1xfc - Revision history

OCA at 14:06, 9 May 2024

2024-05-09T14:06:50Z

←Older revision		Revision as of 14:06, 9 May 2024
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	<StructureSection load='1xfc' size='340' side='right'caption='[[1xfc]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1xfc' size='340' side='right'caption='[[1xfc]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xfc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XFC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PLP:PYRIDOXAL~~-~~5-PHOSPHATE'>PLP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1rcq\|1rcq]], [[1sft\|1sft]], [[2sfp\|2sfp]], [[1bdo\|1bdo]], [[1l6f\|1l6f]], [[1epv\|1epv]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773~~ "~~Bacillus tuberculosis~~" ~~(Zopf 1883) Klein 1884])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [https://pdbe.org/1xfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [https://www.ebi.ac.uk/pdbsum/1xfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xfc ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [~~http~~://pdbe.org/1xfc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xfc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xfc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ALR_MYCTU ALR_MYCTU]] Catalyzes the interconversion of L-alanine and D-alanine.<ref>PMID:11267762</ref>	+	[https://www.uniprot.org/uniprot/ALR_MYCTU ALR_MYCTU] Catalyzes the interconversion of L-alanine and D-alanine.<ref>PMID:11267762</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alanine racemase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Benedik~~, M J~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Briggs~~, J M~~]]	+	[[Category: Benedik MJ]]
-	[[Category: Ebalunode, J]]	+	[[Category: Briggs JM]]
-	[[Category: Im, H]]	+	[[Category: Ebalunode J]]
-	[[Category: Kohn, H]]	+	[[Category: Im H]]
-	[[Category: Krause~~, K L~~]]	+	[[Category: Kohn H]]
-	[[Category: LeMagueres, P]]	+	[[Category: Krause KL]]
-	[[Category: Strych, U]]	+	[[Category: LeMagueres P]]
-	~~[[Category: Alpha-beta barrel]]~~	+	[[Category: Strych U]]
-	~~[[Category: Beta-structure for c-terminal domain]]~~	+
-	~~[[Category: Internal aldimine form]]~~	+
-	~~[[Category: Isomerase~~]]	+

OCA at 09:56, 6 January 2021

2021-01-06T09:56:50Z

←Older revision		Revision as of 09:56, 6 January 2021
Line 1:		Line 1:

	==The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site==		==The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site==
-	<StructureSection load='1xfc' size='340' side='right' caption='[[1xfc]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1xfc' size='340' side='right'caption='[[1xfc]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XFC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rcq\|1rcq]], [[1sft\|1sft]], [[2sfp\|2sfp]], [[1bdo\|1bdo]], [[1l6f\|1l6f]], [[1epv\|1epv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rcq\|1rcq]], [[1sft\|1sft]], [[2sfp\|2sfp]], [[1bdo\|1bdo]], [[1l6f\|1l6f]], [[1epv\|1epv]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [http://pdbe.org/1xfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [http://www.ebi.ac.uk/pdbsum/1xfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xfc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [http://pdbe.org/1xfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [http://www.ebi.ac.uk/pdbsum/1xfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xfc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Alanine racemase\|Alanine racemase]]	+	*[[Alanine racemase 3D structures\|Alanine racemase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Alanine racemase]]		[[Category: Alanine racemase]]
		+	[[Category: Large Structures]]
	[[Category: Benedik, M J]]		[[Category: Benedik, M J]]
	[[Category: Briggs, J M]]		[[Category: Briggs, J M]]

OCA at 07:25, 18 April 2018

2018-04-18T07:25:12Z

←Older revision		Revision as of 07:25, 18 April 2018
Line 1:		Line 1:
		+
	==The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site==		==The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site==
	<StructureSection load='1xfc' size='340' side='right' caption='[[1xfc]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1xfc' size='340' side='right' caption='[[1xfc]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [http://pdbe.org/1xfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [http://www.ebi.ac.uk/pdbsum/1xfc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [http://pdbe.org/1xfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [http://www.ebi.ac.uk/pdbsum/1xfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xfc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/1xfc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/1xfc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:12, 8 February 2016

2016-02-08T22:12:25Z

←Older revision		Revision as of 22:12, 8 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xfc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:51, 10 September 2015

2015-09-10T15:51:14Z

←Older revision		Revision as of 15:51, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1xfc' size='340' side='right' caption='[[1xfc]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1xfc' size='340' side='right' caption='[[1xfc]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rcq\|1rcq]], [[1sft\|1sft]], [[2sfp\|2sfp]], [[1bdo\|1bdo]], [[1l6f\|1l6f]], [[1epv\|1epv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rcq\|1rcq]], [[1sft\|1sft]], [[2sfp\|2sfp]], [[1bdo\|1bdo]], [[1l6f\|1l6f]], [[1epv\|1epv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [http://www.ebi.ac.uk/pdbsum/1xfc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [http://pdbe.org/1xfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [http://www.ebi.ac.uk/pdbsum/1xfc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xfc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Alanine racemase]]		[[Category: Alanine racemase]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Benedik, M J]]		[[Category: Benedik, M J]]
	[[Category: Briggs, J M]]		[[Category: Briggs, J M]]

