1zyn - Revision history

OCA at 08:14, 15 May 2024

2024-05-15T08:14:07Z

←Older revision		Revision as of 08:14, 15 May 2024
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	<StructureSection load='1zyn' size='340' side='right'caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1zyn' size='340' side='right'caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1hyu\|1hyu]]~~, [[~~1zyp~~\|~~1zyp~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [https://pdbe.org/1zyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [https://www.ebi.ac.uk/pdbsum/1zyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [https://pdbe.org/1zyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [https://www.ebi.ac.uk/pdbsum/1zyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AHPF_SALTY AHPF_SALTY]] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.	+	[https://www.uniprot.org/uniprot/AHPF_SALTY AHPF_SALTY] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Jonsson, T J~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-	[[Category: ~~Karplus, P A~~]]	+	[[Category: Jonsson TJ]]
-	[[Category: ~~Poole, L B~~]]	+	[[Category: Karplus PA]]
-	[[Category: ~~Roberts, B R~~]]	+	[[Category: Poole LB]]
-	[[Category: ~~Wood, Z A~~]]	+	[[Category: Roberts BR]]
-	[[Category: ~~Oxidoreductase]]~~	+	[[Category: Wood ZA]]
-	~~[[Category: Thiolate~~]]	+

OCA at 16:36, 3 November 2021

2021-11-03T16:36:56Z

←Older revision		Revision as of 16:36, 3 November 2021
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	<StructureSection load='1zyn' size='340' side='right'caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1zyn' size='340' side='right'caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hyu\|1hyu]], [[1zyp\|1zyp]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hyu\|1hyu]], [[1zyp\|1zyp]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [~~http~~://pdbe.org/1zyn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zyn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [https://pdbe.org/1zyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [https://www.ebi.ac.uk/pdbsum/1zyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AHPF_SALTY AHPF_SALTY]] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.	+	[[https://www.uniprot.org/uniprot/AHPF_SALTY AHPF_SALTY]] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:08, 29 January 2020

2020-01-29T17:08:51Z

←Older revision		Revision as of 17:08, 29 January 2020
Line 1:		Line 1:

	==Oxidized structure of the N-terminal domain of Salmonella typhimurium AhpF==		==Oxidized structure of the N-terminal domain of Salmonella typhimurium AhpF==
-	<StructureSection load='1zyn' size='340' side='right' caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1zyn' size='340' side='right'caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jonsson, T J]]		[[Category: Jonsson, T J]]
	[[Category: Karplus, P A]]		[[Category: Karplus, P A]]

OCA at 06:02, 18 April 2018

2018-04-18T06:02:50Z

←Older revision		Revision as of 06:02, 18 April 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:24, 12 October 2017

2017-10-12T11:24:57Z

←Older revision		Revision as of 11:24, 12 October 2017
Line 1:		Line 1:
		+
	==Oxidized structure of the N-terminal domain of Salmonella typhimurium AhpF==		==Oxidized structure of the N-terminal domain of Salmonella typhimurium AhpF==
	<StructureSection load='1zyn' size='340' side='right' caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1zyn' size='340' side='right' caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hyu\|1hyu]], [[1zyp\|1zyp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hyu\|1hyu]], [[1zyp\|1zyp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [http://pdbe.org/1zyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [http://www.ebi.ac.uk/pdbsum/1zyn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [http://pdbe.org/1zyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [http://www.ebi.ac.uk/pdbsum/1zyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:24, 9 February 2016

2016-02-09T01:24:33Z

←Older revision		Revision as of 01:24, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zyn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:15, 10 September 2015

2015-09-10T17:15:23Z

←Older revision		Revision as of 17:15, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1zyn' size='340' side='right' caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1zyn' size='340' side='right' caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hyu\|1hyu]], [[1zyp\|1zyp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hyu\|1hyu]], [[1zyp\|1zyp]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahpF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [http://pdbe.org/1zyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [http://www.ebi.ac.uk/pdbsum/1zyn PDBsum]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [http://www.ebi.ac.uk/pdbsum/1zyn PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zyn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Jonsson, T J]]		[[Category: Jonsson, T J]]
	[[Category: Karplus, P A]]		[[Category: Karplus, P A]]

