2arq - Revision history

OCA at 08:18, 25 October 2023

2023-10-25T08:18:08Z

←Older revision		Revision as of 08:18, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2arq' size='340' side='right'caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2arq' size='340' side='right'caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2arq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ARQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2arq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ARQ FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ACE:ACETYL+GROUP'>ACE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1jrr\|1jrr]], [[2arr\|2arr]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2arq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arq OCA], [https://pdbe.org/2arq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2arq RCSB], [https://www.ebi.ac.uk/pdbsum/2arq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2arq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2arq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arq OCA], [https://pdbe.org/2arq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2arq RCSB], [https://www.ebi.ac.uk/pdbsum/2arq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2arq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PAI2_HUMAN PAI2_HUMAN]] Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.	+	[https://www.uniprot.org/uniprot/PAI2_HUMAN PAI2_HUMAN] Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Curmi~~, P M~~]]	+	[[Category: Curmi PM]]
-	[[Category: ~~Giusto, D A.~~Di]]	+	[[Category: Di Giusto DA]]
-	[[Category: Harrop~~, S J~~]]	+	[[Category: Harrop SJ]]
-	[[Category: Jankova, L]]	+	[[Category: Jankova L]]
-	[[Category: King~~, G C~~]]	+	[[Category: King GC]]
-	[[Category: Sutherland~~, A P]]~~	+	[[Category: Sutherland AP]]
-	~~[[Category: Hydrolase inhibitor-peptide complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Peptide binding]]~~	+
-	~~[[Category: Serpin~~]]	+

OCA at 06:45, 10 November 2021

2021-11-10T06:45:48Z

←Older revision		Revision as of 06:45, 10 November 2021
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	<StructureSection load='2arq' size='340' side='right'caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2arq' size='340' side='right'caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2arq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ARQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2arq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ARQ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jrr\|1jrr]], [[2arr\|2arr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jrr\|1jrr]], [[2arr\|2arr]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2arq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arq OCA], [~~http~~://pdbe.org/2arq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2arq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2arq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2arq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2arq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arq OCA], [https://pdbe.org/2arq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2arq RCSB], [https://www.ebi.ac.uk/pdbsum/2arq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2arq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PAI2_HUMAN PAI2_HUMAN]] Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.	+	[[https://www.uniprot.org/uniprot/PAI2_HUMAN PAI2_HUMAN]] Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 05:16, 13 February 2020

2020-02-13T05:16:01Z

←Older revision		Revision as of 05:16, 13 February 2020
Line 1:		Line 1:

	==Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh==		==Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh==
-	<StructureSection load='2arq' size='340' side='right' caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='2arq' size='340' side='right'caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2arq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2arq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARQ FirstGlance]. <br>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Curmi, P M]]		[[Category: Curmi, P M]]
	[[Category: Giusto, D A.Di]]		[[Category: Giusto, D A.Di]]

OCA at 07:06, 9 May 2018

2018-05-09T07:06:59Z

←Older revision		Revision as of 07:06, 9 May 2018
Line 1:		Line 1:
		+
	==Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh==		==Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh==
	<StructureSection load='2arq' size='340' side='right' caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2arq' size='340' side='right' caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jrr\|1jrr]], [[2arr\|2arr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jrr\|1jrr]], [[2arr\|2arr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2arq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arq OCA], [http://pdbe.org/2arq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2arq RCSB], [http://www.ebi.ac.uk/pdbsum/2arq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2arq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arq OCA], [http://pdbe.org/2arq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2arq RCSB], [http://www.ebi.ac.uk/pdbsum/2arq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2arq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2arq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2arq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2arq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:01, 11 September 2015

2015-09-11T10:01:53Z

←Older revision		Revision as of 10:01, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2arq' size='340' side='right' caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2arq' size='340' side='right' caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2arq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2arq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARQ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jrr\|1jrr]], [[2arr\|2arr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jrr\|1jrr]], [[2arr\|2arr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2arq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2arq RCSB], [http://www.ebi.ac.uk/pdbsum/2arq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2arq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arq OCA], [http://pdbe.org/2arq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2arq RCSB], [http://www.ebi.ac.uk/pdbsum/2arq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2arq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Curmi, P M]]		[[Category: Curmi, P M]]
	[[Category: Giusto, D A.Di]]		[[Category: Giusto, D A.Di]]

