2auo - Revision history

OCA at 07:29, 23 August 2023

2023-08-23T07:29:59Z

←Older revision		Revision as of 07:29, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2auo' size='340' side='right'caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='2auo' size='340' side='right'caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anadara_inaequivalvis Anadara inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>~~, ~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.53Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3sdh\|3sdh]]~~, ~~[[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [https://pdbe.org/2auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [https://www.ebi.ac.uk/pdbsum/2auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2auo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [https://pdbe.org/2auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [https://www.ebi.ac.uk/pdbsum/2auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2auo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GLB1_ANAIN GLB1_ANAIN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Anadara inaequivalvis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bonham~~, M A~~]]	+	[[Category: Bonham MA]]
-	[[Category: Gibson~~, Q H~~]]	+	[[Category: Gibson QH]]
-	[[Category: Knapp~~, J E~~]]	+	[[Category: Knapp JE]]
-	[[Category: Nichols~~, J C~~]]	+	[[Category: Nichols JC]]
-	[[Category: Royer~~, W E]]~~	+	[[Category: Royer Jr WE]]
-	~~[[Category: Allostery]]~~	+
-	~~[[Category: Oxygen affinity]]~~	+
-	~~[[Category: Oxygen storage-transport complex]]~~	+
-	~~[[Category: Oxygen transport~~]]	+

OCA at 17:12, 20 October 2021

2021-10-20T17:12:20Z

←Older revision		Revision as of 17:12, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='2auo' size='340' side='right'caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='2auo' size='340' side='right'caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure ~~with sequence from [https://en.wikipedia.org/wiki/Anain Anain]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 ANAIN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [https://pdbe.org/2auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [https://www.ebi.ac.uk/pdbsum/2auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2auo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [https://pdbe.org/2auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [https://www.ebi.ac.uk/pdbsum/2auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2auo ProSAT]</span></td></tr>
	</table>		</table>
Line 35:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anain]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bonham, M A]]		[[Category: Bonham, M A]]

OCA at 08:38, 27 January 2021

2021-01-27T08:38:23Z

←Older revision		Revision as of 08:38, 27 January 2021
Line 1:		Line 1:

	==Residue F4 plays a key role in modulating the oxygen affinity and cooperatrivity in Scapharca dimeric hemoglobin==		==Residue F4 plays a key role in modulating the oxygen affinity and cooperatrivity in Scapharca dimeric hemoglobin==
-	<StructureSection load='2auo' size='340' side='right' caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>	+	<StructureSection load='2auo' size='340' side='right'caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 ANAIN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 ANAIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [~~http~~://pdbe.org/2auo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2auo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2auo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [https://pdbe.org/2auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [https://www.ebi.ac.uk/pdbsum/2auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2auo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Anain]]		[[Category: Anain]]
		+	[[Category: Large Structures]]
	[[Category: Bonham, M A]]		[[Category: Bonham, M A]]
	[[Category: Gibson, Q H]]		[[Category: Gibson, Q H]]

OCA at 07:11, 9 May 2018

2018-05-09T07:11:08Z

←Older revision		Revision as of 07:11, 9 May 2018
Line 1:		Line 1:
		+
	==Residue F4 plays a key role in modulating the oxygen affinity and cooperatrivity in Scapharca dimeric hemoglobin==		==Residue F4 plays a key role in modulating the oxygen affinity and cooperatrivity in Scapharca dimeric hemoglobin==
	<StructureSection load='2auo' size='340' side='right' caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='2auo' size='340' side='right' caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 ANAIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 ANAIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [http://pdbe.org/2auo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [http://www.ebi.ac.uk/pdbsum/2auo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [http://pdbe.org/2auo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [http://www.ebi.ac.uk/pdbsum/2auo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2auo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2auo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2auo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2auo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:57, 11 September 2015

2015-09-11T16:57:02Z

←Older revision		Revision as of 16:57, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2auo' size='340' side='right' caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='2auo' size='340' side='right' caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Scapharca_inaequivalvis Scapharca inaequivalvis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 ~~Scapharca inaequivalvis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 ANAIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [http://www.ebi.ac.uk/pdbsum/2auo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [http://pdbe.org/2auo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [http://www.ebi.ac.uk/pdbsum/2auo PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2auo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Scapharca inaequivalvis~~]]	+	[[Category: Anain]]
	[[Category: Bonham, M A]]		[[Category: Bonham, M A]]
	[[Category: Gibson, Q H]]		[[Category: Gibson, Q H]]

OCA at 09:31, 8 January 2015

2015-01-08T09:31:48Z

←Older revision		Revision as of 09:31, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 Scapharca inaequivalvis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 Scapharca inaequivalvis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [http://www.ebi.ac.uk/pdbsum/2auo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [http://www.ebi.ac.uk/pdbsum/2auo PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Scapharca inaequivalvis]]		[[Category: Scapharca inaequivalvis]]
-	[[Category: Bonham, M A.]]	+	[[Category: Bonham, M A]]
-	[[Category: Gibson, Q H.]]	+	[[Category: Gibson, Q H]]
-	[[Category: Knapp, J E.]]	+	[[Category: Knapp, J E]]
-	[[Category: Nichols, J C.]]	+	[[Category: Nichols, J C]]
-	[[Category: Royer, W E.]]	+	[[Category: Royer, W E]]
	[[Category: Allostery]]		[[Category: Allostery]]
	[[Category: Oxygen affinity]]		[[Category: Oxygen affinity]]
	[[Category: Oxygen storage-transport complex]]		[[Category: Oxygen storage-transport complex]]
	[[Category: Oxygen transport]]		[[Category: Oxygen transport]]

