2ac6 - Revision history

OCA at 14:39, 17 November 2021

2021-11-17T14:39:04Z

←Older revision		Revision as of 14:39, 17 November 2021
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	<StructureSection load='2ac6' size='340' side='right'caption='[[2ac6]]' scene=''>		<StructureSection load='2ac6' size='340' side='right'caption='[[2ac6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ac6 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/2ac6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ac6 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ac6 FirstGlance], [https://www.ebi.ac.uk/pdbsum/2ac6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ac6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:28, 13 February 2020

2020-02-13T05:28:11Z

←Older revision		Revision as of 05:28, 13 February 2020
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	==ANGIOTENSIN II TYPE 1A RECEPTOR MODEL==		==ANGIOTENSIN II TYPE 1A RECEPTOR MODEL==
-	<StructureSection load='2ac6' size='340' side='right' caption='[[2ac6]]' scene=''>	+	<StructureSection load='2ac6' size='340' side='right'caption='[[2ac6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Baleanu-Gogonea, C]]		[[Category: Baleanu-Gogonea, C]]

OCA at 07:21, 9 May 2018

2018-05-09T07:21:23Z

←Older revision		Revision as of 07:21, 9 May 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ac6 FirstGlance], [http://www.ebi.ac.uk/pdbsum/2ac6 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ac6 FirstGlance], [http://www.ebi.ac.uk/pdbsum/2ac6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ac6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:18, 11 February 2016

2016-02-11T10:18:23Z

←Older revision		Revision as of 10:18, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==ANGIOTENSIN II TYPE 1A RECEPTOR MODEL==		==ANGIOTENSIN II TYPE 1A RECEPTOR MODEL==
	<StructureSection load='2ac6' size='340' side='right' caption='[[2ac6]]' scene=''>		<StructureSection load='2ac6' size='340' side='right' caption='[[2ac6]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Baleanu-Gogonea, C]]		[[Category: Baleanu-Gogonea, C]]

OCA at 08:53, 10 September 2015

2015-09-10T08:53:40Z

←Older revision		Revision as of 08:53, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ac6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:41, 8 January 2015

2015-01-08T09:41:42Z

←Older revision		Revision as of 09:41, 8 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ac6 FirstGlance], [http://www.ebi.ac.uk/pdbsum/2ac6 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ac6 FirstGlance], [http://www.ebi.ac.uk/pdbsum/2ac6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 05:55, 29 September 2014

2014-09-29T05:55:33Z

←Older revision		Revision as of 05:55, 29 September 2014
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-	~~{{Theoretical_model}}~~	+	==ANGIOTENSIN II TYPE 1A RECEPTOR MODEL==
		+	<StructureSection load='2ac6' size='340' side='right' caption='[[2ac6]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ac6 FirstGlance], [http://www.ebi.ac.uk/pdbsum/2ac6 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We present a three-dimensional model of the rat type 1 receptor (AT1) for the hormone angiotensin II (Ang II). Ang II and the AT1 receptor play a critical role in the cell-signaling process responsible for the actions of renin-angiotensin system in the regulation of blood pressure, water-electrolyte homeostasis and cell growth. Development of improved therapeutics would be significantly enhanced with the availability of a 3D-structure model for the AT1 receptor and of the binding site for agonists and antagonists. This model was constructed using a combination of computation and homology-modeling techniques starting with the experimentally determined three-dimensional structure of bovine rhodopsin (PDB#1F88) as a template. All 359 residues and two disulfide bonds in the rat AT1 receptor have been accounted for in this model. Ramachandran-map analysis and a 1 nanosecond molecular dynamics simulation of the solvated receptor with and without the bound ligand, Ang II, lend credence to the validity of the model. Docking calculations were performed with the agonist, Ang II and the antihypertensive antagonist, losartan. [Figure: see text].

-	~~[[Image~~:~~2ac6~~.~~png\|left\|200px]]~~	+	Model of the whole rat AT1 receptor and the ligand-binding site.,Baleanu-Gogonea C, Karnik S J Mol Model. 2006 Feb;12(3):325-37. Epub 2006 Jan 11. PMID:16404618<ref>PMID:16404618</ref>

-	~~{{STRUCTURE_2ac6\| PDB=2ac6 \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=ANGIOTENSIN II TYPE 1A RECEPTOR MODEL===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_16404618}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:016404618<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Baleanu-Gogonea, C]]		[[Category: Baleanu-Gogonea, C]]

OCA: Protected "2ac6" [edit=sysop:move=sysop]

2012-10-21T09:15:49Z

Protected "2ac6" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:15, 21 October 2012

OCA at 09:15, 21 October 2012

2012-10-21T09:15:46Z

←Older revision		Revision as of 09:15, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:2ac6.png\|left\|200px]]		[[Image:2ac6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ac6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ac6\| PDB=2ac6 \| SCENE= }}		{{STRUCTURE_2ac6\| PDB=2ac6 \| SCENE= }}

	===ANGIOTENSIN II TYPE 1A RECEPTOR MODEL===		===ANGIOTENSIN II TYPE 1A RECEPTOR MODEL===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16404618}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16404618 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16404618}}		{{ABSTRACT_PUBMED_16404618}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AC6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16404618~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016404618</ref><references group="xtra"/>
	[[Category: Baleanu-Gogonea, C]]		[[Category: Baleanu-Gogonea, C]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:59:14 2010''

OCA at 04:59, 8 April 2010

2010-04-08T04:59:15Z

←Older revision		Revision as of 04:59, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:2ac6.png\|left\|200px]]

-	The ~~entry 2AC6~~ is ~~a Theoretical Model titled 'Angiotensin II Type 1A receptor model'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2ac6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2ac6\| PDB=2ac6 \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===ANGIOTENSIN II TYPE 1A RECEPTOR MODEL===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:55:~~22 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_16404618}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16404618 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16404618}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AC6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:16404618</ref><references group="xtra"/>
		+	[[Category: Baleanu-Gogonea, C]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:59:14 2010''