1wc1 - Revision history

OCA at 09:14, 9 May 2024

2024-05-09T09:14:35Z

←Older revision		Revision as of 09:14, 9 May 2024
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	<StructureSection load='1wc1' size='340' side='right'caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='1wc1' size='340' side='right'caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Artpt Artpt~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [https://pdbe.org/1wc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [https://pdbe.org/1wc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O32393_ARTPT O32393_ARTPT]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenylate cyclase]]~~	+	[[Category: Arthrospira platensis]]
-	~~[[Category: Artpt~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Buck, J]]	+	[[Category: Buck J]]
-	[[Category: Levin~~, L R~~]]	+	[[Category: Levin LR]]
-	[[Category: Litvin~~, T N~~]]	+	[[Category: Litvin TN]]
-	[[Category: Steegborn, C]]	+	[[Category: Steegborn C]]
-	[[Category: Wu, H]]	+	[[Category: Wu H]]
-	~~[[Category: Camp signaling]]~~	+
-	~~[[Category: Cyclase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Soluble adenylyl cyclase~~]]	+

OCA at 16:17, 27 October 2021

2021-10-27T16:17:35Z

←Older revision		Revision as of 16:17, 27 October 2021
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	<StructureSection load='1wc1' size='340' side='right'caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='1wc1' size='340' side='right'caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [~~http~~://pdbe.org/1wc1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wc1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [https://pdbe.org/1wc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:14, 22 January 2020

2020-01-22T17:14:10Z

←Older revision		Revision as of 17:14, 22 January 2020
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	==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS==		==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS==
-	<StructureSection load='1wc1' size='340' side='right' caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>	+	<StructureSection load='1wc1' size='340' side='right'caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Adenylyl cyclase\|Adenylyl cyclase]]	+	*[[3D Adenylyl cyclase 3D structures\|3D Adenylyl cyclase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Artpt]]		[[Category: Artpt]]
		+	[[Category: Large Structures]]
	[[Category: Buck, J]]		[[Category: Buck, J]]
	[[Category: Levin, L R]]		[[Category: Levin, L R]]

OCA at 16:00, 11 April 2018

2018-04-11T16:00:43Z

←Older revision		Revision as of 16:00, 11 April 2018
Line 1:		Line 1:
		+
	==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS==		==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS==
	<StructureSection load='1wc1' size='340' side='right' caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='1wc1' size='340' side='right' caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [http://pdbe.org/1wc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [http://pdbe.org/1wc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wc1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wc1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wc1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:18, 11 September 2015

2015-09-11T14:18:24Z

←Older revision		Revision as of 14:18, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1wc1' size='340' side='right' caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='1wc1' size='340' side='right' caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arthrospira_platensis Arthrospira platensis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [http://pdbe.org/1wc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc1 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wc1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
-	[[Category: ~~Arthrospira platensis~~]]	+	[[Category: Artpt]]
	[[Category: Buck, J]]		[[Category: Buck, J]]
	[[Category: Levin, L R]]		[[Category: Levin, L R]]

OCA at 13:20, 6 January 2015

2015-01-06T13:20:49Z

←Older revision		Revision as of 13:20, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Arthrospira platensis]]		[[Category: Arthrospira platensis]]
-	[[Category: Buck, J.]]	+	[[Category: Buck, J]]
-	[[Category: Levin, L R.]]	+	[[Category: Levin, L R]]
-	[[Category: Litvin, T N.]]	+	[[Category: Litvin, T N]]
-	[[Category: Steegborn, C.]]	+	[[Category: Steegborn, C]]
-	[[Category: Wu, H.]]	+	[[Category: Wu, H]]
	[[Category: Camp signaling]]		[[Category: Camp signaling]]
	[[Category: Cyclase]]		[[Category: Cyclase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Soluble adenylyl cyclase]]		[[Category: Soluble adenylyl cyclase]]

