1wmv - Revision history

OCA at 13:45, 9 May 2024

2024-05-09T13:45:15Z

←Older revision		Revision as of 13:45, 9 May 2024
Line 1:		Line 1:

	==Solution structure of the second WW domain of WWOX==		==Solution structure of the second WW domain of WWOX==
-	<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>WOX/FOR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [https://pdbe.org/1wmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [https://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [https://pdbe.org/1wmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [https://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[https://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>	+	[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[https://omim.org/entry/133239 133239].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>	+	[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Booker~~, G W~~]]	+	[[Category: Booker GW]]
-	[[Category: Colella, A]]	+	[[Category: Colella A]]
-	[[Category: Kowalski, K]]	+	[[Category: Kowalski K]]
-	[[Category: Merkel~~, A L~~]]	+	[[Category: Merkel AL]]
-	[[Category: Richards~~, R I]]~~	+	[[Category: Richards RI]]
-	~~[[Category: All-beta]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Ww domain~~]]	+

OCA at 06:58, 2 March 2022

2022-03-02T06:58:35Z

←Older revision		Revision as of 06:58, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [~~http~~://pdbe.org/1wmv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [https://pdbe.org/1wmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [https://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[~~http~~://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>	+	[[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[https://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>	+	[[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:24, 6 January 2021

2021-01-06T09:24:37Z

←Older revision		Revision as of 09:24, 6 January 2021
Line 1:		Line 1:

	==Solution structure of the second WW domain of WWOX==		==Solution structure of the second WW domain of WWOX==
-	<StructureSection load='1wmv' size='340' side='right' caption='[[1wmv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WMV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://pdbe.org/1wmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://pdbe.org/1wmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Booker, G W]]		[[Category: Booker, G W]]
	[[Category: Colella, A]]		[[Category: Colella, A]]

OCA at 16:46, 11 April 2018

2018-04-11T16:46:31Z

←Older revision		Revision as of 16:46, 11 April 2018
Line 1:		Line 1:
		+
	==Solution structure of the second WW domain of WWOX==		==Solution structure of the second WW domain of WWOX==
	<StructureSection load='1wmv' size='340' side='right' caption='[[1wmv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wmv' size='340' side='right' caption='[[1wmv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://pdbe.org/1wmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://pdbe.org/1wmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/1wmv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/1wmv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:00, 7 February 2016

2016-02-07T10:00:52Z

←Older revision		Revision as of 10:00, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wmv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 00:23, 10 September 2015

2015-09-10T00:23:34Z

←Older revision		Revision as of 00:23, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1wmv' size='340' side='right' caption='[[1wmv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wmv' size='340' side='right' caption='[[1wmv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://pdbe.org/1wmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Booker, G W]]		[[Category: Booker, G W]]
	[[Category: Colella, A]]		[[Category: Colella, A]]

OCA at 14:10, 6 January 2015

2015-01-06T14:10:31Z

←Older revision		Revision as of 14:10, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>		[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Booker, G W.]]	+	[[Category: Booker, G W]]
-	[[Category: Colella, A.]]	+	[[Category: Colella, A]]
-	[[Category: Kowalski, K.]]	+	[[Category: Kowalski, K]]
-	[[Category: Merkel, A L.]]	+	[[Category: Merkel, A L]]
-	[[Category: Richards, R I.]]	+	[[Category: Richards, R I]]
	[[Category: All-beta]]		[[Category: All-beta]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Ww domain]]		[[Category: Ww domain]]

OCA at 20:16, 29 September 2014

2014-09-29T20:16:17Z

←Older revision		Revision as of 20:16, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1wmv\| PDB=1wmv \| SCENE= }}~~	+	==Solution structure of the second WW domain of WWOX==
-	===Solution structure of the second WW domain of WWOX===	+	<StructureSection load='1wmv' size='340' side='right' caption='[[1wmv]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref><ref>PMID:15266310</ref><ref>PMID:15073125</ref><ref>PMID:15131042</ref><ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref><ref>PMID:15266310</ref><ref>PMID:15073125</ref><ref>PMID:15131042</ref><ref>PMID:16223882</ref>	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum]</span></td></tr>
-	==Function==	+	<table>
-	[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref><ref>PMID:15548692</ref><ref>PMID:15070730</ref><ref>PMID:16061658</ref><ref>PMID:16219768</ref><ref>PMID:19366691</ref><ref>PMID:19465938</ref>	+	== Disease ==
-		+	[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
-	==~~About this Structure~~==	+	== Function ==
-	[[~~1wmv~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~1WMV OCA~~].	+	[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>
-		+	== Evolutionary Conservation ==
-	==~~Reference~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	<references ~~group="xtra"~~/><~~references~~/>	+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/1wmv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Booker, G W.]]		[[Category: Booker, G W.]]

OCA at 18:04, 24 March 2013

2013-03-24T18:04:40Z

←Older revision		Revision as of 18:04, 24 March 2013
Line 1:		Line 1:
-	[[Image:1wmv.png\|left\|200px]]
-
	{{STRUCTURE_1wmv\| PDB=1wmv \| SCENE= }}		{{STRUCTURE_1wmv\| PDB=1wmv \| SCENE= }}
-
	===Solution structure of the second WW domain of WWOX===		===Solution structure of the second WW domain of WWOX===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref><ref>PMID:15266310</ref><ref>PMID:15073125</ref><ref>PMID:15131042</ref><ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref><ref>PMID:15266310</ref><ref>PMID:15073125</ref><ref>PMID:15131042</ref><ref>PMID:16223882</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref><ref>PMID:15548692</ref><ref>PMID:15070730</ref><ref>PMID:16061658</ref><ref>PMID:16219768</ref><ref>PMID:19366691</ref><ref>PMID:19465938</ref>

	==About this Structure==		==About this Structure==
	[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA].		[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Booker, G W.]]		[[Category: Booker, G W.]]

OCA: Protected "1wmv" [edit=sysop:move=sysop]

2013-01-05T13:51:54Z

Protected "1wmv" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:51, 5 January 2013