1xd6 - Revision history

OCA at 14:05, 9 May 2024

2024-05-09T14:05:58Z

←Older revision		Revision as of 14:05, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XD6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1xd5\|1xd5]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [https://pdbe.org/1xd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [https://www.ebi.ac.uk/pdbsum/1xd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xd6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [https://pdbe.org/1xd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [https://www.ebi.ac.uk/pdbsum/1xd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xd6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q1M0Y9_9ASPA Q1M0Y9_9ASPA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Gastrodia elata]]		[[Category: Gastrodia elata]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hu, Z]]	+	[[Category: Hu Z]]
-	[[Category: Huang~~, R H~~]]	+	[[Category: Huang RH]]
-	[[Category: Liu, W]]	+	[[Category: Liu W]]
-	[[Category: Wang~~, D C~~]]	+	[[Category: Wang DC]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	[[Category: Yang, N]]	+	[[Category: Yang N]]
-	~~[[Category: Antifungal protein]]~~	+
-	~~[[Category: Homogeneous beta-sheet]]~~	+
-	~~[[Category: Monocot mannose-binding lectin]]~~	+
-	~~[[Category: Monomer~~]]	+

OCA at 16:36, 27 October 2021

2021-10-27T16:36:37Z

←Older revision		Revision as of 16:36, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1xd6' size='340' side='right'caption='[[1xd6]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xd6' size='340' side='right'caption='[[1xd6]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xd6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XD6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XD6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xd5\|1xd5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xd5\|1xd5]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [~~http~~://pdbe.org/1xd6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xd6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xd6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [https://pdbe.org/1xd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [https://www.ebi.ac.uk/pdbsum/1xd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xd6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:55, 22 January 2020

2020-01-22T17:55:33Z

←Older revision		Revision as of 17:55, 22 January 2020
Line 1:		Line 1:

	==Crystal structures of novel monomeric monocot mannose-binding lectins from Gastrodia elata==		==Crystal structures of novel monomeric monocot mannose-binding lectins from Gastrodia elata==
-	<StructureSection load='1xd6' size='340' side='right' caption='[[1xd6]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1xd6' size='340' side='right'caption='[[1xd6]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XD6 FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Gastrodia elata]]		[[Category: Gastrodia elata]]
		+	[[Category: Large Structures]]
	[[Category: Hu, Z]]		[[Category: Hu, Z]]
	[[Category: Huang, R H]]		[[Category: Huang, R H]]

OCA at 07:33, 18 April 2018

2018-04-18T07:33:00Z

←Older revision		Revision as of 07:33, 18 April 2018
Line 1:		Line 1:
		+
	==Crystal structures of novel monomeric monocot mannose-binding lectins from Gastrodia elata==		==Crystal structures of novel monomeric monocot mannose-binding lectins from Gastrodia elata==
	<StructureSection load='1xd6' size='340' side='right' caption='[[1xd6]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xd6' size='340' side='right' caption='[[1xd6]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xd5\|1xd5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xd5\|1xd5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [http://pdbe.org/1xd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [http://www.ebi.ac.uk/pdbsum/1xd6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [http://pdbe.org/1xd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [http://www.ebi.ac.uk/pdbsum/1xd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xd6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/1xd6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/1xd6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xd6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:30, 11 September 2015

2015-09-11T09:30:20Z

←Older revision		Revision as of 09:30, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xd5\|1xd5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xd5\|1xd5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [http://www.ebi.ac.uk/pdbsum/1xd6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [http://pdbe.org/1xd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [http://www.ebi.ac.uk/pdbsum/1xd6 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xd6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:06, 6 January 2015

2015-01-06T13:06:17Z

←Older revision		Revision as of 13:06, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XD6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xd5\|1xd5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xd5\|1xd5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [http://www.ebi.ac.uk/pdbsum/1xd6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [http://www.ebi.ac.uk/pdbsum/1xd6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Gastrodia elata]]		[[Category: Gastrodia elata]]
-	[[Category: Hu, Z.]]	+	[[Category: Hu, Z]]
-	[[Category: Huang, R H.]]	+	[[Category: Huang, R H]]
-	[[Category: Liu, W.]]	+	[[Category: Liu, W]]
-	[[Category: Wang, D C.]]	+	[[Category: Wang, D C]]
-	[[Category: Wang, M.]]	+	[[Category: Wang, M]]
-	[[Category: Yang, N.]]	+	[[Category: Yang, N]]
	[[Category: Antifungal protein]]		[[Category: Antifungal protein]]
	[[Category: Homogeneous beta-sheet]]		[[Category: Homogeneous beta-sheet]]
	[[Category: Monocot mannose-binding lectin]]		[[Category: Monocot mannose-binding lectin]]
	[[Category: Monomer]]		[[Category: Monomer]]

