2axj - Revision history

OCA at 07:31, 23 August 2023

2023-08-23T07:31:14Z

←Older revision		Revision as of 07:31, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2axj' size='340' side='right'caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2axj' size='340' side='right'caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~2axh~~\|~~2axh~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [https://pdbe.org/2axj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [https://www.ebi.ac.uk/pdbsum/2axj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [https://pdbe.org/2axj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [https://www.ebi.ac.uk/pdbsum/2axj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axj ProSAT]</span></td></tr>
	</table>		</table>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eisele, L]]	+	[[Category: Eisele L]]
-	[[Category: Guo, Y]]	+	[[Category: Guo Y]]
-	[[Category: Li, H]]	+	[[Category: Li H]]
-	[[Category: Li, Y]]	+	[[Category: Li Y]]
-	[[Category: Li, Z]]	+	[[Category: Li Z]]
-	[[Category: Vranken, S ~~Van~~]]	+	[[Category: Van Vranken S]]
-	[[Category: Zhao, Y]]	+	[[Category: Zhao Y]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Tcr~~]]	+

OCA at 09:41, 5 May 2021

2021-05-05T09:41:21Z

←Older revision		Revision as of 09:41, 5 May 2021
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	<StructureSection load='2axj' size='340' side='right'caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2axj' size='340' side='right'caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axh\|2axh]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2axh\|2axh]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [~~http~~://pdbe.org/2axj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2axj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2axj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [https://pdbe.org/2axj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [https://www.ebi.ac.uk/pdbsum/2axj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axj ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[T-cell receptor\|T-cell receptor]]	+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:12, 24 July 2019

2019-07-24T09:12:12Z

←Older revision		Revision as of 09:12, 24 July 2019
Line 1:		Line 1:

	==Crystal structures of T cell receptor beta chains related to rheumatoid arthritis==		==Crystal structures of T cell receptor beta chains related to rheumatoid arthritis==
-	<StructureSection load='2axj' size='340' side='right' caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='2axj' size='340' side='right'caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 2axj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2axj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[T-cell receptor\|T-cell receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Eisele, L]]		[[Category: Eisele, L]]
	[[Category: Guo, Y]]		[[Category: Guo, Y]]

OCA at 10:54, 12 October 2017

2017-10-12T10:54:35Z

←Older revision		Revision as of 10:54, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal structures of T cell receptor beta chains related to rheumatoid arthritis==		==Crystal structures of T cell receptor beta chains related to rheumatoid arthritis==
	<StructureSection load='2axj' size='340' side='right' caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2axj' size='340' side='right' caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axh\|2axh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axh\|2axh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [http://pdbe.org/2axj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [http://www.ebi.ac.uk/pdbsum/2axj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [http://pdbe.org/2axj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [http://www.ebi.ac.uk/pdbsum/2axj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2axj ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 2axj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2axj" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[T-cell receptor\|T-cell receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:55, 9 February 2016

2016-02-09T14:55:30Z

←Older revision		Revision as of 14:55, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2axj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:20, 10 September 2015

2015-09-10T23:20:57Z

←Older revision		Revision as of 23:20, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2axj' size='340' side='right' caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2axj' size='340' side='right' caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axh\|2axh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axh\|2axh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [http://www.ebi.ac.uk/pdbsum/2axj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [http://pdbe.org/2axj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [http://www.ebi.ac.uk/pdbsum/2axj PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2axj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Eisele, L]]		[[Category: Eisele, L]]
	[[Category: Guo, Y]]		[[Category: Guo, Y]]

OCA at 10:13, 8 January 2015

2015-01-08T10:13:03Z

←Older revision		Revision as of 10:13, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axh\|2axh]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axh\|2axh]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [http://www.ebi.ac.uk/pdbsum/2axj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [http://www.ebi.ac.uk/pdbsum/2axj PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Eisele, L.]]	+	[[Category: Eisele, L]]
-	[[Category: Guo, Y.]]	+	[[Category: Guo, Y]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Li, Y.]]	+	[[Category: Li, Y]]
-	[[Category: Li, Z.]]	+	[[Category: Li, Z]]
-	[[Category: Vranken, S Van.]]	+	[[Category: Vranken, S Van]]
-	[[Category: Zhao, Y.]]	+	[[Category: Zhao, Y]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Tcr]]		[[Category: Tcr]]

