274d - Revision history

OCA at 09:10, 14 February 2024

2024-02-14T09:10:00Z

←Older revision		Revision as of 09:10, 14 February 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [https://pdbe.org/274d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [https://www.ebi.ac.uk/pdbsum/274d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=274d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [https://pdbe.org/274d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [https://www.ebi.ac.uk/pdbsum/274d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=274d ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A 2.3-A X-ray crystal structure analysis has been carried out on the antitumor drug anthramycin, covalently bound to a ten base pair DNA double helix of sequence C-C-A-A-C-G-T-T-G-G. One drug molecule sits within the minor groove at each end of the helix, covalently bound through its C11 position to the N2 amine of the penultimate guanine of the chain. The stereochemical conformation is C11S, C11aS. The natural twist of the anthramycin molecule in the C11aS conformation matches the twist of the minor groove as it winds along the helix; a C11aR drug would only fit into a left-handed helix. The C11S attachment is roughly equatorial to the overall plane of the molecule, whereas a C11R attachment would be axial and would obstruct the fitting of the drug into the groove. The six-membered ring of anthramycin points toward the 3' end of the chain to which it is covalently attached or toward the end of the helix. The acrylamide tail attached to the five-membered ring extends back along the minor groove toward the center of the helix, binding in a manner reminiscent of netropsin or distamycin. The drug-DNA complex is stabilized by hydrogen bonds from C9-OH, N10, and the end of the acrylamide tail to base pair edges on the floor of the minor groove. The origin of anthramycin specificity for three successive purines arises not from specific hydrogen bonds but from the low twist angles adopted by purine-purine steps in a B-DNA helix. Binding of anthramycin induces a low twist at T-G in the T-G-G sequence of this DNA-drug complex, by comparison with the structure of the free DNA. The origin of anthramycin's preference for adenines flanking the alkylated guanine arises from a netropsin-like fitting of the acrylamide tail into the minor groove.
-
-	Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity.,Kopka ML, Goodsell DS, Baikalov I, Grzeskowiak K, Cascio D, Dickerson RE Biochemistry. 1994 Nov 22;33(46):13593-610. PMID:7947769<ref>PMID:7947769</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 274d" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:58, 23 August 2023

2023-08-23T07:58:06Z

←Older revision		Revision as of 07:58, 23 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=274D FirstGlance]. <br>		<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=274D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANT:ANTHRAMYCIN'>ANT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANT:ANTHRAMYCIN'>ANT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [https://pdbe.org/274d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [https://www.ebi.ac.uk/pdbsum/274d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=274d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [https://pdbe.org/274d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [https://www.ebi.ac.uk/pdbsum/274d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=274d ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baikalov, I]]	+	[[Category: Baikalov I]]
-	[[Category: Cascio, D]]	+	[[Category: Cascio D]]
-	[[Category: Dickerson~~, R E~~]]	+	[[Category: Dickerson RE]]
-	[[Category: Goodsell~~, D S~~]]	+	[[Category: Goodsell DS]]
-	[[Category: Grzeskowiak, K]]	+	[[Category: Grzeskowiak K]]
-	[[Category: Kopka~~, M L]]~~	+	[[Category: Kopka ML]]
-	~~[[Category: B-dna]]~~	+
-	~~[[Category: Complexed with drug]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Double helix]]~~	+
-	~~[[Category: Modified~~]]	+

OCA at 14:33, 17 November 2021

2021-11-17T14:33:50Z

←Older revision		Revision as of 14:33, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='274d' size='340' side='right'caption='[[274d]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='274d' size='340' side='right'caption='[[274d]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=274D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=274D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANT:ANTHRAMYCIN'>ANT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANT:ANTHRAMYCIN'>ANT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [~~http~~://pdbe.org/274d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/274d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=274d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [https://pdbe.org/274d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [https://www.ebi.ac.uk/pdbsum/274d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=274d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:25, 13 February 2020

2020-02-13T05:25:59Z

←Older revision		Revision as of 05:25, 13 February 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G, AND A MOLECULAR EXPLANATION OF SPECIFICITY==		==CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G, AND A MOLECULAR EXPLANATION OF SPECIFICITY==
-	<StructureSection load='274d' size='340' side='right' caption='[[274d]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='274d' size='340' side='right'caption='[[274d]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274D FirstGlance]. <br>		<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274D FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Baikalov, I]]		[[Category: Baikalov, I]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]

OCA at 07:18, 9 May 2018

2018-05-09T07:18:11Z

←Older revision		Revision as of 07:18, 9 May 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G, AND A MOLECULAR EXPLANATION OF SPECIFICITY==		==CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G, AND A MOLECULAR EXPLANATION OF SPECIFICITY==
	<StructureSection load='274d' size='340' side='right' caption='[[274d]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='274d' size='340' side='right' caption='[[274d]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274D FirstGlance]. <br>		<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANT:ANTHRAMYCIN'>ANT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANT:ANTHRAMYCIN'>ANT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [http://pdbe.org/274d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [http://www.ebi.ac.uk/pdbsum/274d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [http://pdbe.org/274d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [http://www.ebi.ac.uk/pdbsum/274d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=274d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:17, 11 September 2015

