1wue - Revision history

OCA at 13:34, 13 March 2024

2024-03-13T13:34:20Z

←Older revision		Revision as of 13:34, 13 March 2024
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	==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583==		==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583==
-	<StructureSection load='1wue' size='340' side='right'caption='[[1wue]]' scene=''>	+	<StructureSection load='1wue' size='340' side='right'caption='[[1wue]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [https://pdbe.org/1wue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [https://www.ebi.ac.uk/pdbsum/1wue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wue ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [https://pdbe.org/1wue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [https://www.ebi.ac.uk/pdbsum/1wue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wue ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MENC_ENTFA MENC_ENTFA] Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24872444). Also acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-L-phenylglycine (PubMed:24872444). Since the gene is encoded in a menaquinone synthesis operon, OSB synthase is probably the physiological activity. A pathway that requires NSAR activity has not been identified in this species, so whether NSAR is also a biological activity is unknown (PubMed:24872444).<ref>PMID:24872444</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 22:
	==See Also==		==See Also==
	*[[Mandelate racemase/muconate lactonizing enzyme 3D structures\|Mandelate racemase/muconate lactonizing enzyme 3D structures]]		*[[Mandelate racemase/muconate lactonizing enzyme 3D structures\|Mandelate racemase/muconate lactonizing enzyme 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Enterococcus faecalis V583]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Almo SC]]		[[Category: Almo SC]]

OCA at 06:30, 6 October 2021

2021-10-06T06:30:48Z

←Older revision		Revision as of 06:30, 6 October 2021
Line 1:		Line 1:

	==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583==		==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583==
-	<StructureSection load='1wue' size='340' side='right'caption='[[1wue]]~~, [[Resolution\|resolution]] 2.10Å~~' scene=''>	+	<StructureSection load='1wue' size='340' side='right'caption='[[1wue]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WUE FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [~~http~~://pdbe.org/1wue PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wue PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wue ProSAT], [~~http~~://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [https://pdbe.org/1wue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [https://www.ebi.ac.uk/pdbsum/1wue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wue ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wue ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wue ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The rate of protein evolution is determined by a combination of selective pressure on protein function and biophysical constraints on protein folding and structure. Determining the relative contributions of these properties is an unsolved problem in molecular evolution with broad implications for protein engineering and function prediction. As a case study, we examined the structural divergence of the rapidly evolving o-succinylbenzoate synthase (OSBS) family, which catalyzes a step in menaquinone synthesis in diverse microorganisms and plants. On average, the OSBS family is much more divergent than other protein families from the same set of species, with the most divergent family members sharing <15% sequence identity. Comparing 11 representative structures revealed that loss of quaternary structure and large deletions or insertions are associated with the family's rapid evolution. Neither of these properties has been investigated in previous studies to identify factors that affect the rate of protein evolution. Intriguingly, one subfamily retained a multimeric quaternary structure and has small insertions and deletions compared with related enzymes that catalyze diverse reactions. Many proteins in this subfamily catalyze both OSBS and N-succinylamino acid racemization (NSAR). Retention of ancestral structural characteristics in the NSAR/OSBS subfamily suggests that the rate of protein evolution is not proportional to the capacity to evolve new protein functions. Instead, structural features that are conserved among proteins with diverse functions might contribute to the evolution of new functions.
-
-	Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.,Odokonyero D, Sakai A, Patskovsky Y, Malashkevich VN, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Agarwal R, Wang C, Ozerova ND, Yew WS, Sauder JM, Swaminathan S, Burley SK, Almo SC, Glasner ME Proc Natl Acad Sci U S A. 2014 May 28. pii: 201318703. PMID:24872444<ref>PMID:24872444</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1wue" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Mandelate racemase/muconate lactonizing enzyme 3D structures\|Mandelate racemase/muconate lactonizing enzyme 3D structures]]		*[[Mandelate racemase/muconate lactonizing enzyme 3D structures\|Mandelate racemase/muconate lactonizing enzyme 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Entfa]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Almo~~, S C~~]]	+	[[Category: Almo SC]]
-	[[Category: Burley~~, S K~~]]	+	[[Category: Burley SK]]
-	[[Category: Fedorov~~, A A~~]]	+	[[Category: Fedorov AA]]
-	[[Category: Fedorov~~, E V~~]]	+	[[Category: Fedorov EV]]
-	[[Category: Gerlt~~, J A]]~~	+	[[Category: Gerlt JA]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Yew WS]]
-	[[Category: Yew~~, W S]]~~	+
-	~~[[Category: Enolase superfamily]]~~	+
-	~~[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 11:41, 4 December 2019