OCA at 00:57, 30 September 2014

2014-09-30T00:57:56Z

←Older revision		Revision as of 00:57, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2axj.~~png~~\|~~left~~\|200px]]	+	==Crystal structures of T cell receptor beta chains related to rheumatoid arthritis==
		+	<StructureSection load='2axj' size='340' side='right' caption='[[2axj]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axh\|2axh]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axj RCSB], [http://www.ebi.ac.uk/pdbsum/2axj PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structures of the Vbeta17+ beta chains of two human T cell receptors (TCRs), originally derived from the synovial fluid (SF4) and tissue (C5-1) of a patient with rheumatoid arthritis (RA), have been determined in native (SF4) and mutant (C5-1(F104-->Y/C187-->S)) forms, respectively. These TCR beta chains form homo-dimers in solution and in crystals. Structural comparison reveals that the main-chain conformations in the CDR regions of the C5-1 and SF4 Vbeta17 closely resemble those of a Vbeta17 JM22 in a bound form; however, the CDR3 region shows different conformations among these three Vbeta17 structures. At the side-chain level, conformational differences were observed at the CDR2 regions between our two ligand-free forms and the bound JM22 form. Other significant differences were observed at the Vbeta regions 8-12, 40-44, and 82-88 between C5-1/SF4 and JM22 Vbeta17, implying that there is considerable variability in the structures of very similar beta chains. Structural alignments also reveal a considerable variation in the Vbeta-Cbeta associations, and this may affect ligand recognition. The crystal structures also provide insights into the structure basis of T cell recognition of Mycoplasma arthritidis mitogen (MAM), a superantigen that may be implicated in the development of human RA. Structural comparisons of the Vbeta domains of known TCR structures indicate that there are significant similarities among Vbeta regions that are MAM-reactive, whereas there appear to be significant structural differences among those Vbeta regions that lack MAM-reactivity. It further reveals that CDR2 and framework region (FR) 3 are likely to account for the binding of TCR to MAM.

-	~~{{STRUCTURE_2axj\| PDB=2axj \| SCENE= }}~~	+	Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.,Li H, Van Vranken S, Zhao Y, Li Z, Guo Y, Eisele L, Li Y Protein Sci. 2005 Dec;14(12):3025-38. Epub 2005 Oct 31. PMID:16260763<ref>PMID:16260763</ref>

-	~~===Crystal structures~~ of ~~T cell receptor beta chains related to rheumatoid arthritis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16260763}}~~	+	==See Also==
-		+	*[[T-cell receptor\|T-cell receptor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2axj~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016260763<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eisele, L.]]		[[Category: Eisele, L.]]

OCA: Protected "2axj" [edit=sysop:move=sysop]

2013-01-06T10:16:00Z

Protected "2axj" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:16, 6 January 2013

OCA at 10:15, 6 January 2013

2013-01-06T10:15:57Z

←Older revision		Revision as of 10:15, 6 January 2013
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-	{{Seed}}
	[[Image:2axj.png\|left\|200px]]		[[Image:2axj.png\|left\|200px]]

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	{{STRUCTURE_2axj\| PDB=2axj \| SCENE= }}		{{STRUCTURE_2axj\| PDB=2axj \| SCENE= }}

	===Crystal structures of T cell receptor beta chains related to rheumatoid arthritis===		===Crystal structures of T cell receptor beta chains related to rheumatoid arthritis===

-
-	<!--
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	{{ABSTRACT_PUBMED_16260763}}		{{ABSTRACT_PUBMED_16260763}}

	==About this Structure==		==About this Structure==
-	~~2AXJ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA].	+	[[2axj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXJ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16260763~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016260763</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eisele, L.]]		[[Category: Eisele, L.]]
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	[[Category: Vranken, S Van.]]		[[Category: Vranken, S Van.]]
	[[Category: Zhao, Y.]]		[[Category: Zhao, Y.]]
		+	[[Category: Immune system]]
	[[Category: Tcr]]		[[Category: Tcr]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:38:33 2009''