2aih - Revision history

OCA at 08:18, 15 May 2024

2024-05-15T08:18:01Z

←Older revision		Revision as of 08:18, 15 May 2024
Line 1:		Line 1:

	==1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.==		==1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.==
-	<StructureSection load='2aih' size='340' side='right'caption='[[2aih~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2aih' size='340' side='right'caption='[[2aih]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AIH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [https://pdbe.org/2aih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [https://www.ebi.ac.uk/pdbsum/2aih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aih ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [https://pdbe.org/2aih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [https://www.ebi.ac.uk/pdbsum/2aih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aih ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IBB_LENCU IBB_LENCU]] Inhibitor of trypsin and of chymotrypsin.<ref>PMID:16889634</ref>	+	[https://www.uniprot.org/uniprot/IBB_LENCU IBB_LENCU] Inhibitor of trypsin and of chymotrypsin.<ref>PMID:16889634</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 38:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lens culinaris]]		[[Category: Lens culinaris]]
-	[[Category: Consonni, A]]	+	[[Category: Consonni A]]
-	[[Category: Duranti, M]]	+	[[Category: Duranti M]]
-	[[Category: Galbusera, V]]	+	[[Category: Galbusera V]]
-	[[Category: Negri, A]]	+	[[Category: Negri A]]
-	[[Category: Ragg~~, E M~~]]	+	[[Category: Ragg EM]]
-	[[Category: Scarafoni, A]]	+	[[Category: Scarafoni A]]
-	[[Category: Sessa, F]]	+	[[Category: Sessa F]]
-	[[Category: Tedeschi, G]]	+	[[Category: Tedeschi G]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Trypsin/chymotrypsin bowman-birk inhibitor]]~~	+
-	~~[[Category: Two-strands beta-sheet~~]]	+

OCA at 14:41, 17 November 2021

2021-11-17T14:41:16Z

←Older revision		Revision as of 14:41, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2aih' size='340' side='right'caption='[[2aih]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2aih' size='340' side='right'caption='[[2aih]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AIH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AIH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [~~http~~://pdbe.org/2aih PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2aih PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2aih ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [https://pdbe.org/2aih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [https://www.ebi.ac.uk/pdbsum/2aih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aih ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IBB_LENCU IBB_LENCU]] Inhibitor of trypsin and of chymotrypsin.<ref>PMID:16889634</ref>	+	[[https://www.uniprot.org/uniprot/IBB_LENCU IBB_LENCU]] Inhibitor of trypsin and of chymotrypsin.<ref>PMID:16889634</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Trypsin inhibitor\|Trypsin inhibitor]]	+	*[[Trypsin inhibitor 3D structures\|Trypsin inhibitor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:04, 13 February 2020

2020-02-13T05:04:36Z

←Older revision		Revision as of 05:04, 13 February 2020
Line 1:		Line 1:

	==1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.==		==1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.==
-	<StructureSection load='2aih' size='340' side='right' caption='[[2aih]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2aih' size='340' side='right'caption='[[2aih]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIH FirstGlance]. <br>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lens culinaris]]		[[Category: Lens culinaris]]
	[[Category: Consonni, A]]		[[Category: Consonni, A]]

OCA at 06:53, 9 May 2018

2018-05-09T06:53:49Z

←Older revision		Revision as of 06:53, 9 May 2018
Line 1:		Line 1:
		+
	==1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.==		==1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.==
	<StructureSection load='2aih' size='340' side='right' caption='[[2aih]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2aih' size='340' side='right' caption='[[2aih]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [http://pdbe.org/2aih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [http://www.ebi.ac.uk/pdbsum/2aih PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [http://pdbe.org/2aih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [http://www.ebi.ac.uk/pdbsum/2aih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aih ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/2aih_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/2aih_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:07, 9 February 2016

2016-02-09T04:07:00Z

←Older revision		Revision as of 04:07, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aih ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:28, 10 September 2015

2015-09-10T18:28:21Z

←Older revision		Revision as of 18:28, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [http://www.ebi.ac.uk/pdbsum/2aih PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [http://pdbe.org/2aih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [http://www.ebi.ac.uk/pdbsum/2aih PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2aih" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Trypsin inhibitor\|Trypsin inhibitor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:18, 25 December 2014

2014-12-25T04:18:51Z

←Older revision		Revision as of 04:18, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [http://www.ebi.ac.uk/pdbsum/2aih PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [http://www.ebi.ac.uk/pdbsum/2aih PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IBB_LENCU IBB_LENCU]] Inhibitor of trypsin and of chymotrypsin.<ref>PMID:16889634</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Lens culinaris]]		[[Category: Lens culinaris]]
-	[[Category: Consonni, A.]]	+	[[Category: Consonni, A]]
-	[[Category: Duranti, M.]]	+	[[Category: Duranti, M]]
-	[[Category: Galbusera, V.]]	+	[[Category: Galbusera, V]]
-	[[Category: Negri, A.]]	+	[[Category: Negri, A]]
-	[[Category: Ragg, E M.]]	+	[[Category: Ragg, E M]]
-	[[Category: Scarafoni, A.]]	+	[[Category: Scarafoni, A]]
-	[[Category: Sessa, F.]]	+	[[Category: Sessa, F]]
-	[[Category: Tedeschi, G.]]	+	[[Category: Tedeschi, G]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Trypsin/chymotrypsin bowman-birk inhibitor]]		[[Category: Trypsin/chymotrypsin bowman-birk inhibitor]]
	[[Category: Two-strands beta-sheet]]		[[Category: Two-strands beta-sheet]]