OCA at 02:28, 25 December 2014

2014-12-25T02:28:43Z

←Older revision		Revision as of 02:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XFC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rcq\|1rcq]], [[1sft\|1sft]], [[2sfp\|2sfp]], [[1bdo\|1bdo]], [[1l6f\|1l6f]], [[1epv\|1epv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rcq\|1rcq]], [[1sft\|1sft]], [[2sfp\|2sfp]], [[1bdo\|1bdo]], [[1l6f\|1l6f]], [[1epv\|1epv]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [http://www.ebi.ac.uk/pdbsum/1xfc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [http://www.ebi.ac.uk/pdbsum/1xfc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ALR_MYCTU ALR_MYCTU]] Catalyzes the interconversion of L-alanine and D-alanine.<ref>PMID:11267762</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Alanine racemase]]		[[Category: Alanine racemase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Benedik, M J.]]	+	[[Category: Benedik, M J]]
-	[[Category: Briggs, J M.]]	+	[[Category: Briggs, J M]]
-	[[Category: Ebalunode, J.]]	+	[[Category: Ebalunode, J]]
-	[[Category: Im, H.]]	+	[[Category: Im, H]]
-	[[Category: Kohn, H.]]	+	[[Category: Kohn, H]]
-	[[Category: Krause, K L.]]	+	[[Category: Krause, K L]]
-	[[Category: LeMagueres, P.]]	+	[[Category: LeMagueres, P]]
-	[[Category: Strych, U.]]	+	[[Category: Strych, U]]
	[[Category: Alpha-beta barrel]]		[[Category: Alpha-beta barrel]]
	[[Category: Beta-structure for c-terminal domain]]		[[Category: Beta-structure for c-terminal domain]]
	[[Category: Internal aldimine form]]		[[Category: Internal aldimine form]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 21:59, 29 September 2014

2014-09-29T21:59:26Z

←Older revision		Revision as of 21:59, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xfc.~~png~~\|~~left~~\|200px]]	+	==The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site==
		+	<StructureSection load='1xfc' size='340' side='right' caption='[[1xfc]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XFC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rcq\|1rcq]], [[1sft\|1sft]], [[2sfp\|2sfp]], [[1bdo\|1bdo]], [[1l6f\|1l6f]], [[1epv\|1epv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xfc RCSB], [http://www.ebi.ac.uk/pdbsum/1xfc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/1xfc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report the crystal structure of alanine racemase from Mycobacterium tuberculosis (Alr(Mtb)) at 1.9 A resolution. In our structure, Alr(Mtb) is found to be a dimer formed by two crystallographically different monomers, each comprising 384 residues. The domain makeup of each monomer is similar to that of Bacillus and Pseudomonas alanine racemases and includes both an alpha/beta-barrel at the N-terminus and a C-terminus primarily made of beta-strands. The hinge angle between these two domains is unique for Alr(Mtb), but the active site geometry is conserved. In Alr(Mtb), the PLP cofactor is covalently bound to the protein via an internal aldimine bond with Lys42. No guest substrate is noted in its active site, although some residual electron density is observed in the enzyme's active site pocket. Analysis of the active site pocket, in the context of other known alanine racemases, allows us to propose the inclusion of conserved residues found at the entrance to the binding pocket as additional targets in ongoing structure-aided drug design efforts. Also, as observed in other alanine racemase structures, PLP adopts a conformation that significantly distorts the planarity of the extended conjugated system between the PLP ring and the internal aldimine bond.

-	~~{{STRUCTURE_1xfc\| PDB=1xfc \| SCENE= }}~~	+	The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site.,LeMagueres P, Im H, Ebalunode J, Strych U, Benedik MJ, Briggs JM, Kohn H, Krause KL Biochemistry. 2005 Feb 8;44(5):1471-81. PMID:15683232<ref>PMID:15683232</ref>

-	~~===The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains~~ a ~~conserved entryway into~~ the ~~active site===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15683232}}~~	+	==See Also==
-		+	*[[Alanine racemase\|Alanine racemase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1xfc~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015683232<~~/~~ref~~><~~ref group="xtra">PMID:014674749</ref><references group="xtra"~~/>	+
	[[Category: Alanine racemase]]		[[Category: Alanine racemase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 12:19, 23 January 2013

2013-01-23T12:19:21Z

←Older revision		Revision as of 12:19, 23 January 2013
Line 1:		Line 1:
	[[Image:1xfc.png\|left\|200px]]		[[Image:1xfc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xfc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xfc\| PDB=1xfc \| SCENE= }}		{{STRUCTURE_1xfc\| PDB=1xfc \| SCENE= }}

	===The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site===		===The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15683232}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15683232 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15683232}}		{{ABSTRACT_PUBMED_15683232}}

Line 22:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15683232~~</ref><ref group="xtra">PMID:~~14674749~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015683232</ref><ref group="xtra">PMID:014674749</ref><references group="xtra"/>
	[[Category: Alanine racemase]]		[[Category: Alanine racemase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA: Protected "1xfc" [edit=sysop:move=sysop]

2011-03-15T00:06:30Z

Protected "1xfc" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:06, 15 March 2011

OCA at 00:06, 15 March 2011

2011-03-15T00:06:29Z

←Older revision		Revision as of 00:06, 15 March 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xfc.png\|left\|200px]]		[[Image:1xfc.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~1XFC~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA].	+	[[1xfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFC OCA].

	==Reference==		==Reference==
Line 37:		Line 36:
	[[Category: Beta-structure for c-terminal domain]]		[[Category: Beta-structure for c-terminal domain]]
	[[Category: Internal aldimine form]]		[[Category: Internal aldimine form]]
-		+	[[Category: Isomerase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 03:54:41 2009''~~	+