2019-12-04T11:41:08Z

←Older revision		Revision as of 11:41, 4 December 2019
Line 1:		Line 1:

	==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583==		==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583==
-	<StructureSection load='1wue' size='340' side='right' caption='[[1wue]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1wue' size='340' side='right'caption='[[1wue]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUE FirstGlance]. <br>
Line 25:		Line 25:
	</div>		</div>
	<div class="pdbe-citations 1wue" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1wue" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Mandelate racemase/muconate lactonizing enzyme 3D structures\|Mandelate racemase/muconate lactonizing enzyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Entfa]]		[[Category: Entfa]]
		+	[[Category: Large Structures]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Burley, S K]]		[[Category: Burley, S K]]

OCA at 06:30, 20 December 2017

2017-12-20T06:30:24Z

←Older revision		Revision as of 06:30, 20 December 2017
Line 1:		Line 1:
		+
	==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583==		==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583==
	<StructureSection load='1wue' size='340' side='right' caption='[[1wue]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1wue' size='340' side='right' caption='[[1wue]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [http://pdbe.org/1wue PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [http://www.ebi.ac.uk/pdbsum/1wue PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [http://pdbe.org/1wue PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [http://www.ebi.ac.uk/pdbsum/1wue PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wue ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wue_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wue_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wue ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 38:		Line 39:
	[[Category: Enolase superfamily]]		[[Category: Enolase superfamily]]
	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]		[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
		+	[[Category: PSI, Protein structure initiative]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 10:11, 11 September 2015

2015-09-11T10:11:18Z

←Older revision		Revision as of 10:11, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [http://www.ebi.ac.uk/pdbsum/1wue PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [http://pdbe.org/1wue PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [http://www.ebi.ac.uk/pdbsum/1wue PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wue" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:45, 6 November 2014

2014-11-06T13:45:34Z

←Older revision		Revision as of 13:45, 6 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [http://www.ebi.ac.uk/pdbsum/1wue PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [http://www.ebi.ac.uk/pdbsum/1wue PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Entfa]]		[[Category: Entfa]]
-	[[Category: Almo, S C.]]	+	[[Category: Almo, S C]]
-	[[Category: Burley, S K.]]	+	[[Category: Burley, S K]]
-	[[Category: Fedorov, A A.]]	+	[[Category: Fedorov, A A]]
-	[[Category: Fedorov, E V.]]	+	[[Category: Fedorov, E V]]
-	[[Category: Gerlt, J A~~.]]~~	+	[[Category: Gerlt, J A]]
-	~~[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]~~	+
-	~~[[Category: Yew, W S.]]~~	+
-	~~[[Category: Enolase superfamily]]~~	+
-	~~[[Category: New york sgx research center for structural genomic]]~~	+
-	~~[[Category: Nysgxrc target t2185~~]]	+
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Yew, W S]]
		+	[[Category: Enolase superfamily]]
		+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 05:45, 18 June 2014

2014-06-18T05:45:25Z

←Older revision		Revision as of 05:45, 18 June 2014
Line 38:		Line 38:
	[[Category: New york sgx research center for structural genomic]]		[[Category: New york sgx research center for structural genomic]]
	[[Category: Nysgxrc target t2185]]		[[Category: Nysgxrc target t2185]]
-	[[Category: Protein structure initiative]]
-	[[Category: Psi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 06:51, 11 June 2014

