1zim - Revision history

OCA at 07:15, 9 August 2023

2023-08-09T07:15:46Z

←Older revision		Revision as of 07:15, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1zim' size='340' side='right'caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1zim' size='340' side='right'caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [https://pdbe.org/1zim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [https://www.ebi.ac.uk/pdbsum/1zim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zim ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [https://pdbe.org/1zim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [https://www.ebi.ac.uk/pdbsum/1zim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zim ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:

	==See Also==		==See Also==
		+	*[[Gcn4 3D Structures\|Gcn4 3D Structures]]
	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]		*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Alber, T~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Junior, L Gonzalez~~]]	+	[[Category: Alber T]]
-	[[Category: ~~Woolfson, D N~~]]	+	[[Category: Gonzalez Junior L]]
-	[[Category: ~~Activator]]~~	+	[[Category: Woolfson DN]]
-	~~[[Category: Amino-acid biosynthesis]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Leucine zipper]]~~	+
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 15:36, 3 November 2021

2021-11-03T15:36:35Z

←Older revision		Revision as of 15:36, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1zim' size='340' side='right'caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1zim' size='340' side='right'caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [~~http~~://pdbe.org/1zim PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zim PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zim ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [https://pdbe.org/1zim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [https://www.ebi.ac.uk/pdbsum/1zim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zim ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:01, 5 February 2020

2020-02-05T10:01:06Z

←Older revision		Revision as of 10:01, 5 February 2020
Line 1:		Line 1:

	==GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE==		==GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE==
-	<StructureSection load='1zim' size='340' side='right' caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1zim' size='340' side='right'caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 1zim" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zim" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Alber, T]]		[[Category: Alber, T]]
	[[Category: Junior, L Gonzalez]]		[[Category: Junior, L Gonzalez]]

OCA at 09:26, 2 May 2018

2018-05-02T09:26:29Z

←Older revision		Revision as of 09:26, 2 May 2018
Line 1:		Line 1:
		+
	==GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE==		==GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE==
	<StructureSection load='1zim' size='340' side='right' caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1zim' size='340' side='right' caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [http://pdbe.org/1zim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [http://www.ebi.ac.uk/pdbsum/1zim PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [http://pdbe.org/1zim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [http://www.ebi.ac.uk/pdbsum/1zim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zim ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 1zim" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zim" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Gcn4\|Gcn4]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 28:
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
		+	[[Category: Coiled coil]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Leucine zipper]]		[[Category: Leucine zipper]]
	[[Category: Nuclear protein]]		[[Category: Nuclear protein]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA at 13:06, 10 September 2015

2015-09-10T13:06:06Z

←Older revision		Revision as of 13:06, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1zim' size='340' side='right' caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1zim' size='340' side='right' caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [http://www.ebi.ac.uk/pdbsum/1zim PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [http://pdbe.org/1zim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [http://www.ebi.ac.uk/pdbsum/1zim PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zim" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Alber, T]]		[[Category: Alber, T]]
	[[Category: Junior, L Gonzalez]]		[[Category: Junior, L Gonzalez]]

OCA at 00:26, 25 December 2014

2014-12-25T00:26:06Z

←Older revision		Revision as of 00:26, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [http://www.ebi.ac.uk/pdbsum/1zim PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [http://www.ebi.ac.uk/pdbsum/1zim PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Alber, T.]]	+	[[Category: Alber, T]]
-	[[Category: Junior, L Gonzalez.]]	+	[[Category: Junior, L Gonzalez]]
-	[[Category: Woolfson, D N.]]	+	[[Category: Woolfson, D N]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]

OCA at 08:33, 8 October 2014

2014-10-08T08:33:12Z

←Older revision		Revision as of 08:33, 8 October 2014
Line 1:		Line 1:
-	[[~~Image:~~1zim.~~png~~\|~~left\|200px~~]]	+	==GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE==
		+	<StructureSection load='1zim' size='340' side='right' caption='[[1zim]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zim]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIM FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zim RCSB], [http://www.ebi.ac.uk/pdbsum/1zim PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A conserved asparagine (Asn 16) buried in the interface of the GCN4 leucine zipper selectively favours the parallel, dimeric, coiled-coil structure. To test if other polar residues confer oligomerization specificity, the structural effects of Gln and Lys substitutions for Asn 16 were characterized. Like the wild-type peptide, the Asn 16Lys mutant formed exclusively dimers. In contrast, Gln 16, despite its chemical similarity to Asn, allowed the peptide to form both dimers and trimers. The Gln 16 side chain was accommodated by qualitatively different interactions in the dimer and trimer crystal structures. These findings demonstrate that the structural selectivity of polar residues results not only from the burial of polar atoms, but also depends on the complementarity of the side-chain stereochemistry with the surrounding structural environment.

