1y21 - Revision history

OCA at 06:51, 23 August 2023

2023-08-23T06:51:41Z

←Older revision		Revision as of 06:51, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1y21' size='340' side='right'caption='[[1y21]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1y21' size='340' side='right'caption='[[1y21]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y21]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Acanthia_lectularia Acanthia lectularia~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y21]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cimex_lectularius Cimex lectularius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y21 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ntf\|1ntf]], [[1si6\|1si6]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [https://pdbe.org/1y21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [https://www.ebi.ac.uk/pdbsum/1y21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y21 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [https://pdbe.org/1y21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [https://www.ebi.ac.uk/pdbsum/1y21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y21 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NP_CIMLE NP_CIMLE] Heme-based protein that delivers nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation (Probable). In place of heme, the heme-binding cysteine can also reversibly bind NO when it is present in high concentrations (PubMed:15637157).<ref>PMID:15637157</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acanthia lectularia~~]]	+	[[Category: Cimex lectularius]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Andersen~~, J F~~]]	+	[[Category: Andersen JF]]
-	[[Category: Maes~~, E M~~]]	+	[[Category: Maes EM]]
-	[[Category: Montfort~~, W R~~]]	+	[[Category: Montfort WR]]
-	[[Category: Shokhireva~~, T K~~]]	+	[[Category: Shokhireva TK]]
-	[[Category: Valenzuela~~, J G~~]]	+	[[Category: Valenzuela JG]]
-	[[Category: Walker~~, F A~~]]	+	[[Category: Walker FA]]
-	[[Category: Weichsel, A]]	+	[[Category: Weichsel A]]
-	~~[[Category: Beta-sandwich]]~~	+
-	~~[[Category: Ferrous no complex]]~~	+
-	~~[[Category: Heme protein]]~~	+
-	~~[[Category: Ligand binding protein]]~~	+
-	~~[[Category: No carrier]]~~	+
-	~~[[Category: S-nitrosocysteine~~]]	+

OCA at 16:22, 3 November 2021

2021-11-03T16:22:48Z

←Older revision		Revision as of 16:22, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1y21' size='340' side='right'caption='[[1y21]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1y21' size='340' side='right'caption='[[1y21]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y21]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Acanthia_lectularia Acanthia lectularia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y21]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthia_lectularia Acanthia lectularia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y21 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ntf\|1ntf]], [[1si6\|1si6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ntf\|1ntf]], [[1si6\|1si6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [~~http~~://pdbe.org/1y21 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y21 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y21 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [https://pdbe.org/1y21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [https://www.ebi.ac.uk/pdbsum/1y21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y21 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 16:57, 29 January 2020

2020-01-29T16:57:37Z

←Older revision		Revision as of 16:57, 29 January 2020
Line 1:		Line 1:

	==Crystal Structure of Cimex Nitrophorin NO Complex==		==Crystal Structure of Cimex Nitrophorin NO Complex==
-	<StructureSection load='1y21' size='340' side='right' caption='[[1y21]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='1y21' size='340' side='right'caption='[[1y21]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y21]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthia_lectularia Acanthia lectularia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y21 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y21]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthia_lectularia Acanthia lectularia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y21 FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Acanthia lectularia]]		[[Category: Acanthia lectularia]]
		+	[[Category: Large Structures]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]
	[[Category: Maes, E M]]		[[Category: Maes, E M]]

OCA at 07:14, 18 April 2018

2018-04-18T07:14:31Z

←Older revision		Revision as of 07:14, 18 April 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Cimex Nitrophorin NO Complex==		==Crystal Structure of Cimex Nitrophorin NO Complex==
	<StructureSection load='1y21' size='340' side='right' caption='[[1y21]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='1y21' size='340' side='right' caption='[[1y21]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ntf\|1ntf]], [[1si6\|1si6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ntf\|1ntf]], [[1si6\|1si6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [http://pdbe.org/1y21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [http://www.ebi.ac.uk/pdbsum/1y21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [http://pdbe.org/1y21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [http://www.ebi.ac.uk/pdbsum/1y21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y21 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y21_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y21_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1y21" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1y21" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitrophorin\|Nitrophorin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:12, 9 February 2016

2016-02-09T22:12:46Z

←Older revision		Revision as of 22:12, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y21 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:32, 11 September 2015

2015-09-11T02:32:09Z

←Older revision		Revision as of 02:32, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ntf\|1ntf]], [[1si6\|1si6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ntf\|1ntf]], [[1si6\|1si6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [http://www.ebi.ac.uk/pdbsum/1y21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [http://pdbe.org/1y21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [http://www.ebi.ac.uk/pdbsum/1y21 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y21" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:16, 8 January 2015

