2bdn - Revision history

OCA at 06:24, 3 April 2024

2024-04-03T06:24:10Z

←Older revision		Revision as of 06:24, 3 April 2024
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	<StructureSection load='2bdn' size='340' side='right'caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>		<StructureSection load='2bdn' size='340' side='right'caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [https://pdbe.org/2bdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [https://www.ebi.ac.uk/pdbsum/2bdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.53Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [https://pdbe.org/2bdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [https://www.ebi.ac.uk/pdbsum/2bdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.	+	[https://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bdn ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bdn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Monocyte chemoattractant proteins (MCPs) are cytokines that direct immune cells bearing appropriate receptors to sites of inflammation or injury and are therefore attractive therapeutic targets for inhibitory molecules. 11K2 is a blocking mouse monoclonal antibody active against several human and murine MCPs. A 2.5 A structure of the Fab fragment of this antibody in complex with human MCP-1 has been solved. The Fab blocks CCR2 receptor binding to MCP-1 through an adjacent but distinct binding site. The orientation of the Fab indicates that a single MCP-1 dimer will bind two 11K2 antibodies. Several key residues on the antibody and on human MCPs were predicted to be involved in antibody selectivity. Mutational analysis of these residues confirms their involvement in the antibody-chemokine interaction. In addition to mutations that decreased or disrupted binding, one antibody mutation resulted in a 70-fold increase in affinity for human MCP-2. A key residue missing in human MCP-3, a chemokine not recognized by the antibody, was identified and engineering the preferred residue into the chemokine conferred binding to the antibody.
-
-	Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody.,Reid C, Rushe M, Jarpe M, van Vlijmen H, Dolinski B, Qian F, Cachero TG, Cuervo H, Yanachkova M, Nwankwo C, Wang X, Etienne N, Garber E, Bailly V, de Fougerolles A, Boriack-Sjodin PA Protein Eng Des Sel. 2006 Jul;19(7):317-24. Epub 2006 May 8. PMID:16682434<ref>PMID:16682434</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2bdn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 24:
	*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]		*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]
	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]		*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Bailly, V]]	+	[[Category: Bailly V]]
-	[[Category: Boriack-Sjodin~~, P A~~]]	+	[[Category: Boriack-Sjodin PA]]
-	[[Category: Jarpe, M]]	+	[[Category: Jarpe M]]
-	[[Category: Reid, C]]	+	[[Category: Reid C]]
-	[[Category: Rushe, M]]	+	[[Category: Rushe M]]
-	[[Category: Vlijmen, H ~~van]]~~	+	[[Category: Van Vlijmen H]]
-	~~[[Category: Antibody-antigen complex]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 13:37, 13 October 2021

2021-10-13T13:37:21Z

←Older revision		Revision as of 13:37, 13 October 2021
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	<StructureSection load='2bdn' size='340' side='right'caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>		<StructureSection load='2bdn' size='340' side='right'caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BDN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [~~http~~://pdbe.org/2bdn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bdn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdn ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [https://pdbe.org/2bdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [https://www.ebi.ac.uk/pdbsum/2bdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.	+	[[https://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]		*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]
-	*[[~~User:Coline Perrin/CCL2~~\|~~User:Coline Perrin/CCL2~~]]	+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:10, 11 December 2019

2019-12-11T19:10:31Z

←Older revision		Revision as of 19:10, 11 December 2019
Line 1:		Line 1:

	==Crystal structure of human MCP-1 bound to a blocking antibody, 11K2==		==Crystal structure of human MCP-1 bound to a blocking antibody, 11K2==
-	<StructureSection load='2bdn' size='340' side='right' caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>	+	<StructureSection load='2bdn' size='340' side='right'caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BDN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BDN FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Monocyte chemoattractant protein\|Monocyte chemoattractant protein]]
	*[[User:Coline Perrin/CCL2\|User:Coline Perrin/CCL2]]		*[[User:Coline Perrin/CCL2\|User:Coline Perrin/CCL2]]
	== References ==		== References ==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Bailly, V]]		[[Category: Bailly, V]]

OCA at 18:44, 24 January 2018

2018-01-24T18:44:21Z

←Older revision		Revision as of 18:44, 24 January 2018
Line 1:		Line 1:
		+
	==Crystal structure of human MCP-1 bound to a blocking antibody, 11K2==		==Crystal structure of human MCP-1 bound to a blocking antibody, 11K2==
	<StructureSection load='2bdn' size='340' side='right' caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>		<StructureSection load='2bdn' size='340' side='right' caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BDN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BDN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [http://pdbe.org/2bdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [http://www.ebi.ac.uk/pdbsum/2bdn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [http://pdbe.org/2bdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [http://www.ebi.ac.uk/pdbsum/2bdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bdn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bdn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bdn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:

	==See Also==		==See Also==
-	*[[~~Antibody~~\|~~Antibody~~]]	+	*[[User:Coline Perrin/CCL2\|User:Coline Perrin/CCL2]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 40:
	[[Category: Reid, C]]		[[Category: Reid, C]]
	[[Category: Rushe, M]]		[[Category: Rushe, M]]
-	[[Category: Vlijmen, ~~Hvan~~]]	+	[[Category: Vlijmen, H van]]
	[[Category: Antibody-antigen complex]]		[[Category: Antibody-antigen complex]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 16:36, 11 September 2015

2015-09-11T16:36:43Z

←Older revision		Revision as of 16:36, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2bdn' size='340' side='right' caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>		<StructureSection load='2bdn' size='340' side='right' caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BDN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BDN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [http://www.ebi.ac.uk/pdbsum/2bdn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [http://pdbe.org/2bdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [http://www.ebi.ac.uk/pdbsum/2bdn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bdn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Bailly, V]]		[[Category: Bailly, V]]
	[[Category: Boriack-Sjodin, P A]]		[[Category: Boriack-Sjodin, P A]]

