1zt5 - Revision history

OCA at 08:12, 15 May 2024

2024-05-15T08:12:49Z

←Older revision		Revision as of 08:12, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DIO:1,4~~-~~DIETHYLENE+DIOXIDE'>DIO</scene>~~, ~~<scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.818Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[1zt3\|1zt3]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [https://pdbe.org/1zt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1zt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zt5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [https://pdbe.org/1zt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1zt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zt5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IBP1_HUMAN IBP1_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.<ref>PMID:15972819</ref>	+	[https://www.uniprot.org/uniprot/IBP1_HUMAN IBP1_HUMAN] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.<ref>PMID:15972819</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Campagnoli, M]]	+	[[Category: Campagnoli M]]
-	[[Category: Capaldi, S]]	+	[[Category: Capaldi S]]
-	[[Category: Carrizo~~, M E~~]]	+	[[Category: Carrizo ME]]
-	[[Category: Faggion, B]]	+	[[Category: Faggion B]]
-	[[Category: Galliano, M]]	+	[[Category: Galliano M]]
-	[[Category: Labo, S]]	+	[[Category: Labo S]]
-	[[Category: Minchiotti, L]]	+	[[Category: Minchiotti L]]
-	[[Category: Monaco~~, H L~~]]	+	[[Category: Monaco HL]]
-	[[Category: Perduca, M]]	+	[[Category: Perduca M]]
-	[[Category: Romano, A]]	+	[[Category: Romano A]]
-	[[Category: Sala, A]]	+	[[Category: Sala A]]
-	[[Category: Valli, M]]	+	[[Category: Valli M]]
-	[[Category: Visai, L]]	+	[[Category: Visai L]]
-	~~[[Category: Amniotic fluid]]~~	+
-	~~[[Category: C-terminal domain]]~~	+
-	~~[[Category: Igfbp-1]]~~	+
-	~~[[Category: Insulin-like growth factor binding protein-1]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Peptide binding protein~~]]	+

OCA at 08:24, 10 November 2021

2021-11-10T08:24:34Z

←Older revision		Revision as of 08:24, 10 November 2021
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	<StructureSection load='1zt5' size='340' side='right'caption='[[1zt5]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='1zt5' size='340' side='right'caption='[[1zt5]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zt3\|1zt3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zt3\|1zt3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [~~http~~://pdbe.org/1zt5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zt5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zt5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [https://pdbe.org/1zt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1zt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zt5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IBP1_HUMAN IBP1_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.<ref>PMID:15972819</ref>	+	[[https://www.uniprot.org/uniprot/IBP1_HUMAN IBP1_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.<ref>PMID:15972819</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:51, 5 February 2020

2020-02-05T09:51:03Z

←Older revision		Revision as of 09:51, 5 February 2020
Line 1:		Line 1:

	==C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)==		==C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)==
-	<StructureSection load='1zt5' size='340' side='right' caption='[[1zt5]], [[Resolution\|resolution]] 1.82Å' scene=''>	+	<StructureSection load='1zt5' size='340' side='right'caption='[[1zt5]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1zt5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zt5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Insulin-like growth factor binding protein 3D structures\|Insulin-like growth factor binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Campagnoli, M]]		[[Category: Campagnoli, M]]
	[[Category: Capaldi, S]]		[[Category: Capaldi, S]]

OCA at 09:17, 2 May 2018

2018-05-02T09:17:02Z

←Older revision		Revision as of 09:17, 2 May 2018
Line 1:		Line 1:
		+
	==C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)==		==C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)==
	<StructureSection load='1zt5' size='340' side='right' caption='[[1zt5]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='1zt5' size='340' side='right' caption='[[1zt5]], [[Resolution\|resolution]] 1.82Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zt3\|1zt3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zt3\|1zt3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [http://pdbe.org/1zt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zt5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [http://pdbe.org/1zt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zt5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zt5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/1zt5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/1zt5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zt5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:56, 12 September 2015

2015-09-12T00:56:44Z

←Older revision		Revision as of 00:56, 12 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zt3\|1zt3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zt3\|1zt3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zt5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [http://pdbe.org/1zt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zt5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zt5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:43, 25 December 2014