2015-01-08T10:16:04Z

←Older revision		Revision as of 10:16, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y21]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthia_lectularia Acanthia lectularia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y21 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y21]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthia_lectularia Acanthia lectularia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y21 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ntf\|1ntf]], [[1si6\|1si6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ntf\|1ntf]], [[1si6\|1si6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [http://www.ebi.ac.uk/pdbsum/1y21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [http://www.ebi.ac.uk/pdbsum/1y21 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Acanthia lectularia]]		[[Category: Acanthia lectularia]]
-	[[Category: Andersen, J F.]]	+	[[Category: Andersen, J F]]
-	[[Category: Maes, E M.]]	+	[[Category: Maes, E M]]
-	[[Category: Montfort, W R.]]	+	[[Category: Montfort, W R]]
-	[[Category: Shokhireva, T K.]]	+	[[Category: Shokhireva, T K]]
-	[[Category: Valenzuela, J G.]]	+	[[Category: Valenzuela, J G]]
-	[[Category: Walker, F A.]]	+	[[Category: Walker, F A]]
-	[[Category: Weichsel, A.]]	+	[[Category: Weichsel, A]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
	[[Category: Ferrous no complex]]		[[Category: Ferrous no complex]]

OCA at 10:47, 3 October 2014

2014-10-03T10:47:25Z

←Older revision		Revision as of 10:47, 3 October 2014
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-	~~{{STRUCTURE_1y21~~\| ~~PDB~~=1y21 \| ~~SCENE~~= }}	+	==Crystal Structure of Cimex Nitrophorin NO Complex==
-	===~~Crystal Structure~~ of ~~Cimex Nitrophorin NO Complex~~===	+	<StructureSection load='1y21' size='340' side='right' caption='[[1y21]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15637157}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y21]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthia_lectularia Acanthia lectularia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y21 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ntf\|1ntf]], [[1si6\|1si6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y21 RCSB], [http://www.ebi.ac.uk/pdbsum/1y21 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y21_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Certain bloodsucking insects deliver nitric oxide (NO) while feeding, to induce vasodilation and inhibit blood coagulation. We have expressed, characterized, and determined the crystal structure of the Cimex lectularius (bedbug) nitrophorin, the protein responsible for NO storage and delivery, to understand how the insect successfully handles this reactive molecule. Surprisingly, NO binds not only to the ferric nitrophorin heme, but it can also be stored as an S-nitroso (SNO) conjugate of the proximal heme cysteine (Cys-60) when present at higher concentrations. EPR- and UV-visible spectroscopies, and a crystallographic structure determination to 1.75-A resolution, reveal SNO formation to proceed with reduction of the heme iron, yielding an Fe-NO complex. Stopped-flow kinetic measurements indicate that an ordered reaction mechanism takes place: initial NO binding occurs at the ferric heme and is followed by heme reduction, Cys-60 release from the heme iron, and SNO formation. Release of NO occurs through a reversal of these steps. These data provide, to our knowledge, the first view of reversible metal-assisted SNO formation in a protein and suggest a mechanism for its role in NO release from ferrous heme. This mechanism and Cimex nitrophorin structure are completely unlike those of the nitrophorins from Rhodnius prolixus, where NO protection is provided by a large conformational change that buries the heme nitrosyl complex, highlighting the remarkable evolution of proteins that assist insects in bloodfeeding.

-	~~==About this Structure==~~	+	Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein.,Weichsel A, Maes EM, Andersen JF, Valenzuela JG, Shokhireva TKh, Walker FA, Montfort WR Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):594-9. Epub 2005 Jan 6. PMID:15637157<ref>PMID:15637157</ref>
-	~~[[1y21]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Acanthia_lectularia Acanthia lectularia]. This structure supersedes the now removed PDB entry [http~~:~~//oca~~.~~weizmann~~.~~ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:015637157</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Acanthia lectularia]]		[[Category: Acanthia lectularia]]
	[[Category: Andersen, J F.]]		[[Category: Andersen, J F.]]

OCA at 08:48, 23 April 2014

2014-04-23T08:48:22Z

←Older revision		Revision as of 08:48, 23 April 2014
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-	[[Image:1y21.png\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_1y21\| PDB=1y21 \| SCENE= }}		{{STRUCTURE_1y21\| PDB=1y21 \| SCENE= }}
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	===Crystal Structure of Cimex Nitrophorin NO Complex===		===Crystal Structure of Cimex Nitrophorin NO Complex===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15637157}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_15637157}}		{{ABSTRACT_PUBMED_15637157}}

	==About this Structure==		==About this Structure==
-	[[1y21]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cimex_lectularius Cimex lectularius~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA].	+	[[1y21]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthia_lectularia Acanthia lectularia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nzh 1nzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y21 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015637157</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015637157</ref><references group="xtra"/><references/>
-	[[Category: ~~Cimex lectularius~~]]	+	[[Category: Acanthia lectularia]]
	[[Category: Andersen, J F.]]		[[Category: Andersen, J F.]]
	[[Category: Maes, E M.]]		[[Category: Maes, E M.]]

OCA: Protected "1y21" [edit=sysop:move=sysop]

2012-02-29T08:00:14Z

Protected "1y21" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 29 February 2012