OCA at 20:47, 29 September 2014

2014-09-29T20:47:41Z

←Older revision		Revision as of 20:47, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1wc1.~~png~~\|~~left~~\|200px]]	+	==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS==
		+	<StructureSection load='1wc1' size='340' side='right' caption='[[1wc1]], [[Resolution\|resolution]] 1.93Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wc1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]], [[1wc6\|1wc6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wc1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wc1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In an evolutionarily conserved signaling pathway, 'soluble' adenylyl cyclases (sACs) synthesize the ubiquitous second messenger cyclic adenosine 3',5'-monophosphate (cAMP) in response to bicarbonate and calcium signals. Here, we present crystal structures of a cyanobacterial sAC enzyme in complex with ATP analogs, calcium and bicarbonate, which represent distinct catalytic states of the enzyme. The structures reveal that calcium occupies the first ion-binding site and directly mediates nucleotide binding. The single ion-occupied, nucleotide-bound state defines a novel, open adenylyl cyclase state. In contrast, bicarbonate increases the catalytic rate by inducing marked active site closure and recruiting a second, catalytic ion. The phosphates of the bound substrate analogs are rearranged, which would facilitate product formation and release. The mechanisms of calcium and bicarbonate sensing define a reaction pathway involving active site closure and metal recruitment that may be universal for class III cyclases.

-	~~{{STRUCTURE_1wc1\| PDB=1wc1 \| SCENE= }}~~	+	Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment.,Steegborn C, Litvin TN, Levin LR, Buck J, Wu H Nat Struct Mol Biol. 2005 Jan;12(1):32-7. Epub 2004 Dec 26. PMID:15619637<ref>PMID:15619637</ref>

-	~~===Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15619637}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1wc1]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arthrospira_platensis Arthrospira platensis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA].~~	+

	==See Also==		==See Also==
	*[[Adenylyl cyclase\|Adenylyl cyclase]]		*[[Adenylyl cyclase\|Adenylyl cyclase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015619637<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Arthrospira platensis]]		[[Category: Arthrospira platensis]]

OCA at 13:09, 6 February 2013

2013-02-06T13:09:43Z

←Older revision		Revision as of 13:09, 6 February 2013
Line 3:		Line 3:
	{{STRUCTURE_1wc1\| PDB=1wc1 \| SCENE= }}		{{STRUCTURE_1wc1\| PDB=1wc1 \| SCENE= }}

-	===~~SOLUBLE ADENYLYL CYCLASE CYAC FROM~~ S. ~~PLATENSIS IN COMPLEX WITH RP~~-~~ATPALPHAS~~===	+	===Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS===

	{{ABSTRACT_PUBMED_15619637}}		{{ABSTRACT_PUBMED_15619637}}

OCA at 19:31, 20 October 2012

2012-10-20T19:31:54Z

←Older revision		Revision as of 19:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1wc1]] is a 3 chain structure ~~of [[Adenylyl cyclase]]~~ with sequence from [http://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA].	+	[[1wc1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC1 OCA].

	==See Also==		==See Also==

OCA at 07:39, 27 July 2012

2012-07-27T07:39:27Z

←Older revision		Revision as of 07:39, 27 July 2012
Line 1:		Line 1:
	[[Image:1wc1.png\|left\|200px]]		[[Image:1wc1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1wc1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1wc1\| PDB=1wc1 \| SCENE= }}		{{STRUCTURE_1wc1\| PDB=1wc1 \| SCENE= }}

	===SOLUBLE ADENYLYL CYCLASE CYAC FROM S. PLATENSIS IN COMPLEX WITH RP-ATPALPHAS===		===SOLUBLE ADENYLYL CYCLASE CYAC FROM S. PLATENSIS IN COMPLEX WITH RP-ATPALPHAS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15619637}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15619637 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15619637}}		{{ABSTRACT_PUBMED_15619637}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Adenylyl cyclase]]	+	*[[Adenylyl cyclase\|Adenylyl cyclase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15619637~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015619637</ref><references group="xtra"/>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Arthrospira platensis]]		[[Category: Arthrospira platensis]]