2014-12-25T21:43:07Z

←Older revision		Revision as of 21:43, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zt3\|1zt3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zt3\|1zt3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zt5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zt5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IBP1_HUMAN IBP1_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.<ref>PMID:15972819</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Campagnoli, M.]]	+	[[Category: Campagnoli, M]]
-	[[Category: Capaldi, S.]]	+	[[Category: Capaldi, S]]
-	[[Category: Carrizo, M E.]]	+	[[Category: Carrizo, M E]]
-	[[Category: Faggion, B.]]	+	[[Category: Faggion, B]]
-	[[Category: Galliano, M.]]	+	[[Category: Galliano, M]]
-	[[Category: Labo, S.]]	+	[[Category: Labo, S]]
-	[[Category: Minchiotti, L.]]	+	[[Category: Minchiotti, L]]
-	[[Category: Monaco, H L.]]	+	[[Category: Monaco, H L]]
-	[[Category: Perduca, M.]]	+	[[Category: Perduca, M]]
-	[[Category: Romano, A.]]	+	[[Category: Romano, A]]
-	[[Category: Sala, A.]]	+	[[Category: Sala, A]]
-	[[Category: Valli, M.]]	+	[[Category: Valli, M]]
-	[[Category: Visai, L.]]	+	[[Category: Visai, L]]
	[[Category: Amniotic fluid]]		[[Category: Amniotic fluid]]
	[[Category: C-terminal domain]]		[[Category: C-terminal domain]]

OCA at 01:16, 30 September 2014

2014-09-30T01:16:12Z

←Older revision		Revision as of 01:16, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1zt5.~~png~~\|~~left~~\|200px]]	+	==C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)==
		+	<StructureSection load='1zt5' size='340' side='right' caption='[[1zt5]], [[Resolution\|resolution]] 1.82Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zt3\|1zt3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zt5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/1zt5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Insulin-like growth factor (IGF)-binding protein-1 (IGFBP-1) regulates the activity of the insulin-like growth factors in early pregnancy and is, thus, thought to play a key role at the fetal-maternal interface. The C-terminal domain of IGFBP-1 and three isoforms of the intact protein were isolated from human amniotic fluid, and sequencing of the four N-terminal polypeptide chains showed them to be highly pure. The addition of both intact IGFBP-1 and its C-terminal fragment to cultured fibroblasts has a similar stimulating effect on cell migration, and therefore, the domain has a biological activity on its own. The three-dimensional structure of the C-terminal domain was determined by x-ray crystallography to 1.8 Angstroms resolution. The fragment folds as a thyroglobulin type I domain and was found to bind the Fe(2+) ion in the crystals through the only histidine residue present in the polypeptide chain. Iron (II) decreases the binding of intact IGFBP-1 and the C-terminal domain to IGF-II, suggesting that the metal binding site is close to or part of the surface of interaction of the two molecules.

-	~~{{STRUCTURE_1zt5\| PDB=1zt5 \| SCENE= }}~~	+	Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid.,Sala A, Capaldi S, Campagnoli M, Faggion B, Labo S, Perduca M, Romano A, Carrizo ME, Valli M, Visai L, Minchiotti L, Galliano M, Monaco HL J Biol Chem. 2005 Aug 19;280(33):29812-9. Epub 2005 Jun 22. PMID:15972819<ref>PMID:15972819</ref>

-	~~===C-terminal domain~~ of ~~Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15972819}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1zt5]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015972819<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Campagnoli, M.]]		[[Category: Campagnoli, M.]]

OCA: Protected "1zt5" [edit=sysop:move=sysop]

2013-01-05T17:38:40Z

Protected "1zt5" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:38, 5 January 2013

OCA at 17:38, 5 January 2013

2013-01-05T17:38:38Z

←Older revision		Revision as of 17:38, 5 January 2013
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-	{{Seed}}
	[[Image:1zt5.png\|left\|200px]]		[[Image:1zt5.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1zt5\| PDB=1zt5 \| SCENE= }}		{{STRUCTURE_1zt5\| PDB=1zt5 \| SCENE= }}

	===C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)===		===C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15972819}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15972819 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15972819}}		{{ABSTRACT_PUBMED_15972819}}

	==About this Structure==		==About this Structure==
-	~~1ZT5~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA].	+	[[1zt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15972819~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015972819</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Campagnoli, M.]]		[[Category: Campagnoli, M.]]
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	[[Category: Iron]]		[[Category: Iron]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
-		+	[[Category: Peptide binding protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 08:45:43 2009''~~	+

OCA at 06:45, 18 February 2009

2009-02-18T06:45:44Z

←Older revision		Revision as of 06:45, 18 February 2009
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	==About this Structure==		==About this Structure==
-	1ZT5 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA].	+	1ZT5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA].

	==Reference==		==Reference==
-	Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid., Sala A, Capaldi S, Campagnoli M, Faggion B, Labo S, Perduca M, Romano A, Carrizo ME, Valli M, Visai L, Minchiotti L, Galliano M, Monaco HL, J Biol Chem. 2005 Aug 19;280(33):29812-9. Epub 2005 Jun 22. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15972819 15972819]~~	+	<ref group="xtra">PMID:15972819</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Campagnoli, M.]]		[[Category: Campagnoli, M.]]
	[[Category: Capaldi, S.]]		[[Category: Capaldi, S.]]
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	[[Category: Metal-binding]]		[[Category: Metal-binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 14~~:58:~~01 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:45:43 2009''