1xt7 - Revision history

OCA at 07:12, 9 August 2023

2023-08-09T07:12:11Z

←Older revision		Revision as of 07:12, 9 August 2023
Line 1:		Line 1:

	==Daptomycin NMR Structure==		==Daptomycin NMR Structure==
-	<StructureSection load='1xt7' size='340' side='right'caption='[[1xt7~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1xt7' size='340' side='right'caption='[[1xt7]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xt7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XT7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xt7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_filamentosus Streptomyces filamentosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XT7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene>, <scene name='pdbligand=PRD_000217:Daptomycin'>PRD_000217</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[1t5n\|1t5n]], [[1t5m\|1t5m]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt7 OCA], [https://pdbe.org/1xt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xt7 RCSB], [https://www.ebi.ac.uk/pdbsum/1xt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xt7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt7 OCA], [https://pdbe.org/1xt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xt7 RCSB], [https://www.ebi.ac.uk/pdbsum/1xt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xt7 ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ball, L J]]	+	[[Category: Streptomyces filamentosus]]
-	[[Category: Donarski~~, J A~~]]	+	[[Category: Ball L-J]]
-	[[Category: Goult~~, C M~~]]	+	[[Category: Donarski JA]]
-	[[Category: Micklefield, J]]	+	[[Category: Goult CM]]
-	[[Category: Ramesh, V]]	+	[[Category: Micklefield J]]
-	~~[[Category: Antibiotic]]~~	+	[[Category: Ramesh V]]
-	~~[[Category: Calcium-dependent]]~~	+
-	~~[[Category: Cubicin]]~~	+
-	~~[[Category: Daptomycin]]~~	+
-	~~[[Category: Lipopeptide~~]]	+

OCA at 16:19, 3 November 2021

2021-11-03T16:19:10Z

←Older revision		Revision as of 16:19, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1xt7' size='340' side='right'caption='[[1xt7]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1xt7' size='340' side='right'caption='[[1xt7]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xt7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XT7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xt7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XT7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5n\|1t5n]], [[1t5m\|1t5m]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t5n\|1t5n]], [[1t5m\|1t5m]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt7 OCA], [~~http~~://pdbe.org/1xt7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xt7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xt7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xt7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt7 OCA], [https://pdbe.org/1xt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xt7 RCSB], [https://www.ebi.ac.uk/pdbsum/1xt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xt7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:26, 29 January 2020

2020-01-29T17:26:40Z

←Older revision		Revision as of 17:26, 29 January 2020
Line 1:		Line 1:

	==Daptomycin NMR Structure==		==Daptomycin NMR Structure==
-	<StructureSection load='1xt7' size='340' side='right' caption='[[1xt7]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1xt7' size='340' side='right'caption='[[1xt7]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xt7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XT7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xt7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XT7 FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ball, L J]]		[[Category: Ball, L J]]
	[[Category: Donarski, J A]]		[[Category: Donarski, J A]]

OCA at 07:38, 18 April 2018

2018-04-18T07:38:24Z

←Older revision		Revision as of 07:38, 18 April 2018
Line 1:		Line 1:
		+
	==Daptomycin NMR Structure==		==Daptomycin NMR Structure==
	<StructureSection load='1xt7' size='340' side='right' caption='[[1xt7]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1xt7' size='340' side='right' caption='[[1xt7]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5n\|1t5n]], [[1t5m\|1t5m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5n\|1t5n]], [[1t5m\|1t5m]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt7 OCA], [http://pdbe.org/1xt7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xt7 RCSB], [http://www.ebi.ac.uk/pdbsum/1xt7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt7 OCA], [http://pdbe.org/1xt7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xt7 RCSB], [http://www.ebi.ac.uk/pdbsum/1xt7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xt7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:19, 10 September 2015

2015-09-10T00:19:45Z

←Older revision		Revision as of 00:19, 10 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5n\|1t5n]], [[1t5m\|1t5m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5n\|1t5n]], [[1t5m\|1t5m]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xt7 RCSB], [http://www.ebi.ac.uk/pdbsum/1xt7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt7 OCA], [http://pdbe.org/1xt7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xt7 RCSB], [http://www.ebi.ac.uk/pdbsum/1xt7 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xt7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:50, 22 December 2014

2014-12-22T06:50:40Z

←Older revision		Revision as of 06:50, 22 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1xt7~~\| ~~PDB~~=1xt7 \| ~~SCENE~~= }}	+	==Daptomycin NMR Structure==
-	===~~Daptomycin NMR Structure~~===	+	<StructureSection load='1xt7' size='340' side='right' caption='[[1xt7]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_15227539}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xt7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XT7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5n\|1t5n]], [[1t5m\|1t5m]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xt7 RCSB], [http://www.ebi.ac.uk/pdbsum/1xt7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Daptomycin is an acidic lipopeptide antibiotic, whose three-dimensional structure and mechanism of action is currently unknown. Recently daptomycin, trade name Cubicin, was approved as a drug for the treatment of skin-related infections (M. Larkin Lancet, 2003, 3, 677) and became the first antibiotic of its class to be used in the clinic (A. Raja et al., Nature Rev. Drug Discov., 2003, 2, 943-944). We have carried out a systematic high field NMR study of daptomycin and its binding to calcium ions which is essential for antibiotic activity. In this first report, we demonstrate the sequence-specific resonance assignment of daptomycin under resolved NMR measurement conditions. In addition to this, we have determined the 3D structure of apo-daptomycin and demonstrated a 1 : 1 stoichiometry on the binding to calcium ions. We have also demonstrated that the binding of calcium ions does not result in major conformational changes, but does induce aggregation. This may be an important factor in the mode of action of daptomycin.