OCA at 03:28, 25 December 2014

2014-12-25T03:28:30Z

←Older revision		Revision as of 03:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hyu\|1hyu]], [[1zyp\|1zyp]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hyu\|1hyu]], [[1zyp\|1zyp]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahpF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahpF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [http://www.ebi.ac.uk/pdbsum/1zyn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [http://www.ebi.ac.uk/pdbsum/1zyn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AHPF_SALTY AHPF_SALTY]] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Jonsson, T J.]]	+	[[Category: Jonsson, T J]]
-	[[Category: Karplus, P A.]]	+	[[Category: Karplus, P A]]
-	[[Category: Poole, L B.]]	+	[[Category: Poole, L B]]
-	[[Category: Roberts, B R.]]	+	[[Category: Roberts, B R]]
-	[[Category: Wood, Z A.]]	+	[[Category: Wood, Z A]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Thiolate]]		[[Category: Thiolate]]

OCA at 09:01, 3 October 2014

2014-10-03T09:01:19Z

←Older revision		Revision as of 09:01, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1zyn\| PDB=1zyn \| SCENE= }}~~	+	==Oxidized structure of the N-terminal domain of Salmonella typhimurium AhpF==
-	===Oxidized structure of the N-terminal domain of Salmonella typhimurium AhpF===	+	<StructureSection load='1zyn' size='340' side='right' caption='[[1zyn]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16131664}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zyn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hyu\|1hyu]], [[1zyp\|1zyp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahpF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zyn RCSB], [http://www.ebi.ac.uk/pdbsum/1zyn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The flavoprotein component (AhpF) of Salmonella typhimurium alkyl hydroperoxide reductase contains an N-terminal domain (NTD) with two contiguous thioredoxin folds but only one redox-active disulfide (within the sequence -Cys129-His-Asn-Cys132-). This active site is responsible for mediating the transfer of electrons from the thioredoxin reductase-like segment of AhpF to AhpC, the peroxiredoxin component of the two-protein peroxidase system. The previously reported crystal structure of AhpF possessed a reduced NTD active site, although fully oxidized protein was used for crystallization. To further investigate this active site, we crystallized an isolated recombinant NTD (rNTD); using diffraction data sets collected first at our in-house X-ray source and subsequently at a synchrotron, we showed that the active site disulfide bond (Cys129-Cys132) is oxidized in the native crystals but becomes reduced during synchrotron data collection. The NTD disulfide bond is apparently particularly sensitive to radiation cleavage compared with other protein disulfides. The two data sets provide the first view of an oxidized (disulfide) form of NTD and show that the changes in conformation upon reduction of the disulfide are localized and small. Furthermore, we report the apparent pKa of the active site thiol to be approximately 5.1, a relatively low pKa given its redox potential (approximately 265 mV) compared with most members of the thioredoxin family.

-	~~==Function==~~	+	Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF.,Roberts BR, Wood ZA, Jonsson TJ, Poole LB, Karplus PA Protein Sci. 2005 Sep;14(9):2414-20. PMID:16131664<ref>PMID:16131664</ref>
-	~~[[http://www.uniprot.org/uniprot/AHPF_SALTY AHPF_SALTY]] Serves to protect~~ the ~~cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of~~ redox ~~dyes or~~ of ~~alkyl hydroperoxides when combined with the AhpC protein~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1zyn]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Salmonella_enterica_subsp~~.~~_enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYN OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016131664</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Jonsson, T J.]]		[[Category: Jonsson, T J.]]

OCA at 08:21, 23 April 2014

2014-04-23T08:21:27Z

←Older revision		Revision as of 08:21, 23 April 2014
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-	[[Image:1zyn.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zyn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zyn\| PDB=1zyn \| SCENE= }}		{{STRUCTURE_1zyn\| PDB=1zyn \| SCENE= }}
-
	===Oxidized structure of the N-terminal domain of Salmonella typhimurium AhpF===		===Oxidized structure of the N-terminal domain of Salmonella typhimurium AhpF===
		+	{{ABSTRACT_PUBMED_16131664}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/AHPF_SALTY AHPF_SALTY]] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_16131664}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 16131664 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_16131664}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016131664</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016131664</ref><references group="xtra"/><references/>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Jonsson, T J.]]		[[Category: Jonsson, T J.]]