-	~~{{STRUCTURE_1zim\| PDB=1zim \| SCENE= }}~~	+	Buried polar residues and structural specificity in the GCN4 leucine zipper.,Gonzalez L Jr, Woolfson DN, Alber T Nat Struct Biol. 1996 Dec;3(12):1011-8. PMID:8946854<ref>PMID:8946854</ref>

-	~~===GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_8946854}}~~	+	==See Also==
-		+	*[[Gcn4\|Gcn4]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1zim~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:008946854<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Alber, T.]]		[[Category: Alber, T.]]

OCA: Protected "1zim" [edit=sysop:move=sysop]

2013-01-05T17:52:09Z

Protected "1zim" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:52, 5 January 2013

OCA at 17:52, 5 January 2013

2013-01-05T17:52:07Z

←Older revision		Revision as of 17:52, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1zim.png\|left\|200px]]		[[Image:1zim.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zim", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zim\| PDB=1zim \| SCENE= }}		{{STRUCTURE_1zim\| PDB=1zim \| SCENE= }}

	===GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE===		===GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8946854}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8946854 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8946854}}		{{ABSTRACT_PUBMED_8946854}}

	==About this Structure==		==About this Structure==
-	~~1ZIM is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA].	+	[[1zim]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIM OCA].

	==Reference==		==Reference==
-	~~Buried polar residues and structural specificity in the GCN4 leucine zipper., Gonzalez L Jr, Woolfson DN, Alber T, Nat Struct Biol. 1996 Dec;3(12):1011-8.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~8946854 8946854]~~	+	<ref group="xtra">PMID:008946854</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Single protein]]
	[[Category: Alber, T.]]		[[Category: Alber, T.]]
	[[Category: Junior, L Gonzalez.]]		[[Category: Junior, L Gonzalez.]]
Line 31:		Line 18:
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
-	[[Category: Coiled coil]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Leucine zipper]]		[[Category: Leucine zipper]]
	[[Category: Nuclear protein]]		[[Category: Nuclear protein]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:34:22 2008''

OCA at 01:34, 28 July 2008

2008-07-28T01:34:23Z

←Older revision		Revision as of 01:34, 28 July 2008
Line 1:		Line 1:
-	[[Image:1zim.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1zim.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1zim\| PDB=1zim \| SCENE= }}		{{STRUCTURE_1zim\| PDB=1zim \| SCENE= }}

-	~~'''~~GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE~~'''~~	+	===GCN4-LEUCINE ZIPPER CORE MUTANT ASN16GLN IN THE TRIMERIC STATE===


-	~~==Overview==~~	+	<!--
-	~~A conserved asparagine (Asn 16) buried in the interface of the GCN4 leucine zipper selectively favours the parallel, dimeric, coiled~~-~~coil structure. To test if other polar residues confer oligomerization specificity, the structural effects of Gln and Lys substitutions for Asn 16 were characterized. Like the wild~~-~~type peptide~~, ~~the Asn 16Lys mutant formed exclusively dimers. In contrast~~, ~~Gln 16, despite its chemical similarity to Asn, allowed~~ the ~~peptide~~ to ~~form both dimers and trimers. The Gln 16 side chain was accommodated by qualitatively different interactions in~~ the ~~dimer and trimer crystal structures~~. ~~These findings demonstrate that the structural selectivity of polar residues results not only from the burial of polar atoms~~, ~~but also depends on~~ the ~~complementarity of the side~~-~~chain stereochemistry with the surrounding structural environment.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_8946854}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8946854 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8946854}}

	==About this Structure==		==About this Structure==
Line 32:		Line 36:
	[[Category: Nuclear protein]]		[[Category: Nuclear protein]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 17~~:40:19 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:34:22 2008''