1xcs - Revision history

OCA at 08:49, 14 February 2024

2024-02-14T08:49:40Z

←Older revision		Revision as of 08:49, 14 February 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [https://pdbe.org/1xcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [https://www.ebi.ac.uk/pdbsum/1xcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [https://pdbe.org/1xcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [https://www.ebi.ac.uk/pdbsum/1xcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcs ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structures of the hexamer duplex d(CGTACG)(2) complexed with the intercalating anthraquinone derivative 1,5-bis[3-(diethylamino)propionamido]anthracene-9,10-dione and the acridine derivative 9-acridinyl tetralysine have been solved at 2.0- and 1.4-A resolution, respectively. In both cases, the drugs adopt multiple orientations within a large DNA cavity constituted by two groups of four approximately coplanar bases. Cations play a pivotal role in the crystal structure. Both complexes crystallise in the presence of Co(2+), Ba(2+) and Na(+) ions. They reveal at least two different types of coordination environments: (1) specific sites for Co(2+) interacting with N7 of guanine; (2) a central ionic site formed by four phosphate groups, which can be occupied by different ions. One more ionic site that is not always occupied by ions is also visible in the electron density map. All of them play a role in the crystal structure.
-
-	Variable role of ions in two drug intercalation complexes of DNA.,Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:15926069<ref>PMID:15926069</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1xcs" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:26, 2 August 2023

2023-08-02T11:26:25Z

←Older revision		Revision as of 11:26, 2 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XCS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XCS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [https://pdbe.org/1xcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [https://www.ebi.ac.uk/pdbsum/1xcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [https://pdbe.org/1xcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [https://www.ebi.ac.uk/pdbsum/1xcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcs ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Murshudov~~, G N~~]]	+	[[Category: Murshudov GN]]
-	[[Category: Steiner~~, R A~~]]	+	[[Category: Steiner RA]]
-	[[Category: Subirana~~, J A~~]]	+	[[Category: Subirana JA]]
-	[[Category: Valls, N]]	+	[[Category: Valls N]]
-	[[Category: Wright, G]]	+	[[Category: Wright G]]
-	~~[[Category: Co2+]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Double helix]]~~	+
-	~~[[Category: Drug-dna complex~~]]	+

OCA at 16:36, 27 October 2021

2021-10-27T16:36:21Z

←Older revision		Revision as of 16:36, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1xcs' size='340' side='right'caption='[[1xcs]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='1xcs' size='340' side='right'caption='[[1xcs]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XCS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XCS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [~~http~~://pdbe.org/1xcs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xcs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [https://pdbe.org/1xcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [https://www.ebi.ac.uk/pdbsum/1xcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:15, 22 January 2020

2020-01-22T17:15:39Z

←Older revision		Revision as of 17:15, 22 January 2020
Line 1:		Line 1:

	==structure of oligonucleotide/drug complex==		==structure of oligonucleotide/drug complex==
-	<StructureSection load='1xcs' size='340' side='right' caption='[[1xcs]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='1xcs' size='340' side='right'caption='[[1xcs]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XCS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XCS FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Murshudov, G N]]		[[Category: Murshudov, G N]]
	[[Category: Steiner, R A]]		[[Category: Steiner, R A]]

OCA at 07:00, 18 April 2018

2018-04-18T07:00:20Z

←Older revision		Revision as of 07:00, 18 April 2018
Line 1:		Line 1:
		+
	==structure of oligonucleotide/drug complex==		==structure of oligonucleotide/drug complex==
	<StructureSection load='1xcs' size='340' side='right' caption='[[1xcs]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='1xcs' size='340' side='right' caption='[[1xcs]], [[Resolution\|resolution]] 1.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XCS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XCS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [http://pdbe.org/1xcs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [http://www.ebi.ac.uk/pdbsum/1xcs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [http://pdbe.org/1xcs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [http://www.ebi.ac.uk/pdbsum/1xcs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:02, 11 September 2015

2015-09-11T03:02:25Z

←Older revision		Revision as of 03:02, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XCS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XCS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [http://www.ebi.ac.uk/pdbsum/1xcs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [http://pdbe.org/1xcs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [http://www.ebi.ac.uk/pdbsum/1xcs PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xcs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:55, 22 December 2014

