1xv3 - Revision history

OCA at 09:30, 6 December 2023

2023-12-06T09:30:03Z

←Older revision		Revision as of 09:30, 6 December 2023
Line 1:		Line 1:

	==NMR structure of the synthetic penaeidin 4==		==NMR structure of the synthetic penaeidin 4==
-	<StructureSection load='1xv3' size='340' side='right'caption='[[1xv3~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1xv3' size='340' side='right'caption='[[1xv3]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Penaeus_setiferus Penaeus setiferus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [https://pdbe.org/1xv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv3 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [https://pdbe.org/1xv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~PEN4D_LITSE PEN4D_LITSE]~~] Antibacterial and antifungal activity. Presents chitin-binding activity (By similarity).	+	[https://www.uniprot.org/uniprot/PEN4D_PENST PEN4D_PENST] Antibacterial and antifungal activity. Presents chitin-binding activity (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aumelas, A]]	+	[[Category: Penaeus setiferus]]
-	[[Category: Bachere, E]]	+	[[Category: Aumelas A]]
-	[[Category: Bullesbach~~, E E~~]]	+	[[Category: Bachere E]]
-	[[Category: Cuthbertson~~, B J~~]]	+	[[Category: Bullesbach EE]]
-	[[Category: Gross~~, P S~~]]	+	[[Category: Cuthbertson BJ]]
-	[[Category: Yang, Y]]	+	[[Category: Gross PS]]
-	~~[[Category: Antibiotic]]~~	+	[[Category: Yang Y]]
-	~~[[Category: Antifungal peptide]]~~	+
-	~~[[Category: Antimicrobial peptide]]~~	+
-	~~[[Category: Cysteine-rich]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Oxidative folding]]~~	+
-	~~[[Category: Penaeidin]]~~	+
-	~~[[Category: Proline-rich]]~~	+
-	~~[[Category: Shrimp~~]]	+

OCA at 16:20, 3 November 2021

2021-11-03T16:20:12Z

←Older revision		Revision as of 16:20, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1xv3' size='340' side='right'caption='[[1xv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1xv3' size='340' side='right'caption='[[1xv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [~~http~~://pdbe.org/1xv3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xv3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv3 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [https://pdbe.org/1xv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PEN4D_LITSE PEN4D_LITSE]] Antibacterial and antifungal activity. Presents chitin-binding activity (By similarity).	+	[[https://www.uniprot.org/uniprot/PEN4D_LITSE PEN4D_LITSE]] Antibacterial and antifungal activity. Presents chitin-binding activity (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:41, 29 January 2020

2020-01-29T16:41:47Z

←Older revision		Revision as of 16:41, 29 January 2020
Line 1:		Line 1:

	==NMR structure of the synthetic penaeidin 4==		==NMR structure of the synthetic penaeidin 4==
-	<StructureSection load='1xv3' size='340' side='right' caption='[[1xv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1xv3' size='340' side='right'caption='[[1xv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Aumelas, A]]		[[Category: Aumelas, A]]
	[[Category: Bachere, E]]		[[Category: Bachere, E]]

OCA at 07:01, 18 April 2018

2018-04-18T07:01:54Z

←Older revision		Revision as of 07:01, 18 April 2018
Line 1:		Line 1:
		+
	==NMR structure of the synthetic penaeidin 4==		==NMR structure of the synthetic penaeidin 4==
	<StructureSection load='1xv3' size='340' side='right' caption='[[1xv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1xv3' size='340' side='right' caption='[[1xv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [http://pdbe.org/1xv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv3 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [http://pdbe.org/1xv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 02:05, 12 September 2015

2015-09-12T02:05:23Z

←Older revision		Revision as of 02:05, 12 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv3 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [http://pdbe.org/1xv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xv3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:26, 25 December 2014

