1wtb - Revision history

OCA at 13:49, 9 May 2024

2024-05-09T13:49:20Z

←Older revision		Revision as of 13:49, 9 May 2024
Line 1:		Line 1:

	==Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA==		==Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA==
-	<StructureSection load='1wtb' size='340' side='right'caption='[[1wtb~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1wtb' size='340' side='right'caption='[[1wtb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WTB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WTB FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [https://pdbe.org/1wtb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [https://www.ebi.ac.uk/pdbsum/1wtb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wtb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [https://pdbe.org/1wtb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [https://www.ebi.ac.uk/pdbsum/1wtb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wtb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HNRPD_HUMAN HNRPD_HUMAN]] Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.<ref>PMID:11051545</ref> <ref>PMID:10080887</ref>	+	[https://www.uniprot.org/uniprot/HNRPD_HUMAN HNRPD_HUMAN] Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.<ref>PMID:11051545</ref> <ref>PMID:10080887</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Enokizono, Y]]	+	[[Category: Enokizono Y]]
-	[[Category: Ishikawa, F]]	+	[[Category: Ishikawa F]]
-	[[Category: Katahira, M]]	+	[[Category: Katahira M]]
-	[[Category: Konishi, Y]]	+	[[Category: Konishi Y]]
-	[[Category: Nagata, K]]	+	[[Category: Nagata K]]
-	[[Category: Ouhashi, K]]	+	[[Category: Ouhashi K]]
-	[[Category: Uesugi, S]]	+	[[Category: Uesugi S]]
-	~~[[Category: Auf1]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Dna-binding domain]]~~	+
-	~~[[Category: Hnrnp d]]~~	+
-	~~[[Category: Rna-binding domain]]~~	+
-	~~[[Category: Rrm]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Telomere]]~~	+
-	~~[[Category: Transcription-dna complex~~]]	+

OCA at 16:26, 27 October 2021

2021-10-27T16:26:40Z

←Older revision		Revision as of 16:26, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1wtb' size='340' side='right'caption='[[1wtb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wtb' size='340' side='right'caption='[[1wtb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WTB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WTB FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [~~http~~://pdbe.org/1wtb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wtb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wtb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [https://pdbe.org/1wtb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [https://www.ebi.ac.uk/pdbsum/1wtb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wtb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HNRPD_HUMAN HNRPD_HUMAN]] Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.<ref>PMID:11051545</ref> <ref>PMID:10080887</ref>	+	[[https://www.uniprot.org/uniprot/HNRPD_HUMAN HNRPD_HUMAN]] Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.<ref>PMID:11051545</ref> <ref>PMID:10080887</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:43, 22 January 2020

2020-01-22T17:43:54Z

←Older revision		Revision as of 17:43, 22 January 2020
Line 1:		Line 1:

	==Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA==		==Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA==
-	<StructureSection load='1wtb' size='340' side='right' caption='[[1wtb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1wtb' size='340' side='right'caption='[[1wtb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WTB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WTB FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Nucleoprotein\|Nucleoprotein]]	+	*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Enokizono, Y]]		[[Category: Enokizono, Y]]
	[[Category: Ishikawa, F]]		[[Category: Ishikawa, F]]

OCA at 16:27, 11 April 2018

2018-04-11T16:27:40Z

←Older revision		Revision as of 16:27, 11 April 2018
Line 1:		Line 1:
		+
	==Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA==		==Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA==
	<StructureSection load='1wtb' size='340' side='right' caption='[[1wtb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wtb' size='340' side='right' caption='[[1wtb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WTB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WTB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [http://pdbe.org/1wtb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [http://www.ebi.ac.uk/pdbsum/1wtb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [http://pdbe.org/1wtb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [http://www.ebi.ac.uk/pdbsum/1wtb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wtb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/1wtb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/1wtb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wtb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:08, 11 September 2015

2015-09-11T13:08:38Z

←Older revision		Revision as of 13:08, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1wtb' size='340' side='right' caption='[[1wtb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wtb' size='340' side='right' caption='[[1wtb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WTB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WTB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [http://www.ebi.ac.uk/pdbsum/1wtb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [http://pdbe.org/1wtb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [http://www.ebi.ac.uk/pdbsum/1wtb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wtb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Enokizono, Y]]		[[Category: Enokizono, Y]]
	[[Category: Ishikawa, F]]		[[Category: Ishikawa, F]]

OCA at 16:52, 25 December 2014

2014-12-25T16:52:21Z

←Older revision		Revision as of 16:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WTB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WTB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [http://www.ebi.ac.uk/pdbsum/1wtb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [http://www.ebi.ac.uk/pdbsum/1wtb PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HNRPD_HUMAN HNRPD_HUMAN]] Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.<ref>PMID:11051545</ref> <ref>PMID:10080887</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Enokizono, Y.]]	+	[[Category: Enokizono, Y]]
-	[[Category: Ishikawa, F.]]	+	[[Category: Ishikawa, F]]
-	[[Category: Katahira, M.]]	+	[[Category: Katahira, M]]
-	[[Category: Konishi, Y.]]	+	[[Category: Konishi, Y]]
-	[[Category: Nagata, K.]]	+	[[Category: Nagata, K]]
-	[[Category: Ouhashi, K.]]	+	[[Category: Ouhashi, K]]
-	[[Category: Uesugi, S.]]	+	[[Category: Uesugi, S]]
	[[Category: Auf1]]		[[Category: Auf1]]
	[[Category: Complex]]		[[Category: Complex]]

