2axv - Revision history

OCA at 09:14, 14 February 2024

2024-02-14T09:14:39Z

←Older revision		Revision as of 09:14, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='2axv' size='340' side='right'caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2axv' size='340' side='right'caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXV FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2aw6\|2aw6]]~~, [[~~2awi~~\|~~2awi~~]]~~, [[2axu\|2axu]], [[2axz\|2axz]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [https://pdbe.org/2axv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [https://www.ebi.ac.uk/pdbsum/2axv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [https://pdbe.org/2axv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [https://www.ebi.ac.uk/pdbsum/2axv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q04114_ENTFL Q04114_ENTFL]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2axv ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2axv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Many bacterial activities, including expression of virulence factors, horizontal genetic transfer, and production of antibiotics, are controlled by intercellular signaling using small molecules. To date, understanding of the molecular mechanisms of peptide-mediated cell-cell signaling has been limited by a dearth of published information about the molecular structures of the signaling components. Here, we present the molecular structure of PrgX, a DNA- and peptide-binding protein that regulates expression of the conjugative transfer genes of the Enterococcus faecalis plasmid pCF10 in response to an intercellular peptide pheromone signal. Comparison of the structures of PrgX and the PrgX/pheromone complex suggests that pheromone binding destabilizes PrgX tetramers, opening a 70-bp pCF10 DNA loop required for conjugation repression.
-
-	Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.,Shi K, Brown CK, Gu ZY, Kozlowicz BK, Dunny GM, Ohlendorf DH, Earhart CA Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18596-601. Epub 2005 Dec 8. PMID:16339309<ref>PMID:16339309</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2axv" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Enterococcus ~~proteiformis thiercelin and jouhaud 1903~~]]	+	[[Category: Enterococcus faecalis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brown~~, C K~~]]	+	[[Category: Brown CK]]
-	[[Category: Dunny~~, G M~~]]	+	[[Category: Dunny GM]]
-	[[Category: Earhart~~, C A~~]]	+	[[Category: Earhart CA]]
-	[[Category: Gu~~, Z Y~~]]	+	[[Category: Gu ZY]]
-	[[Category: Kozlowicz~~, B K~~]]	+	[[Category: Kozlowicz BK]]
-	[[Category: Ohlendorf~~, D H~~]]	+	[[Category: Ohlendorf DH]]
-	[[Category: Shi, K]]	+	[[Category: Shi K]]
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Pheromone]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 09:41, 5 May 2021

2021-05-05T09:41:26Z

←Older revision		Revision as of 09:41, 5 May 2021
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	<StructureSection load='2axv' size='340' side='right'caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2axv' size='340' side='right'caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXV FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw6\|2aw6]], [[2awi\|2awi]], [[2axu\|2axu]], [[2axz\|2axz]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2aw6\|2aw6]], [[2awi\|2awi]], [[2axu\|2axu]], [[2axz\|2axz]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [~~http~~://pdbe.org/2axv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2axv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2axv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [https://pdbe.org/2axv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [https://www.ebi.ac.uk/pdbsum/2axv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:10, 24 July 2019

2019-07-24T07:10:28Z

←Older revision		Revision as of 07:10, 24 July 2019
Line 1:		Line 1:

	==Structure of PrgX Y153C mutant==		==Structure of PrgX Y153C mutant==
-	<StructureSection load='2axv' size='340' side='right' caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='2axv' size='340' side='right'caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXV FirstGlance]. <br>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]		[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
		+	[[Category: Large Structures]]
	[[Category: Brown, C K]]		[[Category: Brown, C K]]
	[[Category: Dunny, G M]]		[[Category: Dunny, G M]]

OCA at 07:25, 9 May 2018

2018-05-09T07:25:53Z

←Older revision		Revision as of 07:25, 9 May 2018
Line 1:		Line 1:
		+
	==Structure of PrgX Y153C mutant==		==Structure of PrgX Y153C mutant==
	<StructureSection load='2axv' size='340' side='right' caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2axv' size='340' side='right' caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw6\|2aw6]], [[2awi\|2awi]], [[2axu\|2axu]], [[2axz\|2axz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw6\|2aw6]], [[2awi\|2awi]], [[2axu\|2axu]], [[2axz\|2axz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [http://pdbe.org/2axv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [http://www.ebi.ac.uk/pdbsum/2axv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [http://pdbe.org/2axv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [http://www.ebi.ac.uk/pdbsum/2axv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2axv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:24, 8 February 2016

2016-02-08T03:24:35Z

←Older revision		Revision as of 03:24, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2axv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:24, 10 September 2015

2015-09-10T07:24:20Z

←Older revision		Revision as of 07:24, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2axv' size='340' side='right' caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2axv' size='340' side='right' caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_faecalis Enterococcus faecalis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw6\|2aw6]], [[2awi\|2awi]], [[2axu\|2axu]], [[2axz\|2axz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw6\|2aw6]], [[2awi\|2awi]], [[2axu\|2axu]], [[2axz\|2axz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [http://www.ebi.ac.uk/pdbsum/2axv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [http://pdbe.org/2axv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [http://www.ebi.ac.uk/pdbsum/2axv PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2axv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Enterococcus ~~faecalis~~]]	+	[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
	[[Category: Brown, C K]]		[[Category: Brown, C K]]
	[[Category: Dunny, G M]]		[[Category: Dunny, G M]]

