1w9n - Revision history

OCA at 06:36, 1 May 2024

2024-05-01T06:36:19Z

←Older revision		Revision as of 06:36, 1 May 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/LAN15_STAEP LAN15_STAEP]		[https://www.uniprot.org/uniprot/LAN15_STAEP LAN15_STAEP]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.
-
-	Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis.,Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:15792796<ref>PMID:15792796</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1w9n" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:29, 16 August 2023

2023-08-16T10:29:28Z

←Older revision		Revision as of 10:29, 16 August 2023
Line 1:		Line 1:

	==Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis==		==Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis==
-	<StructureSection load='1w9n' size='340' side='right'caption='[[1w9n~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1w9n' size='340' side='right'caption='[[1w9n]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9N FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9N FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=PRD_000196:EPILANCIN+15X'>PRD_000196</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [https://pdbe.org/1w9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [https://www.ebi.ac.uk/pdbsum/1w9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [https://pdbe.org/1w9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [https://www.ebi.ac.uk/pdbsum/1w9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LAN15_STAEP LAN15_STAEP]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Staphylococcus epidermidis]]		[[Category: Staphylococcus epidermidis]]
-	[[Category: Ekkelenkamp, M]]	+	[[Category: Ekkelenkamp M]]
-	[[Category: Hanssen~~, M G.M~~]]	+	[[Category: Hanssen MGM]]
-	[[Category: Hsu, S ~~T.D]]~~	+	[[Category: Hsu S-TD]]
-	~~[[Category: Jong, A de~~]]	+	[[Category: Milatovic D]]
-	[[Category: Milatovic, D]]	+	[[Category: Verhoef J]]
-	~~[[Category: Nuland, N A.J van~~]]	+	[[Category: De Jong A]]
-	[[Category: Verhoef, J]]	+	[[Category: Van Nuland NAJ]]
-	[[Category: ~~Antibacterial~~]]	+
-	[[Category: ~~Antibiotic]]~~	+
-	~~[[Category: Lanthionine]]~~	+
-	~~[[Category: Thioester]]~~	+
-	~~[[Category: Type a lantibiotic~~]]	+

OCA at 08:16, 10 November 2021

2021-11-10T08:16:26Z

←Older revision		Revision as of 08:16, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1w9n' size='340' side='right'caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1w9n' size='340' side='right'caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W9N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9N FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [~~http~~://pdbe.org/1w9n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w9n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [https://pdbe.org/1w9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [https://www.ebi.ac.uk/pdbsum/1w9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:47, 5 February 2020

2020-02-05T09:47:40Z

←Older revision		Revision as of 09:47, 5 February 2020
Line 1:		Line 1:

	==Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis==		==Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis==
-	<StructureSection load='1w9n' size='340' side='right' caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1w9n' size='340' side='right'caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W9N FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W9N FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Staphylococcus epidermidis]]		[[Category: Staphylococcus epidermidis]]
	[[Category: Ekkelenkamp, M]]		[[Category: Ekkelenkamp, M]]

OCA at 07:38, 4 April 2018

2018-04-04T07:38:04Z

←Older revision		Revision as of 07:38, 4 April 2018
Line 1:		Line 1:
-	==Isolation and characterization of epilancin 15X, a novel ~~lantibiotic~~ from a clinical strain of Staphylococcus epidermidis==	+
		+	==Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis==
	<StructureSection load='1w9n' size='340' side='right' caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1w9n' size='340' side='right' caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://pdbe.org/1w9n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://pdbe.org/1w9n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 25:
	[[Category: Hanssen, M G.M]]		[[Category: Hanssen, M G.M]]
	[[Category: Hsu, S T.D]]		[[Category: Hsu, S T.D]]
-	[[Category: Jong, A De]]	+	[[Category: Jong, A de]]
	[[Category: Milatovic, D]]		[[Category: Milatovic, D]]
-	[[Category: Nuland, N A.J ~~Van~~]]	+	[[Category: Nuland, N A.J van]]
	[[Category: Verhoef, J]]		[[Category: Verhoef, J]]
	[[Category: Antibacterial]]		[[Category: Antibacterial]]