OCA at 21:55, 28 September 2014

2014-09-28T21:55:34Z

←Older revision		Revision as of 21:55, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1wtb.~~png~~\|~~left~~\|200px]]	+	==Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA==
		+	<StructureSection load='1wtb' size='340' side='right' caption='[[1wtb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WTB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iqt\|1iqt]], [[1hd0\|1hd0]], [[1hd1\|1hd1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wtb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wtb RCSB], [http://www.ebi.ac.uk/pdbsum/1wtb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/1wtb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heterogeneous nuclear ribonucleoprotein D, also known as AUF1, has two DNA/RNA-binding domains, each of which can specifically bind to single-stranded d(TTAGGG)n, the human telomeric repeat. Here, the structure of the C-terminal-binding domain (BD2) complexed with single-stranded d(TTAGGG) determined by NMR is presented. The structure has revealed that each residue of the d(TAG) segment is recognized by BD2 in a base-specific manner. The interactions deduced from the structure have been confirmed by gel retardation experiments with mutant BD2 and DNA. It is known that single-stranded DNA with the telomeric repeat tends to form a quadruplex and that the quadruplex has an inhibitory effect on telomere elongation by telomerase. This time it is revealed that BD2 unfolds the quadruplex of such DNA upon binding. Moreover, the effect of BD2 on the elongation by telomerase was examined in vitro. These results suggest the possible involvement of heterogeneous nuclear ribonucleoprotein D in maintenance of the telomere 3'-overhang either through protection of a single-stranded DNA or destabilization of the potentially deleterious quadruplex structure for the elongation by telomerase.

-	~~{{STRUCTURE_1wtb\| PDB=1wtb \| SCENE= }}~~	+	Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D.,Enokizono Y, Konishi Y, Nagata K, Ouhashi K, Uesugi S, Ishikawa F, Katahira M J Biol Chem. 2005 May 13;280(19):18862-70. Epub 2005 Feb 24. PMID:15734733<ref>PMID:15734733</ref>

-	~~===Complex structure~~ of the ~~C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15734733}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1wtb]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA].~~	+

	==See Also==		==See Also==
	*[[Nucleoprotein\|Nucleoprotein]]		*[[Nucleoprotein\|Nucleoprotein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015734733<~~/~~ref~~><~~ref group="xtra">PMID:011531333</ref><ref group="xtra">PMID:010080887</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Enokizono, Y.]]		[[Category: Enokizono, Y.]]

OCA at 19:07, 20 October 2012

2012-10-20T19:07:43Z

←Older revision		Revision as of 19:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1wtb]] is a 2 chain structure ~~of [[Nucleoprotein]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA].	+	[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015734733</ref><ref group="xtra">PMID:011531333</ref><ref group="xtra">PMID:010080887~~</ref><ref group="xtra">PMID:008321232~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015734733</ref><ref group="xtra">PMID:011531333</ref><ref group="xtra">PMID:010080887</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Enokizono, Y.]]		[[Category: Enokizono, Y.]]

OCA at 06:22, 27 July 2012

2012-07-27T06:22:09Z

←Older revision		Revision as of 06:22, 27 July 2012
Line 1:		Line 1:
	[[Image:1wtb.png\|left\|200px]]		[[Image:1wtb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1wtb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1wtb\| PDB=1wtb \| SCENE= }}		{{STRUCTURE_1wtb\| PDB=1wtb \| SCENE= }}

	===Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA===		===Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15734733}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15734733 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15734733}}		{{ABSTRACT_PUBMED_15734733}}

	==About this Structure==		==About this Structure==
-	[[1wtb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA].	+	[[1wtb]] is a 2 chain structure of [[Nucleoprotein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTB OCA].
		+
		+	==See Also==
		+	*[[Nucleoprotein\|Nucleoprotein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15734733~~</ref><ref group="xtra">PMID:~~11531333~~</ref><ref group="xtra">PMID:~~10080887~~</ref><ref group="xtra">PMID:~~8321232~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015734733</ref><ref group="xtra">PMID:011531333</ref><ref group="xtra">PMID:010080887</ref><ref group="xtra">PMID:008321232</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Enokizono, Y.]]		[[Category: Enokizono, Y.]]
Line 39:		Line 31:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Telomere]]		[[Category: Telomere]]
-	[[Category: Transcription/dna complex]]	+	[[Category: Transcription-dna complex]]

OCA: Protected "1wtb" [edit=sysop:move=sysop]

2011-03-15T00:04:16Z

Protected "1wtb" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:04, 15 March 2011