1xsz - Revision history

OCA at 08:53, 14 February 2024

2024-02-14T08:53:06Z

←Older revision		Revision as of 08:53, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1xsz' size='340' side='right'caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>		<StructureSection load='1xsz' size='340' side='right'caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_33152 Atcc 33152~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [https://pdbe.org/1xsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [https://www.ebi.ac.uk/pdbsum/1xsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.41Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [https://pdbe.org/1xsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [https://www.ebi.ac.uk/pdbsum/1xsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8RT31_LEGPN Q8RT31_LEGPN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xsz ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xsz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Legionella pneumophila protein RalF is secreted into host cytosol via the Dot/Icm type IV transporter where it acts to recruit ADP-ribosylation factor (Arf) to pathogen-containing phagosomes in the establishment of a replicative organelle. The presence in RalF of the Sec7 domain, present in all Arf guanine nucleotide exchange factors, has suggested that recruitment of Arf is an early step in pathogenesis. We have determined the crystal structure of RalF and of the isolated Sec7 domain and found that RalF is made up of two domains. The Sec7 domain is homologous to mammalian Sec7 domains. The C-terminal domain forms a cap over the active site in the Sec7 domain and contains a conserved folding motif, previously observed in adaptor subunits of vesicle coat complexes. The importance of the capping domain and of the glutamate in the "glutamic finger," conserved in all Sec7 domains, to RalF functions was examined using three different assays. These data highlight the functional importance of domains other than Sec7 in Arf guanine nucleotide exchange factors to biological activities and suggest novel mechanisms of regulation of those activities.
-
-	The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site.,Amor JC, Swails J, Zhu X, Roy CR, Nagai H, Ingmundson A, Cheng X, Kahn RA J Biol Chem. 2005 Jan 14;280(2):1392-400. Epub 2004 Nov 1. PMID:15520000<ref>PMID:15520000</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1xsz" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 33152]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amor~~, J C~~]]	+	[[Category: Legionella pneumophila]]
-	[[Category: Cheng, X]]	+	[[Category: Amor JC]]
-	[[Category: Ingmundson, A]]	+	[[Category: Cheng X]]
-	[[Category: Kahn~~, R A~~]]	+	[[Category: Ingmundson A]]
-	[[Category: Nagai, H]]	+	[[Category: Kahn RA]]
-	[[Category: Roy~~, C R~~]]	+	[[Category: Nagai H]]
-	[[Category: Swails, J]]	+	[[Category: Roy CR]]
-	~~[[Category: Arf guanine nucleotide exchange factor]]~~	+	[[Category: Swails J]]
-	~~[[Category: Signaling protein~~]]	+

OCA at 16:19, 3 November 2021

2021-11-03T16:19:01Z

←Older revision		Revision as of 16:19, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1xsz' size='340' side='right'caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>		<StructureSection load='1xsz' size='340' side='right'caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [~~http~~://pdbe.org/1xsz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xsz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsz ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [https://pdbe.org/1xsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [https://www.ebi.ac.uk/pdbsum/1xsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:04, 22 January 2020

2020-01-22T18:04:16Z

←Older revision		Revision as of 18:04, 22 January 2020
Line 1:		Line 1:

	==The structure of RalF==		==The structure of RalF==
-	<StructureSection load='1xsz' size='340' side='right' caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>	+	<StructureSection load='1xsz' size='340' side='right'caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 33152]]		[[Category: Atcc 33152]]
		+	[[Category: Large Structures]]
	[[Category: Amor, J C]]		[[Category: Amor, J C]]
	[[Category: Cheng, X]]		[[Category: Cheng, X]]

OCA at 07:39, 18 April 2018

2018-04-18T07:39:09Z

←Older revision		Revision as of 07:39, 18 April 2018
Line 1:		Line 1:
		+
	==The structure of RalF==		==The structure of RalF==
	<StructureSection load='1xsz' size='340' side='right' caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>		<StructureSection load='1xsz' size='340' side='right' caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [http://pdbe.org/1xsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [http://www.ebi.ac.uk/pdbsum/1xsz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [http://pdbe.org/1xsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [http://www.ebi.ac.uk/pdbsum/1xsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xsz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xsz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:45, 7 February 2016

2016-02-07T03:45:11Z

←Older revision		Revision as of 03:45, 7 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xsz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:28, 9 September 2015

2015-09-09T21:28:33Z

←Older revision		Revision as of 21:28, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1xsz' size='340' side='right' caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>		<StructureSection load='1xsz' size='340' side='right' caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Legionella_pneumophila Legionella pneumophila~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [http://www.ebi.ac.uk/pdbsum/1xsz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [http://pdbe.org/1xsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [http://www.ebi.ac.uk/pdbsum/1xsz PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xsz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Legionella pneumophila~~]]	+	[[Category: Atcc 33152]]
	[[Category: Amor, J C]]		[[Category: Amor, J C]]
	[[Category: Cheng, X]]		[[Category: Cheng, X]]

