2ay3 - Revision history

OCA at 06:41, 9 August 2023

2023-08-09T06:41:57Z

←Older revision		Revision as of 06:41, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='2ay3' size='340' side='right'caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ay3' size='340' side='right'caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_17741 Atcc 17741~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MPP:3~~-(3,4~~-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:/~~/~~en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase]~~, ~~with EC number [https~~:~~//www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [https://pdbe.org/2ay3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ay3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ay3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [https://pdbe.org/2ay3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ay3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ay3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TYRB_PARDE TYRB_PARDE]] Shows activities toward both dicarboxylic and aromatic substrates.	+	[https://www.uniprot.org/uniprot/TYRB_PARDE TYRB_PARDE] Shows activities toward both dicarboxylic and aromatic substrates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aromatic-amino-acid transaminase]]
-	[[Category: Atcc 17741]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hirotsu, K~~]]	+	[[Category: Paracoccus denitrificans]]
-	[[Category: ~~Kagamiyama, H~~]]	+	[[Category: Hirotsu K]]
-	[[Category: ~~Okamoto, A~~]]	+	[[Category: Kagamiyama H]]
-	[[Category: ~~Aminotransferase~~]]	+	[[Category: Okamoto A]]

OCA at 06:37, 6 October 2021

2021-10-06T06:37:31Z

←Older revision		Revision as of 06:37, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='2ay3' size='340' side='right'caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ay3' size='340' side='right'caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_17741 Atcc 17741]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_17741 Atcc 17741]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [~~http~~://pdbe.org/2ay3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ay3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ay3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [https://pdbe.org/2ay3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ay3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ay3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TYRB_PARDE TYRB_PARDE]] Shows activities toward both dicarboxylic and aromatic substrates.	+	[[https://www.uniprot.org/uniprot/TYRB_PARDE TYRB_PARDE]] Shows activities toward both dicarboxylic and aromatic substrates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:42, 11 December 2019

2019-12-11T19:42:06Z

←Older revision		Revision as of 19:42, 11 December 2019
Line 1:		Line 1:

	==AROMATIC AMINO ACID AMINOTRANSFERASE WITH 3-(3,4-DIMETHOXYPHENYL)PROPIONIC ACID==		==AROMATIC AMINO ACID AMINOTRANSFERASE WITH 3-(3,4-DIMETHOXYPHENYL)PROPIONIC ACID==
-	<StructureSection load='2ay3' size='340' side='right' caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2ay3' size='340' side='right'caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_17741 Atcc 17741]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_17741 Atcc 17741]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/2ay3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/2ay3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2ay3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ay3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminotransferase 3D structures\|Aminotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	[[Category: Aromatic-amino-acid transaminase]]		[[Category: Aromatic-amino-acid transaminase]]
	[[Category: Atcc 17741]]		[[Category: Atcc 17741]]
		+	[[Category: Large Structures]]
	[[Category: Hirotsu, K]]		[[Category: Hirotsu, K]]
	[[Category: Kagamiyama, H]]		[[Category: Kagamiyama, H]]
	[[Category: Okamoto, A]]		[[Category: Okamoto, A]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]

OCA at 07:04, 29 November 2017

2017-11-29T07:04:08Z

←Older revision		Revision as of 07:04, 29 November 2017
Line 1:		Line 1:
		+
	==AROMATIC AMINO ACID AMINOTRANSFERASE WITH 3-(3,4-DIMETHOXYPHENYL)PROPIONIC ACID==		==AROMATIC AMINO ACID AMINOTRANSFERASE WITH 3-(3,4-DIMETHOXYPHENYL)PROPIONIC ACID==
	<StructureSection load='2ay3' size='340' side='right' caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ay3' size='340' side='right' caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [http://pdbe.org/2ay3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ay3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [http://pdbe.org/2ay3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ay3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ay3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2ay3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ay3" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:32, 8 February 2016

2016-02-08T01:32:55Z

←Older revision		Revision as of 01:32, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ay3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2ay3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ay3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:38, 10 September 2015

2015-09-10T06:38:07Z

←Older revision		Revision as of 06:38, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2ay3' size='340' side='right' caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ay3' size='340' side='right' caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Paracoccus_denitrificans Paracoccus denitrificans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_17741 Atcc 17741]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ay3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [http://pdbe.org/2ay3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ay3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ay3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Aromatic-amino-acid transaminase]]		[[Category: Aromatic-amino-acid transaminase]]
-	[[Category: ~~Paracoccus denitrificans~~]]	+	[[Category: Atcc 17741]]
	[[Category: Hirotsu, K]]		[[Category: Hirotsu, K]]
	[[Category: Kagamiyama, H]]		[[Category: Kagamiyama, H]]
	[[Category: Okamoto, A]]		[[Category: Okamoto, A]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]

