1y7j - Revision history

OCA at 08:01, 15 May 2024

2024-05-15T08:01:01Z

←Older revision		Revision as of 08:01, 15 May 2024
Line 1:		Line 1:

	==NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)==		==NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)==
-	<StructureSection load='1y7j' size='340' side='right'caption='[[1y7j~~]], [[NMR_Ensembles_of_Models \| 21 NMR models~~]]' scene=''>	+	<StructureSection load='1y7j' size='340' side='right'caption='[[1y7j]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [https://pdbe.org/1y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [https://www.ebi.ac.uk/pdbsum/1y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [https://pdbe.org/1y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [https://www.ebi.ac.uk/pdbsum/1y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ASIP_HUMAN ASIP_HUMAN]] Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.	+	[https://www.uniprot.org/uniprot/ASIP_HUMAN ASIP_HUMAN] Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barsh~~, G S~~]]	+	[[Category: Barsh GS]]
-	[[Category: Chai, B]]	+	[[Category: Chai B]]
-	[[Category: Dawson~~, P E~~]]	+	[[Category: Dawson PE]]
-	[[Category: Gantz, I]]	+	[[Category: Gantz I]]
-	[[Category: Jackson~~, P J~~]]	+	[[Category: Jackson PJ]]
-	[[Category: McNulty~~, J C~~]]	+	[[Category: McNulty JC]]
-	[[Category: Millhauser~~, G L~~]]	+	[[Category: Millhauser GL]]
-	[[Category: Thompson~~, D A]]~~	+	[[Category: Thompson DA]]
-	~~[[Category: Cystine knot]]~~	+
-	~~[[Category: Endogenous antagonist]]~~	+
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Inverse agonist]]~~	+
-	~~[[Category: Melanocortin]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 16:49, 20 October 2021

2021-10-20T16:49:24Z

←Older revision		Revision as of 16:49, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='1y7j' size='340' side='right'caption='[[1y7j]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>		<StructureSection load='1y7j' size='340' side='right'caption='[[1y7j]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [~~http~~://pdbe.org/1y7j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y7j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [https://pdbe.org/1y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [https://www.ebi.ac.uk/pdbsum/1y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ASIP_HUMAN ASIP_HUMAN]] Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.	+	[[https://www.uniprot.org/uniprot/ASIP_HUMAN ASIP_HUMAN]] Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:03, 29 January 2020

2020-01-29T17:03:16Z

←Older revision		Revision as of 17:03, 29 January 2020
Line 1:		Line 1:

	==NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)==		==NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)==
-	<StructureSection load='1y7j' size='340' side='right' caption='[[1y7j]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>	+	<StructureSection load='1y7j' size='340' side='right'caption='[[1y7j]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Barsh, G S]]		[[Category: Barsh, G S]]
	[[Category: Chai, B]]		[[Category: Chai, B]]

OCA at 06:47, 25 April 2018

2018-04-25T06:47:21Z

←Older revision		Revision as of 06:47, 25 April 2018
Line 1:		Line 1:
		+
	==NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)==		==NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)==
	<StructureSection load='1y7j' size='340' side='right' caption='[[1y7j]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>		<StructureSection load='1y7j' size='340' side='right' caption='[[1y7j]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [http://pdbe.org/1y7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [http://www.ebi.ac.uk/pdbsum/1y7j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [http://pdbe.org/1y7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [http://www.ebi.ac.uk/pdbsum/1y7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7j_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7j_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:39, 9 February 2016

2016-02-09T20:39:59Z

←Older revision		Revision as of 20:39, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y7j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:51, 11 September 2015

2015-09-11T01:51:22Z

←Older revision		Revision as of 01:51, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [http://www.ebi.ac.uk/pdbsum/1y7j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [http://pdbe.org/1y7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [http://www.ebi.ac.uk/pdbsum/1y7j PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y7j" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:24, 25 December 2014