2014-12-25T22:26:47Z

←Older revision		Revision as of 22:26, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv3 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PEN4D_LITSE PEN4D_LITSE]] Antibacterial and antifungal activity. Presents chitin-binding activity (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aumelas, A.]]	+	[[Category: Aumelas, A]]
-	[[Category: Bachere, E.]]	+	[[Category: Bachere, E]]
-	[[Category: Bullesbach, E E.]]	+	[[Category: Bullesbach, E E]]
-	[[Category: Cuthbertson, B J.]]	+	[[Category: Cuthbertson, B J]]
-	[[Category: Gross, P S.]]	+	[[Category: Gross, P S]]
-	[[Category: Yang, Y.]]	+	[[Category: Yang, Y]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Antifungal peptide]]		[[Category: Antifungal peptide]]

OCA at 08:20, 8 October 2014

2014-10-08T08:20:49Z

←Older revision		Revision as of 08:20, 8 October 2014
Line 1:		Line 1:
-	[[~~Image~~:1xv3.~~png\|left\|200px~~]]	+	==NMR structure of the synthetic penaeidin 4==
		+	<StructureSection load='1xv3' size='340' side='right' caption='[[1xv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV3 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xv3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antimicrobial peptide structure has direct implications for the complexity of functions and mechanisms of action. The penaeidin antimicrobial peptide family from shrimp is divided into multiple class designations based on primary structure. The penaeidin classes are not only characterized by variability in primary sequence but also by variation in target specificity and effectiveness. Whereas class 4 exhibits low isoform diversity within species and is highly conserved between species, the primary sequence of penaeidin class 3 is less conserved between species and exhibits considerable isoform diversity within species. All penaeidins, regardless of class or species, are composed of two dramatically different domains: an unconstrained proline-rich domain and a disulfide bond-stabilized cysteine-rich domain. The proline-rich domain varies in length and is generally less conserved, whereas the spacing and specific residue content of the cysteine-rich domain is more conserved. The structure of the synthetic penaeidin class 4 (PEN4-1) from Litopenaeus setiferus was analyzed using several approaches, including chemical mapping of disulfide bonds, circular dichroism analysis of secondary structural characteristics, and complete characterization of the solution structure of the peptide by proton NMR. L. setiferus PEN4-1 was then compared with the previously characterized structure of penaeidin class 3 from Litopenaeus vannamei. Moreover, the specificity of these antimicrobial peptides was examined through direct comparison of activity against a panel of microbes. The penaeidin classes differ in microbial target specificity, which correlates to variability in specific domain sequence. However, the tertiary structure of the cysteine-rich domain and indeed the overall structure of penaeidins are conserved across classes.

-	~~{{STRUCTURE_1xv3\| PDB=1xv3 \| SCENE= }}~~	+	Solution structure of synthetic penaeidin-4 with structural and functional comparisons with penaeidin-3.,Cuthbertson BJ, Yang Y, Bachere E, Bullesbach EE, Gross PS, Aumelas A J Biol Chem. 2005 Apr 22;280(16):16009-18. Epub 2005 Feb 7. PMID:15699044<ref>PMID:15699044</ref>

-	~~===NMR structure~~ of the ~~synthetic penaeidin 4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15699044}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1xv3]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA].~~	+	</StructureSection>
	[[Category: Aumelas, A.]]		[[Category: Aumelas, A.]]
	[[Category: Bachere, E.]]		[[Category: Bachere, E.]]

OCA: Protected "1xv3" [edit=sysop:move=sysop]

2013-01-05T13:13:41Z

Protected "1xv3" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:13, 5 January 2013

OCA at 13:13, 5 January 2013

2013-01-05T13:13:38Z

←Older revision		Revision as of 13:13, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xv3.png\|left\|200px]]		[[Image:1xv3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xv3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xv3\| PDB=1xv3 \| SCENE= }}		{{STRUCTURE_1xv3\| PDB=1xv3 \| SCENE= }}

	===NMR structure of the synthetic penaeidin 4===		===NMR structure of the synthetic penaeidin 4===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15699044}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15699044 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15699044}}		{{ABSTRACT_PUBMED_15699044}}