2014-12-22T04:55:27Z

←Older revision		Revision as of 04:55, 22 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1xcs\| PDB~~=1xcs \| ~~SCENE~~= }}	+	==structure of oligonucleotide/drug complex==
-	===structure ~~of oligonucleotide~~/~~drug complex=~~==	+	<StructureSection load='1xcs' size='340' side='right' caption='[[1xcs]], [[Resolution\|resolution]] 1.40Å' scene=''>
-	{{~~ABSTRACT_PUBMED_15926069~~}}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XCS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [http://www.ebi.ac.uk/pdbsum/1xcs PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structures of the hexamer duplex d(CGTACG)(2) complexed with the intercalating anthraquinone derivative 1,5-bis[3-(diethylamino)propionamido]anthracene-9,10-dione and the acridine derivative 9-acridinyl tetralysine have been solved at 2.0- and 1.4-A resolution, respectively. In both cases, the drugs adopt multiple orientations within a large DNA cavity constituted by two groups of four approximately coplanar bases. Cations play a pivotal role in the crystal structure. Both complexes crystallise in the presence of Co(2+), Ba(2+) and Na(+) ions. They reveal at least two different types of coordination environments: (1) specific sites for Co(2+) interacting with N7 of guanine; (2) a central ionic site formed by four phosphate groups, which can be occupied by different ions. One more ionic site that is not always occupied by ions is also visible in the electron density map. All of them play a role in the crystal structure.

-	~~==About this Structure==~~	+	Variable role of ions in two drug intercalation complexes of DNA.,Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:15926069<ref>PMID:15926069</ref>
-	~~[[1xcs]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1XCS OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:015926069</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Murshudov, G N.]]	+	== References ==
-	[[Category: Steiner, R A.]]	+	<references/>
-	[[Category: Subirana, J A.]]	+	__TOC__
-	[[Category: Valls, N.]]	+	</StructureSection>
-	[[Category: Wright, G.]]	+	[[Category: Murshudov, G N]]
		+	[[Category: Steiner, R A]]
		+	[[Category: Subirana, J A]]
		+	[[Category: Valls, N]]
		+	[[Category: Wright, G]]
	[[Category: Co2+]]		[[Category: Co2+]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Drug-dna complex]]		[[Category: Drug-dna complex]]

OCA at 08:21, 23 April 2014

2014-04-23T08:21:46Z

←Older revision		Revision as of 08:21, 23 April 2014
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-	[[Image:1xcs.png\|left\|200px]]
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-	<!--
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	{{STRUCTURE_1xcs\| PDB=1xcs \| SCENE= }}		{{STRUCTURE_1xcs\| PDB=1xcs \| SCENE= }}
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	===structure of oligonucleotide/drug complex===		===structure of oligonucleotide/drug complex===
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	{{ABSTRACT_PUBMED_15926069}}		{{ABSTRACT_PUBMED_15926069}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:015926069</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015926069</ref><references group="xtra"/><references/>
	[[Category: Murshudov, G N.]]		[[Category: Murshudov, G N.]]
	[[Category: Steiner, R A.]]		[[Category: Steiner, R A.]]

OCA: Protected "1xcs" [edit=sysop:move=sysop]

2011-11-16T09:53:00Z

Protected "1xcs" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:53, 16 November 2011

OCA at 09:52, 16 November 2011

2011-11-16T09:52:58Z

←Older revision		Revision as of 09:52, 16 November 2011
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-	~~{{Seed}}~~	+	[[Image:1xcs.png\|left\|200px]]
-	[[Image:1xcs.~~gif~~\|left\|200px]]	+

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	==About this Structure==		==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA].	+	[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA].

	==Reference==		==Reference==
-	~~Variable role of ions in two drug intercalation complexes of DNA., Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA, J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~15926069 15926069]~~	+	<ref group="xtra">PMID:015926069</ref><references group="xtra"/>
	[[Category: Murshudov, G N.]]		[[Category: Murshudov, G N.]]
	[[Category: Steiner, R A.]]		[[Category: Steiner, R A.]]
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	[[Category: Wright, G.]]		[[Category: Wright, G.]]
	[[Category: Co2+]]		[[Category: Co2+]]
		+	[[Category: Dna]]
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Drug-dna complex]]		[[Category: Drug-dna complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:44:54 2008''