1wn3 - Revision history

OCA at 07:57, 25 October 2023

2023-10-25T07:57:18Z

←Older revision		Revision as of 07:57, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1wn3' size='340' side='right'caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1wn3' size='340' side='right'caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wlu\|1wlu]], [[1wlv\|1wlv]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [https://pdbe.org/1wn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [https://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wn3 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [https://pdbe.org/1wn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [https://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wn3 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5SJP3_THET8 Q5SJP3_THET8]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thet8~~]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: Kunishima, N]]	+	[[Category: Kunishima N]]
-	[[Category: Miyano, M]]	+	[[Category: Miyano M]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Sugahara M]]
-	[[Category: Sugahara, M]]	+
-	~~[[Category: Hot dog fold]]~~	+
-	~~[[Category: Phenylacetic acid degradation]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Thioesterase]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 16:22, 27 October 2021

2021-10-27T16:22:25Z

←Older revision		Revision as of 16:22, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1wn3' size='340' side='right'caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1wn3' size='340' side='right'caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wlu\|1wlu]], [[1wlv\|1wlv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wlu\|1wlu]], [[1wlv\|1wlv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [~~http~~://pdbe.org/1wn3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wn3 ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [https://pdbe.org/1wn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [https://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wn3 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:27, 22 January 2020

2020-01-22T17:27:51Z

←Older revision		Revision as of 17:27, 22 January 2020
Line 1:		Line 1:

	==Crystal structure of TT0310 protein from Thermus thermophilus HB8==		==Crystal structure of TT0310 protein from Thermus thermophilus HB8==
-	<StructureSection load='1wn3' size='340' side='right' caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1wn3' size='340' side='right'caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Thet8]]		[[Category: Thet8]]
	[[Category: Kunishima, N]]		[[Category: Kunishima, N]]

OCA at 16:13, 11 April 2018

2018-04-11T16:13:46Z

←Older revision		Revision as of 16:13, 11 April 2018
Line 1:		Line 1:
		+
	==Crystal structure of TT0310 protein from Thermus thermophilus HB8==		==Crystal structure of TT0310 protein from Thermus thermophilus HB8==
	<StructureSection load='1wn3' size='340' side='right' caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1wn3' size='340' side='right' caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wlu\|1wlu]], [[1wlv\|1wlv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wlu\|1wlu]], [[1wlv\|1wlv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [http://pdbe.org/1wn3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [http://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [http://pdbe.org/1wn3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [http://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wn3 ProSAT], [http://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/1wn3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/1wn3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:59, 10 February 2016

2016-02-10T02:59:11Z

←Older revision		Revision as of 02:59, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wn3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:43, 11 September 2015

2015-09-11T04:43:01Z

←Older revision		Revision as of 04:43, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1wn3' size='340' side='right' caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1wn3' size='340' side='right' caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus_hb8 Thermus thermophilus hb8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wlu\|1wlu]], [[1wlv\|1wlv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wlu\|1wlu]], [[1wlv\|1wlv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [http://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [http://pdbe.org/1wn3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [http://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wn3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermus thermophilus hb8~~]]	+	[[Category: Thet8]]
	[[Category: Kunishima, N]]		[[Category: Kunishima, N]]
	[[Category: Miyano, M]]		[[Category: Miyano, M]]

OCA at 11:19, 25 December 2014

2014-12-25T11:19:32Z

←Older revision		Revision as of 11:19, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wlu\|1wlu]], [[1wlv\|1wlv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wlu\|1wlu]], [[1wlv\|1wlv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [http://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [http://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Thermus thermophilus hb8]]		[[Category: Thermus thermophilus hb8]]
-	[[Category: Kunishima, N.]]	+	[[Category: Kunishima, N]]
-	[[Category: Miyano, M.]]	+	[[Category: Miyano, M]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sugahara, M.]]	+	[[Category: Sugahara, M]]
	[[Category: Hot dog fold]]		[[Category: Hot dog fold]]
	[[Category: Phenylacetic acid degradation]]		[[Category: Phenylacetic acid degradation]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Thioesterase]]		[[Category: Thioesterase]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 18:30, 29 September 2014

