1w5h - Revision history

OCA at 09:11, 9 May 2024

2024-05-09T09:11:35Z

←Older revision		Revision as of 09:11, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5H FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [https://pdbe.org/1w5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [https://www.ebi.ac.uk/pdbsum/1w5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5h ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [https://pdbe.org/1w5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [https://www.ebi.ac.uk/pdbsum/1w5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
		+	*[[Gcn4 3D Structures\|Gcn4 3D Structures]]
	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]		*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==

OCA at 10:50, 24 November 2022

2022-11-24T10:50:18Z

←Older revision		Revision as of 10:50, 24 November 2022
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	<StructureSection load='1w5h' size='340' side='right'caption='[[1w5h]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1w5h' size='340' side='right'caption='[[1w5h]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5H FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [https://pdbe.org/1w5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [https://www.ebi.ac.uk/pdbsum/1w5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5h ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [https://pdbe.org/1w5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [https://www.ebi.ac.uk/pdbsum/1w5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5h ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ghadiri, M R~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Leman, L J~~]]	+	[[Category: Ghadiri MR]]
-	[[Category: ~~Stout, C D~~]]	+	[[Category: Leman LJ]]
-	[[Category: ~~Yadav, M K~~]]	+	[[Category: Stout CD]]
-	[[Category: ~~Antiparallel four helix bundle]]~~	+	[[Category: Yadav MK]]
-	~~[[Category: Four helix bundle~~]]	+

OCA at 10:30, 17 February 2021

2021-02-17T10:30:14Z

←Older revision		Revision as of 10:30, 17 February 2021
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	<StructureSection load='1w5h' size='340' side='right'caption='[[1w5h]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1w5h' size='340' side='right'caption='[[1w5h]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W5H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5H FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [~~http~~://pdbe.org/1w5h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w5h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [https://pdbe.org/1w5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [https://www.ebi.ac.uk/pdbsum/1w5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[~~Gcn4~~\|~~Gcn4~~]]	+	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:47, 10 May 2019

2019-05-10T11:47:46Z

←Older revision		Revision as of 11:47, 10 May 2019
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	==An anti-parallel four helix bundle.==		==An anti-parallel four helix bundle.==
-	<StructureSection load='1w5h' size='340' side='right' caption='[[1w5h]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1w5h' size='340' side='right'caption='[[1w5h]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5H FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ghadiri, M R]]		[[Category: Ghadiri, M R]]
	[[Category: Leman, L J]]		[[Category: Leman, L J]]

OCA at 07:34, 4 April 2018

2018-04-04T07:34:10Z

←Older revision		Revision as of 07:34, 4 April 2018
Line 1:		Line 1:
-	==~~AN ANTI~~-~~PARALLEL FOUR HELIX BUNDLE~~.==	+
		+	==An anti-parallel four helix bundle.==
	<StructureSection load='1w5h' size='340' side='right' caption='[[1w5h]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1w5h' size='340' side='right' caption='[[1w5h]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [http://pdbe.org/1w5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [http://www.ebi.ac.uk/pdbsum/1w5h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [http://pdbe.org/1w5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [http://www.ebi.ac.uk/pdbsum/1w5h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:23, 11 September 2015

2015-09-11T15:23:34Z

←Older revision		Revision as of 15:23, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5H FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [http://www.ebi.ac.uk/pdbsum/1w5h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [http://pdbe.org/1w5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [http://www.ebi.ac.uk/pdbsum/1w5h PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w5h" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:20, 25 December 2014

2014-12-25T18:20:46Z

←Older revision		Revision as of 18:20, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [http://www.ebi.ac.uk/pdbsum/1w5h PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [http://www.ebi.ac.uk/pdbsum/1w5h PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ghadiri, M R.]]	+	[[Category: Ghadiri, M R]]
-	[[Category: Leman, L J.]]	+	[[Category: Leman, L J]]
-	[[Category: Stout, C D.]]	+	[[Category: Stout, C D]]
-	[[Category: Yadav, M K.]]	+	[[Category: Yadav, M K]]
	[[Category: Antiparallel four helix bundle]]		[[Category: Antiparallel four helix bundle]]
	[[Category: Four helix bundle]]		[[Category: Four helix bundle]]

