1yh3 - Revision history

OCA at 08:03, 15 May 2024

2024-05-15T08:03:20Z

←Older revision		Revision as of 08:03, 15 May 2024
Line 3:		Line 3:
	<StructureSection load='1yh3' size='340' side='right'caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='1yh3' size='340' side='right'caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CD38 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.91Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase~~]~~, with EC number [https://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [https://pdbe.org/1yh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [https://www.ebi.ac.uk/pdbsum/1yh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yh3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [https://pdbe.org/1yh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [https://www.ebi.ac.uk/pdbsum/1yh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yh3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.	+	[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Graeff, R]]	+	[[Category: Graeff R]]
-	[[Category: Hao, Q]]	+	[[Category: Hao Q]]
-	[[Category: Kriksunov~~, I A~~]]	+	[[Category: Kriksunov IA]]
-	[[Category: Lee~~, H C~~]]	+	[[Category: Lee HC]]
-	[[Category: Liu, Q]]	+	[[Category: Liu Q]]
-	[[Category: Munshi, C]]	+	[[Category: Munshi C]]
-	~~[[Category: Cell surface receptor]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane association]]~~	+
-	~~[[Category: Parallel beta sheet]]~~	+
-	~~[[Category: Two domain~~]]	+

OCA at 16:52, 20 October 2021

2021-10-20T16:52:24Z

←Older revision		Revision as of 16:52, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='1yh3' size='340' side='right'caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='1yh3' size='340' side='right'caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [~~http~~://pdbe.org/1yh3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yh3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yh3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [https://pdbe.org/1yh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [https://www.ebi.ac.uk/pdbsum/1yh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yh3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.	+	[[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:45, 20 January 2021

2021-01-20T08:45:33Z

←Older revision		Revision as of 08:45, 20 January 2021
Line 1:		Line 1:

	==Crystal structure of human CD38 extracellular domain==		==Crystal structure of human CD38 extracellular domain==
-	<StructureSection load='1yh3' size='340' side='right' caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>	+	<StructureSection load='1yh3' size='340' side='right'caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [http://pdbe.org/1yh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yh3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yh3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [http://pdbe.org/1yh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yh3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yh3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Graeff, R]]		[[Category: Graeff, R]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]

OCA at 06:34, 25 April 2018

2018-04-25T06:34:14Z

←Older revision		Revision as of 06:34, 25 April 2018
Line 1:		Line 1:
		+
	==Crystal structure of human CD38 extracellular domain==		==Crystal structure of human CD38 extracellular domain==
	<StructureSection load='1yh3' size='340' side='right' caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='1yh3' size='340' side='right' caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [http://pdbe.org/1yh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yh3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [http://pdbe.org/1yh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yh3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yh3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yh/1yh3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yh/1yh3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yh3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:09, 11 September 2015

2015-09-11T15:09:57Z

←Older revision		Revision as of 15:09, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1yh3' size='340' side='right' caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='1yh3' size='340' side='right' caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yh3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [http://pdbe.org/1yh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yh3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1yh3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Graeff, R]]		[[Category: Graeff, R]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]

OCA at 18:12, 25 December 2014

2014-12-25T18:12:02Z

←Older revision		Revision as of 18:12, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yh3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yh3 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Graeff, R.]]	+	[[Category: Graeff, R]]
-	[[Category: Hao, Q.]]	+	[[Category: Hao, Q]]
-	[[Category: Kriksunov, I A.]]	+	[[Category: Kriksunov, I A]]
-	[[Category: Lee, H C.]]	+	[[Category: Lee, H C]]
-	[[Category: Liu, Q.]]	+	[[Category: Liu, Q]]
-	[[Category: Munshi, C.]]	+	[[Category: Munshi, C]]
	[[Category: Cell surface receptor]]		[[Category: Cell surface receptor]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 23:18, 28 September 2014

2014-09-28T23:18:32Z

←Older revision		Revision as of 23:18, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1yh3.~~png\|left~~\|200px]]	+	==Crystal structure of human CD38 extracellular domain==
		+	<StructureSection load='1yh3' size='340' side='right' caption='[[1yh3]], [[Resolution\|resolution]] 1.91Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1yh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YH3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yh3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yh3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yh/1yh3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human CD38 is a multifunctional protein involved in diverse functions. As an enzyme, it is responsible for the synthesis of two Ca2+ messengers, cADPR and NAADP; as an antigen, it is involved in regulating cell adhesion, differentiation, and proliferation. Besides, CD38 is a marker of progression of HIV-1 infection and a negative prognostic marker of B-CLL. We have determined the crystal structure of the soluble extracellular domain of human CD38 to 1.9 A resolution. The enzyme's overall topology is similar to the related proteins CD157 and the Aplysia ADP-ribosyl cyclase, except with large structural changes at the two termini. The extended positively charged N terminus has lateral associations with the other CD38 molecule in the crystallographic asymmetric unit. The analysis of the CD38 substrate binding models revealed two key residues that may be critical in controlling CD38's multifunctionality of NAD hydrolysis, ADP-ribosyl cyclase, and cADPR hydrolysis activities.

-	~~{{STRUCTURE_1yh3\| PDB=1yh3 \| SCENE= }}~~	+	Crystal structure of human CD38 extracellular domain.,Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q Structure. 2005 Sep;13(9):1331-9. PMID:16154090<ref>PMID:16154090</ref>

-	~~===Crystal structure~~ of ~~human CD38 extracellular domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16154090}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1yh3]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA].~~	+

	==See Also==		==See Also==
-	*[[Cluster of Differentiation 38\|Cluster of Differentiation 38]]	+	*[[Cluster of Differentiation CD38\|Cluster of Differentiation CD38]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016154090<~~/~~ref~~><~~ref group="xtra">PMID:019117080</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Graeff, R.]]		[[Category: Graeff, R.]]

OCA at 19:49, 20 October 2012

2012-10-20T19:49:54Z

←Older revision		Revision as of 19:49, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1yh3]] is a 2 chain structure ~~of [[Cluster of Differentiation 38]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA].	+	[[1yh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA].

	==See Also==		==See Also==

OCA at 08:37, 27 July 2012

2012-07-27T08:37:37Z

←Older revision		Revision as of 08:37, 27 July 2012
Line 1:		Line 1:
	[[Image:1yh3.png\|left\|200px]]		[[Image:1yh3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1yh3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1yh3\| PDB=1yh3 \| SCENE= }}		{{STRUCTURE_1yh3\| PDB=1yh3 \| SCENE= }}

	===Crystal structure of human CD38 extracellular domain===		===Crystal structure of human CD38 extracellular domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16154090}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16154090 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16154090}}		{{ABSTRACT_PUBMED_16154090}}

OCA at 15:26, 5 June 2012

2012-06-05T15:26:55Z

←Older revision		Revision as of 15:26, 5 June 2012
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[1yh3]] is a 2 chain structure of ~~[[ADP-ribosyl cyclase 1]] and~~ [[Cluster of Differentiation 38]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA].	+	[[1yh3]] is a 2 chain structure of [[Cluster of Differentiation 38]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YH3 OCA].

	==See Also==		==See Also==
-	*[[~~ADP-ribosyl cyclase 1]]~~	+	*[[Cluster of Differentiation 38\|Cluster of Differentiation 38]]
-	*[[Cluster of Differentiation 38]]	+

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16154090~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016154090</ref><ref group="xtra">PMID:019117080</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Graeff, R.]]		[[Category: Graeff, R.]]