1w2s - Revision history

OCA at 09:09, 9 May 2024

2024-05-09T09:09:55Z

←Older revision		Revision as of 09:09, 9 May 2024
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	<StructureSection load='1w2s' size='340' side='right'caption='[[1w2s]]' scene=''>		<StructureSection load='1w2s' size='340' side='right'caption='[[1w2s]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W2S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W2S FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [https://pdbe.org/1w2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [https://www.ebi.ac.uk/pdbsum/1w2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [https://pdbe.org/1w2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [https://www.ebi.ac.uk/pdbsum/1w2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CO3_HUMAN CO3_HUMAN] Defects in C3 are the cause of complement component 3 deficiency (C3D) [MIM:[https://omim.org/entry/613779 613779]. A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis.<ref>PMID:19913840</ref> <ref>PMID:9596584</ref> <ref>PMID:11387479</ref> <ref>PMID:15713468</ref> <ref>PMID:7961791</ref> [:] Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9) [MIM:[https://omim.org/entry/611378 611378]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.<ref>PMID:19913840</ref> <ref>PMID:17634448</ref> Defects in C3 are a cause of susceptibility to hemolytic uremic syndrome atypical type 5 (AHUS5) [MIM:[https://omim.org/entry/612925 612925]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.<ref>PMID:19913840</ref> <ref>PMID:18796626</ref> <ref>PMID:20513133</ref> Note=Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage.<ref>PMID:19913840</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CO3_HUMAN CO3_HUMAN] C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.<ref>PMID:8376604</ref> <ref>PMID:2909530</ref> <ref>PMID:9059512</ref> <ref>PMID:9555951</ref> <ref>PMID:10432298</ref> <ref>PMID:15833747</ref> <ref>PMID:16333141</ref> <ref>PMID:19615750</ref> Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.<ref>PMID:8376604</ref> <ref>PMID:2909530</ref> <ref>PMID:9059512</ref> <ref>PMID:9555951</ref> <ref>PMID:10432298</ref> <ref>PMID:15833747</ref> <ref>PMID:16333141</ref> <ref>PMID:19615750</ref> Acylation stimulating protein (ASP): adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for GPR77. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of GPR77.<ref>PMID:8376604</ref> <ref>PMID:2909530</ref> <ref>PMID:9059512</ref> <ref>PMID:9555951</ref> <ref>PMID:10432298</ref> <ref>PMID:15833747</ref> <ref>PMID:16333141</ref> <ref>PMID:19615750</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gilbert~~, H E~~]]	+	[[Category: Gilbert HE]]
-	[[Category: Hannan~~, J P~~]]	+	[[Category: Hannan JP]]
-	[[Category: Holers~~, V M~~]]	+	[[Category: Holers VM]]
-	[[Category: Perkins~~, S J]]~~	+	[[Category: Perkins SJ]]
-	~~[[Category: Analytical ultracentrifugation]]~~	+
-	~~[[Category: Complement]]~~	+
-	~~[[Category: Constrained modelling]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunology]]~~	+
-	~~[[Category: Thrombospondin type i repeat]]~~	+
-	~~[[Category: X-ray scattering~~]]	+

OCA at 13:31, 13 October 2021

2021-10-13T13:31:07Z

←Older revision		Revision as of 13:31, 13 October 2021
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	<StructureSection load='1w2s' size='340' side='right'caption='[[1w2s]]' scene=''>		<StructureSection load='1w2s' size='340' side='right'caption='[[1w2s]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W2S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W2S FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [~~http~~://pdbe.org/1w2s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w2s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [https://pdbe.org/1w2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [https://www.ebi.ac.uk/pdbsum/1w2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:32, 8 January 2020

2020-01-08T10:32:38Z

←Older revision		Revision as of 10:32, 8 January 2020
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	==Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering==		==Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering==
-	<StructureSection load='1w2s' size='340' side='right' caption='[[1w2s]]' scene=''>	+	<StructureSection load='1w2s' size='340' side='right'caption='[[1w2s]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2S FirstGlance]. <br>
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Complement C3\|Complement C3]]	+	*[[Complement C3 3D structures\|Complement C3 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gilbert, H E]]		[[Category: Gilbert, H E]]
	[[Category: Hannan, J P]]		[[Category: Hannan, J P]]

OCA at 07:37, 4 April 2018

2018-04-04T07:37:40Z

←Older revision		Revision as of 07:37, 4 April 2018
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		+
	==Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering==		==Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering==
	<StructureSection load='1w2s' size='340' side='right' caption='[[1w2s]]' scene=''>		<StructureSection load='1w2s' size='340' side='right' caption='[[1w2s]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2S FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [http://pdbe.org/1w2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [http://www.ebi.ac.uk/pdbsum/1w2s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [http://pdbe.org/1w2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [http://www.ebi.ac.uk/pdbsum/1w2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2s ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN]] Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:[http://omim.org/entry/610927 610927]]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:17360460</ref> Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7) [MIM:[http://omim.org/entry/614699 614699]]. A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.<ref>PMID:22035880</ref>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN]] Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.<ref>PMID:7753047</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w2s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w2s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w2s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:22, 11 September 2015

