1v0o - Revision history

OCA at 09:07, 9 May 2024

2024-05-09T09:07:34Z

←Older revision		Revision as of 09:07, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='1v0o' size='340' side='right'caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1v0o' size='340' side='right'caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V0O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V0O FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=INR:2,3~~-~~DIOXO-1~~,1~~,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [https://pdbe.org/1v0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [https://www.ebi.ac.uk/pdbsum/1v0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v0o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [https://pdbe.org/1v0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [https://www.ebi.ac.uk/pdbsum/1v0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v0o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~CDC2H_PLAFK CDC2H_PLAFK~~]~~] Plays a key role~~ in the control of the ~~eukaryotic~~ cell cycle. ~~It is required in higher cells~~ for entry into S-phase and mitosis. ~~Component~~ of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).	+	[https://www.uniprot.org/uniprot/CDK2H_PLAFK CDK2H_PLAFK] Serine/threonine-protein kinase (PubMed:8844681, PubMed:14604523). Involved in the control of the cell cycle (By similarity). Required for entry into S-phase and mitosis (By similarity). Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). In schizonts, phosphorylates ORC1 resulting in its dissociation from DNA, relocalization to the cytoplasm and likely its degradation (By similarity).[UniProtKB:P04551]<ref>PMID:14604523</ref> <ref>PMID:8844681</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Burgess, D]]	+	[[Category: Burgess D]]
-	[[Category: Doerig, C]]	+	[[Category: Doerig C]]
-	[[Category: Endicott, J]]	+	[[Category: Endicott J]]
-	[[Category: Holton, S]]	+	[[Category: Holton S]]
-	[[Category: Merckx, A]]	+	[[Category: Merckx A]]
-	[[Category: Noble, M]]	+	[[Category: Noble M]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cdk]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Serine/threonine-protein kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:22, 6 October 2021

2021-10-06T06:22:16Z

←Older revision		Revision as of 06:22, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='1v0o' size='340' side='right'caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1v0o' size='340' side='right'caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1V0O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V0O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [~~http~~://pdbe.org/1v0o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1v0o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1v0o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [https://pdbe.org/1v0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [https://www.ebi.ac.uk/pdbsum/1v0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v0o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CDC2H_PLAFK CDC2H_PLAFK]] Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).	+	[[https://www.uniprot.org/uniprot/CDC2H_PLAFK CDC2H_PLAFK]] Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:30, 1 January 2020

2020-01-01T13:30:36Z

←Older revision		Revision as of 13:30, 1 January 2020
Line 1:		Line 1:

	==Structure of P. falciparum PfPK5-Indirubin-5-sulphonate ligand complex==		==Structure of P. falciparum PfPK5-Indirubin-5-sulphonate ligand complex==
-	<StructureSection load='1v0o' size='340' side='right' caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1v0o' size='340' side='right'caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V0O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V0O FirstGlance]. <br>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Burgess, D]]		[[Category: Burgess, D]]

OCA at 08:17, 28 March 2018

2018-03-28T08:17:57Z

←Older revision		Revision as of 08:17, 28 March 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF~~ P. ~~FALCIPARUM PFPK5~~-~~INDIRUBIN~~-5-~~SULPHONATE LIGAND COMPLEX~~==	+
		+	==Structure of P. falciparum PfPK5-Indirubin-5-sulphonate ligand complex==
	<StructureSection load='1v0o' size='340' side='right' caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1v0o' size='340' side='right' caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [http://pdbe.org/1v0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [http://www.ebi.ac.uk/pdbsum/1v0o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [http://pdbe.org/1v0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [http://www.ebi.ac.uk/pdbsum/1v0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v0o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v0o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v0o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:20, 8 February 2016

2016-02-08T12:20:24Z

←Older revision		Revision as of 12:20, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v0o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:30, 10 September 2015

2015-09-10T11:30:48Z

←Older revision		Revision as of 11:30, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1v0o' size='340' side='right' caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1v0o' size='340' side='right' caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V0O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V0O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [http://www.ebi.ac.uk/pdbsum/1v0o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [http://pdbe.org/1v0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [http://www.ebi.ac.uk/pdbsum/1v0o PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDC2H_PLAFK CDC2H_PLAFK]] Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1v0o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Burgess, D]]		[[Category: Burgess, D]]
	[[Category: Doerig, C]]		[[Category: Doerig, C]]