OCA at 21:37, 29 September 2014

2014-09-29T21:37:49Z

←Older revision		Revision as of 21:37, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xd6.~~png~~\|~~left~~\|200px]]	+	==Crystal structures of novel monomeric monocot mannose-binding lectins from Gastrodia elata==
		+	<StructureSection load='1xd6' size='340' side='right' caption='[[1xd6]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XD6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xd5\|1xd5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xd6 RCSB], [http://www.ebi.ac.uk/pdbsum/1xd6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/1xd6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two isoforms of an antifungal protein, gastrodianin, were isolated from two subspecies of the orchid Gastrodia elata, belonging to the protein superfamily of monocot mannose-specific lectins. In the context that all available structures in this superfamily are oligomers so far, the crystal structures of the orchid lectins, both at 2.0 A, revealed a novel monomeric structure. It resulted from the rearrangement of the C-terminal peptide inclusive of the 12th beta-strand, which changes from the "C-terminal exchange" into a "C-terminal self-assembly" mode. Thus, the overall tertiary scaffold is stabilized with an intramolecular beta-sheet instead of the hybrid observed on subunit/subunit interface in all known homologous dimeric or tetrameric lectins. In contrast to the constrained extended conformation with a cis peptide bond between residues 98 and 99 commonly occurring in oligomers, a beta-hairpin forms from position 97 to 101 with a normal trans peptide bond at the corresponding site in gastrodianin, which determines the topology of the C-terminal peptide and thereby its unique fold pattern. Sequence and structure comparison shows that residue replacement and insertion at the position where the beta-hairpin occurs in association with cis-trans inter-conversion of the specific peptide bond (97-98) are possibly responsible for such a radical structure switch between monomers and oligomers. Moreover, this seems to be a common melody controlling the quaternary states among bulb lectins through studies on sequence alignment. The observations revealed a structural mechanism by which the quaternary organization of monocot mannose binding lectins could be governed. The mutation experiment performed on maltose-binding protein-gastrodianin fusion protein followed by a few biochemical detections provides direct evidence to support this conclusion. Potential carbohydrate recognition sites and biological implications of the orchid lectin based on its monomeric state are also discussed in this paper.

-	~~{{STRUCTURE_1xd6\| PDB=1xd6 \| SCENE= }}~~	+	Structural mechanism governing the quaternary organization of monocot mannose-binding lectin revealed by the novel monomeric structure of an orchid lectin.,Liu W, Yang N, Ding J, Huang RH, Hu Z, Wang DC J Biol Chem. 2005 Apr 15;280(15):14865-76. Epub 2005 Jan 13. PMID:15649901<ref>PMID:15649901</ref>

-	~~===Crystal structures~~ of ~~novel monomeric monocot mannose-binding lectins from Gastrodia elata===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15649901}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1xd6]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gastrodia_elata Gastrodia elata]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015649901<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Gastrodia elata]]		[[Category: Gastrodia elata]]
	[[Category: Hu, Z.]]		[[Category: Hu, Z.]]

OCA: Protected "1xd6" [edit=sysop:move=sysop]

2013-01-05T12:59:49Z

Protected "1xd6" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:59, 5 January 2013

OCA at 12:59, 5 January 2013

2013-01-05T12:59:47Z

←Older revision		Revision as of 12:59, 5 January 2013
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-	{{Seed}}
	[[Image:1xd6.png\|left\|200px]]		[[Image:1xd6.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1xd6\| PDB=1xd6 \| SCENE= }}		{{STRUCTURE_1xd6\| PDB=1xd6 \| SCENE= }}

	===Crystal structures of novel monomeric monocot mannose-binding lectins from Gastrodia elata===		===Crystal structures of novel monomeric monocot mannose-binding lectins from Gastrodia elata===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15649901}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_15649901}}		{{ABSTRACT_PUBMED_15649901}}

	==About this Structure==		==About this Structure==
-	~~1XD6~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA].	+	[[1xd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15649901~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015649901</ref><references group="xtra"/>
	[[Category: Gastrodia elata]]		[[Category: Gastrodia elata]]
	[[Category: Hu, Z.]]		[[Category: Hu, Z.]]
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	[[Category: Monocot mannose-binding lectin]]		[[Category: Monocot mannose-binding lectin]]
	[[Category: Monomer]]		[[Category: Monomer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:46:49 2009''

OCA at 16:46, 17 February 2009

2009-02-17T16:46:51Z

←Older revision		Revision as of 16:46, 17 February 2009
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	==About this Structure==		==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA].	+	1XD6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gastrodia_elata Gastrodia elata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XD6 OCA].

	==Reference==		==Reference==
-	Structural mechanism governing the quaternary organization of monocot mannose-binding lectin revealed by the novel monomeric structure of an orchid lectin., Liu W, Yang N, Ding J, Huang RH, Hu Z, Wang DC, J Biol Chem. 2005 Apr 15;280(15):14865-76. Epub 2005 Jan 13. PMID:[~~http~~:~~//www.ncbi.nlm.nih.gov/pubmed/15649901 15649901~~]	+	<ref group="xtra">PMID:15649901</ref><references group="xtra"/>
		+	[[Category: Gastrodia elata]]
	[[Category: Hu, Z.]]		[[Category: Hu, Z.]]
	[[Category: Huang, R H.]]		[[Category: Huang, R H.]]
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	[[Category: Monomer]]		[[Category: Monomer]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 02~~:49:~~19 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:46:49 2009''