1vws - Revision history

OCA: Redirecting to 3j6y

2014-12-10T15:05:59Z

Redirecting to 3j6y

←Older revision		Revision as of 15:05, 10 December 2014
Line 1:		Line 1:
-	~~==S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I). This entry contains the large subunit ribosomal RNA.==~~	+	#REDIRECT [[3j6y]] This PDB entry is obsolete and replaced by 3j6y
-	~~<StructureSection load='1vws' size='340' side='right' caption='~~[[~~1vws]], [[Resolution\|resolution]] 6.10Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[1vws~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWS FirstGlance]. <br>	+
-	~~</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j6x\|3j6x]], [[1vwu\|1vwu]], [[1vwv\|1vwv]]</td></tr>~~	+
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vws RCSB], [http://www.ebi.ac.uk/pdbsum/1vws PDBsum]</span></td></tr>	+
-	~~<table>~~	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	~~In cap-dependent translation initiation, the open reading frame (ORF) of mRNA is established by the placement of the AUG start codon~~ and initiator tRNA in the ribosomal peptidyl (P) site. Internal ribosome entry sites (IRESs) promote translation of mRNAs in a cap-independent manner. We report two structures of the ribosome-bound Taura syndrome virus (TSV) IRES belonging to the family of Dicistroviridae intergenic IRESs. Intersubunit rotational states differ in these structures, suggesting that ribosome dynamics play a role in IRES translocation. Pseudoknot I of the IRES occupies the ribosomal decoding center at the aminoacyl (A) site in a manner resembling that of the tRNA anticodon-mRNA codon. The structures reveal that the TSV IRES initiates translation by a previously unseen mechanism, which is conceptually distinct from initiator tRNA-dependent mechanisms. Specifically, the ORF of the IRES-driven mRNA is established by the placement of the preceding tRNA-mRNA-like structure in the A site, whereas the 40S P site remains unoccupied during this initial step.	+
-		+
-	Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center.,Koh CS, Brilot AF, Grigorieff N, Korostelev AA Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9139-44. doi:, 10.1073/pnas.1406335111. Epub 2014 Jun 9. PMID:24927574<ref>PMID:24927574</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Saccharomyces cerevisiae]]~~	+
-	~~[[Category: Brilot, A F.]]~~	+
-	~~[[Category: Grigorieff, N.]]~~	+
-	~~[[Category: Koh, C S.]]~~	+
-	~~[[Category: Korostelev, A A.]]~~	+
-	~~[[Category: Intergenic ire]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Translation initiation]]~~	+
-	~~[[Category: Tsv ire]]~~	+

OCA at 13:26, 20 August 2014

2014-08-20T13:26:04Z

←Older revision		Revision as of 13:26, 20 August 2014
Line 6:		Line 6:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vws RCSB], [http://www.ebi.ac.uk/pdbsum/1vws PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vws RCSB], [http://www.ebi.ac.uk/pdbsum/1vws PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In cap-dependent translation initiation, the open reading frame (ORF) of mRNA is established by the placement of the AUG start codon and initiator tRNA in the ribosomal peptidyl (P) site. Internal ribosome entry sites (IRESs) promote translation of mRNAs in a cap-independent manner. We report two structures of the ribosome-bound Taura syndrome virus (TSV) IRES belonging to the family of Dicistroviridae intergenic IRESs. Intersubunit rotational states differ in these structures, suggesting that ribosome dynamics play a role in IRES translocation. Pseudoknot I of the IRES occupies the ribosomal decoding center at the aminoacyl (A) site in a manner resembling that of the tRNA anticodon-mRNA codon. The structures reveal that the TSV IRES initiates translation by a previously unseen mechanism, which is conceptually distinct from initiator tRNA-dependent mechanisms. Specifically, the ORF of the IRES-driven mRNA is established by the placement of the preceding tRNA-mRNA-like structure in the A site, whereas the 40S P site remains unoccupied during this initial step.
		+
		+	Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center.,Koh CS, Brilot AF, Grigorieff N, Korostelev AA Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9139-44. doi:, 10.1073/pnas.1406335111. Epub 2014 Jun 9. PMID:24927574<ref>PMID:24927574</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA: Protected "1vws" [edit=sysop:move=sysop]

2014-06-11T08:49:46Z

Protected "1vws" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:49, 11 June 2014

OCA: New page: ==S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I). This entry contains the large subunit ribosomal RNA.==
2014-06-11T08:49:42Z

New page: ==S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I). This entry contains the large subunit ribosomal RNA.== <StructureSection load='1vws' s...

New page
==S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I). This entry contains the large subunit ribosomal RNA.==
<StructureSection load='1vws' size='340' side='right' caption='[[1vws]], [[Resolution|resolution]] 6.10Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1vws]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWS FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3j6x|3j6x]], [[1vwu|1vwu]], [[1vwv|1vwv]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vws RCSB], [http://www.ebi.ac.uk/pdbsum/1vws PDBsum]</span></td></tr>
<table>
TOC
</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Brilot, A F.]]
[[Category: Grigorieff, N.]]
[[Category: Koh, C S.]]
[[Category: Korostelev, A A.]]
[[Category: Intergenic ire]]
[[Category: Ribosome]]
[[Category: Translation initiation]]
[[Category: Tsv ire]]