OCA at 14:08, 6 January 2015

2015-01-06T14:08:40Z

←Older revision		Revision as of 14:08, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V0O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V0O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [http://www.ebi.ac.uk/pdbsum/1v0o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [http://www.ebi.ac.uk/pdbsum/1v0o PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Burgess, D.]]	+	[[Category: Burgess, D]]
-	[[Category: Doerig, C.]]	+	[[Category: Doerig, C]]
-	[[Category: Endicott, J.]]	+	[[Category: Endicott, J]]
-	[[Category: Holton, S.]]	+	[[Category: Holton, S]]
-	[[Category: Merckx, A.]]	+	[[Category: Merckx, A]]
-	[[Category: Noble, M.]]	+	[[Category: Noble, M]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cdk]]		[[Category: Cdk]]

OCA at 19:19, 29 September 2014

2014-09-29T19:19:28Z

←Older revision		Revision as of 19:19, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1v0o.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF P. FALCIPARUM PFPK5-INDIRUBIN-5-SULPHONATE LIGAND COMPLEX==
		+	<StructureSection load='1v0o' size='340' side='right' caption='[[1v0o]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1v0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V0O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INR:2,3-DIOXO-1,1,2,3-TETRAHYDRO-2,3-BIINDOLE-5-SULFONIC+ACID'>INR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lch\|1lch]], [[1ob3\|1ob3]], [[1v0b\|1v0b]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v0o RCSB], [http://www.ebi.ac.uk/pdbsum/1v0o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v0o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium falciparum cell cycle regulators are promising targets for antimalarial drug design. We have determined the structure of PfPK5, the first structure of a P. falciparum protein kinase and the first of a cyclin-dependent kinase (CDK) not derived from humans. The fold and the mechanism of inactivation of monomeric CDKs are highly conserved across evolution. ATP-competitive CDK inhibitors have been developed as potential leads for cancer therapeutics. These studies have identified regions of the CDK active site that can be exploited to achieve significant gains in inhibitor potency and selectivity. We have cocrystallized PfPK5 with three inhibitors that target such regions. The sequence differences between PfPK5 and human CDKs within these inhibitor binding sites suggest that selective inhibition is an attainable goal. Such compounds will be useful tools for P. falciparum cell cycle studies, and will provide lead compounds for antimalarial drug development.

-	~~{{STRUCTURE_1v0o\| PDB=1v0o \| SCENE= }}~~	+	Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition.,Holton S, Merckx A, Burgess D, Doerig C, Noble M, Endicott J Structure. 2003 Nov;11(11):1329-37. PMID:14604523<ref>PMID:14604523</ref>

-	~~===STRUCTURE OF P. FALCIPARUM PFPK5-INDIRUBIN-5-SULPHONATE LIGAND COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14604523}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1v0o]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:014604523<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Burgess, D.]]		[[Category: Burgess, D.]]

OCA: Protected "1v0o" [edit=sysop:move=sysop]

2013-01-05T12:18:46Z

Protected "1v0o" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:18, 5 January 2013

OCA at 12:18, 5 January 2013

2013-01-05T12:18:43Z

←Older revision		Revision as of 12:18, 5 January 2013
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-	{{Seed}}
	[[Image:1v0o.png\|left\|200px]]		[[Image:1v0o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1v0o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1v0o\| PDB=1v0o \| SCENE= }}		{{STRUCTURE_1v0o\| PDB=1v0o \| SCENE= }}

	===STRUCTURE OF P. FALCIPARUM PFPK5-INDIRUBIN-5-SULPHONATE LIGAND COMPLEX===		===STRUCTURE OF P. FALCIPARUM PFPK5-INDIRUBIN-5-SULPHONATE LIGAND COMPLEX===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14604523}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14604523 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14604523}}		{{ABSTRACT_PUBMED_14604523}}

	==About this Structure==		==About this Structure==
-	~~1V0O~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA].	+	[[1v0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0O OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14604523~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014604523</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Burgess, D.]]		[[Category: Burgess, D.]]
Line 36:		Line 24:
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:57:25 2009''