OCA at 19:34, 24 December 2014

2014-12-24T19:34:54Z

←Older revision		Revision as of 19:34, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ay3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ay3 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TYRB_PARDE TYRB_PARDE]] Shows activities toward both dicarboxylic and aromatic substrates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Aromatic-amino-acid transaminase]]		[[Category: Aromatic-amino-acid transaminase]]
	[[Category: Paracoccus denitrificans]]		[[Category: Paracoccus denitrificans]]
-	[[Category: Hirotsu, K.]]	+	[[Category: Hirotsu, K]]
-	[[Category: Kagamiyama, H.]]	+	[[Category: Kagamiyama, H]]
-	[[Category: Okamoto, A.]]	+	[[Category: Okamoto, A]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]

OCA at 03:01, 30 September 2014

2014-09-30T03:01:27Z

←Older revision		Revision as of 03:01, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2ay3.~~png\|left~~\|200px]]	+	==AROMATIC AMINO ACID AMINOTRANSFERASE WITH 3-(3,4-DIMETHOXYPHENYL)PROPIONIC ACID==
		+	<StructureSection load='2ay3' size='340' side='right' caption='[[2ay3]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ay3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AY3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPP:3-(3,4-DIMETHOXYPHENYL)PROPIONIC+ACID'>MPP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-amino-acid_transaminase Aromatic-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.57 2.6.1.57] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ay3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ay3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ay3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/2ay3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Paracoccus denitrificans aromatic amino acid aminotransferase (EC 2. 6.1.57; pdAroAT) binds with a series of aliphatic monocarboxylates attached to the bulky hydrophobic groups. To analyze the properties of the active site in this enzyme, we determined the tertiary structures of pdAroAT complexed with nine different inhibitors. Comparison of these active site structures showed that the active site of pdAroAT consists of two parts with contrary properties: rigidity and flexibility. The regions that interact with the carboxylates and methylene chains of the inhibitors gave essentially the same structures among these complexes, exhibiting the rigid property, which would involve fixing the substrate at the proper orientation for efficient catalysis. The region that interacts with the terminal hydrophobic groups of the inhibitors gave versatile structures according to the structures of the terminal groups, showing that this region is structurally flexible. This is mainly achieved by the conformational versatility of the side chains of Asp15, Lys16, Asn142, Arg292, and Ser296. These residues formed in the active site hydrogen bond networks, which were adaptable for the structures of the terminal hydrophobic groups of the inhibitors, with a small deformation or partial destruction according to the shapes and sizes of the inhibitors. These observations illustrate how the flexibility and rigidity in the active site can be used for the substrate binding and recognition.

-	~~{{STRUCTURE_2ay3\| PDB=2ay3 \| SCENE= }}~~	+	The active site of Paracoccus denitrificans aromatic amino acid aminotransferase has contrary properties: flexibility and rigidity.,Okamoto A, Ishii S, Hirotsu K, Kagamiyama H Biochemistry. 1999 Jan 26;38(4):1176-84. PMID:9930977<ref>PMID:9930977</ref>

-	~~===AROMATIC AMINO ACID AMINOTRANSFERASE WITH 3-(3~~,~~4-DIMETHOXYPHENYL)PROPIONIC ACID===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9930977}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2ay3]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009930977<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Aromatic-amino-acid transaminase]]		[[Category: Aromatic-amino-acid transaminase]]
	[[Category: Paracoccus denitrificans]]		[[Category: Paracoccus denitrificans]]

OCA: Protected "2ay3" [edit=sysop:move=sysop]

2013-01-06T12:11:40Z

Protected "2ay3" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:11, 6 January 2013

OCA at 12:11, 6 January 2013

2013-01-06T12:11:38Z

←Older revision		Revision as of 12:11, 6 January 2013
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-	{{Seed}}
	[[Image:2ay3.png\|left\|200px]]		[[Image:2ay3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ay3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2ay3\| PDB=2ay3 \| SCENE= }}		{{STRUCTURE_2ay3\| PDB=2ay3 \| SCENE= }}

	===AROMATIC AMINO ACID AMINOTRANSFERASE WITH 3-(3,4-DIMETHOXYPHENYL)PROPIONIC ACID===		===AROMATIC AMINO ACID AMINOTRANSFERASE WITH 3-(3,4-DIMETHOXYPHENYL)PROPIONIC ACID===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9930977}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9930977 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9930977}}		{{ABSTRACT_PUBMED_9930977}}

	==About this Structure==		==About this Structure==
-	~~2AY3~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA].	+	[[2ay3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AY3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9930977~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009930977</ref><references group="xtra"/>
	[[Category: Aromatic-amino-acid transaminase]]		[[Category: Aromatic-amino-acid transaminase]]
	[[Category: Paracoccus denitrificans]]		[[Category: Paracoccus denitrificans]]
Line 30:		Line 18:
	[[Category: Okamoto, A.]]		[[Category: Okamoto, A.]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:50:47 2009''