2015-09-11T01:17:19Z

←Older revision		Revision as of 01:17, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274D FirstGlance]. <br>		<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANT:ANTHRAMYCIN'>ANT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANT:ANTHRAMYCIN'>ANT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [http://www.ebi.ac.uk/pdbsum/274d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [http://pdbe.org/274d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [http://www.ebi.ac.uk/pdbsum/274d PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 274d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:23, 15 January 2015

2015-01-15T18:23:43Z

←Older revision		Revision as of 18:23, 15 January 2015
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baikalov, I.]]	+	[[Category: Baikalov, I]]
-	[[Category: Cascio, D.]]	+	[[Category: Cascio, D]]
-	[[Category: Dickerson, R E.]]	+	[[Category: Dickerson, R E]]
-	[[Category: Goodsell, D S.]]	+	[[Category: Goodsell, D S]]
-	[[Category: Grzeskowiak, K.]]	+	[[Category: Grzeskowiak, K]]
-	[[Category: Kopka, M L.]]	+	[[Category: Kopka, M L]]
	[[Category: B-dna]]		[[Category: B-dna]]
	[[Category: Complexed with drug]]		[[Category: Complexed with drug]]

OCA at 08:26, 8 October 2014

2014-10-08T08:26:02Z

←Older revision		Revision as of 08:26, 8 October 2014
Line 1:		Line 1:
-	[[~~Image:~~274d.~~png~~\|~~left\|200px~~]]	+	==CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G, AND A MOLECULAR EXPLANATION OF SPECIFICITY==
		+	<StructureSection load='274d' size='340' side='right' caption='[[274d]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274D FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANT:ANTHRAMYCIN'>ANT</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=274d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=274d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=274d RCSB], [http://www.ebi.ac.uk/pdbsum/274d PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A 2.3-A X-ray crystal structure analysis has been carried out on the antitumor drug anthramycin, covalently bound to a ten base pair DNA double helix of sequence C-C-A-A-C-G-T-T-G-G. One drug molecule sits within the minor groove at each end of the helix, covalently bound through its C11 position to the N2 amine of the penultimate guanine of the chain. The stereochemical conformation is C11S, C11aS. The natural twist of the anthramycin molecule in the C11aS conformation matches the twist of the minor groove as it winds along the helix; a C11aR drug would only fit into a left-handed helix. The C11S attachment is roughly equatorial to the overall plane of the molecule, whereas a C11R attachment would be axial and would obstruct the fitting of the drug into the groove. The six-membered ring of anthramycin points toward the 3' end of the chain to which it is covalently attached or toward the end of the helix. The acrylamide tail attached to the five-membered ring extends back along the minor groove toward the center of the helix, binding in a manner reminiscent of netropsin or distamycin. The drug-DNA complex is stabilized by hydrogen bonds from C9-OH, N10, and the end of the acrylamide tail to base pair edges on the floor of the minor groove. The origin of anthramycin specificity for three successive purines arises not from specific hydrogen bonds but from the low twist angles adopted by purine-purine steps in a B-DNA helix. Binding of anthramycin induces a low twist at T-G in the T-G-G sequence of this DNA-drug complex, by comparison with the structure of the free DNA. The origin of anthramycin's preference for adenines flanking the alkylated guanine arises from a netropsin-like fitting of the acrylamide tail into the minor groove.

-	~~{{STRUCTURE_274d\| PDB=274d \| SCENE= }}~~	+	Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity.,Kopka ML, Goodsell DS, Baikalov I, Grzeskowiak K, Cascio D, Dickerson RE Biochemistry. 1994 Nov 22;33(46):13593-610. PMID:7947769<ref>PMID:7947769</ref>

-	~~===CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G~~, ~~AND A MOLECULAR EXPLANATION OF SPECIFICITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7947769}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[274d]] is a 1 chain structure. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA].~~	+	</StructureSection>
	[[Category: Baikalov, I.]]		[[Category: Baikalov, I.]]
	[[Category: Cascio, D.]]		[[Category: Cascio, D.]]

OCA: Protected "274d" [edit=sysop:move=sysop]

2013-01-06T12:07:36Z

Protected "274d" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:07, 6 January 2013

OCA at 12:07, 6 January 2013

2013-01-06T12:07:33Z

←Older revision		Revision as of 12:07, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:274d.png\|left\|200px]]		[[Image:274d.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_274d", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_274d\| PDB=274d \| SCENE= }}		{{STRUCTURE_274d\| PDB=274d \| SCENE= }}

	===CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G, AND A MOLECULAR EXPLANATION OF SPECIFICITY===		===CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G, AND A MOLECULAR EXPLANATION OF SPECIFICITY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_7947769}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 7947769 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_7947769}}		{{ABSTRACT_PUBMED_7947769}}

	==About this Structure==		==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA].	+	[[274d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=274D OCA].
-		+
-	~~==Reference==~~	+
-	Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity., Kopka ML, Goodsell DS, Baikalov I, Grzeskowiak K, Cascio D, Dickerson RE, Biochemistry. 1994 Nov 22;33(46):13593-610. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7947769 7947769]	+
	[[Category: Baikalov, I.]]		[[Category: Baikalov, I.]]
	[[Category: Cascio, D.]]		[[Category: Cascio, D.]]
Line 32:		Line 17:
	[[Category: B-dna]]		[[Category: B-dna]]
	[[Category: Complexed with drug]]		[[Category: Complexed with drug]]
		+	[[Category: Dna]]
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Modified]]		[[Category: Modified]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:24:22 2008''