2014-12-25T09:24:20Z

←Older revision		Revision as of 09:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [http://www.ebi.ac.uk/pdbsum/1y7j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [http://www.ebi.ac.uk/pdbsum/1y7j PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ASIP_HUMAN ASIP_HUMAN]] Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Barsh, G S.]]	+	[[Category: Barsh, G S]]
-	[[Category: Chai, B.]]	+	[[Category: Chai, B]]
-	[[Category: Dawson, P E.]]	+	[[Category: Dawson, P E]]
-	[[Category: Gantz, I.]]	+	[[Category: Gantz, I]]
-	[[Category: Jackson, P J.]]	+	[[Category: Jackson, P J]]
-	[[Category: McNulty, J C.]]	+	[[Category: McNulty, J C]]
-	[[Category: Millhauser, G L.]]	+	[[Category: Millhauser, G L]]
-	[[Category: Thompson, D A.]]	+	[[Category: Thompson, D A]]
	[[Category: Cystine knot]]		[[Category: Cystine knot]]
	[[Category: Endogenous antagonist]]		[[Category: Endogenous antagonist]]

OCA at 20:32, 29 September 2014

2014-09-29T20:32:38Z

←Older revision		Revision as of 20:32, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1y7j.~~png~~\|~~left~~\|200px]]	+	==NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)==
		+	<StructureSection load='1y7j' size='340' side='right' caption='[[1y7j]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y7k\|1y7k]], [[1hyk\|1hyk]], [[1mr0\|1mr0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [http://www.ebi.ac.uk/pdbsum/1y7j PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7j_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Expression of the agouti signaling protein (ASIP) during hair growth produces the red/yellow pigment pheomelanin. ASIP, and its neuropeptide homolog the agouti-related protein (AgRP) involved in energy balance, are novel, paracrine signaling molecules that act as inverse agonists at distinct subsets of melanocortin receptors. Ubiquitous ASIP expression in mice gives rise to a pleiotropic phenotype characterized by a uniform yellow coat color, obesity, overgrowth, and metabolic derangements similar to type II diabetes in humans. Here we report the synthesis and NMR structure of ASIP's active, cysteine-rich, C-terminal domain. ASIP adopts the inhibitor cystine knot fold and, along with AgRP, are the only known mammalian proteins in this structure class. Moreover, ASIP populates two distinct conformers resulting from a cis peptide bond at Pro102-Pro103 and a coexistence of cis/trans isomers of Ala104-Pro105. Pharmacologic studies of Pro-->Ala mutants demonstrate that the minor conformation with two cis peptide bonds is responsible for activity at all MCRs. The loop containing the heterogeneous Ala-Pro peptide bond is conserved in mammals, and suggests that ASIP is either trapped by evolution in this unusual configuration or possesses function outside of strict MCR antagonism.

-	~~{{STRUCTURE_1y7j\| PDB=1y7j \| SCENE= }}~~	+	Structures of the agouti signaling protein.,McNulty JC, Jackson PJ, Thompson DA, Chai B, Gantz I, Barsh GS, Dawson PE, Millhauser GL J Mol Biol. 2005 Mar 4;346(4):1059-70. Epub 2005 Jan 25. PMID:15701517<ref>PMID:15701517</ref>

-	~~===NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y~~, ~~S124Y)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15701517}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y7j]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1Y7J OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015701517<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Barsh, G S.]]		[[Category: Barsh, G S.]]
	[[Category: Chai, B.]]		[[Category: Chai, B.]]

OCA: Protected "1y7j" [edit=sysop:move=sysop]

2013-01-05T17:26:26Z

Protected "1y7j" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:26, 5 January 2013

OCA at 17:26, 5 January 2013

2013-01-05T17:26:23Z

←Older revision		Revision as of 17:26, 5 January 2013
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-	{{Seed}}
	[[Image:1y7j.png\|left\|200px]]		[[Image:1y7j.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1y7j", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1y7j\| PDB=1y7j \| SCENE= }}		{{STRUCTURE_1y7j\| PDB=1y7j \| SCENE= }}

	===NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)===		===NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15701517}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15701517 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15701517}}		{{ABSTRACT_PUBMED_15701517}}

	==About this Structure==		==About this Structure==
-	~~1Y7J~~ is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA].	+	[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15701517~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015701517</ref><references group="xtra"/>
	[[Category: Barsh, G S.]]		[[Category: Barsh, G S.]]
	[[Category: Chai, B.]]		[[Category: Chai, B.]]
Line 38:		Line 26:
	[[Category: Inverse agonist]]		[[Category: Inverse agonist]]
	[[Category: Melanocortin]]		[[Category: Melanocortin]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 12:35:57 2009''~~	+