OCA at 08:17, 8 October 2014

2014-10-08T08:17:01Z

←Older revision		Revision as of 08:17, 8 October 2014
Line 1:		Line 1:
-	[[~~Image:~~1w5h.~~png~~\|~~left~~\|~~200px~~]]	+	==AN ANTI-PARALLEL FOUR HELIX BUNDLE.==
		+	<StructureSection load='1w5h' size='340' side='right' caption='[[1w5h]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5H FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5k\|1w5k]], [[1w5l\|1w5l]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w5h RCSB], [http://www.ebi.ac.uk/pdbsum/1w5h PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A detailed understanding of the mechanisms by which particular amino acid sequences can give rise to more than one folded structure, such as for proteins that undergo large conformational changes or misfolding, is a long-standing objective of protein chemistry. Here, we describe the crystal structures of a single coiled-coil peptide in distinct parallel and antiparallel tetrameric configurations and further describe the parallel or antiparallel crystal structures of several related peptide sequences; the antiparallel tetrameric assemblies represent the first crystal structures of GCN4-derived peptides exhibiting such a configuration. Intriguingly, substitution of a single solvent-exposed residue enabled the parallel coiled-coil tetramer GCN4-pLI to populate the antiparallel configuration, suggesting that the two configurations are close enough in energy for subtle sequence changes to have important structural consequences. We present a structural analysis of the small changes to the helix register and side-chain conformations that accommodate the two configurations and have supplemented these results using solution studies and a molecular dynamics energetic analysis using a replica exchange methodology. Considering the previous examples of structural nonspecificity in coiled-coil peptides, the findings reported here not only emphasize the predisposition of the coiled-coil motif to adopt multiple configurations but also call attention to the associated risk that observed crytstal structures may not represent the only (or even the major) species present in solution.

-	~~{{STRUCTURE_1w5h\| PDB=1w5h \| SCENE= }}~~	+	Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution.,Yadav MK, Leman LJ, Price DJ, Brooks CL 3rd, Stout CD, Ghadiri MR Biochemistry. 2006 Apr 11;45(14):4463-73. PMID:16584182<ref>PMID:16584182</ref>

-	~~===AN ANTI-PARALLEL FOUR HELIX BUNDLE~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16584182}}~~	+	==See Also==
-		+	*[[Gcn4\|Gcn4]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1w5h~~]] ~~is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA].~~	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016584182<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Ghadiri, M R.]]		[[Category: Ghadiri, M R.]]
	[[Category: Leman, L J.]]		[[Category: Leman, L J.]]

OCA: Protected "1w5h" [edit=sysop:move=sysop]

2013-01-05T12:47:40Z

Protected "1w5h" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:47, 5 January 2013

OCA at 12:47, 5 January 2013

2013-01-05T12:47:36Z

←Older revision		Revision as of 12:47, 5 January 2013
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-	{{Seed}}
	[[Image:1w5h.png\|left\|200px]]		[[Image:1w5h.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1w5h", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1w5h\| PDB=1w5h \| SCENE= }}		{{STRUCTURE_1w5h\| PDB=1w5h \| SCENE= }}

	===AN ANTI-PARALLEL FOUR HELIX BUNDLE.===		===AN ANTI-PARALLEL FOUR HELIX BUNDLE.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16584182}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16584182 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16584182}}		{{ABSTRACT_PUBMED_16584182}}

	==About this Structure==		==About this Structure==
-	~~1W5H is a~~ [[~~Single protein~~]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA].	+	[[1w5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5H OCA].

	==Reference==		==Reference==
-	Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution., Yadav MK, Leman LJ, Price DJ, Brooks CL 3rd, Stout CD, Ghadiri MR, Biochemistry. 2006 Apr 11;45(14):4463-73. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16584182 16584182]~~	+	<ref group="xtra">PMID:016584182</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Ghadiri, M R.]]		[[Category: Ghadiri, M R.]]
-	[[Category: Leman, L.]]	+	[[Category: Leman, L J.]]
	[[Category: Stout, C D.]]		[[Category: Stout, C D.]]
	[[Category: Yadav, M K.]]		[[Category: Yadav, M K.]]
	[[Category: Antiparallel four helix bundle]]		[[Category: Antiparallel four helix bundle]]
-		+	[[Category: Four helix bundle]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 29 08:52:31 2008''~~	+