2014-09-29T18:30:31Z

←Older revision		Revision as of 18:30, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1wn3.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of TT0310 protein from Thermus thermophilus HB8==
		+	<StructureSection load='1wn3' size='340' side='right' caption='[[1wn3]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wn3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WN3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXC:HEXANOYL-COENZYME+A'>HXC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wlu\|1wlu]], [[1wlv\|1wlv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wn3 RCSB], [http://www.ebi.ac.uk/pdbsum/1wn3 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wn3 TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/1wn3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hot dog fold proteins sharing the characteristic "hot dog" fold are known to involve certain coenzyme A binding enzymes with various oligomeric states. In order to elucidate the oligomerization-function relationship of the hot dog fold proteins, crystal structures of the phenylacetate degradation protein PaaI from Thermus thermophilus HB8 (TtPaaI), a tetrameric acyl-CoA thioesterase with the hot dog fold, have been determined and compared with those of other family members. In the liganded crystal forms with coenzyme A derivatives, only two of four intersubunit catalytic pockets of the TtPaaI tetramer are occupied by the ligands. A detailed structural comparison between several liganded and unliganded forms reveals that a subtle rigid-body rearrangement of subunits within 2 degrees upon binding of the first two ligand molecules can induce a strict negative cooperativity to prevent further binding at the remaining two pockets, indicating that the so-called "half-of-the-sites reactivity" of oligomeric enzymes is visualized for the first time. Considering kinetic and mutational analyses together, a possible reaction mechanism of TtPaaI is proposed; one tetramer binds only two acyl-CoA molecules with a novel asymmetric induced-fit mechanism and carries out the hydrolysis according to a base-catalyzed reaction through activation of a water molecule by Asp48. From a structural comparison with other family members, it is concluded that a subgroup of the hot dog fold protein family, referred to as "asymmetric hot dog thioesterases" including medium chain acyl-CoA thioesterase II from Escherichia coli and human thioesterase III, might share the same oligomerization mode and the asymmetric induced-fit mechanism as observed in TtPaaI.

-	~~{{STRUCTURE_1wn3\| PDB=1wn3 \| SCENE= }}~~	+	A novel induced-fit reaction mechanism of asymmetric hot dog thioesterase PAAI.,Kunishima N, Asada Y, Sugahara M, Ishijima J, Nodake Y, Sugahara M, Miyano M, Kuramitsu S, Yokoyama S, Sugahara M J Mol Biol. 2005 Sep 9;352(1):212-28. PMID:16061252<ref>PMID:16061252</ref>

-	~~===Crystal structure~~ of ~~TT0310 protein from Thermus thermophilus HB8===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16061252}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1wn3]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016061252<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermus thermophilus hb8]]		[[Category: Thermus thermophilus hb8]]
	[[Category: Kunishima, N.]]		[[Category: Kunishima, N.]]

OCA: Protected "1wn3" [edit=sysop:move=sysop]

2013-01-05T11:09:56Z

Protected "1wn3" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:09, 5 January 2013

OCA at 11:09, 5 January 2013

2013-01-05T11:09:52Z

←Older revision		Revision as of 11:09, 5 January 2013
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-	{{Seed}}
	[[Image:1wn3.png\|left\|200px]]		[[Image:1wn3.png\|left\|200px]]

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	{{STRUCTURE_1wn3\| PDB=1wn3 \| SCENE= }}		{{STRUCTURE_1wn3\| PDB=1wn3 \| SCENE= }}

	===Crystal structure of TT0310 protein from Thermus thermophilus HB8===		===Crystal structure of TT0310 protein from Thermus thermophilus HB8===

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	==About this Structure==		==About this Structure==
-	~~1WN3~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus~~ Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA].	+	[[1wn3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16061252~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016061252</ref><references group="xtra"/>
-	[[Category: Thermus thermophilus]]	+	[[Category: Thermus thermophilus hb8]]
	[[Category: Kunishima, N.]]		[[Category: Kunishima, N.]]
	[[Category: Miyano, M.]]		[[Category: Miyano, M.]]
Line 35:		Line 23:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Thioesterase]]		[[Category: Thioesterase]]
-		+	[[Category: Unknown function]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 14:52:42 2009''~~	+