OCA at 09:46, 8 January 2015

2015-01-08T09:46:55Z

←Older revision		Revision as of 09:46, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw6\|2aw6]], [[2awi\|2awi]], [[2axu\|2axu]], [[2axz\|2axz]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw6\|2aw6]], [[2awi\|2awi]], [[2axu\|2axu]], [[2axz\|2axz]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [http://www.ebi.ac.uk/pdbsum/2axv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [http://www.ebi.ac.uk/pdbsum/2axv PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Enterococcus faecalis]]		[[Category: Enterococcus faecalis]]
-	[[Category: Brown, C K.]]	+	[[Category: Brown, C K]]
-	[[Category: Dunny, G M.]]	+	[[Category: Dunny, G M]]
-	[[Category: Earhart, C A.]]	+	[[Category: Earhart, C A]]
-	[[Category: Gu, Z Y.]]	+	[[Category: Gu, Z Y]]
-	[[Category: Kozlowicz, B K.]]	+	[[Category: Kozlowicz, B K]]
-	[[Category: Ohlendorf, D H.]]	+	[[Category: Ohlendorf, D H]]
-	[[Category: Shi, K.]]	+	[[Category: Shi, K]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
	[[Category: Pheromone]]		[[Category: Pheromone]]
	[[Category: Repressor]]		[[Category: Repressor]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 00:33, 30 September 2014

2014-09-30T00:33:23Z

←Older revision		Revision as of 00:33, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2axv.~~png~~\|~~left~~\|200px]]	+	==Structure of PrgX Y153C mutant==
		+	<StructureSection load='2axv' size='340' side='right' caption='[[2axv]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2aw6\|2aw6]], [[2awi\|2awi]], [[2axu\|2axu]], [[2axz\|2axz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [http://www.ebi.ac.uk/pdbsum/2axv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many bacterial activities, including expression of virulence factors, horizontal genetic transfer, and production of antibiotics, are controlled by intercellular signaling using small molecules. To date, understanding of the molecular mechanisms of peptide-mediated cell-cell signaling has been limited by a dearth of published information about the molecular structures of the signaling components. Here, we present the molecular structure of PrgX, a DNA- and peptide-binding protein that regulates expression of the conjugative transfer genes of the Enterococcus faecalis plasmid pCF10 in response to an intercellular peptide pheromone signal. Comparison of the structures of PrgX and the PrgX/pheromone complex suggests that pheromone binding destabilizes PrgX tetramers, opening a 70-bp pCF10 DNA loop required for conjugation repression.

-	~~{{STRUCTURE_2axv\| PDB=2axv \| SCENE= }}~~	+	Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.,Shi K, Brown CK, Gu ZY, Kozlowicz BK, Dunny GM, Ohlendorf DH, Earhart CA Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18596-601. Epub 2005 Dec 8. PMID:16339309<ref>PMID:16339309</ref>

-	~~===Structure~~ of ~~PrgX Y153C mutant===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16339309}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2axv]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterococcus_faecalis Enterococcus faecalis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016339309<~~/~~ref~~><~~ref group="xtra">PMID:016300404</ref><references group="xtra"~~/>	+
	[[Category: Enterococcus faecalis]]		[[Category: Enterococcus faecalis]]
	[[Category: Brown, C K.]]		[[Category: Brown, C K.]]

OCA: Protected "2axv" [edit=sysop:move=sysop]

2013-01-06T09:55:37Z

Protected "2axv" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:55, 6 January 2013

OCA at 09:55, 6 January 2013

2013-01-06T09:55:35Z

←Older revision		Revision as of 09:55, 6 January 2013
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-	{{Seed}}
	[[Image:2axv.png\|left\|200px]]		[[Image:2axv.png\|left\|200px]]

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	{{STRUCTURE_2axv\| PDB=2axv \| SCENE= }}		{{STRUCTURE_2axv\| PDB=2axv \| SCENE= }}

	===Structure of PrgX Y153C mutant===		===Structure of PrgX Y153C mutant===

-
-	<!--
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	{{ABSTRACT_PUBMED_16339309}}		{{ABSTRACT_PUBMED_16339309}}

	==About this Structure==		==About this Structure==
-	~~2AXV~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA].	+	[[2axv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16339309~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016339309</ref><ref group="xtra">PMID:016300404</ref><references group="xtra"/>
	[[Category: Enterococcus faecalis]]		[[Category: Enterococcus faecalis]]
	[[Category: Brown, C K.]]		[[Category: Brown, C K.]]
Line 33:		Line 21:
	[[Category: Shi, K.]]		[[Category: Shi, K.]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
-	[[Category: Domain]]
	[[Category: Pheromone]]		[[Category: Pheromone]]
	[[Category: Repressor]]		[[Category: Repressor]]
-		+	[[Category: Transcription]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 18:27:18 2009''~~	+