2014-06-11T06:51:46Z

←Older revision		Revision as of 06:51, 11 June 2014
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-	[[~~Image~~:1wue.~~png\|left~~\|200px]]	+	==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583==
		+	<StructureSection load='1wue' size='340' side='right' caption='[[1wue]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [http://www.ebi.ac.uk/pdbsum/1wue PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wue_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The rate of protein evolution is determined by a combination of selective pressure on protein function and biophysical constraints on protein folding and structure. Determining the relative contributions of these properties is an unsolved problem in molecular evolution with broad implications for protein engineering and function prediction. As a case study, we examined the structural divergence of the rapidly evolving o-succinylbenzoate synthase (OSBS) family, which catalyzes a step in menaquinone synthesis in diverse microorganisms and plants. On average, the OSBS family is much more divergent than other protein families from the same set of species, with the most divergent family members sharing <15% sequence identity. Comparing 11 representative structures revealed that loss of quaternary structure and large deletions or insertions are associated with the family's rapid evolution. Neither of these properties has been investigated in previous studies to identify factors that affect the rate of protein evolution. Intriguingly, one subfamily retained a multimeric quaternary structure and has small insertions and deletions compared with related enzymes that catalyze diverse reactions. Many proteins in this subfamily catalyze both OSBS and N-succinylamino acid racemization (NSAR). Retention of ancestral structural characteristics in the NSAR/OSBS subfamily suggests that the rate of protein evolution is not proportional to the capacity to evolve new protein functions. Instead, structural features that are conserved among proteins with diverse functions might contribute to the evolution of new functions.

-	~~{{STRUCTURE_1wue\| PDB=1wue \| SCENE= }}~~	+	Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.,Odokonyero D, Sakai A, Patskovsky Y, Malashkevich VN, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Agarwal R, Wang C, Ozerova ND, Yew WS, Sauder JM, Swaminathan S, Burley SK, Almo SC, Glasner ME Proc Natl Acad Sci U S A. 2014 May 28. pii: 201318703. PMID:24872444<ref>PMID:24872444</ref>

-	~~===Crystal structure of protein GI:29375081~~, ~~unknown member~~ of ~~enolase superfamily from enterococcus faecalis V583===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	==~~About this Structure~~==	+	<references/>
-	~~[[1wue]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA].~~	+	__TOC__
-	[[Category: ~~Enterococcus faecalis~~]]	+	</StructureSection>
		+	[[Category: Entfa]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]
	[[Category: Burley, S K.]]		[[Category: Burley, S K.]]

OCA: Protected "1wue" [edit=sysop:move=sysop]

2013-01-05T13:40:12Z

Protected "1wue" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:40, 5 January 2013

OCA at 13:40, 5 January 2013

2013-01-05T13:40:10Z

←Older revision		Revision as of 13:40, 5 January 2013
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-	{{Seed}}
	[[Image:1wue.png\|left\|200px]]		[[Image:1wue.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~1WUE~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA].	+	[[1wue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA].
	[[Category: Enterococcus faecalis]]		[[Category: Enterococcus faecalis]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]
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	[[Category: Fedorov, E V.]]		[[Category: Fedorov, E V.]]
	[[Category: Gerlt, J A.]]		[[Category: Gerlt, J A.]]
-	[[Category: NYSGXRC, New York ~~Structural GenomiX~~ Research ~~Consortium~~.]]	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
	[[Category: Yew, W S.]]		[[Category: Yew, W S.]]
	[[Category: Enolase superfamily]]		[[Category: Enolase superfamily]]
-	[[Category: New york ~~structural genomix~~ research ~~consortium~~]]	+	[[Category: New york sgx research center for structural genomic]]
	[[Category: Nysgxrc target t2185]]		[[Category: Nysgxrc target t2185]]
	[[Category: Protein structure initiative]]		[[Category: Protein structure initiative]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Unknown function]]		[[Category: Unknown function]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 18:40:06 2008''