2015-09-11T22:22:41Z

←Older revision		Revision as of 22:22, 11 September 2015
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	<StructureSection load='1w2s' size='340' side='right' caption='[[1w2s]]' scene=''>		<StructureSection load='1w2s' size='340' side='right' caption='[[1w2s]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2S FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [http://www.ebi.ac.uk/pdbsum/1w2s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [http://pdbe.org/1w2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [http://www.ebi.ac.uk/pdbsum/1w2s PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w2s" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gilbert, H E]]		[[Category: Gilbert, H E]]
	[[Category: Hannan, J P]]		[[Category: Hannan, J P]]

OCA at 12:54, 6 January 2015

2015-01-06T12:54:16Z

←Older revision		Revision as of 12:54, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [http://www.ebi.ac.uk/pdbsum/1w2s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [http://www.ebi.ac.uk/pdbsum/1w2s PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN]] Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:[http://omim.org/entry/610927 610927]]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:17360460</ref> Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7) [MIM:[http://omim.org/entry/614699 614699]]. A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.<ref>PMID:22035880</ref>		[[http://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN]] Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:[http://omim.org/entry/610927 610927]]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:17360460</ref> Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7) [MIM:[http://omim.org/entry/614699 614699]]. A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.<ref>PMID:22035880</ref>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gilbert, H E.]]	+	[[Category: Gilbert, H E]]
-	[[Category: Hannan, J P.]]	+	[[Category: Hannan, J P]]
-	[[Category: Holers, V M.]]	+	[[Category: Holers, V M]]
-	[[Category: Perkins, S J.]]	+	[[Category: Perkins, S J]]
	[[Category: Analytical ultracentrifugation]]		[[Category: Analytical ultracentrifugation]]
	[[Category: Complement]]		[[Category: Complement]]

OCA at 19:38, 29 September 2014

2014-09-29T19:38:07Z

←Older revision		Revision as of 19:38, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1w2s~~\| ~~PDB~~=1w2s ~~\| SCENE~~= }}	+	==Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering==
-	===~~SOLUTION STRUCTURE OF~~ CR2 SCR 1-2 ~~IN ITS COMPLEX WITH C3D BY~~ X-~~RAY SCATTERING===~~	+	<StructureSection load='1w2s' size='340' side='right' caption='[[1w2s]]' scene=''>
-	~~{{ABSTRACT_PUBMED_15713468}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3d\|1c3d]], [[1ghq\|1ghq]], [[1ly2\|1ly2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w2s RCSB], [http://www.ebi.ac.uk/pdbsum/1w2s PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN]] Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:[http://omim.org/entry/610927 610927]]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:17360460</ref> Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7) [MIM:[http://omim.org/entry/614699 614699]]. A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.<ref>PMID:22035880</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN]] Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.<ref>PMID:7753047</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w2s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Complement receptor type 2 (CR2, CD21) forms a tight complex with C3d, a fragment of C3, the major complement component. Previous crystal structures of the C3d-CR2 SCR 1-2 complex and free CR2 SCR 1-2 showed that the two SCR domains of CR2 form contact with each other in a closed V-shaped structure. SCR 1 and SCR 2 are connected by an unusually long eight-residue linker peptide. Medium-resolution solution structures for CR2 SCR 1-2, C3d, and their complex were determined by X-ray scattering and analytical ultracentrifugation. CR2 SCR 1-2 is monomeric. For CR2 SCR 1-2, its radius of gyration R(G) of 2.12(+/-0.05) nm, its maximum length of 10nm and its sedimentation coefficient s20,w(o) of 1.40(+/-0.03) S do not agree with those calculated from the crystal structures, and instead suggest an open structure. Computer modelling of the CR2 SCR1-2 solution structure was based on the structural randomisation of the eight-residue linker peptide joining SCR 1 and SCR 2 to give 9950 trial models. Comparisons with the X-ray scattering curve indicated that the most favoured arrangements for the two SCR domains corresponded to an open V-shaped structure with no contacts between the SCR domains. For C3d, X-ray scattering and sedimentation velocity experiments showed that it exists as a monomer-dimer equilibrium with a dissociation constant of 40 microM. The X-ray scattering curve for monomeric C3d gave an R(G) value of 1.95 nm, and this together with its s20,w(o) value of 3.17 S gave good agreement with the monomeric C3d crystal structure. Modelling of the C3d dimer gave good agreements with its scattering and ultracentrifugation parameters. For the complex, scattering and ultracentrifugation experiments showed that there was no dimerisation, indicating that the C3d dimerisation site was located close to the CR2 SCR 1-2 binding site. The R(G) value of 2.44(+/-0.1) nm, its length of 9 nm and its s20,w(o) value of 3.45(+/-0.01) S showed that its structure was not much more elongated than that of C3d. Calculations with 9950 models of CR2 SCR 1-2 bound to C3d through SCR 2 showed that SCR 1 formed an open V-shaped structure with SCR 2 and was capable of interacting with the surface of C3d. We conclude that the open V-shaped structures formed by CR2 SCR 1-2, both when free and when bound to C3d, are optimal for the formation of a tight two-domain interaction with its ligand C3d.