	==About this Structure==		==About this Structure==
-	~~1XV3 is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA].	+	[[1xv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA].
-		+
-	~~==Reference==~~	+
-	Solution structure of synthetic penaeidin-4 with structural and functional comparisons with penaeidin-3., Cuthbertson BJ, Yang Y, Bachere E, Bullesbach EE, Gross PS, Aumelas A, J Biol Chem. 2005 Apr 22;280(16):16009-18. Epub 2005 Feb 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15699044 15699044]	+
-	~~[[Category: Single protein]]~~	+
	[[Category: Aumelas, A.]]		[[Category: Aumelas, A.]]
	[[Category: Bachere, E.]]		[[Category: Bachere, E.]]
Line 31:		Line 15:
	[[Category: Gross, P S.]]		[[Category: Gross, P S.]]
	[[Category: Yang, Y.]]		[[Category: Yang, Y.]]
		+	[[Category: Antibiotic]]
	[[Category: Antifungal peptide]]		[[Category: Antifungal peptide]]
	[[Category: Antimicrobial peptide]]		[[Category: Antimicrobial peptide]]
	[[Category: Cysteine-rich]]		[[Category: Cysteine-rich]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
-	[[Category: Nmr]]
	[[Category: Oxidative folding]]		[[Category: Oxidative folding]]
	[[Category: Penaeidin]]		[[Category: Penaeidin]]
	[[Category: Proline-rich]]		[[Category: Proline-rich]]
	[[Category: Shrimp]]		[[Category: Shrimp]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:00:58 2008''

OCA at 13:00, 29 July 2008

2008-07-29T13:00:58Z

←Older revision		Revision as of 13:00, 29 July 2008
Line 1:		Line 1:
-	[[Image:1xv3.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1xv3.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1xv3\| PDB=1xv3 \| SCENE= }}		{{STRUCTURE_1xv3\| PDB=1xv3 \| SCENE= }}

-	~~'''~~NMR structure of the synthetic penaeidin 4~~'''~~	+	===NMR structure of the synthetic penaeidin 4===


-	~~==Overview==~~	+	<!--
-	~~Antimicrobial peptide structure has direct implications for the complexity of functions and mechanisms of action.~~ The penaeidin antimicrobial peptide family from shrimp is divided into multiple class designations based on primary structure. The penaeidin classes are not only characterized by variability in primary sequence but also by variation in target specificity and effectiveness. Whereas class 4 exhibits low isoform diversity within species and is highly conserved between species, ~~the primary sequence of penaeidin class 3 is less conserved between species and exhibits considerable isoform diversity within species. All penaeidins~~, regardless of class or species, are composed of two dramatically different domains: an unconstrained proline-rich domain and a disulfide bond-stabilized cysteine-rich domain. The proline-rich domain varies in length and is generally less conserved, whereas the ~~spacing and specific residue content of~~ the ~~cysteine-rich domain is more conserved. The structure of the synthetic penaeidin class 4~~ (PEN4-1) from Litopenaeus setiferus was analyzed using several approaches, including chemical mapping of disulfide bonds, circular dichroism analysis of secondary structural characteristics, and complete characterization of the solution structure of the peptide by proton NMR. L. ~~setiferus PEN4-1 was then compared with the previously characterized structure of penaeidin class 3 from Litopenaeus vannamei. Moreover~~, the ~~specificity of these antimicrobial peptides was examined through direct comparison of activity against a panel of microbes~~. ~~The penaeidin classes differ in microbial target specificity, which correlates to variability in specific domain sequence. However, the tertiary structure of the cysteine~~-~~rich domain and indeed the overall structure of penaeidins are conserved across classes.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_15699044}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15699044 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15699044}}

	==About this Structure==		==About this Structure==
-	1XV3 is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA].	+	1XV3 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV3 OCA].

	==Reference==		==Reference==
Line 36:		Line 40:
	[[Category: Proline-rich]]		[[Category: Proline-rich]]
	[[Category: Shrimp]]		[[Category: Shrimp]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 15~~:32:37 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:00:58 2008''