OCA at 02:30, 29 September 2014

2014-09-29T02:30:07Z

←Older revision		Revision as of 02:30, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2auo.~~png~~\|~~left~~\|200px]]	+	==Residue F4 plays a key role in modulating the oxygen affinity and cooperatrivity in Scapharca dimeric hemoglobin==
		+	<StructureSection load='2auo' size='340' side='right' caption='[[2auo]], [[Resolution\|resolution]] 1.53Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2auo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[2hbi\|2hbi]], [[3hbi\|3hbi]], [[4sdh\|4sdh]], [[2aup\|2aup]], [[2auq\|2auq]], [[2aur\|2aur]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HbI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6561 Scapharca inaequivalvis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2auo RCSB], [http://www.ebi.ac.uk/pdbsum/2auo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2auo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Residue F4 (Phe 97) undergoes the most dramatic ligand-linked transition in Scapharca dimeric hemoglobin, with its packing in the heme pocket in the unliganded (T) state suggested to be a primary determinant of its low affinity. Mutation of Phe 97 to Leu (previously reported), Val, and Tyr increases oxygen affinity from 8- to 100-fold over that of the wild type. The crystal structures of F97L and F97V show side chain packing in the heme pocket for both R and T state structures. In contrast, in the highest-affinity mutation, F97Y, the tyrosine side chain remains in the interface (high-affinity conformation) even in the unliganded state. Comparison of these mutations reveals a correlation between side chain packing in the heme pocket and oxygen affinity, indicating that greater mass in the heme pocket lowers oxygen affinity due to impaired movement of the heme iron into the heme plane. The results indicate that a key hydrogen bond, previously hypothesized to have a central role in regulation of oxygen affinity, plays at most only a small role in dictating ligand affinity. Equivalent mutations in sperm whale myoglobin alter ligand affinity by only 5-fold. The dramatically different responses to mutations at the F4 position result from subtle, but functionally critical, stereochemical differences. In myoglobin, an eclipsed orientation of the proximal His relative to the A and C pyrrole nitrogen atoms provides a significant barrier for high-affinity ligand binding. In contrast, the staggered orientation of the proximal histidine found in liganded HbI renders its ligand affinity much more susceptible to packing contacts between F4 and the heme group. These results highlight very different strategies used by cooperative hemoglobins in molluscs and mammals to control ligand affinity by modulation of the stereochemistry on the proximal side of the heme.

-	~~{{STRUCTURE_2auo\| PDB=2auo \| SCENE= }}~~	+	Residue F4 plays a key role in modulating oxygen affinity and cooperativity in Scapharca dimeric hemoglobin.,Knapp JE, Bonham MA, Gibson QH, Nichols JC, Royer WE Jr Biochemistry. 2005 Nov 8;44(44):14419-30. PMID:16262242<ref>PMID:16262242</ref>

-	~~===Residue F4 plays~~ a ~~key role in modulating~~ the ~~oxygen affinity and cooperatrivity in Scapharca dimeric hemoglobin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16262242}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2auo]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA].~~	+

	==See Also==		==See Also==
-	*[[Hemoglobin\|Hemoglobin]]	+	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016262242<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Scapharca inaequivalvis]]		[[Category: Scapharca inaequivalvis]]
	[[Category: Bonham, M A.]]		[[Category: Bonham, M A.]]

OCA at 20:27, 20 October 2012

2012-10-20T20:27:50Z

←Older revision		Revision as of 20:27, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2auo]] is a 2 chain structure ~~of [[Hemoglobin]]~~ with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA].	+	[[2auo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA].

	==See Also==		==See Also==

OCA: Protected "2auo" [edit=sysop:move=sysop]

2012-07-27T10:33:54Z

Protected "2auo" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:33, 27 July 2012

OCA at 10:33, 27 July 2012

2012-07-27T10:33:52Z

←Older revision		Revision as of 10:33, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2auo.png\|left\|200px]]		[[Image:2auo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2auo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2auo\| PDB=2auo \| SCENE= }}		{{STRUCTURE_2auo\| PDB=2auo \| SCENE= }}

	===Residue F4 plays a key role in modulating the oxygen affinity and cooperatrivity in Scapharca dimeric hemoglobin===		===Residue F4 plays a key role in modulating the oxygen affinity and cooperatrivity in Scapharca dimeric hemoglobin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16262242}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16262242 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16262242}}		{{ABSTRACT_PUBMED_16262242}}

	==About this Structure==		==About this Structure==
-	~~2AUO~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA].	+	[[2auo]] is a 2 chain structure of [[Hemoglobin]] with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUO OCA].
		+
		+	==See Also==
		+	*[[Hemoglobin\|Hemoglobin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16262242~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016262242</ref><references group="xtra"/>
	[[Category: Scapharca inaequivalvis]]		[[Category: Scapharca inaequivalvis]]
	[[Category: Bonham, M A.]]		[[Category: Bonham, M A.]]
	[[Category: Gibson, Q H.]]		[[Category: Gibson, Q H.]]
-	[[Category: Jr., W E.Royer.]]
	[[Category: Knapp, J E.]]		[[Category: Knapp, J E.]]
	[[Category: Nichols, J C.]]		[[Category: Nichols, J C.]]
		+	[[Category: Royer, W E.]]
	[[Category: Allostery]]		[[Category: Allostery]]
	[[Category: Oxygen affinity]]		[[Category: Oxygen affinity]]
		+	[[Category: Oxygen storage-transport complex]]
	[[Category: Oxygen transport]]		[[Category: Oxygen transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:15:24 2009''