-	~~==About this Structure==~~	+	NMR structure determination and calcium binding effects of lipopeptide antibiotic daptomycin.,Ball LJ, Goult CM, Donarski JA, Micklefield J, Ramesh V Org Biomol Chem. 2004 Jul 7;2(13):1872-8. Epub 2004 Jun 15. PMID:15227539<ref>PMID:15227539</ref>
-	~~[[1xt7]] is a 1 chain~~ structure. ~~Full experimental information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1XT7 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:015227539</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Ball, L J.]]	+	== References ==
-	[[Category: Donarski, J A.]]	+	<references/>
-	[[Category: Goult, C M.]]	+	__TOC__
-	[[Category: Micklefield, J.]]	+	</StructureSection>
-	[[Category: Ramesh, V.]]	+	[[Category: Ball, L J]]
		+	[[Category: Donarski, J A]]
		+	[[Category: Goult, C M]]
		+	[[Category: Micklefield, J]]
		+	[[Category: Ramesh, V]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Calcium-dependent]]		[[Category: Calcium-dependent]]

OCA at 08:49, 23 April 2014

2014-04-23T08:49:08Z

←Older revision		Revision as of 08:49, 23 April 2014
Line 1:		Line 1:
-	[[Image:1xt7.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xt7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xt7\| PDB=1xt7 \| SCENE= }}		{{STRUCTURE_1xt7\| PDB=1xt7 \| SCENE= }}
-
	===Daptomycin NMR Structure===		===Daptomycin NMR Structure===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15227539}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15227539 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15227539}}		{{ABSTRACT_PUBMED_15227539}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:015227539</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015227539</ref><references group="xtra"/><references/>
	[[Category: Ball, L J.]]		[[Category: Ball, L J.]]
	[[Category: Donarski, J A.]]		[[Category: Donarski, J A.]]

OCA: Protected "1xt7" [edit=sysop:move=sysop]

2011-07-27T05:23:25Z

Protected "1xt7" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:23, 27 July 2011

OCA at 05:23, 27 July 2011

2011-07-27T05:23:24Z

←Older revision		Revision as of 05:23, 27 July 2011
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-	{{Seed}}
	[[Image:1xt7.png\|left\|200px]]		[[Image:1xt7.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA].	+	[[1xt7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA].

	==Reference==		==Reference==
-	NMR structure determination and calcium binding effects of lipopeptide antibiotic daptomycin., Ball LJ, Goult CM, Donarski JA, Micklefield J, Ramesh V, Org Biomol Chem. 2004 Jul 7;2(13):1872-8. Epub 2004 Jun 15. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~15227539 15227539]~~	+	<ref group="xtra">PMID:015227539</ref><references group="xtra"/>
	[[Category: Ball, L J.]]		[[Category: Ball, L J.]]
	[[Category: Donarski, J A.]]		[[Category: Donarski, J A.]]
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	[[Category: Ramesh, V.]]		[[Category: Ramesh, V.]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
		+	[[Category: Calcium-dependent]]
		+	[[Category: Cubicin]]
		+	[[Category: Daptomycin]]
	[[Category: Lipopeptide]]		[[Category: Lipopeptide]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:21:12 2008''

OCA at 12:21, 27 July 2008

2008-07-27T12:21:16Z

←Older revision		Revision as of 12:21, 27 July 2008
Line 1:		Line 1:
-	[[Image:1xt7.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1xt7.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1xt7\| PDB=1xt7 \| SCENE= }}		{{STRUCTURE_1xt7\| PDB=1xt7 \| SCENE= }}

-	~~'''~~Daptomycin NMR Structure~~'''~~	+	===Daptomycin NMR Structure===


-	~~==Overview==~~	+	<!--
-	~~Daptomycin is an acidic lipopeptide antibiotic, whose three~~-~~dimensional structure and mechanism of action is currently unknown. Recently daptomycin, trade name Cubicin, was approved as a drug for the treatment of skin~~-~~related infections (M. Larkin Lancet~~, ~~2003~~, ~~3, 677) and became~~ the ~~first antibiotic of its class~~ to ~~be used in~~ the ~~clinic~~ (A. ~~Raja et al~~., ~~Nature Rev. Drug Discov., 2003, 2, 943-944). We have carried out a systematic high field NMR study of daptomycin and its binding to calcium ions which~~ is ~~essential for antibiotic activity. In this first report, we demonstrate~~ the ~~sequence-specific resonance assignment of daptomycin under resolved NMR measurement conditions~~. ~~In addition to this, we have determined the 3D structure of apo~~-daptomycin and demonstrated a 1 : 1 stoichiometry on the binding to calcium ions. We have also demonstrated that the binding of calcium ions does not result in major conformational changes, but does induce aggregation. This may be an important factor in the mode of action of daptomycin.	+	The line below this paragraph, {{ABSTRACT_PUBMED_15227539}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15227539 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15227539}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT7 OCA].

	==Reference==		==Reference==
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	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Lipopeptide]]		[[Category: Lipopeptide]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3~~ 15:28:48 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:21:12 2008''