1xum - Revision history

OCA at 16:19, 3 November 2021

2021-11-03T16:19:58Z

←Older revision		Revision as of 16:19, 3 November 2021
Line 4:		Line 4:
	<StructureSection load='1xum' size='340' side='right'caption='[[1xum]]' scene=''>		<StructureSection load='1xum' size='340' side='right'caption='[[1xum]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XUM FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XUM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xum FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1xum PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xum ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xum FirstGlance], [https://www.ebi.ac.uk/pdbsum/1xum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xum ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:14, 29 January 2020

2020-01-29T17:14:39Z

←Older revision		Revision as of 17:14, 29 January 2020
Line 2:		Line 2:

	==THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR==		==THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR==
-	<StructureSection load='1xum' size='340' side='right' caption='[[1xum]]' scene=''>	+	<StructureSection load='1xum' size='340' side='right'caption='[[1xum]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUM FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUM FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Buckler, D R]]		[[Category: Buckler, D R]]
	[[Category: Cheng, S]]		[[Category: Cheng, S]]

OCA at 07:28, 18 April 2018

2018-04-18T07:28:59Z

←Older revision		Revision as of 07:28, 18 April 2018
Line 5:		Line 5:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUM FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xum FirstGlance], [http://www.ebi.ac.uk/pdbsum/1xum PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xum FirstGlance], [http://www.ebi.ac.uk/pdbsum/1xum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xum ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:08, 11 February 2016

2016-02-11T10:08:24Z

←Older revision		Revision as of 10:08, 11 February 2016
Line 1:		Line 1:
		+	{{Theoretical_model}}
		+
	==THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR==		==THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR==
	<StructureSection load='1xum' size='340' side='right' caption='[[1xum]]' scene=''>		<StructureSection load='1xum' size='340' side='right' caption='[[1xum]]' scene=''>
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Buckler, D R]]		[[Category: Buckler, D R]]
	[[Category: Cheng, S]]		[[Category: Cheng, S]]

OCA at 01:06, 10 September 2015

2015-09-10T01:06:50Z

←Older revision		Revision as of 01:06, 10 September 2015
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xum" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:37, 18 December 2014

2014-12-18T12:37:22Z

←Older revision		Revision as of 12:37, 18 December 2014
Line 1:		Line 1:
-	~~{{Theoretical_model}}~~	+	==THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR==
		+	<StructureSection load='1xum' size='340' side='right' caption='[[1xum]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUM FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xum FirstGlance], [http://www.ebi.ac.uk/pdbsum/1xum PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Glycoprotein hormones influence the development and function of the ovary, testis and thyroid by binding to specific high-affinity receptors. The extracellular domains of these receptors are members of the leucine-rich repeat (LRR) protein superfamily and are responsible for the high-affinity binding. The crystal structure of a glycoprotein hormone, namely human choriogonadotropin (hCG), is known, but neither the receptor structure, mode of hormone binding, nor mechanism for activation, have been established. RESULTS: Despite very low sequence similarity between exon-demarcated LRRs in the receptors and the LRRs of porcine ribonuclease inhibitor (RI), the secondary structures for the two repeat sets are found to be alike Constraints on curvature and beta-barrel geometry from the sequence pattern for repeated beta alpha units suggest that the receptors contain three-dimensional structures similar to that of RI. With the RI crystal structure as a template, models were constructed for exons 2-8 of the receptors. The model for this portion of the choriogonadotropin receptor is complementary in shape and electrostatic characteristics to the surface of hCG at an identified focus of hormone-receptor interaction. CONCLUSIONS: The predicted models for the structures and mode of hormone binding of the glycoprotein hormone receptors are to a large extent consistent with currently available biochemical and mutational data. Repeated sequences in beta-barrel proteins are shown to have general implications for constraints on structure. Averaging techniques used here to recognize the structural motif in these receptors should also apply to other proteins with repeated sequences.

-	~~{{STRUCTURE_1xum\| PDB=1xum \| SCENE= }}~~	+	Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.,Jiang X, Dreano M, Buckler DR, Cheng S, Ythier A, Wu H, Hendrickson WA, el Tayar N Structure. 1995 Dec 15;3(12):1341-53. PMID:8747461<ref>PMID:8747461</ref>
-	~~===THEORETICAL MODEL OF THE LIGAND~~-~~BINDING REGION OF~~ A ~~GLYCOPROTEIN HORMONE RECEPTOR===~~	+
-	~~{{ABSTRACT_PUBMED_8747461}}~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:008747461</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Buckler, D R]]		[[Category: Buckler, D R]]
	[[Category: Cheng, S]]		[[Category: Cheng, S]]

OCA at 18:58, 24 March 2013

2013-03-24T18:58:30Z

←Older revision		Revision as of 18:58, 24 March 2013
Line 1:		Line 1:
	{{Theoretical_model}}		{{Theoretical_model}}
-
-	[[Image:1xum.png\|left\|200px]]

	{{STRUCTURE_1xum\| PDB=1xum \| SCENE= }}		{{STRUCTURE_1xum\| PDB=1xum \| SCENE= }}
-
	===THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR===		===THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR===
-
	{{ABSTRACT_PUBMED_8747461}}		{{ABSTRACT_PUBMED_8747461}}

	==Reference==		==Reference==
-	<ref group="xtra">PMID:008747461</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008747461</ref><references group="xtra"/><references/>
	[[Category: Buckler, D R]]		[[Category: Buckler, D R]]
	[[Category: Cheng, S]]		[[Category: Cheng, S]]

OCA: Protected "1xum" [edit=sysop:move=sysop]

2012-10-21T09:12:30Z

Protected "1xum" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:12, 21 October 2012

OCA at 09:12, 21 October 2012

2012-10-21T09:12:27Z

←Older revision		Revision as of 09:12, 21 October 2012
Line 1:		Line 1:
	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1xum.png\|left\|200px]]		[[Image:1xum.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xum", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xum\| PDB=1xum \| SCENE= }}		{{STRUCTURE_1xum\| PDB=1xum \| SCENE= }}

	===THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR===		===THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8747461}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8747461 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8747461}}		{{ABSTRACT_PUBMED_8747461}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUM OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8747461~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008747461</ref><references group="xtra"/>
	[[Category: Buckler, D R]]		[[Category: Buckler, D R]]
	[[Category: Cheng, S]]		[[Category: Cheng, S]]
Line 33:		Line 19:
	[[Category: Wu, H]]		[[Category: Wu, H]]
	[[Category: Ythier, A]]		[[Category: Ythier, A]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:53:03 2010''

OCA at 04:53, 8 April 2010

2010-04-08T04:53:03Z

←Older revision		Revision as of 04:53, 8 April 2010
Line 1:		Line 1:
-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1xum.png\|left\|200px]]

-	The ~~entry 1XUM~~ is ~~a Theoretical Model titled 'THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1xum", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1xum\| PDB=1xum \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===THEORETICAL MODEL OF THE LIGAND-BINDING REGION OF A GLYCOPROTEIN HORMONE RECEPTOR===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:54:~~44 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_8747461}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8747461 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8747461}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:8747461</ref><references group="xtra"/>
		+	[[Category: Buckler, D R]]
		+	[[Category: Cheng, S]]
		+	[[Category: Dreano, M]]
		+	[[Category: El Tayar, N]]
		+	[[Category: Hendrickson, W A]]
		+	[[Category: Jiang, X]]
		+	[[Category: Wu, H]]
		+	[[Category: Ythier, A]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:53:03 2010''