OCA at 19:05, 25 December 2014

2014-12-25T19:05:45Z

←Older revision		Revision as of 19:05, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BDN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BDN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [http://www.ebi.ac.uk/pdbsum/2bdn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [http://www.ebi.ac.uk/pdbsum/2bdn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Bailly, V.]]	+	[[Category: Bailly, V]]
-	[[Category: Boriack-Sjodin, P A.]]	+	[[Category: Boriack-Sjodin, P A]]
	[[Category: Jarpe, M]]		[[Category: Jarpe, M]]
-	[[Category: Reid, C.]]	+	[[Category: Reid, C]]
-	[[Category: Rushe, M.]]	+	[[Category: Rushe, M]]
-	[[Category: Vlijmen, Hvan.]]	+	[[Category: Vlijmen, Hvan]]
	[[Category: Antibody-antigen complex]]		[[Category: Antibody-antigen complex]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 23:52, 29 September 2014

2014-09-29T23:52:52Z

←Older revision		Revision as of 23:52, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2bdn.~~png\|left~~\|200px]]	+	==Crystal structure of human MCP-1 bound to a blocking antibody, 11K2==
		+	<StructureSection load='2bdn' size='340' side='right' caption='[[2bdn]], [[Resolution\|resolution]] 2.53Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BDN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [http://www.ebi.ac.uk/pdbsum/2bdn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bdn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Monocyte chemoattractant proteins (MCPs) are cytokines that direct immune cells bearing appropriate receptors to sites of inflammation or injury and are therefore attractive therapeutic targets for inhibitory molecules. 11K2 is a blocking mouse monoclonal antibody active against several human and murine MCPs. A 2.5 A structure of the Fab fragment of this antibody in complex with human MCP-1 has been solved. The Fab blocks CCR2 receptor binding to MCP-1 through an adjacent but distinct binding site. The orientation of the Fab indicates that a single MCP-1 dimer will bind two 11K2 antibodies. Several key residues on the antibody and on human MCPs were predicted to be involved in antibody selectivity. Mutational analysis of these residues confirms their involvement in the antibody-chemokine interaction. In addition to mutations that decreased or disrupted binding, one antibody mutation resulted in a 70-fold increase in affinity for human MCP-2. A key residue missing in human MCP-3, a chemokine not recognized by the antibody, was identified and engineering the preferred residue into the chemokine conferred binding to the antibody.

-	~~{{STRUCTURE_2bdn\| PDB=2bdn \| SCENE= }}~~	+	Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody.,Reid C, Rushe M, Jarpe M, van Vlijmen H, Dolinski B, Qian F, Cachero TG, Cuervo H, Yanachkova M, Nwankwo C, Wang X, Etienne N, Garber E, Bailly V, de Fougerolles A, Boriack-Sjodin PA Protein Eng Des Sel. 2006 Jul;19(7):317-24. Epub 2006 May 8. PMID:16682434<ref>PMID:16682434</ref>

-	~~===Crystal structure of human MCP-1 bound to a blocking antibody~~, ~~11K2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16682434}}~~	+	==See Also==
-		+	*[[Antibody\|Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2bdn~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016682434<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Bailly, V.]]		[[Category: Bailly, V.]]

OCA: Protected "2bdn" [edit=sysop:move=sysop]

2013-01-06T09:21:37Z

Protected "2bdn" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:21, 6 January 2013

OCA at 09:21, 6 January 2013

2013-01-06T09:21:33Z

←Older revision		Revision as of 09:21, 6 January 2013
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-	{{Seed}}
	[[Image:2bdn.png\|left\|200px]]		[[Image:2bdn.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2bdn\| PDB=2bdn \| SCENE= }}		{{STRUCTURE_2bdn\| PDB=2bdn \| SCENE= }}

	===Crystal structure of human MCP-1 bound to a blocking antibody, 11K2===		===Crystal structure of human MCP-1 bound to a blocking antibody, 11K2===

-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 16682434 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16682434}}		{{ABSTRACT_PUBMED_16682434}}

	==About this Structure==		==About this Structure==
-	~~2BDN~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA].	+	[[2bdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16682434~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016682434</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Bailly, V.]]		[[Category: Bailly, V.]]
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	[[Category: Vlijmen, Hvan.]]		[[Category: Vlijmen, Hvan.]]
	[[Category: Antibody-antigen complex]]		[[Category: Antibody-antigen complex]]
-		+	[[Category: Immune system]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 03:57:00 2009''~~	+

OCA at 01:57, 18 February 2009

2009-02-18T01:57:02Z

←Older revision		Revision as of 01:57, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2BDN is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA].	+	2BDN is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA].

	==Reference==		==Reference==
-	Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody., Reid C, Rushe M, Jarpe M, van Vlijmen H, Dolinski B, Qian F, Cachero TG, Cuervo H, Yanachkova M, Nwankwo C, Wang X, Etienne N, Garber E, Bailly V, de Fougerolles A, Boriack-Sjodin PA, Protein Eng Des Sel. 2006 Jul;19(7):317-24. Epub 2006 May 8. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16682434 16682434]~~	+	<ref group="xtra">PMID:16682434</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Bailly, V.]]		[[Category: Bailly, V.]]
	[[Category: Boriack-Sjodin, P A.]]		[[Category: Boriack-Sjodin, P A.]]
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	[[Category: Antibody-antigen complex]]		[[Category: Antibody-antigen complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 10~~:07:~~15 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:57:00 2009''