1y00 - Revision history

OCA at 07:59, 15 May 2024

2024-05-15T07:59:23Z

←Older revision		Revision as of 07:59, 15 May 2024
Line 1:		Line 1:

	==Solution structure of the Carbon Storage Regulator protein CsrA==		==Solution structure of the Carbon Storage Regulator protein CsrA==
-	<StructureSection load='1y00' size='340' side='right'caption='[[1y00~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1y00' size='340' side='right'caption='[[1y00]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>csrA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [https://pdbe.org/1y00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [https://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y00 ProSAT], [https://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [https://pdbe.org/1y00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [https://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y00 ProSAT], [https://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CSRA_ECOLI CSRA_ECOLI]] Binds to mRNA to regulate post-transcriptional activity. Affects glycogen biosynthesis, gluconeogenesis, cell size and surface properties. Regulates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially through selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA. Binds to and reduces levels of probable diguanylate cyclases ycdT and ydeH.<ref>PMID:11298291</ref> <ref>PMID:18713317</ref> <ref>PMID:19460094</ref>	+	[https://www.uniprot.org/uniprot/CSRA_ECOLI CSRA_ECOLI] Binds to mRNA to regulate post-transcriptional activity. Affects glycogen biosynthesis, gluconeogenesis, cell size and surface properties. Regulates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially through selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA. Binds to and reduces levels of probable diguanylate cyclases ycdT and ydeH.<ref>PMID:11298291</ref> <ref>PMID:18713317</ref> <ref>PMID:19460094</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Gehring K]]
-	[[Category: Gehring, K]]	+	[[Category: Gutierrez P]]
-	[[Category: Gutierrez, P]]	+	[[Category: Li Y]]
-	[[Category: Li, Y]]	+	[[Category: Liu Q]]
-	[[Category: Liu, Q]]	+	[[Category: Osborne MJ]]
-	[[Category: Osborne~~, M J]]~~	+
-	~~[[Category: Bsgi]]~~	+
-	~~[[Category: Carbon storage regulation]]~~	+
-	~~[[Category: Rna binding protein~~]]	+

OCA at 07:10, 2 March 2022

2022-03-02T07:10:46Z

←Older revision		Revision as of 07:10, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1y00' size='340' side='right'caption='[[1y00]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y00' size='340' side='right'caption='[[1y00]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [~~http~~://pdbe.org/1y00 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y00 ProSAT], [~~http~~://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [https://pdbe.org/1y00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [https://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y00 ProSAT], [https://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CSRA_ECOLI CSRA_ECOLI]] Binds to mRNA to regulate post-transcriptional activity. Affects glycogen biosynthesis, gluconeogenesis, cell size and surface properties. Regulates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially through selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA. Binds to and reduces levels of probable diguanylate cyclases ycdT and ydeH.<ref>PMID:11298291</ref> <ref>PMID:18713317</ref> <ref>PMID:19460094</ref>	+	[[https://www.uniprot.org/uniprot/CSRA_ECOLI CSRA_ECOLI]] Binds to mRNA to regulate post-transcriptional activity. Affects glycogen biosynthesis, gluconeogenesis, cell size and surface properties. Regulates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially through selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA. Binds to and reduces levels of probable diguanylate cyclases ycdT and ydeH.<ref>PMID:11298291</ref> <ref>PMID:18713317</ref> <ref>PMID:19460094</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:27, 6 January 2021

2021-01-06T10:27:36Z

←Older revision		Revision as of 10:27, 6 January 2021
Line 1:		Line 1:

	==Solution structure of the Carbon Storage Regulator protein CsrA==		==Solution structure of the Carbon Storage Regulator protein CsrA==
-	<StructureSection load='1y00' size='340' side='right' caption='[[1y00]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1y00' size='340' side='right'caption='[[1y00]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [http://pdbe.org/1y00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [http://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y00 ProSAT], [http://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [http://pdbe.org/1y00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [http://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y00 ProSAT], [http://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Gehring, K]]		[[Category: Gehring, K]]

OCA at 06:57, 18 April 2018

2018-04-18T06:57:46Z

←Older revision		Revision as of 06:57, 18 April 2018
Line 1:		Line 1:
		+
	==Solution structure of the Carbon Storage Regulator protein CsrA==		==Solution structure of the Carbon Storage Regulator protein CsrA==
	<StructureSection load='1y00' size='340' side='right' caption='[[1y00]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y00' size='340' side='right' caption='[[1y00]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [http://pdbe.org/1y00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [http://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [http://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [http://pdbe.org/1y00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [http://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y00 ProSAT], [http://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y00_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y00_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:06, 7 February 2016

