Also==		==See Also==
-	*[[Favorites]]	+	*[[Joel Sussman's Favorites\|Joel Sussman's Favorites]]
-	*[[Joel Sussman's Favorites]]	+	*[[Serum Paraoxonase\|Serum Paraoxonase]]
-	*[[Serum Paraoxonase]]	+	*[[User:Boris Brumshtein\|User:Boris Brumshtein]]
-	*[[User:Boris Brumshtein]]	+

	==Reference==		==Reference==
	<ref group="xtra">PMID:015098021</ref><references group="xtra"/>		<ref group="xtra">PMID:015098021</ref><references group="xtra"/>
-	[[Category: ~~Homo sapiens, oryctolagus cuniculus, mus musculus, rattus~~ rattus]]	+	[[Category: Rattus rattus]]
	[[Category: Aharoni, A.]]		[[Category: Aharoni, A.]]
	[[Category: Brumshtein, B.]]		[[Category: Brumshtein, B.]]

OCA at 11:19, 14 February 2012

2012-02-14T11:19:02Z

←Older revision		Revision as of 11:19, 14 February 2012
Line 24:		Line 24:
	*[[Favorites]]		*[[Favorites]]
	*[[Joel Sussman's Favorites]]		*[[Joel Sussman's Favorites]]
		+	*[[Serum Paraoxonase]]
	*[[User:Boris Brumshtein]]		*[[User:Boris Brumshtein]]

OCA: Protected "1v04" [edit=sysop:move=sysop]

2012-02-14T11:08:51Z

Protected "1v04" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:08, 14 February 2012