OCA at 01:56, 11 September 2015

2015-09-11T01:56:05Z

←Older revision		Revision as of 01:56, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://pdbe.org/1w9n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w9n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:33, 8 December 2014

2014-12-08T08:33:38Z

←Older revision		Revision as of 08:33, 8 December 2014
Line 2:		Line 2:
	<StructureSection load='1w9n' size='340' side='right' caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1w9n' size='340' side='right' caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. <br>	+	<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W9N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 13:
	Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis.,Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:15792796<ref>PMID:15792796</ref>		Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis.,Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:15792796<ref>PMID:15792796</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus epidermidis]]		[[Category: Staphylococcus epidermidis]]
-	[[Category: Ekkelenkamp, M.]]	+	[[Category: Ekkelenkamp, M]]
-	[[Category: Hanssen, M G.M.]]	+	[[Category: Hanssen, M G.M]]
-	[[Category: Hsu, S T.D.]]	+	[[Category: Hsu, S T.D]]
-	[[Category: Jong, A De.]]	+	[[Category: Jong, A De]]
-	[[Category: Milatovic, D.]]	+	[[Category: Milatovic, D]]
-	[[Category: Nuland, N A.J Van.]]	+	[[Category: Nuland, N A.J Van]]
-	[[Category: Verhoef, J.]]	+	[[Category: Verhoef, J]]
	[[Category: Antibacterial]]		[[Category: Antibacterial]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]

OCA at 09:46, 1 May 2014

2014-05-01T09:46:10Z

←Older revision		Revision as of 09:46, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='1w9n' size='340' side='right' caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1w9n' size='340' side='right' caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. <br>	+	<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. <br>
-	<b>[[Non-Standard_Residue\|NonStd Res:]]</b> <scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>
-	<b>[[Related_structure\|Related:]]</b> [[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]<br>	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]</td></tr>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.		The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.
Line 13:		Line 15:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:08, 30 April 2014

2014-04-30T10:08:15Z

←Older revision		Revision as of 10:08, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. <br>		[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. <br>
-	<b>Related:</b> [[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]<br>	+	<b>[[Non-Standard_Residue\|NonStd Res:]]</b> <scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene><br>
		+	<b>[[Related_structure\|Related:]]</b> [[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.		The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.

OCA at 08:29, 30 April 2014

2014-04-30T08:29:42Z

←Older revision		Revision as of 08:29, 30 April 2014
Line 1:		Line 1:
-	[[~~Image:~~1w9n.~~png~~\|~~left~~\|~~200px~~]]	+	==Isolation and characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis==
		+	<StructureSection load='1w9n' size='340' side='right' caption='[[1w9n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. <br>
		+	<b>Related:</b> [[1aj1\|1aj1]], [[1mqx\|1mqx]], [[1mqy\|1mqy]], [[1mqz\|1mqz]], [[1qow\|1qow]], [[1wco\|1wco]], [[2dde\|2dde]], [[2ktn\|2ktn]], [[2kto\|2kto]]<br>
		+	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	== Publication Abstract from PubMed ==
		+	The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.

-	~~{{STRUCTURE_1w9n\| PDB=1w9n \| SCENE= }}~~	+	Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis.,Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:15792796<ref>PMID:15792796</ref>

-	~~===Isolation and characterization of epilancin 15X~~, a ~~novel lantibiotic from a clinical strain~~ of ~~Staphylococcus epidermidis===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	== References ==
-	~~{{ABSTRACT_PUBMED_15792796}}~~	+	<references/>
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	~~[[1w9n]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]~~. ~~Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015792796<~~/~~ref~~><~~ref group="xtra">PMID:015361862</ref><ref group="xtra">PMID:012056898</ref><ref group="xtra">PMID:012562773</ref><references group="xtra"~~/>	+
	[[Category: Staphylococcus epidermidis]]		[[Category: Staphylococcus epidermidis]]
	[[Category: Ekkelenkamp, M.]]		[[Category: Ekkelenkamp, M.]]