OCA at 09:50, 8 January 2015

2015-01-08T09:50:18Z

←Older revision		Revision as of 09:50, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [http://www.ebi.ac.uk/pdbsum/1xsz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [http://www.ebi.ac.uk/pdbsum/1xsz PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Legionella pneumophila]]		[[Category: Legionella pneumophila]]
-	[[Category: Amor, J C.]]	+	[[Category: Amor, J C]]
-	[[Category: Cheng, X.]]	+	[[Category: Cheng, X]]
-	[[Category: Ingmundson, A.]]	+	[[Category: Ingmundson, A]]
-	[[Category: Kahn, R A.]]	+	[[Category: Kahn, R A]]
-	[[Category: Nagai, H.]]	+	[[Category: Nagai, H]]
-	[[Category: Roy, C R.]]	+	[[Category: Roy, C R]]
-	[[Category: Swails, J.]]	+	[[Category: Swails, J]]
	[[Category: Arf guanine nucleotide exchange factor]]		[[Category: Arf guanine nucleotide exchange factor]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 18:48, 29 September 2014

2014-09-29T18:48:26Z

←Older revision		Revision as of 18:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1xsz.~~png\|left~~\|200px]]	+	==The structure of RalF==
		+	<StructureSection load='1xsz' size='340' side='right' caption='[[1xsz]], [[Resolution\|resolution]] 1.41Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xsz RCSB], [http://www.ebi.ac.uk/pdbsum/1xsz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xsz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Legionella pneumophila protein RalF is secreted into host cytosol via the Dot/Icm type IV transporter where it acts to recruit ADP-ribosylation factor (Arf) to pathogen-containing phagosomes in the establishment of a replicative organelle. The presence in RalF of the Sec7 domain, present in all Arf guanine nucleotide exchange factors, has suggested that recruitment of Arf is an early step in pathogenesis. We have determined the crystal structure of RalF and of the isolated Sec7 domain and found that RalF is made up of two domains. The Sec7 domain is homologous to mammalian Sec7 domains. The C-terminal domain forms a cap over the active site in the Sec7 domain and contains a conserved folding motif, previously observed in adaptor subunits of vesicle coat complexes. The importance of the capping domain and of the glutamate in the "glutamic finger," conserved in all Sec7 domains, to RalF functions was examined using three different assays. These data highlight the functional importance of domains other than Sec7 in Arf guanine nucleotide exchange factors to biological activities and suggest novel mechanisms of regulation of those activities.

-	~~{{STRUCTURE_1xsz\| PDB=1xsz \| SCENE= }}~~	+	The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site.,Amor JC, Swails J, Zhu X, Roy CR, Nagai H, Ingmundson A, Cheng X, Kahn RA J Biol Chem. 2005 Jan 14;280(2):1392-400. Epub 2004 Nov 1. PMID:15520000<ref>PMID:15520000</ref>

-	~~===The structure~~ of ~~RalF===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15520000}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1xsz]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Legionella_pneumophila Legionella pneumophila]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015520000<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Legionella pneumophila]]		[[Category: Legionella pneumophila]]
	[[Category: Amor, J C.]]		[[Category: Amor, J C.]]

OCA: Protected "1xsz" [edit=sysop:move=sysop]

2013-01-05T11:34:01Z

Protected "1xsz" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:34, 5 January 2013

OCA at 11:33, 5 January 2013

2013-01-05T11:33:58Z

←Older revision		Revision as of 11:33, 5 January 2013
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-	{{Seed}}
	[[Image:1xsz.png\|left\|200px]]		[[Image:1xsz.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1xsz\| PDB=1xsz \| SCENE= }}		{{STRUCTURE_1xsz\| PDB=1xsz \| SCENE= }}

	===The structure of RalF===		===The structure of RalF===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15520000}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_15520000}}		{{ABSTRACT_PUBMED_15520000}}

	==About this Structure==		==About this Structure==
-	~~1XSZ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA].	+	[[1xsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15520000~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015520000</ref><references group="xtra"/>
	[[Category: Legionella pneumophila]]		[[Category: Legionella pneumophila]]
	[[Category: Amor, J C.]]		[[Category: Amor, J C.]]
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	[[Category: Swails, J.]]		[[Category: Swails, J.]]
	[[Category: Arf guanine nucleotide exchange factor]]		[[Category: Arf guanine nucleotide exchange factor]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 10:58:04 2009''~~	+