1wan - Revision history

OCA at 09:27, 6 December 2023

2023-12-06T09:27:58Z

←Older revision		Revision as of 09:27, 6 December 2023
Line 1:		Line 1:

	==DNA DTA TRIPLEX, NMR, 7 STRUCTURES==		==DNA DTA TRIPLEX, NMR, 7 STRUCTURES==
-	<StructureSection load='1wan' size='340' side='right'caption='[[1wan~~]], [[NMR_Ensembles_of_Models \| 7 NMR models~~]]' scene=''>	+	<StructureSection load='1wan' size='340' side='right'caption='[[1wan]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WAN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WAN FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3:1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-4-(3-BENZAMIDO)PHENYLIMIDAZOLE'>D3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D3:1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-4-(3-BENZAMIDO)PHENYLIMIDAZOLE'>D3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wan OCA], [https://pdbe.org/1wan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wan RCSB], [https://www.ebi.ac.uk/pdbsum/1wan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wan ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wan OCA], [https://pdbe.org/1wan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wan RCSB], [https://www.ebi.ac.uk/pdbsum/1wan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wan ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dervan~~, P B~~]]	+	[[Category: Dervan PB]]
-	[[Category: Feigon, J]]	+	[[Category: Feigon J]]
-	[[Category: Gillespie, P]]	+	[[Category: Gillespie P]]
-	[[Category: Koshlap~~, K M~~]]	+	[[Category: Koshlap KM]]
-	[[Category: Wang, E]]	+	[[Category: Wang E]]
-	~~[[Category: Deoxyribonucleic acid]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Intercalator]]~~	+
-	~~[[Category: Triplex~~]]	+

OCA at 16:16, 27 October 2021

2021-10-27T16:16:35Z

←Older revision		Revision as of 16:16, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1wan' size='340' side='right'caption='[[1wan]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1wan' size='340' side='right'caption='[[1wan]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WAN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WAN FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3:1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-4-(3-BENZAMIDO)PHENYLIMIDAZOLE'>D3</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3:1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-4-(3-BENZAMIDO)PHENYLIMIDAZOLE'>D3</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wan OCA], [~~http~~://pdbe.org/1wan PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wan RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wan PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wan ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wan OCA], [https://pdbe.org/1wan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wan RCSB], [https://www.ebi.ac.uk/pdbsum/1wan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wan ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:25, 22 January 2020

2020-01-22T17:25:58Z

←Older revision		Revision as of 17:25, 22 January 2020
Line 1:		Line 1:

	==DNA DTA TRIPLEX, NMR, 7 STRUCTURES==		==DNA DTA TRIPLEX, NMR, 7 STRUCTURES==
-	<StructureSection load='1wan' size='340' side='right' caption='[[1wan]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>	+	<StructureSection load='1wan' size='340' side='right'caption='[[1wan]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WAN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WAN FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Dervan, P B]]		[[Category: Dervan, P B]]
	[[Category: Feigon, J]]		[[Category: Feigon, J]]

OCA at 16:12, 11 April 2018

2018-04-11T16:12:21Z

←Older revision		Revision as of 16:12, 11 April 2018
Line 1:		Line 1:
		+
	==DNA DTA TRIPLEX, NMR, 7 STRUCTURES==		==DNA DTA TRIPLEX, NMR, 7 STRUCTURES==
	<StructureSection load='1wan' size='340' side='right' caption='[[1wan]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1wan' size='340' side='right' caption='[[1wan]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WAN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WAN FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3:1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-4-(3-BENZAMIDO)PHENYLIMIDAZOLE'>D3</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3:1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-4-(3-BENZAMIDO)PHENYLIMIDAZOLE'>D3</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wan OCA], [http://pdbe.org/1wan PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wan RCSB], [http://www.ebi.ac.uk/pdbsum/1wan PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wan OCA], [http://pdbe.org/1wan PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wan RCSB], [http://www.ebi.ac.uk/pdbsum/1wan PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wan ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:51, 10 September 2015

2015-09-10T14:51:54Z

←Older revision		Revision as of 14:51, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WAN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WAN FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3:1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-4-(3-BENZAMIDO)PHENYLIMIDAZOLE'>D3</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3:1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-4-(3-BENZAMIDO)PHENYLIMIDAZOLE'>D3</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wan RCSB], [http://www.ebi.ac.uk/pdbsum/1wan PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wan OCA], [http://pdbe.org/1wan PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wan RCSB], [http://www.ebi.ac.uk/pdbsum/1wan PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wan" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:27, 15 January 2015

2015-01-15T16:27:38Z

←Older revision		Revision as of 16:27, 15 January 2015
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dervan, P B.]]	+	[[Category: Dervan, P B]]
-	[[Category: Feigon, J.]]	+	[[Category: Feigon, J]]
-	[[Category: Gillespie, P.]]	+	[[Category: Gillespie, P]]
-	[[Category: Koshlap, K M.]]	+	[[Category: Koshlap, K M]]
-	[[Category: Wang, E.]]	+	[[Category: Wang, E]]
	[[Category: Deoxyribonucleic acid]]		[[Category: Deoxyribonucleic acid]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Intercalator]]		[[Category: Intercalator]]
	[[Category: Triplex]]		[[Category: Triplex]]