-	~~==Disease==~~	+	Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study.,Gilbert HE, Eaton JT, Hannan JP, Holers VM, Perkins SJ J Mol Biol. 2005 Feb 25;346(3):859-73. Epub 2005 Jan 12. PMID:15713468<ref>PMID:15713468</ref>
-	~~[[http://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN]] Genetic variations in~~ CR2 ~~are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM~~:~~[http://omim.org/entry/610927 610927]]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is~~ an ~~inflammatory,~~ and ~~often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin~~, ~~joints~~, ~~kidneys~~, ~~and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:17360460</ref> Defects in CR2 are the cause of immunodeficiency~~, ~~common variable~~, ~~type 7~~ (~~CVID7~~) ~~[MIM~~:~~[http://omim~~.org/entry/614699 614699]]. A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.<ref>PMID:~~22035880~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot~~/~~CR2_HUMAN CR2_HUMAN]] Receptor for complement C3Dd~~, ~~for~~ the ~~Epstein-Barr virus on human B-cells and T-cells and for HNRPU~~. ~~Participates in B lymphocytes activation~~.<~~ref~~>~~PMID:7753047~~</~~ref~~>	+	</div>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~1w2s~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA].	+	*[[Complement C3\|Complement C3]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:015713468</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Eaton, J T.]]
	[[Category: Gilbert, H E.]]		[[Category: Gilbert, H E.]]
	[[Category: Hannan, J P.]]		[[Category: Hannan, J P.]]

OCA at 01:37, 25 March 2013

2013-03-25T01:37:21Z

←Older revision		Revision as of 01:37, 25 March 2013
Line 1:		Line 1:
-	[[Image:1w2s.png\|left\|200px]]
-
	{{STRUCTURE_1w2s\| PDB=1w2s \| SCENE= }}		{{STRUCTURE_1w2s\| PDB=1w2s \| SCENE= }}
-
	===SOLUTION STRUCTURE OF CR2 SCR 1-2 IN ITS COMPLEX WITH C3D BY X-RAY SCATTERING===		===SOLUTION STRUCTURE OF CR2 SCR 1-2 IN ITS COMPLEX WITH C3D BY X-RAY SCATTERING===
		+	{{ABSTRACT_PUBMED_15713468}}

-	~~{{ABSTRACT_PUBMED_15713468}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN]] Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:[http://omim.org/entry/610927 610927]]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:17360460</ref> Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7) [MIM:[http://omim.org/entry/614699 614699]]. A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.<ref>PMID:22035880</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN]] Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.<ref>PMID:7753047</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015713468</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015713468</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eaton, J T.]]		[[Category: Eaton, J T.]]

OCA: Protected "1w2s" [edit=sysop:move=sysop]

2013-01-05T12:51:11Z

Protected "1w2s" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:51, 5 January 2013

OCA at 12:51, 5 January 2013

2013-01-05T12:51:07Z

←Older revision		Revision as of 12:51, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1w2s.png\|left\|200px]]		[[Image:1w2s.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1w2s", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1w2s\| PDB=1w2s \| SCENE= }}		{{STRUCTURE_1w2s\| PDB=1w2s \| SCENE= }}

	===SOLUTION STRUCTURE OF CR2 SCR 1-2 IN ITS COMPLEX WITH C3D BY X-RAY SCATTERING===		===SOLUTION STRUCTURE OF CR2 SCR 1-2 IN ITS COMPLEX WITH C3D BY X-RAY SCATTERING===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15713468}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15713468 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15713468}}		{{ABSTRACT_PUBMED_15713468}}

	==About this Structure==		==About this Structure==
-	~~1W2S~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA].	+	[[1w2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2S OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15713468~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015713468</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eaton, J T.]]		[[Category: Eaton, J T.]]
Line 38:		Line 26:
	[[Category: Thrombospondin type i repeat]]		[[Category: Thrombospondin type i repeat]]
	[[Category: X-ray scattering]]		[[Category: X-ray scattering]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:08:06 2010''