2016-02-07T20:06:32Z

←Older revision		Revision as of 20:06, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y00 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:35, 10 September 2015

2015-09-10T04:35:51Z

←Older revision		Revision as of 04:35, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1y00' size='340' side='right' caption='[[1y00]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y00' size='340' side='right' caption='[[1y00]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [http://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [http://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [http://pdbe.org/1y00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [http://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [http://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y00" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Gehring, K]]		[[Category: Gehring, K]]

OCA at 17:56, 24 December 2014

2014-12-24T17:56:10Z

←Older revision		Revision as of 17:56, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [http://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [http://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [http://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [http://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSRA_ECOLI CSRA_ECOLI]] Binds to mRNA to regulate post-transcriptional activity. Affects glycogen biosynthesis, gluconeogenesis, cell size and surface properties. Regulates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially through selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA. Binds to and reduces levels of probable diguanylate cyclases ycdT and ydeH.<ref>PMID:11298291</ref> <ref>PMID:18713317</ref> <ref>PMID:19460094</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: ~~BSGI, Montreal-Kingston Bacterial~~ Structural ~~Genomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Gehring, K.]]	+	[[Category: Gehring, K]]
-	[[Category: Gutierrez, P.]]	+	[[Category: Gutierrez, P]]
-	[[Category: Li, Y.]]	+	[[Category: Li, Y]]
-	[[Category: Liu, Q.]]	+	[[Category: Liu, Q]]
-	[[Category: Osborne, M J.]]	+	[[Category: Osborne, M J]]
	[[Category: Bsgi]]		[[Category: Bsgi]]
	[[Category: Carbon storage regulation]]		[[Category: Carbon storage regulation]]
-	[[Category: Montreal-kingston bacterial structural genomics initiative]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
-	[[Category: Structural genomic]]

OCA at 18:51, 29 September 2014

2014-09-29T18:51:24Z

←Older revision		Revision as of 18:51, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1y00.~~png\|left~~\|200px]]	+	==Solution structure of the Carbon Storage Regulator protein CsrA==
		+	<StructureSection load='1y00' size='340' side='right' caption='[[1y00]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">csrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [http://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [http://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y00_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The carbon storage regulator A (CsrA) is a protein responsible for the repression of a variety of stationary-phase genes in bacteria. In this work, we describe the nuclear magnetic resonance (NMR)-based structure of the CsrA dimer and its RNA-binding properties. CsrA is a dimer of two identical subunits, each composed of five strands, a small alpha-helix and a flexible C terminus. NMR titration experiments suggest that the beta1-beta2 and beta3-beta4 loops and the C-terminal helix are important elements in RNA binding. Even though the beta3-beta4 loop contains a highly conserved RNA-binding motif, GxxG, typical of KH domains, our structure excludes CsrA from being a member of this protein family, as previously suggested. A mechanism for the recognition of mRNAs downregulated by CsrA is proposed.

-	~~{{STRUCTURE_1y00\| PDB=1y00 \| SCENE= }}~~	+	Solution structure of the carbon storage regulator protein CsrA from Escherichia coli.,Gutierrez P, Li Y, Osborne MJ, Pomerantseva E, Liu Q, Gehring K J Bacteriol. 2005 May;187(10):3496-501. PMID:15866937<ref>PMID:15866937</ref>

-	~~===Solution structure~~ of the ~~Carbon Storage Regulator protein CsrA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15866937}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y00]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015866937<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]		[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]

OCA: Protected "1y00" [edit=sysop:move=sysop]

2013-01-05T11:38:37Z

Protected "1y00" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:38, 5 January 2013

OCA at 11:38, 5 January 2013

2013-01-05T11:38:34Z

←Older revision		Revision as of 11:38, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1y00.png\|left\|200px]]		[[Image:1y00.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1y00", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1y00\| PDB=1y00 \| SCENE= }}		{{STRUCTURE_1y00\| PDB=1y00 \| SCENE= }}

	===Solution structure of the Carbon Storage Regulator protein CsrA===		===Solution structure of the Carbon Storage Regulator protein CsrA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15866937}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15866937 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15866937}}		{{ABSTRACT_PUBMED_15866937}}

	==About this Structure==		==About this Structure==
-	~~1Y00~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA].	+	[[1y00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15866937~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015866937</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]		[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
Line 34:		Line 22:
	[[Category: Carbon storage regulation]]		[[Category: Carbon storage regulation]]
	[[Category: Montreal-kingston bacterial structural genomics initiative]]		[[Category: Montreal-kingston bacterial structural genomics initiative]]
		+	[[Category: Rna binding protein]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:12:15 2009''