1y7q - Revision history

OCA at 08:01, 15 May 2024

2024-05-15T08:01:07Z

←Older revision		Revision as of 08:01, 15 May 2024
Line 1:		Line 1:

	==Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain==		==Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain==
-	<StructureSection load='1y7q' size='340' side='right'caption='[[1y7q~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1y7q' size='340' side='right'caption='[[1y7q]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ZNF174, ZSCAN8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [https://pdbe.org/1y7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [https://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [https://pdbe.org/1y7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [https://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ZN174_HUMAN ZN174_HUMAN]] Transcriptional repressor.<ref>PMID:7673192</ref>	+	[https://www.uniprot.org/uniprot/ZN174_HUMAN ZN174_HUMAN] Transcriptional repressor.<ref>PMID:7673192</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Collins, T]]	+	[[Category: Collins T]]
-	[[Category: Ivanov, D]]	+	[[Category: Ivanov D]]
-	[[Category: Maki~~, J L~~]]	+	[[Category: Maki JL]]
-	[[Category: Stone~~, J R~~]]	+	[[Category: Stone JR]]
-	[[Category: Wagner, G]]	+	[[Category: Wagner G]]
-	~~[[Category: C2h2 zinc finger associated]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Retroviral capsid c-terminal domain]]~~	+
-	~~[[Category: Scan domain]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 16:49, 20 October 2021

2021-10-20T16:49:41Z

←Older revision		Revision as of 16:49, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='1y7q' size='340' side='right'caption='[[1y7q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y7q' size='340' side='right'caption='[[1y7q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [~~http~~://pdbe.org/1y7q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [https://pdbe.org/1y7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [https://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZN174_HUMAN ZN174_HUMAN]] Transcriptional repressor.<ref>PMID:7673192</ref>	+	[[https://www.uniprot.org/uniprot/ZN174_HUMAN ZN174_HUMAN]] Transcriptional repressor.<ref>PMID:7673192</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:41, 20 January 2021

2021-01-20T08:41:00Z

←Older revision		Revision as of 08:41, 20 January 2021
Line 1:		Line 1:

	==Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain==		==Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain==
-	<StructureSection load='1y7q' size='340' side='right' caption='[[1y7q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1y7q' size='340' side='right'caption='[[1y7q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://pdbe.org/1y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://pdbe.org/1y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Collins, T]]		[[Category: Collins, T]]
	[[Category: Ivanov, D]]		[[Category: Ivanov, D]]

OCA at 06:49, 25 April 2018

2018-04-25T06:49:49Z

←Older revision		Revision as of 06:49, 25 April 2018
Line 1:		Line 1:
		+
	==Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain==		==Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain==
	<StructureSection load='1y7q' size='340' side='right' caption='[[1y7q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y7q' size='340' side='right' caption='[[1y7q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://pdbe.org/1y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://pdbe.org/1y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:14, 9 February 2016

2016-02-09T17:14:29Z

←Older revision		Revision as of 17:14, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y7q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:24, 11 September 2015

2015-09-11T00:24:24Z

←Older revision		Revision as of 00:24, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1y7q' size='340' side='right' caption='[[1y7q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y7q' size='340' side='right' caption='[[1y7q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://pdbe.org/1y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y7q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Collins, T]]		[[Category: Collins, T]]
	[[Category: Ivanov, D]]		[[Category: Ivanov, D]]

OCA at 08:17, 25 December 2014

2014-12-25T08:17:53Z

←Older revision		Revision as of 08:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZN174_HUMAN ZN174_HUMAN]] Transcriptional repressor.<ref>PMID:7673192</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Collins, T.]]	+	[[Category: Collins, T]]
-	[[Category: Ivanov, D.]]	+	[[Category: Ivanov, D]]
-	[[Category: Maki, J L.]]	+	[[Category: Maki, J L]]
-	[[Category: Stone, J R.]]	+	[[Category: Stone, J R]]
-	[[Category: Wagner, G.]]	+	[[Category: Wagner, G]]
	[[Category: C2h2 zinc finger associated]]		[[Category: C2h2 zinc finger associated]]
	[[Category: Dimer]]		[[Category: Dimer]]

OCA at 19:36, 29 September 2014

2014-09-29T19:36:11Z

←Older revision		Revision as of 19:36, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1y7q.~~png\|left~~\|200px]]	+	==Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain==
		+	<StructureSection load='1y7q' size='340' side='right' caption='[[1y7q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Retroviral assembly is driven by multiple interactions mediated by the Gag polyprotein, the main structural component of the forming viral shell. Critical determinants of Gag oligomerization are contained within the C-terminal domain (CTD) of the capsid protein, which also harbors a conserved sequence motif, the major homology region (MHR), in the otherwise highly variable Gag. An unexpected clue about the MHR function in retroviral assembly emerges from the structure of the zinc finger-associated SCAN domain we describe here. The SCAN dimer adopts a fold almost identical to that of the retroviral capsid CTD but uses an entirely different dimerization interface caused by swapping the MHR-like element between the monomers. Mutations in retroviral capsid proteins and functional data suggest that a SCAN-like MHR-swapped CTD dimer forms during immature particle assembly. In the SCAN-like dimer, the MHR contributes the major part of the large intertwined dimer interface explaining its functional significance.

-	~~{{STRUCTURE_1y7q\| PDB=1y7q \| SCENE= }}~~	+	Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain.,Ivanov D, Stone JR, Maki JL, Collins T, Wagner G Mol Cell. 2005 Jan 7;17(1):137-43. PMID:15629724<ref>PMID:15629724</ref>

-	~~===Mammalian SCAN domain dimer is~~ a ~~domain-swapped homologue~~ of the ~~HIV capsid C-terminal domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15629724}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y7q]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015629724<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Collins, T.]]		[[Category: Collins, T.]]

OCA: Protected "1y7q" [edit=sysop:move=sysop]

2013-01-05T17:29:25Z

Protected "1y7q" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:29, 5 January 2013

OCA at 17:29, 5 January 2013

2013-01-05T17:29:23Z

←Older revision		Revision as of 17:29, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1y7q.png\|left\|200px]]		[[Image:1y7q.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1y7q", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1y7q\| PDB=1y7q \| SCENE= }}		{{STRUCTURE_1y7q\| PDB=1y7q \| SCENE= }}

	===Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain===		===Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15629724}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15629724 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15629724}}		{{ABSTRACT_PUBMED_15629724}}

	==About this Structure==		==About this Structure==
-	~~1Y7Q~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA].	+	[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15629724~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015629724</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Collins, T.]]		[[Category: Collins, T.]]
Line 34:		Line 22:
	[[Category: Retroviral capsid c-terminal domain]]		[[Category: Retroviral capsid c-terminal domain]]
	[[Category: Scan domain]]		[[Category: Scan domain]]
-		+	[[Category: Transcription]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 11:26:31 2009''~~	+