OCA at 08:28, 8 October 2014

2014-10-08T08:28:46Z

←Older revision		Revision as of 08:28, 8 October 2014
Line 1:		Line 1:
-	[[~~Image:~~1wan.~~png~~\|~~left\|200px~~]]	+	==DNA DTA TRIPLEX, NMR, 7 STRUCTURES==
		+	<StructureSection load='1wan' size='340' side='right' caption='[[1wan]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WAN FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3:1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-4-(3-BENZAMIDO)PHENYLIMIDAZOLE'>D3</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wan RCSB], [http://www.ebi.ac.uk/pdbsum/1wan PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have used NMR spectroscopy to study a pyrimidine-purine-pyrimidine DNA triplex containing a non-natural base, 1-(2-deoxy-beta-D-ribofuranosyl)-4-(3-benzamido)phenylimidazole (D3), in the third strand. The D3 base has been previously shown to specifically recognize T-A and C-G base-pairs via intercalation on the 3' side (with respect to the purine strand) of the target base pair, instead of forming sequence-specific hydrogen bonds. 1H resonance assignments have been made for the D3 base and most of the non-loop portion of the triplex. The solution structure of the triplex was calculated using restrained molecular dynamics and complete relaxation matrix refinement. The duplex portion of the triplex has an over-all helical structure that is more similar to B-DNA than to A-DNA. The three aromatic rings of the D3 base stack on the bases of all three strands and mimic a triplet. The conformation of the D3 base and its sequence specificity are discussed.

-	~~{{STRUCTURE_1wan\| PDB=1wan \| SCENE= }}~~	+	Solution structure of a pyrimidine-purine-pyrimidine triplex containing the sequence-specific intercalating non-natural base D3.,Wang E, Koshlap KM, Gillespie P, Dervan PB, Feigon J J Mol Biol. 1996 Apr 19;257(5):1052-69. PMID:8632468<ref>PMID:8632468</ref>

-	~~===DNA DTA TRIPLEX~~, ~~NMR, 7 STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8632468}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1wan]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA].~~	+	</StructureSection>
	[[Category: Dervan, P B.]]		[[Category: Dervan, P B.]]
	[[Category: Feigon, J.]]		[[Category: Feigon, J.]]

OCA: Protected "1wan" [edit=sysop:move=sysop]

2013-01-05T12:37:06Z

Protected "1wan" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:37, 5 January 2013

OCA at 12:37, 5 January 2013

2013-01-05T12:37:02Z

←Older revision		Revision as of 12:37, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1wan.png\|left\|200px]]		[[Image:1wan.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1wan", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1wan\| PDB=1wan \| SCENE= }}		{{STRUCTURE_1wan\| PDB=1wan \| SCENE= }}

	===DNA DTA TRIPLEX, NMR, 7 STRUCTURES===		===DNA DTA TRIPLEX, NMR, 7 STRUCTURES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8632468}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8632468 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8632468}}		{{ABSTRACT_PUBMED_8632468}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA].	+	[[1wan]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA].
-		+
-	~~==Reference==~~	+
-	Solution structure of a pyrimidine-purine-pyrimidine triplex containing the sequence-specific intercalating non-natural base D3., Wang E, Koshlap KM, Gillespie P, Dervan PB, Feigon J, J Mol Biol. 1996 Apr 19;257(5):1052-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8632468 8632468]	+
	[[Category: Dervan, P B.]]		[[Category: Dervan, P B.]]
	[[Category: Feigon, J.]]		[[Category: Feigon, J.]]
Line 30:		Line 15:
	[[Category: Wang, E.]]		[[Category: Wang, E.]]
	[[Category: Deoxyribonucleic acid]]		[[Category: Deoxyribonucleic acid]]
		+	[[Category: Dna]]
	[[Category: Intercalator]]		[[Category: Intercalator]]
	[[Category: Triplex]]		[[Category: Triplex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:19:13 2008''

OCA at 03:19, 28 July 2008

2008-07-28T03:19:15Z

←Older revision		Revision as of 03:19, 28 July 2008
Line 1:		Line 1:
-	[[Image:1wan.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1wan.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1wan\| PDB=1wan \| SCENE= }}		{{STRUCTURE_1wan\| PDB=1wan \| SCENE= }}

-	~~'''~~DNA DTA TRIPLEX, NMR, 7 STRUCTURES~~'''~~	+	===DNA DTA TRIPLEX, NMR, 7 STRUCTURES===


-	~~==Overview==~~	+	<!--
-	~~We have used NMR spectroscopy to study a pyrimidine~~-~~purine~~-~~pyrimidine DNA triplex containing a non-natural base~~, ~~1-(2-deoxy-beta-D-ribofuranosyl)-4-(3-benzamido)phenylimidazole (D3)~~, in the ~~third strand. The D3 base has been previously shown~~ to ~~specifically recognize T-A and C-G base-pairs via intercalation on~~ the ~~3' side~~ (~~with respect to the purine strand~~) ~~of the target base pair~~, ~~instead of forming sequence-specific hydrogen bonds. 1H resonance assignments have been made for~~ the ~~D3 base and most of the non-loop portion of the triplex~~. ~~The solution structure of the triplex was calculated using restrained molecular dynamics and complete relaxation matrix refinement. The duplex portion of the triplex has an over~~-~~all helical structure that is more similar to B~~-~~DNA than to A-DNA. The three aromatic rings of the D3 base stack on the bases of all three strands and mimic a triplet. The conformation of the D3 base and its sequence specificity are discussed.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_8632468}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8632468 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8632468}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAN OCA].

	==Reference==		==Reference==
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	[[Category: Intercalator]]		[[Category: Intercalator]]
	[[Category: Triplex]]		[[Category: Triplex]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 13~~:23:24 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:19:13 2008''