OCA at 02:30, 30 September 2014

2014-09-30T02:30:37Z

←Older revision		Revision as of 02:30, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2aih.~~png\|left~~\|200px]]	+	==1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.==
		+	<StructureSection load='2aih' size='340' side='right' caption='[[2aih]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aih RCSB], [http://www.ebi.ac.uk/pdbsum/2aih PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/2aih_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bowman-Birk serine protease inhibitors are a family of small plant proteins, whose physiological role has not been ascertained as yet, while chemopreventive anticarcinogenic properties have repeatedly been claimed. In this work we present data on the isolation of a lentil (Lens culinaris, L., var. Macrosperma) seed trypsin inhibitor (LCTI) and its functional and structural characterization. LCTI is a 7448 Da double-headed trypsin/chymotrypsin inhibitor with dissociation constants equal to 0.54 nM and 7.25 nM for the two proteases, respectively. The inhibitor is, however, hydrolysed by trypsin in a few minutes timescale, leading to a dramatic loss of its affinity for the enzyme. This is due to a substantial difference in the kon and k*on values (1.1 microM-1.s-1 vs. 0.002 microM-1.s-1), respectively, for the intact and modified inhibitor. A similar behaviour was not observed with chymotrypsin. The twenty best NMR structures concurrently showed a canonical Bowman-Birk inhibitor (BBI) conformation with two antipodal beta-hairpins containing the inhibitory domains. The tertiary structure is stabilized by ion pairs and hydrogen bonds involving the side chain and backbone of Asp10-Asp26-Arg28 and Asp36-Asp52 residues. At physiological pH, the final structure results in an asymmetric distribution of opposite charges with a negative electrostatic potential, centred on the C-terminus, and a highly positive potential, surrounding the antitryptic domain. The segment 53-55 lacks the anchoring capacity found in analogous BBIs, thus rendering the protein susceptible to hydrolysis. The inhibitory properties of LCTI, related to the simultaneous presence of two key amino acids (Gln18 and His54), render the molecule unusual within the natural Bowman-Birk inhibitor family.

-	~~{{STRUCTURE_2aih\| PDB=2aih \| SCENE= }}~~	+	Inhibitory properties and solution structure of a potent Bowman-Birk protease inhibitor from lentil (Lens culinaris, L) seeds.,Ragg EM, Galbusera V, Scarafoni A, Negri A, Tedeschi G, Consonni A, Sessa F, Duranti M FEBS J. 2006 Sep;273(17):4024-39. Epub 2006 Aug 2. PMID:16889634<ref>PMID:16889634</ref>

-	~~===1H-NMR solution structure of a trypsin~~/~~chymotrypsin Bowman-Birk inhibitor from Lens culinaris.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16889634}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2aih]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lens_culinaris Lens culinaris]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016889634<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Lens culinaris]]		[[Category: Lens culinaris]]
	[[Category: Consonni, A.]]		[[Category: Consonni, A.]]

OCA: Protected "2aih" [edit=sysop:move=sysop]

2013-01-06T11:42:46Z

Protected "2aih" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:42, 6 January 2013

OCA at 11:42, 6 January 2013

2013-01-06T11:42:41Z

←Older revision		Revision as of 11:42, 6 January 2013
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-	{{Seed}}
	[[Image:2aih.png\|left\|200px]]		[[Image:2aih.png\|left\|200px]]

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	{{STRUCTURE_2aih\| PDB=2aih \| SCENE= }}		{{STRUCTURE_2aih\| PDB=2aih \| SCENE= }}

	===1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.===		===1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.===

-
-	<!--
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	{{ABSTRACT_PUBMED_16889634}}		{{ABSTRACT_PUBMED_16889634}}

	==About this Structure==		==About this Structure==
-	~~2AIH~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA].	+	[[2aih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lens_culinaris Lens culinaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16889634~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016889634</ref><references group="xtra"/>
	[[Category: Lens culinaris]]		[[Category: Lens culinaris]]
	[[Category: Consonni, A.]]		[[Category: Consonni, A.]]
Line 33:		Line 21:
	[[Category: Sessa, F.]]		[[Category: Sessa, F.]]
	[[Category: Tedeschi, G.]]		[[Category: Tedeschi, G.]]
		+	[[Category: Hydrolase]]
	[[Category: Trypsin/chymotrypsin bowman-birk inhibitor]]		[[Category: Trypsin/chymotrypsin bowman-birk inhibitor]]
	[[Category: Two-strands beta-sheet]]		[[Category: Two-strands beta-sheet]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:20:39 2009''