OCA at 14:52, 25 December 2014

2014-12-25T14:52:03Z

←Older revision		Revision as of 14:52, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~2arq.~~png~~\|~~left~~\|200px]]	+	==Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh==
		+	<StructureSection load='2arq' size='340' side='right' caption='[[2arq]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2arq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARQ FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jrr\|1jrr]], [[2arr\|2arr]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2arq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2arq RCSB], [http://www.ebi.ac.uk/pdbsum/2arq PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PAI2_HUMAN PAI2_HUMAN]] Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2arq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The serine protease inhibitor (serpin) superfamily is involved in a wide range of cellular processes including fibrinolysis, angiogenesis, apoptosis, inflammation, metastasis and viral pathogenesis. Here, we investigate the unique mousetrap inhibition mechanism of serpins through saturation mutagenesis of the P8 residue for a typical family member, plasminogen activator inhibitor-2 (PAI-2). A number of studies have proposed an important role for the P8 residue in the efficient insertion and stabilisation of the cleaved reactive centre loop (RCL), which is a key event in the serpin inhibitory mechanism. The importance of this residue for inhibition of the PAI-2 protease target urinary plasminogen activator (urokinase, uPA) is confirmed, although a high degree of tolerance to P8 substitution is observed. Out of 19 possible PAI-2 P8 mutants, 16 display inhibitory activities within an order of magnitude of the wild-type P8 Thr species. Crystal structures of complexes between PAI-2 and RCL-mimicking peptides with P8 Met or Asp mutations are determined, and structural comparison with the wild-type complex substantiates the ability of the S8 pocket to accommodate disparate side-chains. These data indicate that the identity of the P8 residue is not a determinant of efficient RCL insertion, and provide further evidence for functional plasticity of key residues within enzyme structures. Poor correlation of observed PAI-2 P8 mutant activities with a range of physicochemical, evolutionary and thermodynamic predictive indices highlights the practical limitations of existing approaches to predicting the molecular phenotype of protein variants.

-	~~{{STRUCTURE_2arq\| PDB=2arq \| SCENE= }}~~	+	Plasminogen activator inhibitor-2 is highly tolerant to P8 residue substitution--implications for serpin mechanistic model and prediction of nsSNP activities.,Di Giusto DA, Sutherland AP, Jankova L, Harrop SJ, Curmi PM, King GC J Mol Biol. 2005 Nov 11;353(5):1069-80. Epub 2005 Sep 22. PMID:16214170<ref>PMID:16214170</ref>

-	~~===Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16214170}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2arq]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA].~~	+

	==See Also==		==See Also==
	*[[Plasminogen activator inhibitor\|Plasminogen activator inhibitor]]		*[[Plasminogen activator inhibitor\|Plasminogen activator inhibitor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016214170<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Curmi, P M.]]	+	[[Category: Curmi, P M]]
-	[[Category: Giusto, D A.Di.]]	+	[[Category: Giusto, D A.Di]]
-	[[Category: Harrop, S J.]]	+	[[Category: Harrop, S J]]
-	[[Category: Jankova, L.]]	+	[[Category: Jankova, L]]
-	[[Category: King, G C.]]	+	[[Category: King, G C]]
-	[[Category: Sutherland, A P.]]	+	[[Category: Sutherland, A P]]
	[[Category: Hydrolase inhibitor-peptide complex]]		[[Category: Hydrolase inhibitor-peptide complex]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Peptide binding]]		[[Category: Peptide binding]]
	[[Category: Serpin]]		[[Category: Serpin]]

OCA at 18:01, 20 October 2012

2012-10-20T18:01:33Z

←Older revision		Revision as of 18:01, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2arq]] is a 2 chain structure ~~of [[Plasminogen activator inhibitor]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA].	+	[[2arq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA].

	==See Also==		==See Also==

OCA: Protected "2arq" [edit=sysop:move=sysop]

2012-07-27T02:45:01Z

Protected "2arq" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:45, 27 July 2012

OCA at 02:44, 27 July 2012

2012-07-27T02:44:59Z

←Older revision		Revision as of 02:44, 27 July 2012
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-	{{Seed}}
	[[Image:2arq.png\|left\|200px]]		[[Image:2arq.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2arq\| PDB=2arq \| SCENE= }}		{{STRUCTURE_2arq\| PDB=2arq \| SCENE= }}

	===Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh===		===Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16214170}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16214170 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16214170}}		{{ABSTRACT_PUBMED_16214170}}

	==About this Structure==		==About this Structure==
-	~~2ARQ~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA].	+	[[2arq]] is a 2 chain structure of [[Plasminogen activator inhibitor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA].
		+
		+	==See Also==
		+	*[[Plasminogen activator inhibitor\|Plasminogen activator inhibitor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16214170~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016214170</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Curmi, P M.]]		[[Category: Curmi, P M.]]
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	[[Category: King, G C.]]		[[Category: King, G C.]]
	[[Category: Sutherland, A P.]]		[[Category: Sutherland, A P.]]
		+	[[Category: Hydrolase inhibitor-peptide complex]]
		+	[[Category: Inhibitor]]
	[[Category: Peptide binding]]		[[Category: Peptide binding]]
	[[Category: Serpin]]		[[Category: Serpin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:11:36 2009''

OCA at 17:11, 17 February 2009

2009-02-17T17:11:37Z

←Older revision		Revision as of 17:11, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ARQ is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA].	+	2ARQ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARQ OCA].

	==Reference==		==Reference==
-	Plasminogen activator inhibitor-2 is highly tolerant to P8 residue substitution--implications for serpin mechanistic model and prediction of nsSNP activities., Di Giusto DA, Sutherland AP, Jankova L, Harrop SJ, Curmi PM, King GC, J Mol Biol. 2005 Nov 11;353(5):1069-80. Epub 2005 Sep 22. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16214170 16214170]~~	+	<ref group="xtra">PMID:16214170</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Curmi, P M.]]		[[Category: Curmi, P M.]]
	[[Category: Giusto, D A.Di.]]		[[Category: Giusto, D A.Di.]]
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	[[Category: Serpin]]		[[Category: Serpin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 03:~~19:~~58 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:11:36 2009''